Abstracts Archive - Page 1238 of 2425 - ACR Meeting Abstracts

Abstract Number: 487 • 2017 ACR/ARHP Annual Meeting
ARE ANTI-Citrullinated Protein Antibody Levels Associated with Periodontal Disease in Rheumatoid Arthritis?
Jerián González Febles¹, Fernando Sánchez-Alonso², Jorge Luis Garnier Rodríguez³, Mariano Sanz Alonso¹, Federico Díaz-González⁴ and Beatriz Rodriguez Lozano^5,6, ¹Periodontology, Universidad Complutense de Madrid, Madrid, Spain, ²Unidad de Investigación, Spanish Society of Rheumatology, Madrid, Spain, ³Odontology, Dental Clinic Garnier, S/C Tenerife, Spain, ⁴Servicio de Reumatología. Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, ⁵Rheumatology, Rheumatology Department. Hospital Universitario de Canarias, S/C TENERIFE, Spain, ⁶Rheumatology, Hospital de Canarias, S/C Tenerife, Spain
Background/Purpose: Positivity of anti-citrullinated peptides antibodies (ACPA) indicates severity in Rheumatoid Arthritis (RA). There is evidence for chronic periodontitis (PD) in RA autoimmune response by…
Abstract Number: 488 • 2017 ACR/ARHP Annual Meeting
Increased Expression of TNF-α and PAD-2 in Human Monocytes Following Treatment with Protein Modified with Malondialdehyde-Acetaldehyde (MAA) and Citrulline
Logan M. Duryee¹, Michael J. Duryee², Dahn L Clemens¹, Evan M. Ryan¹, Carlos D. Hunter², Lynell W. Klassen³, James R. O'Dell³, Daniel R. Anderson¹, Ted R. Mikuls⁴ and Geoffrey M. Thiele¹, ¹University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁴Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: We have previously shown that malondialdehyde-acetaldehyde (MAA) and citrullinated proteins are present together in the synovial tissues of rheumatoid arthritis (RA) patients. Macrophage are…
Abstract Number: 489 • 2017 ACR/ARHP Annual Meeting
Endotypic Clustering of Rheumatoid Arthritis Patients through the Use of Tissue Specific Serum Biomarkers Identifies Structural Progressors
Joseph Patrick Michele Blair¹, Cecilie Liv Bager¹, Line Mærsk Staunstrup¹, Henning Bay Nielsen¹, Morten Karsdal² and Anne-C. Bay-Jensen³, ¹ProScion, Herlev, Denmark, ²Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, ³Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Treatment of RA patients is guided by measures of disease activity such as DAS28, best practice recommendation, and less often by a treat-to-target approach.…
Abstract Number: 490 • 2017 ACR/ARHP Annual Meeting
Clinical and Biomarker Factors in the Prediction of Future Inflammatory Arthritis in ACPA Positive Subjects without Inflammatory Arthritis at Baseline
John P. Gerstenberger¹, Colin I. O'Donnell², Sarah L. Dill³, Randall Tagg⁴, Masoud Asadi-Zeydabadi⁴, M. Kristen Demoruelle⁵, V. Michael Holers⁶ and Kevin D. Deane⁷, ¹Department of Medicine, University of Colorado Denver School of Medicine, Aurora, CO, ²University of Colorado Denver School of Medicine, Aurora, CO, ³Division of Rheumatology, University of Colorado Denver School of Medicine, Aurora, CO, ⁴Department of Physics, University of Colorado Denver, Denver, CO, ⁵1775 Aurora Ct, 1775 Aurora Ct, Aurora, CO, ⁶Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁷Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Antibodies to citrullinated protein antigens (ACPA) can identify individuals who may develop future inflammatory arthritis (IA) and classifiable rheumatoid arthritis (RA). Indeed, there are…
Abstract Number: 491 • 2017 ACR/ARHP Annual Meeting
Streptococcus Species Enriched in the Oral Cavity of RA Patients: A Persistent Source of Peptidoglycan-Polysaccharide Polymers Which Drive Disseminated Synovial Inflammation
Rabia Moentadj¹, Linda Rehaume², Paraic O Cuiv³, Kate Ormerod⁴, Muralidhara Maradana³, Vanessa Anne Lakis³, Mark Morrison², Philip Hugenholtz⁴, Helen Benham⁵, Kim-Anh Lê Cao⁶ and Ranjeny Thomas¹, ¹University of Queensland Diamantina Institute, Brisbane, Australia, ²The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, ³The University of Queensland Diamantina Institute, Brisbane, Australia, ⁴Australian Centre for Ecogenomics, The University of Queensland, Brisbane, Australia, ⁵The University of Queensland Faculty of Medicine, Brisbane, Australia, ⁶School of Mathematics and Statistics, Centre for Systems Genomics, The University of Melbourne, Melbourne, Australia
Background/Purpose: In Rheumatoid Arthritis (RA), genetic predisposition and environmental risk factors promote dysbiosis of oral and fecal microbiota. We hypothesized that specific microbial taxa (operational…
Abstract Number: 492 • 2017 ACR/ARHP Annual Meeting
Is Leukotoxin_A Produced By Aggregatibacter Actynomycetemcomitans Important for Initiating Autoimmune Responses Underlying Rheumatoid Arthritis?
Mikhail Volkov¹, Jacqueline Dekkers¹, Bruno G. Loos², Sergio Bizzarro², Tom W.J. Huizinga³, Helle A. Praetorius⁴, Rene E.M. Toes⁵ and Diane van der Woude¹, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit, Amsterdam, Netherlands, ³Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands, ⁴Department of Biomedicine, Aarhus University, Aarhus, Denmark, ⁵Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: In a recent publication in Science Translational Medicine, Konig et al. (2016) describe a potential explanation for the link between periodontal infection and RA.…
Abstract Number: 493 • 2017 ACR/ARHP Annual Meeting
Methotrexate Is an Antibacterial Drug Metabolized By Human Gut Bacteria
Renuka R. Nayak¹, Kye Stapleton-Gray², Colleen O'Loughlin³, Michael Fischbach⁴ and Peter J. Turnbaugh⁵, ¹Department of Medicine, Division of Rheumatology, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ²Carnegie Mellon University, Pittsburgh, PA, ³University of California, San Francisco, San Francisco, CA, ⁴Department of Bioengineering and Therapeutic Sciences,, University of California, San Francisco, San Francisco, CA, ⁵Microbiology and Immunology, University of California, San Francisco, San Francisco, CA
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology causing inflammation and irreversible damage in joints and other organs. Methotrexate (MTX) is first-line…
Abstract Number: 494 • 2017 ACR/ARHP Annual Meeting
The Oral Microbiome Is Altered in Patients with Rheumatoid Arthritis
Sheila Arvikar¹, Hatice Hasturk², Klemen Strle³, Daniel Nguyen⁴, Marcy B. Bolster⁵, Deborah Collier⁶, Alpdogan Kantarci² and Allen Steere¹, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ²Department of Applied Oral Health Sciences, Forsyth, Cambridge, MA, ³Department of Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ⁴Forsyth, Cambridge, MA, ⁵Rheumatology, Allergy and Immunology, Endocrine Associates, Massachusetts General Hospital, Boston, MA, ⁶Rheumatology, Massachusetts General Hospital, Boston, MA
Background/Purpose: The mouth is the second most abundantly colonized mucosal surface in the human body. Periodontitis, a polymicrobial infectious and inflammatory disease of tooth-supporting structures,…
Abstract Number: 495 • 2017 ACR/ARHP Annual Meeting
Efficacy of Tofacitinib in Patients with Moderate to Severe Rheumatoid Arthritis By Baseline C-Reactive Protein Levels and Erythrocyte Sedimentation Rates
Sergio Schwartzman¹, Ronald F van Vollenhoven², Alan K Matsumoto³, Dana Orange⁴, Shweta Shah⁵, Ryan DeMasi⁵, Haiyun Fan⁵, Palle Dahl⁶, Ann Wouters⁷ and Edward C. Keystone⁸, ¹Hospital for Special Surgery, New York, NY, ²Karolinska Institute, Stockholm, Sweden, ³Arthritis & Rheumatism Associates, Wheaton, MD, ⁴Rockefeller University; Hospital for Special Surgery; and New York Genome Center, New York, NY, ⁵Pfizer Inc, Collegeville, PA, ⁶Pfizer Inc, Ballerup, Denmark, ⁷Pfizer Inc, New York, NY, ⁸University of Toronto, Toronto, ON, Canada
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. This post-hoc analysis investigated the impact of inflammation severity at baseline (BL)…
Abstract Number: 496 • 2017 ACR/ARHP Annual Meeting
Repeated Rituximab Infusions for the Therapy of Rheumatoid Arthritis Is Not Associated with Increased Rates of Serious Infections
Dimitrios A. Pappas^1,2, George W. Reed^1,3, Steve Zlotnick⁴, Jennie Best⁴, Robert Magner³, Gioia Persuitte¹ and Jeffrey D Greenberg^1,5, ¹Corrona, LLC, Southborough, MA, ²Department of Medicine, Division of Rheumatology, Columbia University, College of Physicians and Surgeons, New York, NY, ³University of Massachusetts Medical School, Worcester, MA, ⁴Genentech, Inc., South San Francisco, CA, ⁵NYU School of Medicine, New York, NY
Background/Purpose: Extended observations in clinical trials have not demonstrated an increased risk of serious infection events (SIE) in patients with rheumatoid arthritis (RA) treated with…
Abstract Number: 497 • 2017 ACR/ARHP Annual Meeting
The JAK1 Selective Inhibitor Filgotinib Regulates Both Enthesis and Colon Inflammation in a Mouse Model of Psoriatic Arthritis
Catherine Robin-Jagerschmidt¹, Stéphanie Lavazais¹, Florence Marsais¹, Maté Ongenaert², Alain Monjardet¹, Angélina Cauvin¹, Corinne Saccomani¹, Isabelle Parent¹, Didier Merciris¹, Emilie Chanudet¹, Roland Blanqué¹, Monica Borgonovi¹, Liên Lepescheux¹, Marielle Auberval¹, Sonia Dupont¹, Philippe Clément-Lacroix¹ and René Galien¹, ¹Galapagos SASU, Romainville, France, ²Galapagos NV, Mechelen, Belgium
Background/Purpose: Because of their pleotropic role in cytokine signaling, Janus Kinases (JAKs) are key players in inflammatory diseases. Among the 4 members of the JAK…
Abstract Number: 498 • 2017 ACR/ARHP Annual Meeting
Response to Abatacept of Different Patterns of Interstitial Lung Disease in Rheumatoid Arthritis. Multicenter Study of 63 Patients
Carlos Fernández-Díaz¹, Santos Castañeda², Clara Ojeda-Garcia³, Alejandro Olivé⁴, Patricia Carreira⁵, Trinidad Perez Sandoval⁶, Miriam Retuerto Guerrero⁷, Evelin Cecilia Cervantes Pérez⁸, Samantha Rodriguez⁹, Bryan Josue Robles Flores¹⁰, Blanca Hernández-Cruz¹¹, Ana Urruticoechea-Arana¹², Olga Maiz¹³, Desiree Palma¹⁴, Luis Arboleya¹⁵, Gema Bonilla¹⁶, Manuel Rodríguez-Gómez¹⁷, Concepción Delgado¹⁸, Rosa Expósito¹⁹, Ana Ruibal Escribano²⁰, Juan Blanco Madrigal²¹, José Antonio Bernal²², Paloma Vela²³, Belen Alvarez-Rodriguez²⁴, María Concepción Fito Manteca²⁵, Javier Narváez²⁶, Manuel Jose Moreno²⁷, Mireia López-Corbeto²⁸, Natalia Mena-Vazquez²⁹, S. Romero-Yuste³⁰, Clara Aguilera-Cros³¹, Sergi Ordoñez³², Ignacio Villa-Blanco³³, Nuria Vegas-Revenga¹, Victor Mora-Cuesta³⁴, Javier Loricera¹, Miguel Angel González-Gay¹, José Luis Hernandez³⁵ and Ricardo Blanco¹, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ²Hospital Universitario de La Princesa, Madrid. Spain, Madrid, Spain, ³Rheumatology, Hospital Virgen de la Macarena, Sevilla, Spain, ⁴Rheumatology, Hospital Germans Trias i Pujol, Badalona, Spain, ⁵Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ⁶Rheumatology, Hospital de León, LEÓN, Spain, ⁷Rheumatology, Hospital de León, Leon, Spain, ⁸Rheumatology, Hospital Santiago de Compostela, Santiago de Compostela, Spain, ⁹H. German Trias., Barcelona, Spain, ¹⁰Rheumatology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain, ¹¹Rheumatology, Hospital Universitario Virgen Macarena, Sevilla, Spain, ¹²Rheumatology Department. Hospital Can Misses, IBIZA, Spain, ¹³Hospital Donostia. Spain, San Sebastian, Spain, ¹⁴Rheumatology, Rafael Mendez Hospital, Spain., Lorca (Murcia), Spain, ¹⁵Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain, ¹⁶Hospital Universitario La Paz, Madrid, Spain, ¹⁷Complejo Hospitalario Universitario de Ourense, Ourense, Spain, ¹⁸H. Clínico Universitario Lozano Blesa, Zaragoza, Spain, ¹⁹Rheumatology, Hospital Comarcal de Laredo. Spain, Laredo, Spain, ²⁰Rheumatology, Hospital Universitario de Araba, Vittoria, Spain, ²¹Rheumatology, Hospital de Basurto, BIlbao, Spain, ²²Reumatología, Hospital Universitario del Vinalopó, Elche, Spain, ²³Reumatología, Hospital General Universitario de Alicante. Alicante. Spain, Alicante, Spain, ²⁴Hospital Txagorritxu, Vittoria, Spain, ²⁵Reumatología, Hospital de Navarra, Pamplona, Spain, ²⁶Rheumatology Department, Hospital de Bellvitge. Barcelona. Spain, L’Hospitalet de Llobregat, Spain, ²⁷Rheumatology, Hospital Virgen de la Arrixaca, MURCIA, Spain, ²⁸Hospital Universitario Vall d´Hebron, Barcelona, Spain, ²⁹Rheumatology, Hospital Universitario de Malaga, Malaga, Spain, ³⁰H. Pontevedra, Pontevedra, Spain, ³¹Rheumatology, Hospital Virgen del Rocio, Sevilla, Spain, ³²Hospital Universitario Arnau de Vilanova, Vilanova, Spain, ³³Hospital de Sierrallana, Sierrallana, Spain, ³⁴Neumology, Hospital Universitario Marqués de Valdecilla, IDIVAL,, Santander, Spain, ³⁵Division of Internal Medicine., Hospital Universitario Marqués de Valdecilla, IDIVAL,, Santander, Spain
Background/Purpose: Disease modifying antirheumatic drugs (DMARD) such as methotrexate (MTX), ) or antiTNFα have been implicated in exacerbation of Interstitial lung disease (ILD)of rheumatoid arthritis…
Abstract Number: 499 • 2017 ACR/ARHP Annual Meeting
Assessment of Early Improvement in Pain and Other ACR Components As Predictors for Achieving Low Disease Activity or Remission in Three Phase 3 Trials of RA Patients Treated with Baricitinib
Michael Weinblatt¹, Mark C. Genovese², Joel Kremer³, Luna Sun⁴, Himanshu Patel⁴, Alisa Koch⁴, David Muram⁴, Jeffrey R. Curtis⁵, Cynthia J. Larmore⁴ and Baojin Zhu⁴, ¹Brigham and Women’s Hospital, Boston, MA, ²Stanford University Medical Center, Palo Alto, CA, ³The Center for Rheumatology, Albany Medical College, Albany, NY, ⁴Eli Lilly and Company, Indianapolis, IN, ⁵University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The purpose of this analysis was to assess whether early improvement in ACR components could act as predictors of low disease activity (LDA)…
Abstract Number: 500 • 2017 ACR/ARHP Annual Meeting
Low Patient Global Assessment Scores in Rheumatoid Arthritis Are Associated with Pain and Physical Function in Patients Treated with Tofacitinib: A Post-Hoc Analysis of Phase 3 Trials
Vibeke Strand¹, Rieke Alten², Jeffrey Kaine³, Arif Soonasra⁴, Christopher W Murray⁴, Haiyun Fan⁴, Christopher F Mojcik⁵ and Gene Wallenstein⁶, ¹Stanford University, Palo Alto, CA, ²Schlosspark-Klinik, University Medicine Berlin, Berlin, Germany, ³Sarasota Arthritis Research Center, Sarasota, FL, ⁴Pfizer Inc, Collegeville, PA, ⁵Pfizer Inc, New York, NY, ⁶Pfizer Inc, Groton, CT
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We examined associations of pain and physical function with Patient…
Abstract Number: 501 • 2017 ACR/ARHP Annual Meeting
Patient-Reported Outcomes of Long-Term Upadacitinib Use in Patients with Rheumatoid Arthritis: Interim Analysis Results of a Phase 2, Open-Label Extension Study
Vibeke Strand¹, Namita Tundia² and Alan Friedman², ¹Stanford University, Palo Alto, CA, ²AbbVie Inc., North Chicago, IL
Background/Purpose: Janus kinase (JAK) inhibitors are being evaluated for treatment of active rheumatoid arthritis (RA). The efficacy of upadacitinib (UPA), a selective JAK inhibitor, in…

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