ACR Meeting Abstracts

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  • Abstract Number: 412 • 2017 ACR/ARHP Annual Meeting

    Baseline Values for Plantar Pressure and Background Characteristics As Indicators for the Limit of Conservative Treatment of Rheumatoid Forefoot Deformity

    Hyunho Lee1, Hajime Ishikawa1, Asami Abe1, Yumi Nomura1, Eriko Hasegawa1, Chinatsu Takai1, Daisuke Kobayashi1, Hiroshi Otani1, Satoshi Ito1, Takanobu Sumino2, Takao Ishii2, Shu Saito3, Yasuaki Tokuhashi4, Kiyoshi Nakazono1 and Akira Murasawa1, 1Department of Rheumatology, Niigata Rheumatic Center, Shibata, Japan, 2Department of Orthopaedic Surgery, Kawaguchi Municipal Medical Center, Kawaguchi, Japan, 3Department of Orthopaedic Surgery, Nihon University School of Medicine, Itabishi, Japan, 4Department of Orthopaedic Surgery, Nihon University School of Medicine, Itabiashi, Japan

    Background/Purpose: Forefoot deformities are commonly seen in patients with RA. It has been reported that nearly 90% of the patients have foot problems.1,2 Patients with…
  • Abstract Number: 413 • 2017 ACR/ARHP Annual Meeting

    Economic Burden Associated with Anti-Cyclic Citrullinated Peptide Antibody Positivity in Patients Newly Diagnosed with RA

    J An1, Z Bider2, J Kang1, E Alemao3, SE Connolly3 and TC Cheetham1, 1Western University of Health Sciences, Pomona, CA, 2Southern California Permanente Medical Group, Pasadena, CA, 3Bristol-Myers Squibb, Princeton, NJ

    Background/Purpose: Anti-cyclic citrullinated peptide (anti-CCP) antibody positivity has been suggested as a strong predictor of joint erosion as well as a potential biomarker for guiding…
  • Abstract Number: 414 • 2017 ACR/ARHP Annual Meeting

    Multi-Biomarker Disease Activity and Autoantibody Status Lead to Cost Effective Tapering Algorithms in Rheumatoid Arthritis Patients in Sustained Remission

    Melanie Hagen1, Matthias Englbrecht2, Judith Haschka3, Michaela Reiser4, Arnd Kleyer5, Axel J. Hueber6, Bernhard Manger7, Camille Figueiredo8, Jayme Fogagnolo Cobra9, Hans-Peter Tony10, Stefanie Finzel11, Stefan Kleinert12, Joerg Wendler13, Florian Schuch13, Monika Ronneberger13, Martin Feuchtenberger14, Martin Fleck15,16, Karin Manger17, Matthias Schmitt-Haendle18, H.-M. Lorenz19, HG Nüßlein20, Rieke Alten21, Joerg C. Henes22, Klaus Krüger23, Georg Schett2 and Juergen Rech24, 1University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, 3Medical Department II, St. Vincent Hospital, the VINFORCE Study Group, Academic Teaching Hospital of Medical University of Vienna, Vienna, Austria, Vienna, Austria, 4Department of Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 5Dept of Medicine 3, Rheumatology and Clinical Immunology, Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany, 6Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 7Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 8Institution de Rheumatologia, Sao Paolo, Brazil, 9Instituto de Reumatologia de Sao Paolo, Sao Paolo, Brazil, 10Rheumatology/Clinical Immunology, University of Würzburg, Würzburg, Germany, 11University of Freiburg, Freiburg, Germany, 12Rheumatologische Schwerpunktpraxis Erlangen, Erlangen, Germany, 13Schwerpunktpraxis Rheumatologie, Erlangen, Germany, 14Rheumatologie/Klinische Immunologie, Kreiskliniken Altötting-Burghausen, Burghausen, Germany, 15Department of Rheumatology and Clinical Immunology, Asklepios Medical Center Bad Abbach, Bad Abbach, Germany, 16Internal Medicine I, University Medical Center of Regensburg, Regensburg, Germany, 17Rheumatology Practice Bamberg, Bamberg, Germany, 18Rheumatology Practice, Bayreuth, Germany, Bayreuth, Germany, 19Rheumatology, University Heidelberg, Heidelberg, Germany, 20Rheumatology Practice Nuremberg, Nuremberg, Germany, 21Schlosspark-Klinik, University Medicine Berlin, Berlin, Germany, 22Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, 23Praxiszentrum St.Bonifatius, Munich, Germany, 24Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany

    Background/Purpose: Achieving remission is the ultimate treatment goal in patients with rheumatoid arthritis (RA). With the development and wider use of highly effective disease modifying…
  • Abstract Number: 415 • 2017 ACR/ARHP Annual Meeting

    Baricitinib Reduces GlycA Levels in Phase 2 and Phase 3 Clinical Trials in Patients with Moderate to Severe Rheumatoid Arthritis

    Joel Kremer1, Paul Emery2, Margery A. Connelly3, James D. Otvos4, Steven H. Zuckerman5, Giacomo Ruotolo5, Lei Chen5, Maher Issa5, William L. Macias5 and Iain B. McInnes6, 1Albany Medical College, Albany, NY, 2Leeds MSK Biomed/Chapel Allerton Hospital, Leeds, United Kingdom, 3Laboratory Corporation of America Holdings (LabCorp), Morrisvile, NC, 4Laboratory Corporation of America Holding (LabCorp), Morrisville, NC, 5Eli Lilly and Company, Indianapolis, IN, 6University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Baricitinib (bari) is an oral selective inhibitor of Janus kinase (JAK) 1/JAK2.1 In the European Union, bari is approved for the treatment of moderate…
  • Abstract Number: 416 • 2017 ACR/ARHP Annual Meeting

    The Impact of Therapy on Anti-Carbamylated Protein Antibody Isotypes and Serostatus in Patients with Early RA Treated with Abatacept and MTX

    LA Trouw1, SE Connolly2, A Johnsen2, J Ye2, MA Maldonado2, REM Toes1 and TWJ Huizinga1, 1Leiden University Medical Center, Leiden, Netherlands, 2Bristol-Myers Squibb, Princeton, NJ

    Background/Purpose: Maturation of autoantibody responses has been suggested to be a proxy for disease maturation. Autoantibody responses against post-translationally modified antigens are present in autoimmune…
  • Abstract Number: 417 • 2017 ACR/ARHP Annual Meeting

    Improvement in Overall Work Productivity Among Biologic-NaïVe Patients with Rheumatoid Arthritis Treated with Tocilizumab Subcutaneous Injection: A Prospective, Real World, Observational Study in Japan

    Yoshiya Tanaka1, Hideto Kameda2, Kazuyoshi Saito3, Yuko Kaneko4, Eiichi Tanaka5, Shinsuke Yasuda6, Naoto Tamura7, Keishi Fujio8, Takao Fujii9, Toshihisa Kojima10, Tatsuhiko Anzai11, Chikuma Hamada12, Yoshihisa Fujino13, Shinya Matsuda13 and Hitoshi Kohsaka14, 1The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, 2Division of Rheumatology, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan, 3Tobata General Hospital, Fukuoka, Japan, 4Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 5Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 6Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, 7Department of Internal Medicine and Rheumatology, Juntedo University School of Medicine, Tokyo, Japan, 8Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan, 9Department of Rheumatism and Collagen Disease, Wakayama Medical University, Wakayama, Japan, 10Nagoya Univ. Grad. Schl. of Med., Nagoya, Japan, 11Data Science Division, Statistics Analysis Department 1, EPS Corporation, Tokyo, Japan, 12Department of Information and Computer Technology, Tokyo University of Science, Tokyo, Japan, 13Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 14Department of Rheumatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

    Background/Purpose: This is the first study assessing the effect of subcutaneous tocilizumab (TCZ-SC) and/or conventional synthetic DMARDs (csDMARDs) on work productivity and activity impairment (WPAI)…
  • Abstract Number: 418 • 2017 ACR/ARHP Annual Meeting

    Exploratory Analysis  to Identify Factors Associated with Risk of Structural Progression, Defined As Change from Baseline

    Désirée van der Heijde1, Patrick Durez2, Georg Schett3, Esperanza Naredo4, Mikkel Østergaard5, Gabriella Meszaros6, Pedro Lopez-Romero7, Francesco de Leonardis6 and Roy Fleischmann8, 1Leiden University Medical Center, Leiden, Netherlands, 2UCL-Saint Luc, Bruxelles, Belgium, 3Department of Internal Medicine III, Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, 4Hospital Universitario Fundación Jimenez Diaz, Madrid, Spain, 5Glostrup Hospital, Rigshospitalet, Glostrup, Denmark, 6Eli Lilly and Company, Indianapolis, IN, 7Europe Research Center, Eli Lilly and Company, Madrid, Spain, 8University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: Baricitinib (BARI), an oral inhibitor of Janus kinase (JAK)1 and JAK2, is being developed for the treatment of RA. RA-BEGIN (NCT01711359) was a phase…
  • Abstract Number: 419 • 2017 ACR/ARHP Annual Meeting

    Abatacept Initiation in Chilean Patients with Long Lasting Rheumatoid Arthritis. Hospital Padre Hurtado Experience

    Omar Valenzuela1, María Paz Poblete2, Claudia Mardones2, Sebastián Ibáñez1, Katherine Mogollones2, Francisco Silva1 and María José Villar2, 1Rheumatology department, Hospital Padre Hurtado, Santiago, Chile, 2Hospital Padre Hurtado, Santiago, Chile

    Background/Purpose: Since the year 2016 Rheumatoid Arthritis (RA) patients in the Chilean public health system can access biologic treatment if they have active disease refractory…
  • Abstract Number: 420 • 2017 ACR/ARHP Annual Meeting

    Machine Learning in Rheumatology: Development and Validation of a Predictive Model for Rheumatoid Arthritis Mortality Using Random Survival Forests

    Luis Rodriguez-Rodriguez1, José M Lezcano-Valverde2, Fernando Salazar3, Leticia León2, Esther Toledano4, Juan A Jover Jover5, Eduardo Soudah3, Benjamín Fernández-Gutiérrez5, Isidoro Gonzalez-Alvaro6 and Lydia A Alcazar1, 1Rheumatology Department and Heath Research Institute (IdISSC), Hospital Clinico San Carlos, Madrid, Spain, 2Rheumatology Department, Hospital Clínical San Carlos, and IdISSC, Madrid, Spain, 3International Centre for Numerical Methods in Engineering (CIMNE), Madrid, Spain, 4Rheumatology, Hospital Clínical San Carlos, Madrid, Spain, 5Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 6Rheumatology Department, Hospital Universitario la Princesa, IIS-Princesa, Madrid, Spain

    Background/Purpose: Rheumatoid arthritis (RA) is associated with increased mortality. Traditional survival techniques used to identify mortality risk factors, such as the Cox proportional hazards model…
  • Abstract Number: 421 • 2017 ACR/ARHP Annual Meeting

    Serum Calprotectin Is Not Predictive for Successful Dose Reduction or Discontinuation of TNF Inhibitors in RA Patients with Low Disease Activity

    Nathan den Broeder1, Lieke Tweehuysen1, Noortje van Herwaarden1, Thomas Vogl2, F.H.J. van den Hoogen1, Rogier Thurlings3 and Alfons A Den Broeder1, 1Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 2University of Muenster, Muenster, Germany, 3Rheumatology, Radboudumc, Nijmegen, Netherlands

    Background/Purpose: Dose reduction and discontinuation of TNF inhibitors (TNFi) have been shown feasible in a large proportion of RA patients with low disease activity.1 To…
  • Abstract Number: 422 • 2017 ACR/ARHP Annual Meeting

    No Added Predictive Value of Serum Calprotectin for Treatment Response to Adalimumab or Etanercept in RA Patients

    Lieke Tweehuysen1, Nathan den Broeder1, Leo .A.B. Joosten2, Thomas Vogl3, F.H.J. van den Hoogen4, Rogier Thurlings5 and Alfons A Den Broeder1, 1Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 2Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, 3University of Muenster, Muenster, Germany, 4Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, 5Rheumatology, Radboudumc, Nijmegen, Netherlands

    Background/Purpose: To date, no clinically useful baseline biomarkers have been found to predict response to TNF inhibitor (TNFi) treatment .1 Calprotectin was shown to be…
  • Abstract Number: 423 • 2017 ACR/ARHP Annual Meeting

    Refractory Pain in Spite of Inflammation Control after Start of Anti-TNF Therapy in RA: Observational Data from Southern Sweden

    Tor Olofsson1, Johan K Wallman2, Maria EC Schelin3, Anna Jöud4 and Jon Lampa5, 1Lund University, Department of Clinical Sciences Lund, Rheumatology, Lund, Sweden, Lund, Sweden, 2Department of Clincial Sciences Lund, Rheumatology, Lund University, Lund, Sweden, 3Lund University, Department of Clinical Sciences Lund, Oncology, Lund, Sweden, Lund, Sweden, 4Lund University, Department of Laboratory Medicine Lund, Division of Occupational and Environmental Medicine, Lund, Sweden, Lund, Sweden, 5Karolinska Institute, Department of Medicine, Rheumatology Unit, Stockholm, Sweden, Stockholm, Sweden

    Background/Purpose: Pain is a dominant and debilitating feature of RA, but while a lot of focus has been put on the occurrence and management of…
  • Abstract Number: 424 • 2017 ACR/ARHP Annual Meeting

    Re-Establishment of Efficacy of Tofacitinib, an Oral Janus Kinase Inhibitor, in Rheumatoid Arthritis Patients after Temporary Discontinuation

    Jeffrey Kaine1, John Tesser2, Ryan DeMasi3, Liza Takiya3, Lisy Wang4, Mark Snyder3, Haiyun Fan4 and Jürgen Wollenhaupt5, 1Sarasota Arthritis Research Center, Sarasota, FL, 2Arizona Arthritis & Rheumatology Associates, Glendale, AZ, 3Pfizer Inc, Collegeville, PA, 4Pfizer Inc, Groton, CT, 5Schön-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We assessed tofacitinib efficacy and safety after temporary discontinuation and…
  • Abstract Number: 425 • 2017 ACR/ARHP Annual Meeting

    Efficacy of Monotherapy of the Biologic Dmards in Patients with Rheumatoid Arthritis: Real Life Data from the Hong Kong Biologics Registry

    Chi Chiu Mok, Ting Hung Wan and Lai Shan Fong, Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong

    Background/Purpose: To report the prevalence and efficacy of biologic DMARD (bDMARD) monotherapy in real life treatment of rheumatoid arthritis (RA). Methods: RA patients registered in…
  • Abstract Number: 426 • 2017 ACR/ARHP Annual Meeting

    Serum Levels of the Anti-TNF Biologics Correlate with Clinical Efficacy in Patients with Inflammatory Arthritis

    Chi Chiu Mok1, Lai Shan Fong1, Ling Yin Ho2 and Chi Hung To3, 1Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, 2Dept of Medicine, Tuen Mun Hospital, Hong Kong SAR, Hong Kong, 3Medicine, Pok Oi Hospital, Hong Kong, Hong Kong

    Background/Purpose: To study the correlation between levels of the anti-TNF biologics and clinical efficacy in patients with inflammatory arthritis Methods: Adult patients who fulfilled the…
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