Abstracts Archive - Page 1230 of 2425 - ACR Meeting Abstracts

Abstract Number: 367 • 2017 ACR/ARHP Annual Meeting
Interleukin-1 Receptor Antagonist Is a Potential Treatment for Undifferentiated Autoinflammatory Syndromes
Ananta Subedi¹, Daniella Schwartz², Karyl Barron³, Daniel L. Kastner⁴ and Amanda Ombrello⁵, ¹National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD, ²NIAMS - Rheumatology, National Institutes of Health, Bethesda, MD, ³National Institutes of Health, Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, ⁴Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ⁵Inflammatory Disease Section, NHGRI/NIH, Bethesda, MD
Background/Purpose: The autoinflammatory diseases (AIDs) are a group of disorders of the innate immune system characterized by seemingly unprovoked inflammation1. A variety of genetic alterations…
Abstract Number: 368 • 2017 ACR/ARHP Annual Meeting
Evaluation of Efficacy and Safety of Opocalcium Colchicine, and Anti-IL1 Treatment in Childhood Colchicine-Resistant Familial Mediterranean Fever
Kenan Barut, Amra Adrovic, Sezgin Sahin, Asli Kaplan and Ozgur Kasapcopur, Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey
Background/Purpose: The colchicine-resistant FMF (crFMF) is defined as 6 or more polyserositis attacks in the last year despite the regular usage of colchicine in the…
Abstract Number: 369 • 2017 ACR/ARHP Annual Meeting
Hepatitis A Virus Vaccination in Juvenile-Onset Systemic Lupus Erythematosus
Sevinc Mertoglu¹, Sezgin Sahin¹, Omer Faruk Beser², Amra Adrovic¹, Kenan Barut¹, Pelin Yuksel³, Soner Sazak⁴, Bekir Kocazeybek⁵ and Ozgur Kasapcopur¹, ¹Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey, ²Pediatric Gastroenterology, Department of Pediatrics, Okmeydani Education and Training Hospital, Istanbul, Turkey, ³Microbiology, Istanbul University, Cerrahpasa Medical School, Department of Microbiology, Istanbul, Turkey, ⁴Pediatrics, Department of Pediatrics, Okmeydani Education and Training Hospital, Istanbul, Turkey, ⁵Istanbul University, Cerrahpasa Medical School, Department of Microbiology, Istanbul, Turkey
Background/Purpose: Various infections play significant roles in flares of systemic lupus erythematosus (SLE). Hepatitis A virus is one of these infectious agents that has high…
Abstract Number: 370 • 2017 ACR/ARHP Annual Meeting
Validation of 2016 ACR/EULAR Classification Criteria of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis in Japanese Patients
Masaki Shimizu¹, Mao Mizuta¹, Takahiro Yasumi², Naomi Iwata³, Yuka Okura⁴, Noriko Kinjo⁵, Hiroaki Umebayashi⁶, Tomohiro Kubota⁷, Yasuo Nakagishi⁸, Kenichi Nishimura⁹, Masato Yashiro¹⁰, Junko Yasumura¹¹, Kazuko Yamazaki¹², Hiroyuki Wakiguchi¹³, Nami Okamoto¹⁴ and Masaaki Mori¹⁵, ¹Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan, ²Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Department of Immunology and Infectious Diseases, Aichi Children’s Health and Medical Center, Obu, Japan, ⁴Department of Pediatrics, KKR Sapporo Medical Center, Sapporo, Japan, ⁵Department of Pediatrics, Faculty of medicine, University of the Ryukyus, Nakagami-gun, Japan, ⁶Department of Rheumatics, Miyagi Children’s Hospital, Sendai, Japan, ⁷Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, Kagoshima, Japan, ⁸Department of Pediatric Rheumatology, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan, ⁹Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ¹⁰Department of Pediatrics, Okayama University Hospital, Okayama, Japan, ¹¹Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan, ¹²Department of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan, ¹³Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Japan, ¹⁴Department of Pediatrics, Osaka Medical College, Takatsuki, Japan, ¹⁵Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Background/Purpose: To validate the 2016 ACR/EULAR classification criteria of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (s-JIA) in Japanese patients. Methods: A combination…
Abstract Number: 371 • 2017 ACR/ARHP Annual Meeting
Longer Term Outcomes of Chronic Relapsing Multifocal Osteomyelitis in a UK Tertiary Adolescent and Young Adult Rheumatology Centre
Kristina E.N. Clark¹, Francesca Josephs², Nicola Daly³, Claire Louise Murphy³ and Debajit Sen⁴, ¹Rheumatology, University college London Hospitals, London, United Kingdom, ²rhuematology, UCL, London, United Kingdom, ³Rheumatology, University College London Hospital, London, United Kingdom, ⁴Adolescent Rheumatology Department, University College London Hospital NHS Trust, London, United Kingdom
Background/Purpose: Chronic relapsing multifocal osteomyelitis (CRMO) is a rare autoinflammatory bone condition presenting primarily in children & adolescents. It characteristically affects the epiphysis & metaphysis…
Abstract Number: 372 • 2017 ACR/ARHP Annual Meeting
Phenotype of Chronic Recurrent Multifocal Osteomyelitis in a Tertiary Referral Centre: The Great Ormond Street Hospital Experience
Kulsoom Riaz¹ and Sandrine Lacassagne², ¹Paediatric Rheumatology/Gastroenterology, Great Ormond Street Hospital, London, United Kingdom, ²Paediatric Rheumatology, Great Ormond Street Hospital, London, United Kingdom
Background/Purpose: Recurrent Multifocal Osteomyelitis (CRMO) is an aseptic inflammatory bone disease that typically affects the metaphases of the long bones. It affects children, adolescents and…
Abstract Number: 373 • 2017 ACR/ARHP Annual Meeting
a Retrospective Study of Clinical Factors Influencing the Development of Overlapping Disease Features in Pediatric Patients with Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Spondyloarthropathies (SpA)
Lillian Lim¹, Jyoti Panwar², Jennifer Stimec³, Shirley M.L. Tse⁴, Brian M. Feldman⁵ and Ronald M. Laxer⁶, ¹Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada, ²Christian Medical College, Vellore, India, Vellore, India, ³The Hospital for Sick Children, Toronto, ON, Canada, ⁴Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ⁵Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁶Div of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Some studies have suggested that chronic recurrent multifocal osteomyelitis (CRMO) and spondyloarthropathies (SpA) fall on a spectrum of disease, as they have been noted…
Abstract Number: 374 • 2017 ACR/ARHP Annual Meeting
A Pilot Study of Infrared Thermal Imaging to Detect Active Bone Lesions in Children with Chronic Nonbacterial Osteomyelitis
Yongdong Zhao¹, Ramesh Iyer², Lucas Reichley¹, Assaf Oron³, Averi Kitsch⁴, Seth Friedman⁵, Savannah Partridge⁴ and Carol A Wallace¹, ¹University of Washington, Department of Pediatrics, Seattle, WA, ²Division of Radiology, University of Washington, Seattle Children’s Hospital, Seattle, WA, ³Center for Clinical and Translational Research, Seattle Children’s Research Institute, Seattle, WA, ⁴Department of Radiology, University of Washington, Seattle, WA, ⁵Division of Radiology, University of Washington, Seattle Children's Hospital, Seattle, WA
Background/Purpose: Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease. For detection of active bone lesions, bone scintigraphy and magnetic resonance imaging (MRI) are much…
Abstract Number: 375 • 2017 ACR/ARHP Annual Meeting
Controlled Discontinuation of Colchicine Therapy in Familial Mediterranean Fever Patients with Single MEFV Mutation
Yonatan Butbul Aviel¹, Shafe Fahoum² and Riva Brik³, ¹Department of Pediatrics B Pediatric Rheumatology Service, Ruth Rappaport Children's Hospital, Rambam Medical Center, Haifa, Israel, Haifa, Israel, ²Department of Pediatrics B,, , Ruth Children's Hospital, Rambam Medical Center, Haifa, Israel, Pediatric Rheumatology Service, .Rappaport Faculty of Medicine, Technion-lsrael Institute of Technology, Haifa, Israel, ³Pediatrics, Rambam Medical Center, Haifa, Israel
Background/Purpose: Familial Mediterranean fever (FMF) traditionally has been considered an autosomal recessive disease; however, the diagnosis remains predominantly clinical, since mutations cannot always be identified…
Abstract Number: 376 • 2017 ACR/ARHP Annual Meeting
Improvement of Disease Activity in Patients with Colchicine-Resistant FMF, Hids/Mkd and TRAPS Assessed By Autoinflammatory Disease Activity Index (AIDAI): Results from a Randomized Phase III Trial
Isabelle Koné-Paut¹, Michaël Hofer², Susanne Benseler³, Jasmin B. Kuemmerle-Deschner⁴, Annette Jansson⁵, Itzhak Rosner⁶, Raffaele Manna⁷, Sara Murias⁸, Omer Karadag⁹, Lori Tucker¹⁰, Ilonka Orban¹¹, Vincent Tormey¹², Maria Alessio¹³, Huri Ozdogan¹⁴ and Fabrizio De Benedetti¹⁵, ¹Bicêtre Hospital, APHP, Univeristy Paris Sud, Paris, France, ²Unité romande d’immuno-rhumatologie pédiatrique, CHUV, University of Lausanne, Genova, Italy, ³Alberta Children's Hospital, Calgary, AB, Canada, ⁴University Hospital Tuebingen, Tuebingen, Germany, ⁵Ludwig Maximilian University, Munich, Germany, ⁶Bnai-Zion Medical Center, Haifa, Israel, ⁷Department of Internal Medicine, Università Cattolica Sacro Cuore, Rome, Italy, ⁸Hospital Infantil La Paz, Madrid, Spain, ⁹Hacettepe University Faculty of Medicine, Ankara, Turkey, ¹⁰BC Children's Hospital, Vancouver, BC, Canada, ¹¹Orszagos Reumatologial es Fizioterepias, Budapest, Hungary, ¹²University College Hospital Galway, Galway, Ireland, ¹³A Osped-Universit Policlinico Federico II, Univ degli Studi di Napoli, Napoli, Italy, ¹⁴Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Division of Rheumatology, Istanbul, Turkey, ¹⁵Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Genoa, Italy
Background/Purpose: AIDAI is a novel, validated tool for the assessment of disease activity across a wide spectrum of autoinflammatory diseases including recurrent fever syndromes such…
Abstract Number: 377 • 2017 ACR/ARHP Annual Meeting
Novel Insights into Periodic Fever Syndromes
Tiffany Hoang¹, Shreya Shrestha¹ and Daniel Albert², ¹Dartmouth Medical School, Lebanon, NH, ²Medicine/Rheumatology, Dartmouth-Hitchcock Med Ctr, Lebanon, NH
Background/Purpose: The Periodic Fever Syndromes (PFS) are a rapidly expanding group of disorders primarily of the innate immune system that often affect the inflammasome. In…
Abstract Number: 378 • 2017 ACR/ARHP Annual Meeting
Musculoskeletal Features in Copa Syndrome
William B. Lapin¹, Monica Marcus², Andrea A. Ramirez³, Marietta M. de Guzman³ and Levi B. Watkin^4,5, ¹Department of Pediatrics, Division of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ²Pediatric Immunology, Allergy and Rheumatology, Texas Children's Hospital, Houston, TX, ³Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ⁴Department of Pediatrics, Division of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, ⁵Texas Children's Hospital, Center for Human Immunobiology, Houston, TX
Background/Purpose: COPA syndrome is a newly discovered primary immunodeficiency resulting in immune dysregulation showing autosomal dominant inheritance with incomplete penetrance. Its name is derived from…
Abstract Number: 379 • 2017 ACR/ARHP Annual Meeting
H Syndrome: Five New Cases from the United States with Novel Features and Responses to Therapy
Jessica Bloom¹, Clara Lin², Lisa F. Imundo³, Stephen Guthery⁴, Shelly Stepenaskie⁵, Csaba Galambos⁶, Amy Lowichik⁷ and John F. Bohnsack⁸, ¹Pediatrics, Children's Hospital Colorado, Aurora, CO, ²Pediatric Rheumatology, Children's Hospital Colorado, Aurora, CO, ³Pediatrics, Columbia University Medical Center, New York, NY, ⁴Department of Pediatrics,, University of Utah, Salt Lake City, UT, ⁵Pathology and Dermatology, University of New Mexico, Albuquerque, NM, ⁶Pathology, Children's Hospital Colorado, Aurora, CO, ⁷Pathology, University of Utah, Salt Lake City, UT, ⁸Division of Allergy, Immunology and Pediatric Rheumatology, University of Utah, Salt Lake City, UT
Background/Purpose: H Syndrome is an autosomal recessive disorder characterized by cutaneous hyperpigmentation, hypertrichosis, and induration with numerous systemic manifestations. The syndrome is caused by mutations…
Abstract Number: 380 • 2017 ACR/ARHP Annual Meeting
Treatment Outcomes of Down Syndrome Arthropathy
Jordan T. Jones¹, Leena Danawala², Nasreen Talib³ and Mara L Becker⁴, ¹Rheumatology Division, Children's Mercy Kansas City, Kansas City, MO, ²University of Missouri-Kansas City School of Medicine, Kansas City, MO, ³General Pediatrics, Children's Mercy Kansas City, Kansas City, MO, ⁴Rheumatology, Children's Mercy Kansas City, Kansas City, MO
Background/Purpose: Crude prevalence estimates indicate Down syndrome arthropathy (DA) is 3-8 times more common than juvenile idiopathic arthritis (JIA), however, DA is still largely under…
Abstract Number: 381 • 2017 ACR/ARHP Annual Meeting
Down’s Arthritis (DA) – Clinical and Radiological Features of Arthritis in Children with Trisomy 21
Charlene Foley, Emma Jane Mac Dermott and Orla Killeen, National Centre for Paediatric Rheumatology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland
Background/Purpose: Down's Arthritis (DA) was first reported in the literature in 1984. Crude estimates suggest higher incidence and prevalence rates of DA compared with Juvenile…

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