Abstracts Archive - Page 1224 of 2425 - ACR Meeting Abstracts

Abstract Number: 276 • 2017 ACR/ARHP Annual Meeting
Follow-up of Patients with Musculoskeletal Manifestations Related to Chikungunya Fever
Paula Murari-Nascimento¹, Ana Beatriz Vargas-Santos², Natalia Fortes¹, Heruza Zogbi³, Otília Santos³, Patricia Brasil³, Guilherme Calvet³, Rogério Valls³, Carlos Andrade³, Andre Siqueira³, Geraldo Castelar-Pinheiro², Letícia Pereira¹ and Rodrigo B. Chaves-Amorim⁴, ¹State University of Rio de Janeiro, Rio de Janeiro, Brazil, ²Internal Medicine - Rheumatology, State University of Rio de Janeiro, Rio de Janeiro, Brazil, ³Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation – FIOCRUZ, Rio de Janeiro, Brazil, ⁴Universidade do Estado do Rio de Janeiro - UERJ, Rio de Janeiro, Brazil
Background/Purpose: Chikungunya fever (CHIK) has joint involvement as a striking characteristic, which may persist for months. This study aimed to better understand the clinical impact of…
Abstract Number: 277 • 2017 ACR/ARHP Annual Meeting
Rheumatic Conditions Appearing De Novo after Infection with Chikungunya Virus in Venezuelan Patients
Yurilis Fuentes-Silva¹, Carlota Acosta², Luisa Ortega³, Martin A Rodriguez⁴, Soham Al Snih⁵, Ivan Amaya⁶ and Irama Maldonado³, ¹Division of Rheumatology/Internal Medicine Department, 1Unidad de Reumatología adscrita al Centro Nacional de Enfermedades Reumáticas. Complejo Hospitalario Universitario Ruiz y Páez, Ciudad Bolivar, Venezuela (Bolivarian Republic of), ²1Unidad de Reumatología adscrita al Centro Nacional de Enfermedades Reumáticas. Complejo Hospitalario Universitario Ruiz y Páez, Ciudad Bolivar, Venezuela (Bolivarian Republic of), ³Internal Medicine, 1Unidad de Reumatología adscrita al Centro Nacional de Enfermedades Reumáticas. Complejo Hospitalario Universitario Ruiz y Páez, Ciudad Bolivar, Venezuela (Bolivarian Republic of), ⁴Division of Rheumatology/Internal Medicine Department, Centro Nacional de Enfermedades Reumaticas. Hospital Universitario de Caracas, Caracas, Venezuela (Bolivarian Republic of), ⁵University of Texas Medical Branch, Galveston, TX, ⁶Facultad de Bioanálisis. Universidad de Oriente, Cudad Bolivar, Venezuela (Bolivarian Republic of)
Background/Purpose: It is well known that viral infections can trigger autoimmune rheumatic diseases. In 2,014 there was an outbreak of Chikungunya (CHIK) virus infection in…
Abstract Number: 278 • 2017 ACR/ARHP Annual Meeting
Corticosteroid Use, Biologic Therapy Switching, Smoking and Renal Failure Are Associated with Serious Infections in Rheumatoid Arthritis Patients Treated with Biologics: Data from Two Latin-American Registries
Maria de la Vega¹, Gustavo Casado², Gustavo Citera², Ieda Maria Magalhães Laurindo³, Georges Christopoulos³, Miguel Angel Descalzo⁴ and Roberto Ranza⁵, ¹on behalf of BiobadaSar study group, Sociedad Argentina de Reumatologia, Buenos aires, Argentina, ²on behalf of BiobadaSar study group, Sociedad Argentina de Reumatologia, Buenos Aires, Argentina, ³on behalf of the BiobadaBrasil study group, Sociedade Brasileira de Reumatologia, São Paulo, Brazil, ⁴Unidad de Investigación Fundación Piel Sana Academia Española de Dermatología y Venerología, Madrid, Spain, ⁵on behalf of the BiobadaBrasil study group, Sociedade Brasileira de Reumatologia, Uberlandia, Brazil
Background/Purpose: Infections are the most frequent and concerning serious adverse events related to rheumatoid arthritis (RA) treatment with biologic drugs (bDMARDs). Their safety profile might…
Abstract Number: 279 • 2017 ACR/ARHP Annual Meeting
the Usefulness of Cytomegalovirus Infection Strategy in Patients with Connective-Tissue Disease, Based on the Guidelines of the Japan Society for Hematopoietic Cell Transplantation 2011
Rika Suzuki¹, Yasuyoshi Kusanagi², Takashi Nakanishi², Hideyuki Horikoshi³, Fumihiko Kimura¹ and Kenji Itoh¹, ¹Department of Hematology and Rheumatology, Division of Internal medicine, National Defense Medical College, Saitama, Japan, ²Department of Hematology and Rheumatology, Division of Internal medicine, National Defence Medical College, Tokorozawa, Japan, ³National Defence Medical College, Tokorozawa, Japan
Background/Purpose: Cytomegalovirus (CMV) infection is a life-threatening complication in immunocompromized hosts. There are no official guidelines for CMV infection management in patients with connective-tissue diseases…
Abstract Number: 280 • 2017 ACR/ARHP Annual Meeting
Reasons Why Patients Failed Vaccinations Vs Influenza and Pneumococcus. Monocentric Cross-Sectional Study.
Maria Chiara Ditto¹, Alberto Batticciotto¹, Maria Chiara Gerardi¹, Federica Rigamonti², Rossella Talotta¹ and Piercarlo Sarzi-Puttini¹, ¹Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milano, Italy, ²Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milan, Italy
Background/Purpose: immunosuppressive therapies and bDAMRDs expecially, increase the risk of infections. According to the EULAR guidelines, all patients affected by autoimmune/inflammatory diseases should receive vaccinations…
Abstract Number: 281 • 2017 ACR/ARHP Annual Meeting
Direct Medical Costs Associated with the Extrahepatic Manifestations of Hepatitis C Virus Infection in France
Patrice Cacoub¹, Mathieu vautier², Anne-Claire Desbois³, David Saadoun⁴ and Zobair Younossi⁵, ¹Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, ²Médecine Interne 1, Hôpital Pitié-Salpêtrière, Paris, France, ³Hôpital Pitié-Salpêtrière, Internal Medicine and Clinical Immunology, Paris, France, ⁴Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), F-75005, Paris, France; INSERM, UMR_S 959, F-75013, Paris, France; CNRS, FRE3632, F-75005, Paris, France; AP-HP, Groupe Hospitalier, Paris, France, ⁵Medicine, Inova Fairfax Hospital, Falls Church, Falls Church, VT
Background/Purpose: The economic impact of the extrahepatic manifestations (EHM) of hepatitis C virus (HCV) infection remains unknown for France. To estimate the prevalence of HCV-EHM…
Abstract Number: 282 • 2017 ACR/ARHP Annual Meeting
The Value of Imaging As an Early Noninvasive Test for Prosthetic Joint Septic Arthritis
Kevin Byrne¹, Mary Louise Fowler², Sarah Lieber³, Robert Shmerling⁴ and Ziv Paz³, ¹Boston University School of Medicine, Boston, MA, ²2Boston University School of Medicine, Boston, MA, ³Beth Israel Deaconess Medical Center, Boston, MA, ⁴Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA
Background/Purpose: Medical imaging is commonly obtained in evaluating patients with suspected prosthetic joint septic arthritis (PJSA); it may be helpful to detect other pathology in…
Abstract Number: 284 • 2017 ACR/ARHP Annual Meeting
Metabolic Activity Sustains Macrophage Cytokine Production in Rheumatoid Arthritis and Coronary Artery Disease
Cornelia M. Weyand¹, Markus Zeisbrich¹, Lukas Brosig², Barbara Wallis¹, Niall Roche³, Janice Lin¹ and Jorg Goronzy⁴, ¹Medicine: Immunology and Rheumatology, Stanford University, Stanford, CA, ²Medicine: Immunology and Rheumatology, Stanford University, Stanfod, CA, ³The Arthritis Center, Pleasanton, CA, ⁴Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Accelerated atherosclerosis has become increasingly recognized as a complication of chronic inflammatory disease, such as in patients with rheumatoid arthritis (RA). RA patients have…
Abstract Number: 285 • 2017 ACR/ARHP Annual Meeting
Liver X Receptor-α (LXRα) Modulates Macrophage Phenotype and Disease Activity in SLE
Shuhong Han¹, Haoyang Zhuang¹, Pui Lee², Stepan Shumyak¹, Jingfan Wu¹, Chao Xie³, Hui Li³, Lijun Yang³ and Westley Reeves⁴, ¹Medicine, University of Florida, Gainesville, FL, ²Harvard Medical School, Boston, MA, ³Pathology, Immunology and laboratory medicine, University of Florida, Gainesville, FL, ⁴Rheumatology & Clinical Immology, University of Florida, Gainesville, FL
Background/Purpose: LXRα is an oxysterol-regulated transcription factor that plays a key role in reverse cholesterol transport by inducing the expression of ATP binding cassette A1…
Abstract Number: 286 • 2017 ACR/ARHP Annual Meeting
Serum Amyloid a Aggravates Rheumatoid Arthritis By Activating NFAT5-Mediated Migration of Macrophages
Yu-Mi Kim Sr.¹, Donghyun Kim Sr.¹, Seung-Ah Yoo Sr.², Jung Hee Koh Sr.², Jin-Sun Kong Sr.² and Wan-Uk Kim Sr.³, ¹Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea, Republic of (South), ²The Catholic University of Korea, Center for Integrative Rheumatoid Transcriptomics and Dynamics, seoul, Korea, Republic of (South), ³The Catholic University of Korea, Department of Internal Medicine, seoul, Korea, Republic of (South)
Background/Purpose: Serum amyloid A (SAA) is an acute phase protein and its serum levels may increase up to 1000-fold over normal levels during inflammation, triggering…
Abstract Number: 287 • 2017 ACR/ARHP Annual Meeting
Anti-TNF Agents Induce Alternative Macrophages
Yannick Degboé¹, Benjamin Rauwel², Michel Baron², Jean Frédéric Boyer², Alain Cantagrel², Arnaud Constantin³ and Jean-Luc Davignon², ¹Centre de Physiopathologie Toulouse Purpan, INSERM UMR 1043, Toulouse, France, ²CPTP, INSERM UMR 1043, Toulouse, France, ³Department of Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, Toulouse, France
Background/Purpose: Macrophages contribute to the pathogenesis of rheumatoid arthritis (RA). They can display various states of activation or « polarization », characterized by distinct functions…
Abstract Number: 288 • 2017 ACR/ARHP Annual Meeting
The Rheumatoid Arthritis Susceptibility Gene C5orf30 Is an Immunomodulator in Macrophages
Emma Dorris¹, Karen Creevey¹, John Moylett¹, Simon Tazzyman², Munitta Muthana² and Anthony G. Wilson¹, ¹UCD School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland, ²University of Sheffield Medical School, Sheffield, United Kingdom
Background/Purpose: rs26232 in the first intron of C5orf30 has been associated with risk of developing rheumatoid arthritis (RA) and severity of tissue damage. C5orf30 is…
Abstract Number: 289 • 2017 ACR/ARHP Annual Meeting
HDL Modified with Malondialdehyde-Acetaldehyde (MAA) Is Bound and Rapidly Internalized By Human THP-1 Monocytes
Michael J. Duryee¹, Dahn L Clemens², Logan M. Duryee², Karen C. Easterling³, Carlos D. Hunter⁴, Lynell W. Klassen⁵, James R. O'Dell⁶, Daniel R. Anderson², Ted R. Mikuls⁵ and Geoffrey M. Thiele², ¹Research Services, Omaha VA Medical Center, Omaha, NE, ²University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁴Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁵Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁶Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Rheumatoid arthritis (RA) is associated with an increased cardiovascular disease (CVD) burden, one that appears to be mitigated by increased concentrations of circulating HDL…
Abstract Number: 290 • 2017 ACR/ARHP Annual Meeting
Characterization of Neutrophil Subsets and Neutrophil Extracellular Traps in Pyogenic Arthritis, Pyoderma Gangrenosum and Acne (PAPA) Syndrome
Pragnesh Mistry¹, Carmelo Carmona-Rivera¹, Nickie Seto¹, Monica Purmalek¹, Amanda Ombrello², Ivona Aksentijevich², Daniel L. Kastner² and Mariana J. Kaplan¹, ¹Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, MD, ²Inflammatory Disease Section, NHGRI/NIH, Bethesda, MD
Background/Purpose: Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is an autosomal dominant autoinflammatory disorder caused by mutations in the PSTPIP1/CD2BP1 gene. PAPA syndrome is…
Abstract Number: 291 • 2017 ACR/ARHP Annual Meeting
A Novel Real-Time Imaging Technique to Quantify Neutrophil Extracellular Traps and Distinguish Mechanisms of Cell Death in Neutrophils
Sarthak Gupta¹, Diana Chan², Kristien Zaal³, Evelyn Ralston⁴ and Mariana J. Kaplan², ¹Systemic Autoimmunity Branch, National Institue of Arthritis, and Musculoskelatal and Skin Diseases/NIH, Bethesda, MD, ²Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases/NIH, Bethesda, MD, ³Light Imaging Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Light Imaging Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases/NIH, Bethesda, MD
Background/Purpose: Neutrophils play a key role in host defenses and have recently been implicated in the pathogenesis of autoimmune diseases by several mechanisms including formation…

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