Abstract Number: 81 • 2017 ACR/ARHP Annual Meeting
Selective Inhibition of the Immunoproteasome Subunit LMP7 Is Not Sufficient for Blocking Cytokine Production or Attenuating Progression of Experimental Arthritis
Background/Purpose: The proteasome inhibitor (PI) PR-957/ONX 0914 blocks cytokine production in vitro and attenuates disease progression in experimental models of rheumatoid arthritis (RA) (Nature Medicine…Abstract Number: 82 • 2017 ACR/ARHP Annual Meeting
CKD-506, a Novel Inhibitor of Histone Deacetylase 6 (HDAC6) Has a Therapeutic Potential in Rheumatoid Arthritis and Inflammatory Bowel Disease
Background/Purpose: Autoimmune disease such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) is a chronic inflammatory disorder, significantly limiting quality of life. Even though…Abstract Number: 83 • 2017 ACR/ARHP Annual Meeting
Whole Blood Stimulations Identify Elevated T Cell Cytokines and Altered Granulocyte/Dendritic Cell Signaling in SLE Patients with Variable Disease Activity
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by loss of immune tolerance to self-antigens and periods of waxing and waning disease. The clinical aspects of…Abstract Number: 84 • 2017 ACR/ARHP Annual Meeting
Physiological Autoantibodies Against the Endthelin Receptor Type-a Are Critically Involved in the Homeostasis of Immune Cells
Background/Purpose: G protein-coupled receptors (GPCRs) are a family of integral membrane proteins mediating cell trafficking and cellular homeostasis. In the last decades, several functional autoantibodies…Abstract Number: 85 • 2017 ACR/ARHP Annual Meeting
Enhanced IFN-γ STAT1 Signaling in CD4 T Cell Populations and Attenuated IL-2 STAT5 Signaling Contribute to the Pathogenesis of Rheumatoid Arthritis (RA)
Background/Purpose: Type I (IFN-α) and type II (IFN-γ) interferons are important mediators of autoimmunity. However, there is conflicting evidence regarding the contribution of IFN-γ to…Abstract Number: 86 • 2017 ACR/ARHP Annual Meeting
Regulation of Interleukin-1β Signaling By Inhibition of O-Glc-Nacase in Rheumatoid Arthritis Synovial Fibroblasts
Background/Purpose: O-GlcNAcylation is an important post-translational modification of nuclear and cytosolic proteins involved in the cytokine signaling networks. Studies show both pro- and anti-inflammatory roles…Abstract Number: 87 • 2017 ACR/ARHP Annual Meeting
A Novel Histone Deacetylase 6 Inhibitor, CKD-M808, Regulates the Adhesion and Migration of Fibroblast-like Synoviocytes, and Enhances Suppressive Function of Regulatory T Cells in Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by bone and cartilage destruction with leukocyte infiltration and activation at synovial tissue. Recently,…Abstract Number: 88 • 2017 ACR/ARHP Annual Meeting
Mind Map Use in Rheumatology Education
Background/Purpose: Medical knowledge is a constantly expanding and changing field. One of the challenges for healthcare professionals, including doctors in training, is to be able…Abstract Number: 89 • 2017 ACR/ARHP Annual Meeting
The CLASS-Rheum (Critical Literature Assessment Skills Support – Rheumatology) Question-Based Tool Is Associated with Sustained Improvement in Knowledge of Relevant Epidemiology and Biostatistics in Rheumatology Fellows
Background/Purpose: Understanding epidemiology and biostatistics (epi/biostats) is crucial for rheumatologists to interpret literature and make appropriate data-driven clinical decisions. Based on retrieval-enhanced learning theory, we…Abstract Number: 90 • 2017 ACR/ARHP Annual Meeting
Developing a Pediatric Rheumatology Curriculum for Pediatric Residents
Background/Purpose: The purpose of this project was to develop a curriculum to teach residents these skills. Due to a paucity of pediatric rheumatologists and the…Abstract Number: 91 • 2017 ACR/ARHP Annual Meeting
Development of Musculoskeletal Physical Examination Checklists: A Formal Consensus Project Involving National Educators
Background/Purpose: Musculoskeletal (MSK) physical exam checklists for a Veterans Affairs (VA) continuing professional development (CPD) course were developed and validated in a broad educational effort…Abstract Number: 92 • 2017 ACR/ARHP Annual Meeting
Hospital for Special Surgery Academy of Rheumatology Medical Educators: 5 Year Outcomes Demonstrate the Value of Supporting Education Research in the Academic Environment
Background/Purpose: It has been previously demonstrated that educators do not receive the same recognition as their colleagues in clinical and basic science, and financial support…Abstract Number: 93 • 2017 ACR/ARHP Annual Meeting
Peer-Developed E-Learning Resource Can Address Rheumatology Knowledge Gaps in Junior Learners
Background/Purpose: The symptoms related to Rheumatologic diseases are responsible for one third of visits to general practitioners, yet medical students and residents remain inadequately prepared…Abstract Number: 94 • 2017 ACR/ARHP Annual Meeting
Validity Evidence for an Objective Structured Clinical Examination Station to Assess Knee Arthrocentesis Skill
Background/Purpose: We developed an objective structured clinical examination (OSCE) station to guide preceptors’ observations of trainees’ performance of simulated knee arthrocentesis and to organize feedback…Abstract Number: 95 • 2017 ACR/ARHP Annual Meeting
Globalisation of Paediatric Musculoskeletal Matters’ (PMM)
Background/Purpose: paediatric musculoskeletal matters’ (PMM–www.pmmonline.org) is a free, evidence-based and peer reviewed open e-resource for paediatric musculoskeletal (MSK) medicine targeting non-MSK specialists. Since launch (Nov-2014)…
ACR Meeting Abstracts