Abstracts Archive - Page 1200 of 2425 - ACR Meeting Abstracts

Abstract Number: 2933 • 2018 ACR/ARHP Annual Meeting
Non-Invasive Tape Sampling Reveals RNA Gene Clusters in Cutaneous Lupus Erythematosus That Discriminate Affected from Unaffected and Healthy Volunteer Skin
Joseph F. Merola¹, Wenting Wang², Carrie Wager³, Stefan Hamann², Xueli Zhang³, Alice Thai², Chris Roberts², Christina Lam⁴, Cristina Musselli², Galina Marsh², Dania Rabah², Catherine Barbey⁵, Nathalie Franchimont² and Taylor L. Reynolds², ¹Clinical Unit for Research Innovation & Trials, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Biogen, Cambridge, MA, ³Formerly of Biogen, Cambridge, MA, ⁴Boston University Medical School, Boston, MA, ⁵Biogen, Zug, Switzerland
Background/Purpose: Punch biopsy, the standard diagnostic and monitoring procedure for patients with cutaneous lupus erythematosus (CLE), impedes patient recruitment and follow up due to risk…
Abstract Number: 2934 • 2018 ACR/ARHP Annual Meeting
Myocardial Microscopic Fibrosis Assessed By T1 Mapping Sequences on Cardiac Magnetic Resonance Imaging Predicts Cardiac Events in Systemic Sclerosis: Data from a Prospective Cohort Study on 40 Patients
Benjamin Terrier¹, Agnès Dechartres², Hervé Gouya³, Alexis Régent⁴, Bertrand Dunogué⁵, Pascal Cohen⁶, Alice Berezne⁷, Claire Le Jeunne⁸, Paul Legmann³, Olivier Vignaux³ and Luc Mouthon⁹, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France, ²Epidemiology, Hotel Dieu, Paris, France, ³Radiology, Cochin hospital, Paris, France, ⁴Department of Internal Medicine, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (APHP), Université Paris Descartes, Paris, France, ⁵Internal Medicine, Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁶Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, ⁷Internal Medicine, CH Annecy, Annecy, France, ⁸Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁹Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France
Background/Purpose: Studies have shown that myocardial involvement may occur in systemic sclerosis (SSc) and lead to cardiac failure. We showed previously that cardiac magnetic resonance…
Abstract Number: 2935 • 2018 ACR/ARHP Annual Meeting
A Practical Classification of Systemic Sclerosis Using Subset and Autoantibodies for the Purpose of Early Risk Stratification
Svetlana I. Nihtyanova¹, Emma C. Derrett-Smith², Carmen Maria Fonseca³, Voon H. Ong² and Christopher P. Denton⁴, ¹Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ²Division of Medicine, University College London, London, United Kingdom, ³Department of Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁴University College London, London, United Kingdom
Background/Purpose: The Le Roy et al. classification of SSc into limited and diffuse cutaneous subtype remains the most commonly used. Nevertheless, autoantibodies are much better…
Abstract Number: 2936 • 2018 ACR/ARHP Annual Meeting
Esophageal Erosion Predicts Progression of Lung Disease in Patients with Systemic Sclerosis
Silvia Laura Bosello¹, Enrico De Lorenzis¹, Gerlando Natalello², Giovanni Battista Canestrari¹, Laura Gigante¹, Lucrezia Verardi¹, Ludovica Berardini³ and Elisa Gremese¹, ¹Division of Rheumatology, Fondazione Policlinico Universitario A.Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy, ²Division of Rhematology, Fondazione Policlinico Universitario A.Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy, ³Division of Respiratory Medicine, Fondazione Policlinico Universitario A.Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose: Interstitial lung disease (ILD) is the leading cause of death in Systemic Sclerosis (SSc) but its pathogenesis is not fully understood. Esophageal disease is…
Abstract Number: 2937 • 2018 ACR/ARHP Annual Meeting
Anti-Vinculin Antibodies in Systemic Sclerosis (SSc): A Potential Biomarker Linking Vascular and Gastrointestinal System Involvement in Two Phenotypically Distinctive SSc Groups
Yossra A Suliman¹, Suzanne Kafaja², Gianluca Bagnato³, Mohamed Alemam⁴, Isela Valera⁵, Walter Morales⁶, Mark Pimentel⁷, Francesco Del Galdo⁸ and Daniel E. Furst⁹, ¹Rheumatology and Rehabilitation dept., Rheumatology and Rehabilitation dept. Assiut university hospital, Assiut Egypt, Assiut, Egypt, ²Department of Internal Medicine, University of California Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ³Leeds Musculoskeletal Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁴Clinical Pathology and Laboratory Medicine Department, Lecturer, Qena, Egypt, ⁵Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, ⁶GI Motility Program, Research associate, Los Angeles, CA, ⁷Gastrointestinal, Cedar Sinai Medical Center, Los Angeles, CA, ⁸Leeds Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁹Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Vinculin is a cytoskeletal protein that plays a major role in cell-cell and cell-extracellular matrix adhesion thus regulating cell growth, migration and function of…
Abstract Number: 2938 • 2018 ACR/ARHP Annual Meeting
Evaluation of American College of Rheumatology Provisional Composite Response Index in Systemic Sclerosis (ACR CRISS) in a Phase 3 Randomized Controlled Trial
Dinesh Khanna¹, Celia J. F. Lin², Helen Spotswood³, Jeffrey Siegel², Angelika Jahreis², Christopher P. Denton⁴ and Daniel E. Furst⁵, ¹Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, ²Genentech, Inc., South San Francisco, CA, ³Roche Products Ltd., Welwyn Garden City, United Kingdom, ⁴University College London, London, United Kingdom, ⁵University of California Los Angeles, Los Angeles, CA
Background/Purpose: Treatment with the IL-6 receptor inhibitor tocilizumab (TCZ) in early progressive systemic sclerosis (SSc; focuSSced trial; NCT02453256) resulted in numeric improvements in skin sclerosis…
Abstract Number: 2939 • 2018 ACR/ARHP Annual Meeting
Clinical Features Associated with Severe Lower Bowel Involvement in Systemic Sclerosis
Eric Dein¹, Laura K. Hummers², Christopher A. Mecoli^3,4 and Zsuzsanna McMahan⁵, ¹Department of Internal Medicine, Johns Hopkins Bayview, Baltimore, MD, ²Medical and Rheumatology, Johns Hopkins University, Baltimore, MD, ³Internal Medicine/Rheumatology, Johns Hopkins University, Baltimore, MD, ⁴Rheumatology, Johns Hopkins University, Baltimore, MD, ⁵Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Although up to 90% of scleroderma (SSc) patients are affected by gastrointestinal (GI) dysmotility, clinical features of patients with severe lower gastrointestinal involvement are…
Abstract Number: 2940 • 2018 ACR/ARHP Annual Meeting
Complementary Practices As Alternatives to Pain: Effectiveness of a Pain Management Program for Patients in an Orthopedic Clinic
Maggie Wimmer, Robyn Wiesel, Berenice Adams, Mikhaila Goldman, Titilayo Ologhobo, Yu Sun, Mavis Seehaus, Sandra Goldsmith and Laura Robbins, Hospital for Special Surgery, New York, NY
Background/Purpose: In 2018, according to the National Institute of Health, opioid misuse and addiction is a major public health issue. Approximately 70% of individuals who…
Abstract Number: 2941 • 2018 ACR/ARHP Annual Meeting
Reach and Effectiveness of a Health Communications Campaign Promoting Self Management Education: Results of a Pilot Test of the Learn More. Feel Better. Campaign
Teresa Brady¹, Meghan Lewis², Carla Cartwright², Anne Hvizdak³ and Sara Lasker⁴, ¹Clarity Consulting and Communications, Atlanta, GA, ²Porter Novelli, Atlanta, GA, ³Bureau of Aging and Disability Resources, Wisconsin Department of Health Services, Madison, WI, ⁴Healthy & Hygge, Madison, WI
Background/Purpose: Learn More. Feel Better. (LMFB) is a multi-modal marketing campaign to promote self-management education (SME) as a chronic disease management strategy. The campaign targets…
Abstract Number: 2942 • 2018 ACR/ARHP Annual Meeting
Dyadic Study of Partner Social Support for Physical Activity and Its Role in the Initiation and Maintenance of Increased Physical Activity Among Insufficiently Active People with Hip/Knee Osteoarthritis
Christine Rini¹, Derek Hales², Stephanie Bahorski², Mary Altpeter², Dana Carthron³, Ashley Phillips², Julie Upchurch², Ida Griesemer², Heather Wasser², Sandra Soto², Shelby Rimmler², Beyla Patel², Katrina Ellis² and Leigh F. Callahan⁴, ¹Biomedical Research, Hackensack University Medical Center, Hackensack, NJ, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of Michigan, Ann Arbor, MI, ⁴Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: People who increase their physical activity (PA) (e.g., in an intervention) typically return to a less active lifestyle within 3-6 months. Yet, the health…
Abstract Number: 2943 • 2018 ACR/ARHP Annual Meeting
Helping a Non-Urban Community Walk with Ease: A Feasibility Pilot Study of an Arthritis Activity Intervention
Amanda Perez¹, Brock Polnaszek², Douglas White³, Lee Walraven⁴, Chelsea Barnes⁴ and Christie M. Bartels¹, ¹Rheumatology/Medicine, University of Wisconsin - Madison, Madison, WI, ²Obstetrics and Gynecology, Washington University, St. Louis, MO, ³Gundersen Lutheran - Onalaska Clinic, Onalaska, WI, ⁴La Crosse Area Family YMCA, La Crosse, WI
Background/Purpose: An estimated 54 million US adults have arthritis, and more than half are not receiving the recommended physical activity (MMWR, 2018). Walk With Ease…
Abstract Number: 2944 • 2018 ACR/ARHP Annual Meeting
Longitudinal Outcomes and Predictors of E-Learning Effectiveness in Patients with Axial Spondyloarthritis: A Randomized Controlled Trial
Daeria O. Lawson¹, Ahmed Omar^1,2, Rita Kang³, Nigil Haroon^1,2, Robert D Inman^1,4 and Laura Passalent^1,5, ¹Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, ³Patient and Family Education, Toronto Western Hospital, Toronto, ON, Canada, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, ⁵Department of Physical Therapy, University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada
Background/Purpose: There is evidence that education programs are effective (e.g. improved disease activity and quality of life) for patients with arthritis, but little is known…
Abstract Number: 2945 • 2018 ACR/ARHP Annual Meeting
Culturally Enhanced Pain Coping Skills Training for African Americans with Osteoarthritis
Kelli Allen¹, Tamara Somers², Lisa Campbell³, Cynthia Coffman⁴, Liubov Arbeeva⁵, Crystal Cene⁶, Eugene Oddone⁷ and Francis Keefe², ¹Rheumatology, University of North Carolina at Chapel Hill and Durham VA Medical Center, Durham, NC, ²Duke University Medical Center, Durham, NC, ³East Carolina University, Greenville, NC, ⁴Health Services Research, Durham VA Medical Center and Duke University Medical Center, Durham, NC, ⁵TARC, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁶University of North Carolina, Chapel Hill, NC, ⁷Duke University Medical Center and Durham VA Medical Center, Durham, NC
Background/Purpose: African Americans (AAs) bear a disproportionate burden of osteoarthritis (OA), with greater pain and disability compared with Non-Hispanic Whites. Pain coping skills training (PCST)…
Abstract Number: 2946 • 2018 ACR/ARHP Annual Meeting
T Peripheral Helper Cells Are Expanded in the Circulation of Active SLE Patients and Correlate with CD21low B Cells
Deepak Rao¹, Alexandra Bocharnikov², Chamith Fonseka³, Joshua Keegan², Betty Diamond⁴, Jennifer Anolik⁵, Peter Nigrovic¹, Soumya Raychaudhuri^3,6, James A. Lederer⁷ and Michael Brenner⁸, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, ⁵Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁶Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute, Harvard University, Cambridge, MA, ⁷Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁸Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Pathologic T cell-B cell interactions and production of autoantibodies are hallmark features of SLE. T follicular helper (Tfh) cells are generally considered the principal…
Abstract Number: 2947 • 2018 ACR/ARHP Annual Meeting
Peripheral Helper T Cells in Systemic Lupus Erythematosus
Ayako Makiyama^1,2, Asako Chiba¹, Goh Murayama³, Ken Yamaji³, Naoto Tamura³ and Sachiko Miyake¹, ¹Immunology, Juntendo University School of Medicine, Tokyo, Japan, ²Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ³Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Autoreactive T-B cell interactions in lymphoid tissue have been thought to play a crucial role in the autoantibody production in systemic lupus erythematosus (SLE).…

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