Abstracts Archive - Page 1193 of 2607 - ACR Meeting Abstracts

Abstract Number: 98 • 2018 ACR/ARHP Annual Meeting
Presence of Apoptotic Microparticle Containing Immune Complexes in Asymptomatic ANA+ Individuals Despite the Absence of Inflammation
Carolina Muñoz-Grajales^1,2, Dennisse Bonilla¹, Ariana Karanxha¹, Dario Ferri^1,2, Earl Silverman³, Sindhu Johnson⁴, Arthur Bookman⁵, Zahi Touma^5,6 and Joan E. Wither^1,2,5,7, ¹Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Department of Immunology, Department of Immunology, University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, Mount Sinai Hospital and University Health Network, Toronto, ON, Canada, ⁵Division of Rheumatology, University Health Network, Toronto, ON, Canada, ⁶University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁷Department of Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada
Background/Purpose: Currently, little is known about what distinguishes asymptomatic Anti-Nuclear Antibody (ANA) positive individuals (ANA+NS) who will progress to Systemic Lupus Erythematosus (SLE) from those…
Abstract Number: 99 • 2018 ACR/ARHP Annual Meeting
DC-Hil+ Myeloid-Derived Suppressor Cells Are Elevated in the Peripheral Blood and Lesional Skin of Cutaneous Lupus Patients
Stephanie Florez-Pollack¹, Lin-chiang Tseng¹, Masato Kobayashi¹, Gregory Hosler^1,2, Kiyoshi Ariizumi¹ and Benjamin F. Chong¹, ¹Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, ²Propath, Dallas, TX
Background/Purpose: Myeloid derived suppressor cells (MDSCs) are major T cell suppressors, and their dysfunction has been implicated in the pathophysiology of autoimmune diseases. MDSCs suppress…
Abstract Number: 100 • 2018 ACR/ARHP Annual Meeting
Glycosphingolipids and Proteins in Urine Exosomes: Potential Biomarkers of Lupus Nephritis
Tamara K. Nowling¹, Jessalyn Rodgers¹, Jim C. Oates², Michael Janech³ and Richard Drake⁴, ¹Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ³Medicine/Nephrology, Medical University of South Carolina, Charleston, SC, ⁴Pharmacology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Exosomes, extracellular vesicles that are abundant in human urine and contain proteins from renal cells, are a potential source of biomarkers of renal disease…
Abstract Number: 101 • 2018 ACR/ARHP Annual Meeting
Regulation of Monocyte Function By Epstein Barr Virus Interleukin-10 (vIL10) in Systemic Lupus Erythematosus
Neelakshi R. Jog¹, Eliza Chakravarty¹, Joel M. Guthridge¹ and Judith A. James^2,3, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease characterized by periods of elevated and suppressed disease activity. Epstein Barr Virus (EBV) has been…
Abstract Number: 102 • 2018 ACR/ARHP Annual Meeting
Estrogen Controls the Expression of Serine Arginine-Rich Splicing Factor 1 (SRSF1) in Human T Lymphocytes Via Transcriptional and Post-Transcriptional Mechanisms
Julian F. Oviedo¹, Elena N. Cravens¹ and Vaishali R. Moulton^2,3, ¹Beth Israel Deaconess Medical Center, Harvard Medical School, Medicine/Rheumatology, Boston, MA, ²Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA, ³Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic debilitating autoimmune disease that primarily afflicts women in the childbearing years. Female hormones especially estrogen are implicated…
Abstract Number: 103 • 2018 ACR/ARHP Annual Meeting
Identification of IL-17+ and IL-10+ TCRαβ+ CD4- CD8- double Negative (DN) T Cell Subsets in Lupus-Prone Mice and Patients with SLE and Their Significance in Predicting Renal Involvement
Yi Li¹, Hao Li², Vasileios C. Kyttaris³ and George C Tsokos⁴, ¹Medicine, BIDMC, Boston, MA, ²Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, Boston, MA, ⁴Division of Rheumatology, Department of Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, Boston, MA
Background/Purpose: We have previously shown that DN T cells are expanded in both lupus-prone mice and patients with SLE and we have demonstrated that this…
Abstract Number: 104 • 2018 ACR/ARHP Annual Meeting
Identification of a Gut Pathobiont Immunostimulatory Lipoglycan Antigen Linked to Lupus Nephritis
Gregg Silverman¹, Nicolas Gisch², Aidana Omarbekova³ and Doua F. Azzouz⁴, ¹Department of Medicine, New York University School of Medicine, New York, NY, ²Research Center Borstel, Schleswig-Holstein, Germany, ³New York University School of Medicine, New York, NY, ⁴Medicine, New York University School of Medicine, New York, NY
Background/Purpose: A transmissible agent has long been suspected in SLE. In a discovery cohort we found that,compared with healthy subjects, Lupus patients had a five-fold…
Abstract Number: 105 • 2018 ACR/ARHP Annual Meeting
Immunologic Properties of Cutaneous Lupus Erythematosus (CLE) Patients Refractory to Antimalarials Compared to Patients That Respond to Antimalarials
Majid Zeidi^1,2, Krisha Desai^3,4, Hee Joo Kim^3,4,5 and Victoria P. Werth^3,4, ¹University of Pennsylvania, Philadelphia, PA, ²Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, ³Department of Dermatology, Corporal Michael J. Crescenz VAMC, Philadelphia, PA, ⁴Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ⁵Department of Dermatology, Gachon Gil Medical Center, School of Medicine, Gachon University, Incheon, Korea, Republic of (South)
Background/Purpose: Two major therapies for cutaneous lupus erythematosus (CLE) are the antimalarials, hydroxychloroquine (HCQ) and quinacrine (QC). HCQ is often the first-line therapy for CLE,…
Abstract Number: 106 • 2018 ACR/ARHP Annual Meeting
Highly Elevated Levels of Anti-Mitochondrial Antibodies in Systemic Lupus Erythematosus and Rheumatoid Arthritis
Richard Moore¹ and Christian Lood², ¹Division of Rheumatology, University of Washington, Seattle, WA, ²Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: We recently described the phenomenon in systemic lupus erythematosus (SLE) in which mitochondria are extruded into the extracellular space during formation of neutrophil extracellular…
Abstract Number: 107 • 2018 ACR/ARHP Annual Meeting
Apolipoprotein L1 Risk Variants, Renal Histopathology, and Prognosis in African American SLE Nephritis Patients: A Cohort Study
Ashira Blazer¹, Ming Wu², Nancyanne Schmidt³, Alana Engelbrecht⁴, Feng-Xia Liang⁵, Robert M. Clancy⁶, Jill P. Buyon⁷ and H. Michael Belmont⁸, ¹Internal Medicine Division of Rheumatology, NYU School of Medicine, New York, NY, ²Department of Pathology, New York University, New York, NY, ³Internal Medicine, New York University School of Medicine, New York, NY, ⁴Rheumatology, NYU Langone Health, New York, NY, ⁵Office of Science and Research, New York University School of Medicine, New York, NY, ⁶Colton Center for Autoimmunity, New York University, New York, NY, ⁷Rheumatology, NYU School of Medicine, New York, NY, ⁸Division of Rheumatology, New York University, New York, NY
Background/Purpose: Apolipoprotein L1 (APOL1) risk variants (RV), G1 and G2, associate with CKD in African Americans (AA) and are evolutionarily preserved due to improved infectious…
Abstract Number: 108 • 2018 ACR/ARHP Annual Meeting
Sex-Specific Expression of CXorf21 Provide Molecular Explanation for the Fundamental Difference in Male and Female Immune Response: An Explanation for Female-Bias SLE Pathogenesis
R. Hal Scofield¹, Valerie M Harris², Biji T. Kurien³ and Kristi A. Koelsch⁴, ¹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Okalahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is complex autoimmune disorders characterized by B cell hyperactivity resulting in autoantibody and cytokine production. Approximately 90% of patients are…
Abstract Number: 109 • 2018 ACR/ARHP Annual Meeting
Unique miRNA Signatures Detected in Extracellular Vesicles from Patients with Systemic Lupus Erythematous
Ifeoma Okafor¹, Nicholas A. Young², Giancarlo R. Valiente³, Emily Schwarz¹, Peter Harb¹, Caitlin Henry¹, William Willis², Emily Sullivan⁴, Kyle Jablonski⁵, Lai-Chu Wu¹, Naomi I. Maria⁶, Anne Davidson⁷, Elisha D.O. Roberson⁸ and Wael Jarjour⁹, ¹Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴The Ohio State Univeristy Wexner Medical Center, Columbus, OH, ⁵The Ohio State University Wexner Medical Center, Columbus, OH, ⁶Center for Autoimmunnity, Musculoskeletal & Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ⁷Feinstein Institute for Medical Research, Manhasset, NY, ⁸Depts. of Medicine and Genetics, Division of Rheumatology, Washington University, St. Louis, MO, ⁹Department of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Recent studies have identified distinct changes in cellular miRNA (miR) expression associated with systemic lupus erythematous (SLE). We have previously shown that toll-like receptor…
Abstract Number: 110 • 2018 ACR/ARHP Annual Meeting
Single-Cell RNA-Seq Analysis of ANA+ Healthy and SLE Patients Show Variations in Activated Stress Response and Regulatory Pathways
Miles C. Smith¹, Samantha Slight-Webb¹, Susan R. Macwana¹, Judith A. James^2,3 and Joel M. Guthridge¹, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Medicine & Pathology, Univ. of Oklahoma, Okla, OK
Background/Purpose: One hallmark of the autoimmune disease Systemic lupus erythematosus (SLE) is the presence of antinuclear antibodies (ANAs). While the specificities and levels can indicate…
Abstract Number: 111 • 2018 ACR/ARHP Annual Meeting
BAFF Inhibition Attenuates Fibrosis in Bleomycin-Induced Scleroderma Model Via Modulating the Regulatory and Effector B-Cell Balance
Takashi Matsushita¹, Tadahiro Kobayashi², Yasuhito Hamaguchi², Minoru Hasegawa³, Manabu Fujimoto⁴ and Kazuhiko Takehara¹, ¹Kanazawa University, Department of Dermatology, Kanazawa, Japan, ²Department of Dermatology, Kanazawa University, Kanazawa, Japan, ³University of Fukui, Department of Dermatology, Fukui, Japan, ⁴University of Tsukuba, Faculty of Medicine, Department of Dermatology, Tsukuba, Japan
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by skin and lung fibrosis. Over 90% of patients with SSc are positive for autoantibodies. In…
Abstract Number: 112 • 2018 ACR/ARHP Annual Meeting
Evidence for Altered Peroxisome Proliferator Activated Receptor (PPAR) Pathway Activity in a Transgenic Mouse Model of Scleroderma (TβRIIΔk-fib): Analysis of Mouse Skin, Lung and Explanted Cells
Emma C. Derrett-Smith^1,2, Shiwen Xu¹, Rachel K. Hoyles³, Olivier Lacombe⁴, Pierre Broqua⁴, Jean-Louis Junien⁴, Irena Konstantinova⁵ and Christopher P. Denton^6,7, ¹Division of Medicine, University College London, London, United Kingdom, ²Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ³Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom, ⁴Inventiva, DAIX, France, ⁵Inventiva, Daix, France, ⁶UCL Division of Medicine, Royal Free Campus, London, United Kingdom, ⁷Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom
Background/Purpose: The TβRIIΔk-fib transgenic (TG) mouse model of scleroderma carries a fibroblast-specific TGFβ receptor II mutation resulting in balanced up-regulation of TGFβ signalling and replicates…

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