ACR Meeting Abstracts

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  • Abstract Number: 2723 • 2018 ACR/ARHP Annual Meeting

    Patient Experience in ANCA-Associated Vasculitis Evolves over Time from Diagnosis and Both Benefits and Adverse Impacts Are Felt with Current Therapy

    Peter Rutherford1, Dieter Goette1, James O`Donoghue2 and Xierong Liu2, 1Medical Affairs, Vifor Pharma, Zurich, Switzerland, 2Elma Research, London, United Kingdom

    Background/Purpose: ANCA-associated vasculitis (AAV) leads to both acute illness and a long-term condition in which the disease remits and relapses. Therapy is often complex and…
  • Abstract Number: 2724 • 2018 ACR/ARHP Annual Meeting

    Variable Response to Induction Therapy and Significant Burden of Treatment Adverse Events over the First 12 Months in Incident ANCA-Associated Vasculitis (AAV) Patients – a Study of Routine Clinical Practice in the EU

    Peter Rutherford1, Dieter Goette1, Melinda Stamm2 and Xierong Liu2, 1Medical Affairs, Vifor Pharma, Zurich, Switzerland, 2Elma Research, London, United Kingdom

    Background/Purpose: Aims of therapy in incident AAV patients include ensuring rapid diagnosis, assessment of comorbidity, disease activity, and vasculitis damage before commencing treatment with a…
  • Abstract Number: 2725 • 2018 ACR/ARHP Annual Meeting

    Clinical Characteristics and Long-Term Follow-up of 382 Microscopic Polyangiitis Patients

    Yann Nguyen1, Christian Pagnoux2, Alexandre Karras3, Thomas Quémeneur4, Francois Maurier5, Mohamed Hamidou6, Alain Le Quellec7, Noémie Jourde-Chiche8, Pascal Cohen1, Alexis Régent1, François Lifermann9, Arsène Mékinian10, Chahéra Khouatra11, Eric Hachulla12, Jacques Ninet13, Jacques Pourrat14, Marc Ruivard15, Pascal Godmer16, Jean-Francois Viallard17, Benjamin Terrier1, Luc Mouthon1, Loïc Guillevin1 and Xavier Puéchal1, 1Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, 2Division of Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, 3Department of Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, Paris, France, 4Department of Internal Medicine, CH of Valenciennes, France, Valenciennes, France, 5Médecine interne, Hôpitaux Privés de Metz, Metz, France, 6Department of Internal Medicine, CHU de Nantes, France, Nantes, France, 7Department of Internal Medicine, Hôpital Saint-Eloi, CHU de Montpellier, France, Montpellier, France, 8Nephrology, Department of Nephrology, AP-HM, CHU Conception, Marseille, France, Marseille, France, 9Dax, Dax, France, 10Department of Internal Medicine, Hôpital Saint-Antoine, APHP, Paris, France, Paris, France, 11Department of Respiratory Medicine, National Reference Center for Rare Pulmonary Diseases, Hospices civils de Lyon, Hôpital Louis Pradel, Lyon, France, Lyon, France, 12Department of Internal Medicine, National Reference Center for Systemic Sclerosis, Hôpital Claude Huriez, CHRU Lille, France, Lille, France, 13Department of Internal Medicine, Hôpital Edouard Herriot HCL, CHU de Lyon, France, Lyon, France, 14Department of Nephrology, Hôpital de Rangueil, CHU Toulouse, France, Toulouse, France, 15Department of Internal Medicine, CHU Estang, Clermont-Ferrand, France, Clermont-ferrand, France, 16Department of Internal Medicine, CH Vannes, France, Vannes, France, 17Department of Internal Medicine, Hôpital Haut-Lévêque, Bordeaux, France, CHU Bordeaux, France

    Background/Purpose: Microscopic polyangiitis (MPA) is a systemic ANCA-associated small-vessel necrotizing vasculitis characterized by general symptoms, and visceral manifestations, including rapidly progressive glomerulonephritis and alveolar hemorrhage.…
  • Abstract Number: 2726 • 2018 ACR/ARHP Annual Meeting

    Severe Infections in Systemic Necrotizing Vasculitis: Incidence and Risk Factors

    Claudia Elizabeth Pena1, Ana Carolina Costi2, Lucila Garcia3, Mariana Pera4 and Mercedes Garcia1, 1Rheumatology, HIGA General San Martin La Plata, La Plata, Argentina, 2Rheumatology Section, HIGA General San Martin La Plata, La Plata, Argentina, 3HIGA General San Martin La Plata, La Plata, Argentina, 4HIGA General San Martin La Plata, la plata, Argentina

    Background/Purpose: Infections in patients with systemic necrotizing vasculitis represent one of the main causes of mortality. Risk factors of infection such as corticosteroid use, intensity…
  • Abstract Number: 2727 • 2018 ACR/ARHP Annual Meeting

    Prevalence of Clinical and Subclinical Ophthalmologic Manifestations in Association with Systemic Symptoms, Disease Activity and Damage in Patients with Granulomatosis with Polyangiitis

    Andrea Hinojosa-Azaola1, Annette García-Castro2 and Alejandra Juárez-Flores3, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 2Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 3Ophthalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: Ophthalmologic involvement in Granulomatosis with Polyangiitis (GPA) is present in 50-60% of the patients and can affect any part of the ocular glove and…
  • Abstract Number: 2728 • 2018 ACR/ARHP Annual Meeting

    Validation of the Draft Classification Criteria of Granulomatosis with Polyangiitis (GPA) Amongst Indian Patients with ANCA Associated Vasculitis

    Aman Sharma1, Adarsh MB2, GSRSNK Naidu3, Manish Rathi4, Kusum Sharma5, Varun Dhir6, Ritambhra Nada7, Ranjana Minz8 and Sanjay Jain9, 1Clinical Immunology and Rheumatology Services, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, Chandigarh, India, 2Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, Chandigarh, India, 3PGIMER, cHANDIGARH, India, 4Department of Nephrology,, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 5Department of Medical Microbiology,, PGIMER,, Chandigarh, India, 6Internal Medicine (Rheumatology Unit), Postgraduate Institute of Medical Education and Research, Chandigarh, India, Chandigarh, India, 7Postgraduate Institute of Medical Education and Research, Chandigarh, India, 8Department of Immunopathology,, PGIMER,, Chandigarh, India, 9Postgraduate Institute of Medical Education and Research, Chandigarh, India, CHANDIGARH, India

    Background/Purpose: A draft classification criteria of GPA was proposed at ACR meeting in San Diego in 2017. The present criteria is a modification of ACR/EULAR…
  • Abstract Number: 2729 • 2018 ACR/ARHP Annual Meeting

    Increased Risk of Cerebrovascular Accident Among Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Systematic Review and Meta-Analysis of Cohort Studies

    Patompong Ungprasert1, Karn Wijarnpreecha2 and Wisit Cheungpasitporn3, 1Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, 2Internal medicine, Bassett medical center, cooperstown, NY, 3Medicine, University of Mississippi Medical center, Jackson, MS

    Increased Risk of Cerebrovascular Accident among Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Systematic Review and Meta-analysis of Cohort StudiesAbstractBackground/Purpose: An increased risk of cardiovascular…
  • Abstract Number: 2730 • 2018 ACR/ARHP Annual Meeting

    Handgrip Strength Predicts the Risk of Bone Fracture and Severe Adverse Events in Patients with Systemic Necrotizing Vasculitis

    Soledad Henriquez1, Bertrand Dunogué2, Raphaël Porcher3, Alexis Régent1, Pascal Cohen4, Alice Bérezné1, Sami Kolta5, Claire Le Jeunne1, Luc Mouthon6, Christian Roux5, Loïc Guillevin7, Karine Briot8 and Benjamin Terrier9, 1Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 2Internal Medicine, Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 3Université Paris Descartes Sorbonne Paris, Paris, France, 4Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, 5Department of Rheumatology, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 6Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France, 7Medecine Interne, Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 8Department of Rheumatology, Cochin Hospital and Epidemiology and Biostatistics Unit,Sorbonne Paris Cité Reserach Center,Paris Descartes University,INSERM U1153, Paris, France, 9National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France

    Background/Purpose: Sarcopenia, characterized by progressive loss of both muscle mass and muscle strength, has been associated with poor outcomes in various diseases. Muscle weakness is…
  • Abstract Number: 2731 • 2018 ACR/ARHP Annual Meeting

    Clinical Characteristics and Outcomes of ANCA-Vasculitides Associated Renal Disease in a Multi-Ethnic Population from a County Hospital

    Shilpa Arora1, Ambrish Athavale2 and Peter Hart2, 1Medicine, John H Jr Stroger Hospital of Cook County, Chicago, IL, 2John H Jr Stroger Hospital of Cook County, Chicago, IL

    Background/Purpose: Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and renal-limited vasculitis (RLV). We aimed to study the clinical features…
  • Abstract Number: 2732 • 2018 ACR/ARHP Annual Meeting

    Peripheral Neuropathy Is More Common in Microscopic Polyangiitis Than in Granulomatosis with Polyangiitis: Data from a Single Tertiary Referral Center

    Mehmet Nedim Taş1, Mete Kara1, Sertaç Ketenci1, Mete Pekdiker2, Raika Durusoy3, Fikret Bademkıran4, Gokhan Keser5 and Kenan Aksu5, 1Rheumatology, Ege University Medical Faculty, izmir, Turkey, 2Adult Rheumatology, Ege University Medical Faculty, izmir, Turkey, 3Public Health, Ege University Medical Faculty, izmir, Turkey, 4Neurology, Ege University Medical Faculty, izmir, Turkey, 5Rheumatology, Ege University Medical Faculty, Izmir, Turkey

    Background/Purpose: Among many other organs and systems, ANCA-associated vasculitis (AAV) may also affect nervous system in up to more than half of patients, resulting in…
  • Abstract Number: 2733 • 2018 ACR/ARHP Annual Meeting

    From a Myth to a Menace: Increased Disease Severity and Poor Outcomes in an Urban Cohort of African-American Patients with ANCA-Associat­ed Vasculitis

    Kathleen Maksimowicz-McKinnon1, Philip McCarthy2, Sandeep Soman3 and John McKinnon3, 1Rheumatology, Henry Ford Hospital, Detroit, MI, 2Michigan State University College of Osteopathic Medicine, East Lansing, MI, 3Henry Ford Hospital, Detroit, MI

    Background/Purpose: Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a systemic inflammatory disorder frequently associated with significant disability and morbidity, which may lead to end-stage renal disease…
  • Abstract Number: 2734 • 2018 ACR/ARHP Annual Meeting

    The Effect of Age at Diagnosis on Mortality in ANCA-Associated Vasculitides

    Mete Kara1, Mehmet Nedim Taş1, Raika Durusoy2, Sertaç Ketenci1, Mete Pekdiker3, Hande Ece Öz4, Gülay Aşçı5, Gokhan Keser6 and Kenan Aksu4, 1Rheumatology, Ege University Medical Faculty, izmir, Turkey, 2Public Health, Ege University Medical Faculty, izmir, Turkey, 3Adult Rheumatology, Ege University Medical Faculty, izmir, Turkey, 4Rheumatology, Ege University Medical Faculty, İzmir, Turkey, 5Nephrology, Ege University Medical Faculty, İzmir, Turkey, 6Rheumatology, Ege University Medical Faculty, Izmir, Turkey

    Background/Purpose: Elderly patients with ANCA associated vasculitides (AAV) seem to have clinical differences compared to younger patients. The aim of this study is to compare…
  • Abstract Number: 2735 • 2018 ACR/ARHP Annual Meeting

    Identifying ANCA-Associated Vasculitis Cases in Electronic Health Records Using Natural Language Processing

    Zachary Wallace1, John H. Stone2 and Hyon K. Choi3, 1Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Rheumatology (Medicine), Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA

    Background/Purpose: Epidemiologic studies of ANCA-associated vasculitis (AAV) using large data sets are often limited by the lack of validated definitions of AAV cases that can…
  • Abstract Number: 2736 • 2018 ACR/ARHP Annual Meeting

    Value of Histology for Diagnosis and Classification in ANCA Associated Vasculitis

    Julia Kronfeldner1, Johanna Eifert1, Stefanie Quickert1, Peter Oelzner1, Martin Busch1, Claus Kroegel2, Gunter Wolf1, Benjamin Seeliger3 and Thomas Neumann4,5, 1Department of Internal Medicine III, Jena University Hospital, Jena, Germany, 2Department of Internal Medicine I, Jena University Hospital, Jena, Germany, 3Department of Respiratory Medicine, Medical School Hannover, Hannover, Germany, 4Internal Medicine III, Jena University Hospital, Jena, Germany, 5Department of Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland

    Background/Purpose: Diagnosis of ANCA-associated vasculitis (AAV) and the classification of granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA) is based…
  • Abstract Number: 2737 • 2018 ACR/ARHP Annual Meeting

    Opportunistic Infections in Medium and Small-Sized Vessel Vasculitis: Based on a Retrospectivestudy on 108 Patients

    Raphaele Mestiri1, Lafarge Antoine2, Jean-Jacques Tudesq3, Marc Pineton de Chambrun4, Melanie Roriz5, Stéphane Bally6, Laurent Alric7, Damien Sène8, Thomas Quémeneur9, Cécile-Audrey Durel10, Brigitte Gilson11, Alice Berezne12, Anne-Marie Ruppert13, Raphaele Seror14, Philippe Guilpain15, Xavier Puéchal16, Luc Mouthon17, Loïc Guillevin16 and Benjamin Terrier18, 1Internal Medicine, Cochin hospital, Paris, France, 2Medecine Interne, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France, 3Internal Medicine, CHU Montpellier, Montpellier, France, 4Université Pierre et Marie Curie, Paris, France, 5Université Paris-Diderot, Paris, France, 6Nephrology, CH Chambery, Chambery, France, 7Internal Medicine, CHU Toulouse, Toulouse, France, 8Lariboisière Hospital, Paris Diderot University, Paris, France, 9Department of Internal Medicine, CH of Valenciennes, France, Valenciennes, France, 10Internal Medicine, Hôpital Edouard Herriot, lyon, France, 11Internal Medicine, CH Verdun, Verdun, France, 12Internal Medicine, CH Annecy, Annecy, France, 13Pulmonology, Tenon hospital, Paris, France, 14Hopitaux Universitaires Paris Sud, Kremlin Bicetre, France, Rheumatology, Université Paris Sud, Le Kremlin Bicetre, France, 15Montpellier, Montpellier, France, 16Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, 17Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France, 18Centre de Référence des Maladies Auto-immunes et Systémiques Rares, Vascularites Nécrosantes et Sclérodermie Systémique, Service de Médecine Interne, Hôpital Cochin, APHP, INSERM U1016, Université Paris Descartes, Paris, France

    Background/Purpose: Overall survival has been markedly improved during the last decades in systemic vasculitis. In contrast, the use of immunosuppressive agents led to an increased…
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