Abstracts Archive - Page 1186 of 2607 - ACR Meeting Abstracts

Abstract Number: PP06 • 2018 ACR/ARHP Annual Meeting
Learning to Self-Advocate in the Transition from Pediatric to Adult Lupus Care
Denita Perry¹ and Diane Gross², ¹Unaffiliated, Joilet, IL, ²Lupus Research Alliance, New York, NY
Background/Diagnosis: I was diagnosed with lupus at age 15. I was starting my sophomore year of high school and noticed a rash that the doctor…
Abstract Number: PP07 • 2018 ACR/ARHP Annual Meeting
Strengthening My Resiliency: How My Interprofessional Healthcare Team and I Improved My Management of Lupus
Cecilia Amoakohene¹, Jorge Sanchez-Guerrero², Murray Urowitz², Dafna D Gladman², Zahi Touma² and Laura Wakani², ¹Unaffiliated, Toronto, ON, Canada, ²University of Toronto Lupus Research Program, Toronto Western Hospital, Toronto, ON, Canada
Background/Diagnosis: I was diagnosed with systemic lupus erythematosus (SLE) at the age of eleven and have experienced multiple SLE flares, hospitalizations, invasive procedures and complex…
Abstract Number: PP08 • 2018 ACR/ARHP Annual Meeting
Communication, Support, and Advocacy Lead to Improved Health and Quality of Life
Christele Felix, AztraZeneca, Gaithersburg, MD
Background/Diagnosis: In 2007 I was diagnosed with Lupus which has since then wreaked havoc on my kidneys, lungs, GI tract, peripheral nervous system, to name…
Abstract Number: PP09 • 2018 ACR/ARHP Annual Meeting
Improved Quality of Life and Decreased Symptoms of Lupus with Diet, Exercise, and Functional Medicine
Marisa Zeppieri-Caruana, Lupus Chick, New York, NY
Background/Diagnosis: Like most people who live with a chronic illness and/or autoimmune disease, my story started long before I realized. Symptoms came and went throughout…
Abstract Number: PP10 • 2018 ACR/ARHP Annual Meeting
Using a Mobile App to Facilitate Patient-Doctor Discussions to Make Informed Decisions Regarding ‘Painsomnia’
Shelley Fritz¹, Kristine Carandang² and Dawn Gibson³, ¹ArthritisPower Patient Partner: CreakyJoints/Global Healthy Living Foundation, Tampa, FL, ²Chan Division of Occupational Science & Occupational Therapy, University of Southern California, Los Angeles, CA, ³Founder #SpoonieChat; CreakyJoints/Global Healthy Living Foundation Patient Partner, Upper Nyack, NY
Background/Diagnosis: As a patient with AS, Dawn founded #SpoonieChat to provide a space on twitter for people living with chronic diseases to support each other.…
Abstract Number: PP11 • 2018 ACR/ARHP Annual Meeting
The Road Less Traveled– Nontraditional Approaches to Increased Patient Adherence and Positive Outcomes
Carlene Harrison, AstraZeneca, Gaithersburg, MD
Background/Diagnosis: African-American female diagnosed with SLE, Lupus Nephritis, Discoid Lupus, and Raynaud’s Phenomenon in 2011. Symptoms included joint pain, edema in the ankles, malar rash,…
Abstract Number: PP12 • 2018 ACR/ARHP Annual Meeting
Living a Full Life with A.S. Through Adaptations
Gail Wright, Spondylitis Association of America, Buffalo Grove, IL
Background/Diagnosis: After running a half marathon and 2 5’ks, I had unexplained back/ hip pain that wouldn’t resolve. I returned to my PT. After 3…
Abstract Number: PP13 • 2018 ACR/ARHP Annual Meeting
Support Groups and Patient Centred Care; Making a Difference in the Lives of People with Autoimmune and Rheumatic Conditions in Ghana
Paulina Padiki Narh¹, Abdul Aziz A. Adodo Can-Tamakloe¹ and Ida Dzifa Dey², ¹The Rheumatology Initiative tRi, Accra, Ghana, ²Department of Medicine, Rheumatology Unit, School of Medicine and Dentistry,University of Ghana, Accra, Ghana
Background/Diagnosis: I felt relieved when my diagnosis was confirmed, but upon hearing Lupus and Nephritis and no cure, I felt shattered. I was referred to…
Abstract Number: 1 • 2018 ACR/ARHP Annual Meeting
Profiling of B-Cell Related Factors and Its Decoy Receptors in Rheumatoid Arthritis: Potential Clues for Patient Stratification
Javier Rodríguez-Carrio^1,2, Mercedes Alperi-López³, Patricia López¹, Francisco Javier Ballina-García⁴ and Ana Suárez¹, ¹Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, ²Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain, ³Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, ⁴Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain
Background/Purpose: B-cell over-activation plays a key role in the pathogenesis of rheumatoid arthritis (RA), thus being recognized as a therapeutic target. However, the activation of…
Abstract Number: 2 • 2018 ACR/ARHP Annual Meeting
The Influence of Abatacept on Human B Cell Functions
Ming-Han Chen¹, Yen-Po Tsao², Chuen-Miin Leu³ and Chang Youh Tsai³, ¹Division of Allergy- Immunology- Rheumatology, Department of Medicine, Division of Allergy- Immunology- Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ²Division of Allergy- Immunology- Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ³National Yang-Ming University, Taipei, Taiwan
Background/Purpose: Cytotoxic T lymphocyte antigen-4 (CTLA-4) competes with CD28 for binding the CD80/CD86 on antigen presenting cells to inhibit further activation of T cells. Abatacept,…
Abstract Number: 3 • 2018 ACR/ARHP Annual Meeting
Interferon-Alpha Disrupts DNA-Specific B Cell Tolerance in 3H9 Mice
Dario Ferri¹, Yuriy Baglaenko², Ariana Karanxha¹, Kieran Manion¹, Carolina Grajales¹ and Joan E. Wither¹, ¹Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Department of Biomedical Informatics, Brigham Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: A central mediator of Systemic Lupus Erythematosus (SLE) pathogenesis is interferon-alpha (IFNα), which is elevated in the serum of SLE patients. IFNα has been…
Abstract Number: 4 • 2018 ACR/ARHP Annual Meeting
Anti-Jo1 Positive Myositis Patients Display a Characteristic IgG Fc-Glycan Profile Which Is Further Enhanced in Anti-Jo1 Autoantibodies
Catia Fernandes-Cerqueira^1,2, Nuria Renard^1,2, Antonella Notarnicola^1,2, Edvard Wigren^1,2,3, Susanne Graslund^1,2,3, Roman Zubarev⁴, Ingrid E. Lundberg^1,2 and Susanna L. Lundström⁴, ¹Department of Medicine, Division of Rheumatology, Karolinska Institutet, Stockholm, Sweden, ²Center for Molecular Medicine, Stockholm, Sweden, ³Structural Genomics Consortium, Stockholm, Sweden, ⁴Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry I, Stockholm, Sweden
Background/Purpose: IgG Fc-glycans affect IgG function and are altered in autoimmune diseases and autoantibodies. Anti-histidyl tRNA synthetase autoantibodies (anti-Jo1) are frequent in myositis associated with…
Abstract Number: 5 • 2018 ACR/ARHP Annual Meeting
Short Chain Fatty Acid Acetate Induces Regulatory B Cells in Mice and Humans, Which Can Protect Against Arthritis
Claire I. Daien^1,2,3, Julie Mielle^1,4, Rachel Audo^1,2,5, Lake-Ee Quek¹, James Krycer¹, Gauthier Rathat⁶, Gabriela Pinget¹, Sumaiya Hoque⁷, Charles Mackay⁸, Jian Tan⁹ and Laurence Macia¹, ¹Charles Perkins Centre, The University of Sydney, Sydney, Australia, ²IGMM, CNRS UMR5535, Montpellier, Montpellier, France, ³Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, ⁴IGMM CNRS UMR5535, Montpellier, France, ⁵Rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, ⁶Arnaud-de-Villeneuve Hospital, Montpellier, France, ⁷Charles Perkins Centre, The University of Sydney, Sydney, France, ⁸Monash University, Melbourne, Australia, ⁹Charles Perkins Centre, The University of Sydney, Montpellier, Australia
Background/Purpose: Autoimmunity and more broadly non-communicable diseases develop with the imbalance between anti- and pro-inflammatory immune cell subsets, leading to an uncontrolled and damaging inflammation.…
Abstract Number: 6 • 2018 ACR/ARHP Annual Meeting
Ro52/Trim21 Influences Follicular B Cell Homeostasis and Immunoglobulin Production
Margarita Ivanchenko¹, Susanna Brauner², Gudny Ella Thorlacius¹, Aurélie Ambrosi¹ and Marie Wahren-Herlenius¹, ¹Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²Neuroimmunology Unit, Department of Clinical Neurosciences, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, Solna, Sweden
Background/Purpose: Systemic rheumatic diseases are characterized by abnormal B cell activation with autoantibody production and hypergammaglobulinemia. The autoantigen Ro52/SSA, also denoted TRIM21, is a major…
Abstract Number: 7 • 2018 ACR/ARHP Annual Meeting
RNA Sequencing Detection of Gene Dysregulation in B Cells Sorted from Salivary Gland Tissue and from Peripheral Blood Reveals New Pathways Involved in Primary Sjögren’s Syndrome Pathophysiology
Elodie Rivière^1,2, Nicolas Tchitchek¹, Gaetane Nocturne^1,3, Juliette Pascaud¹, Saida Boudaoud¹, Alice Thai⁴, Normand Allaire⁴, Bernd Jagla⁵, Michael Mingueneau⁴ and Xavier Mariette^1,3, ¹Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre & Fontenay aux Roses, France, ²Arthritis Fondation Courtin, Paris, France, ³Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ⁴Immunology Research, Biogen, Cambridge, MA, ⁵Biomarker Discovery Platform UTechS CB, Hub de Bioinformatique et biostatistique C3IB, Institut Pasteur, Paris, France
Background/Purpose: Primary Sjögren's syndrome (pSS) is a chronic auto-immune disorder characterized by lymphocytic infiltrates and destruction of the salivary glands. Chronic B cell activation, the…

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