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  • Abstract Number: 2708 • 2018 ACR/ARHP Annual Meeting

    Current Management of Early Diffuse Cutaneous Systemic Sclerosis in US Scleroderma Centers

    Rebecca B. Blank1, Jessica K. Gordon2, Jackie Szymonifka3, Shervin Assassi4, Elana J. Bernstein5, Flavia V. Castelino6, Robyn T. Domsic7, Faye N. Hant8, Monique Hinchcliff9, Kate Homer10, Ami A. Shah11, Victoria Shanmugam12, Virginia D. Steen13, Tracy M. Frech14 and Dinesh Khanna15, 1Internal Medicine, New York Presbyterian-Weill Cornell Hospital, New York, NY, 2Rheumatology, Hospital for Special Surgery, New York, NY, 3Hospital for Special Surgery, New York, NY, 4University of Texas McGovern Medical School, Houston, TX, 5Rheumatology, Columbia University, New York, NY, 6Rheumatology, Harvard Medical School, Boston, MA, 7Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 8Rheumatology, Medical University of South Carolina, Charleston, SC, 9Division of Rheumatology, Northwestern University Medical School, Chicago, IL, 10Department of Internal Medicine, Rheumatology Division, Scleroderma Program, University of Michigan, Ann Arbor, MI, 11Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 12Rheumatology, The George Washington University, Washington, DC, 13Rheumatology, MedStar Georgetown University Hospital, Washington, DC, 14Division of Rheumatology, University of Utah, Salt Lake City, UT, 15Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI

    Background/Purpose: Standard treatment for the diverse aspects of diffuse cutaneous systemic sclerosis (dcSSc) is not yet well defined although experts have described therapeutic algorithms.  The…
  • Abstract Number: 2709 • 2018 ACR/ARHP Annual Meeting

    Conversion of Normal Mean Pulmonary Arterial Pressure to Pulmonary Hypertension in Systemic Sclerosis – a Longitudinal Observational Study

    Amber Young1, Scott H. Visovatti2, Tom Cascino2, Nektarios Vasilottos3, Vallerie McLaughlin2 and Dinesh Khanna1, 1Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, 2Division of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 3Department of Internal Medicine, University of Michigan, Ann Arbor, MI

    Background/Purpose: Pulmonary hypertension (PH) is one of the leading causes of mortality in patients with systemic sclerosis (SSc). Active screening detects PH earlier and may…
  • Abstract Number: 2710 • 2018 ACR/ARHP Annual Meeting

    Physical Activity Trackers Work Well As a Monitor of Physical Activity in Systemic Sclerosis

    Amber Young1, Elizabeth A. Jackson2 and Dinesh Khanna1, 1Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, 2Division of Cardiovascular Disease, Division of Cardiovascular Disease, University of Alabama, Birmingham, AL

    Background/Purpose: Systemic sclerosis (SSc) patients have reduced physical function, exercise capacity and health related quality of life (HRQOL). The objective of this study was to…
  • Abstract Number: 2711 • 2018 ACR/ARHP Annual Meeting

    Comparison of Gastric Antral Vascular Ectasia Associated with Systemic Sclerosis with That Associated with Other Diseases: Are There Differences?

    Rabeea Mirza1, Yuxuan Jin2, Donald F. Kirby3 and Soumya Chatterjee1,4, 1Rheumatic and Immunologic Disease, Cleveland Clinic, Cleveland, OH, 2Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, 3Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, 4Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH

     Background/Purpose: Gastric antral vascular ectasia (GAVE) is a pathologic angioectasia with a characteristic endoscopic appearance. Rugal folds with dilated blood vessels radiate from the antrum…
  • Abstract Number: 2712 • 2018 ACR/ARHP Annual Meeting

    Evaluation of Longitudinal Outcomes in Scleroderma Patients with Negative Immunofluorescent Anti-Nuclear Antibodies

    Mayce Haj-Ali1, Derek Jones2, Sean McNish3, Sarah Stupp3, Marissa Mangini3 and Victoria Shanmugam4, 1Department of Medicince, The George Washington University School of Medicine and Health Sciences, Washington, DC, 2The George Washington University, Washington, DC, 3The George Washington University School of Medicine and Health Sciences, Washington, DC, 4Rheumatology, The George Washington University, Washington, DC

    Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease characterized by inflammation, fibrosis, and vasculopathy. Historical data indicates approximately 90% of patients with SSc test positive…
  • Abstract Number: 2713 • 2018 ACR/ARHP Annual Meeting

    Is Effectiveness of Immunosuppression for Interstitial Lung Disease in Systemic Sclerosis (SSc) Modified By Lung Disease Severity or SSc Duration?

    Sabrina Hoa1, Sasha Bernatsky2, Russell Steele3 and Marie Hudson1, 1Jewish General Hospital, Lady Davis Institute and McGill University, Montreal, QC, Canada, 2Divisions of Rheumatology and Clinical Epidemiology, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 3Department of Mathematics and Statistics, McGill University, Montreal, QC, Canada

    Background/Purpose: Interstitial lung disease (ILD) is a leading cause of mortality in SSc. Immunosuppression is used to treat ILD, but little is known about its…
  • Abstract Number: 2714 • 2018 ACR/ARHP Annual Meeting

    Significance of Anti-Neutrophil Cytoplasmic Antibodies in Systemic Sclerosis

    Jayne Moxey1,2, Molla Huq2, Susanna Proudman3, Joanne Sahhar4,5, Gene-Siew Ngian4,5, Jennifer Walker6, Gemma Strickland1, Michelle Wilson1, Laura Ross1,2, Gabor Major7,8, Janet Roddy9, Wendy Stevens1 and Mandana Nikpour1,2, 1St Vincent's Hospital, Melbourne, Australia, Melbourne, Australia, 2The University of Melbourne, Melbourne, Australia, Melbourne, Australia, 3Royal Adelaide Hospital, Rheumatology Unit and University of Adelaide, Discipline of Medicine, Adelaide, Australia, 4Monash Health, Melbourne, Australia, Melbourne, Australia, 5Monash University, Melbourne, Australia, Melbourne, Australia, 6Royal Adelaide Hospital, Adelaide, Australia, Adelaide, Australia, 7University of Newcastle, Newcastle, Australia, Newcastle, Australia, 8Royal Newcastle Centre, John Hunter Hospital, Newcastle, Australia, Newcastle, Australia, 9Fiona Stanley Hospital, Perth, Australia, Perth, Australia

    Background/Purpose: ANCA are detected in 0-11.7% (1) of patients with systemic sclerosis (SSc) and only a minority of these patients will develop an overlap syndrome with…
  • Abstract Number: 2715 • 2018 ACR/ARHP Annual Meeting

    The Effect of an Intensive Controlled 6-Moth Physical-Occupational Therapy Program with Subsequent 6-Month Follow-up Period in Patients with Systemic Sclerosis – Preliminary Data

    Maja Spiritovic1,2, Hana Smucrova2, Sabina Oreska2,3, Hana Storkanova2,3, Barbora Hermankova1,2, Petr Cesak4, Adela Rathouska2, Olga Ruzickova2,5, Karel Pavelka2,3, Ladislav Šenolt2,3, Jiri Vencovsky2,6, Radim Becvar2,3 and Michal Tomcik2,3, 1Department of Physiotherapy, Faculty of Physical Education and Sports, Charles University, Prague, Czech Republic, Prague, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 3Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 4Body Composition Laboratory, Faculty of Physical Education and Sports, Charles University, Prague, Czech Republic, Prague, Czech Republic, 5Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 6Department Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Involvement of the skin and musculoskeletal system is associated with impaired quality of life in patients with systemic sclerosis (SSc). Data on efficacy of…
  • Abstract Number: 2716 • 2018 ACR/ARHP Annual Meeting

    A New Score to Predict Digital Ulcers Combining Clinical Data, Imaging and Patient History in Systemic Sclerosis

    Stefanie Friedrich1,2, Susanne Lueders3, Gerd R. Burmester4, Gabriela Riemekasten5 and Sarah Ohrndorf4, 1Department of of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin; Germany, Berlin, Germany, 2Department of Radiology, Charité University Hospital, Berlin; Germany, Berlin, Germany, 3Department of Gastroenterology and Rheumatology, Charité Universitätsmedizin Berlin, Berlin, Germany, 4Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany, 5Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany

    Background/Purpose: Ischemic complications such as digital ulcers (DU) are a common complication in systemic sclerosis (SSc) patients. The aim of this study was to combine…
  • Abstract Number: 2717 • 2018 ACR/ARHP Annual Meeting

    Factors Predicting Severe Infections in Patients with Systemic Necrotizing Vasculitides Based on Data from 733 Patients Enrolled in Randomized–Controlled Trials

    Lafarge Antoine1, Christian Pagnoux2, Xavier Puéchal3, Maxime Samson4, Mohamed Hamidou5, Alexandre Karras6, Thomas Quémeneur7, Matthieu Groh8, Luc Mouthon3, Loïc Guillevin3 and Benjamin Terrier9, 1Medecine Interne, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France, 2Division of Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, 3Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France, 4Department of Internal Medicine and Clinical Immunology, François-Mitterrand Teaching Hospital, University of Bourgogne-Franche-Comté, Dijon, France, 5Department of Internal Medicine, CHU de Nantes, France, Nantes, France, 6Department of Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, Paris, France, 7Department of Internal Medicine, CH of Valenciennes, France, Valenciennes, France, 8Internal Medicine, Foch, Suresnes, France, 9National Referral Center for Rare Systemic Autoimmune Diseases, Paris Cochin, France, Paris, France

    Background/Purpose: Although overall survival of patients with systemic necrotizing vasculitides (SNVs) has improved markedly over the last 20 years, infectious complications remain a major cause…
  • Abstract Number: 2718 • 2018 ACR/ARHP Annual Meeting

    Comparison of Various ANCA Detection Methods in Predominantly MPO ANCA-Associated Vasculitis Cohort

    Yasuhiro Katsumata1, Ken-ei Sada2, Tomohiro Kameda3, Hiroaki Dobashi3, Hisashi Yamanaka4 and Masayoshi Harigai5, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama, Japan, 3Internal Medicine Division of Hematology, Rheumatology, and Respiratory Medicine, Kagawa University, Kagawa, Japan, 4Institute of Rheumatology, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 5Tokyo Women's Medical University, Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo, Japan

    Background/Purpose: In 2017, the multicenter European Vasculitis Study Group (EUVAS) evaluated the diagnostic accuracy of a wide spectrum of detection tests of MPO and PR3-ANCAs…
  • Abstract Number: 2719 • 2018 ACR/ARHP Annual Meeting

    Tracking the Risk of Infections in ANCA-Associated Vasculitis: Results from a Scottish Matched-Cohort Study

    Shifa Sarica1, Neeraj Dhaun2, Jan Sznajd3, John Harvie3, Nicola Joss3, John McLaren4, Lucy McGeoch5, Nicole Amft6, Vinod Kumar7, Angharad Marks1, Corri Black1 and Neil Basu1, 1Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom, 2University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom, 3Department of Rheumatology, Raigmore Hospital, Inverness, United Kingdom, 4Fife Rheumatic Diseases Unit, Whyteman's Brae Hospital, Kirkcaldy, United Kingdom, 5Center for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, United Kingdom, 6Department of Rheumatology, Western General Hospital, Edinburgh, United Kingdom, 7Rheumatology Department, Ninewells Hospital, Dundee, United Kingdom

    Background/Purpose: Evaluation of infection risk in ANCA-associated vasculitis (AAV) has been limited to small, selected populations and/or serious episodes. In this large study, we aimed…
  • Abstract Number: 2720 • 2018 ACR/ARHP Annual Meeting

    30-Day Hospital Readmission for Granulomatosis with Polyangiitis: Analysis from National Readmission Database

    Yiming Luo1, Changchuan Jiang1, Ana Belen Arevalo Molina1, Shane Murray1, Maria Salgado2 and Jiehui Xu3, 1Department of Medicine, Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY, 2Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, 3Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, NY

    Background/Purpose: Granulomatosis with polyangiitis (GPA) is a systemic vasculitis with multi-organ involvement which can lead to frequent hospitalizations. Our study is to investigate characteristics and…
  • Abstract Number: 2721 • 2018 ACR/ARHP Annual Meeting

    Venous Thromboembolism in ANCA Associated Vasculitis. a Population-Based Cohort Study from Southern Sweden

    Matina Liapi1, David Jayne2, Mårten Segelmark3 and Aladdin Mohammad4, 1Medicine, Blekinge Hospital, Karlskrona, Sweden, 2Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 3Clinical Sciences, Nephrology, Lund University, Lund, Sweden, 4Rheumatology, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden

    Background/Purpose: To estimate the rate and predictors of venous thromboembolic events (VTEs) in a population-based cohort of patients with ANCA- associated vasculitis (AAV). Methods: 322…
  • Abstract Number: 2722 • 2018 ACR/ARHP Annual Meeting

    Incidence and Predictors of Severe Infections in ANCA Associated Vasculitis in a Population-Based Cohort – Preliminary Results

    Jens Rathmann1, David Jayne2, Goran Jönsson3, Mårten Segelmark4, Jan-Åke Nilsson5 and Aladdin Mohammad2, 1Rheumatology, Skanes University Hospital, Lund, Lund, Sweden, 2Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 3Clinical Sciences Lund, Department of Infection Medicine, Lund University, Lund, Sweden, 4Clinical Sciences, Nephrology, Lund University, Lund, Sweden, 5Department of Rheumatology, Skåne University Hospital, Malmö, Sweden

    Background/Purpose: To determine the incidence rates, predictors and outcome of severe infections in ANCA associated vasculitis (AAV). Methods: We conducted a population-based cohort study in…
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