Abstracts Archive - Page 1161 of 2607 - ACR Meeting Abstracts

Abstract Number: 374 • 2019 ACR/ARP Annual Meeting
The INBUILD Trial of Nintedanib in Patients with Progressive Fibrosing Interstitial Lung Diseases: Subgroup with Autoimmune Diseases
Eric Matteson¹, Clive Kelly ², Jörg Distler ³, Anna Maria Hoffmann-Vold ⁴, James Seibold ⁵, Shikha Mittoo ⁶, Oliver Distler ⁷, Rainer-Georg Goeldner ⁸, Rozsa Schlenker-Herceg ⁹, Susanne Stowasser ¹⁰, Manuel Quaresma ¹⁰ and Kevin Flaherty ¹¹, ¹Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA, Rochester, ²Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK, Newcastle, United Kingdom, ³Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, ⁴Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁵Scleroderma Research Consultants LLC, Aiken, South Carolina, USA, Aiken, ⁶University Health Network, Toronto, Ontario, Canada, Toronto, Canada, ⁷Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, ⁸Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany, Biberach, Germany, ⁹Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA, Ridgefield, ¹⁰Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, Ingelheim am Rhein, Germany, ¹¹University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, MI
Background/Purpose: Some patients with autoimmune disease develop progressive fibrosing interstitial lung disease (ILD) characterized by increasing fibrosis on HRCT, decline in lung function, worsening symptoms…
Abstract Number: 375 • 2019 ACR/ARP Annual Meeting
Experience with Biologic Agents for the Treatment of Cardiac Sarcoidosis in a U.S. Academic Medical Center
Anjani Pillarisetty¹, Mithun Devraj ², Farooq Sheikh ³ and Florina Constantinescu ¹, ¹MedStar Washington Hospital Center, Department of Rheumatology, Washington, DC, ²MedStar Washington Hospital Center, Department of Internal Medicine, Washington, DC, ³MedStar Washington Hospital Center, MedStar Heart and Vascular Institute, Washington, DC
Background/Purpose: Sarcoidosis is a multisystem granulomatous disease of unclear etiology characterized histologically by non-caseating granulomas. While clinically manifest cardiac involvement occurs in only about 5%…
Abstract Number: 376 • 2019 ACR/ARP Annual Meeting
Long-term Outcome and Prognostic Factors of Patients with Interstitial Pneumonia with Autoimmune Features: A Single Center Large-scale Observational Cohort Study
Okinori Murata¹, Katsuya Suzuki ², Nobuhito Sasaki ³, Tsutomu Takeuchi ² and Makoto Maemondo ³, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan, ³Division of Pulmonary medicine, Allergy, and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Japan
Background/Purpose: Patients with idiopathic interstitial pneumonia (IIP) may have features of connective tissue diseases (CTDs). The term interstitial pneumonia with autoimmune features (IPAF) has been…
Abstract Number: 377 • 2019 ACR/ARP Annual Meeting
Novel Approach to the Treatment of Cardiac Sarcoidosis with TNF-alpha Inhibition
Matthew Baker¹, Khushboo Sheth ¹, Julia Simard ², Stanford Shoor ¹ and Mark Genovese ³, ¹Stanford University, Palo Alto, CA, ²Stanford University School of Medicine, Palo Alto, CA, ³Stanford University, Stanford, CA
Background/Purpose: Sarcoidosis is a systemic inflammatory disease characterized by the presence of noncaseating granulomas. When it affects the myocardium, it can result in electrical conduction…
Abstract Number: 378 • 2019 ACR/ARP Annual Meeting
Systemic and Ocular Sarcoidosis Study of 381 Patients from a Single Universitary Centre in the Last 20 Years
Lara Sanchez-Bilbao¹, Belén Atienza-Mateo ¹, Iñigo Gonzalez-Mazon ², Jose Luis Martín-Varillas ¹, Rosalia Demetrio ³, Vanesa Calvo-Río ⁴, Eva Peña Sainz-Pardo ⁵, Raul Fernandez-Ramon ³, Jorge Javier Gaitan-Valdizan ³, Miguel A Gonzalez-Gay ¹ and Ricardo Blanco ¹, ¹Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Spain, ²Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, ³Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁴Hospital Universitario Marques de Valdecilla, Santander, Spain, ⁵Pediatrics, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain
Background/Purpose: Sarcoidosis is a multisystemic inflammatory disease characterized by non-caseating epitheliod granulomas. Ocular involvement is the presenting symptom in approximately 20-30% in form of uveitis,…
Abstract Number: 379 • 2019 ACR/ARP Annual Meeting
Neurosarcoidosis: An Evaluation Based on the Neurosarcoidosis Consortium Consensus Group
Thieroff George¹, Huzaefah Syed ², Thomas Iden ², Aamer Syed ², Trang Le ² and Alicia Zukas ³, ¹VCU Medical Center, Richmond, VA, ²VCU Medical Center, Richmond, VA, ³Virginia Commonwealth University, Richmond, VA
Background/Purpose: The 2018 Neurosarcoidosis Consortium Consensus Group (NCCG) attempted to increase specificity in diagnosing neurocsarcoidosis from the 2013 World Association of Sarcoidosis and Other Granulomatous…
Abstract Number: 380 • 2019 ACR/ARP Annual Meeting
Seasonal Clustering of Acute Sarcoidosis in South-West Germany and Associations with Particulate Matter Air Pollution
Philipp Rustler¹, Dirk Schindler ², Reinhard Voll ¹ and Florian Kollert ³, ¹Division of Rheumatology and Clinical Immunology, Medical Centre - University of Freiburg, Freiburg, Germany, ²Environmental Meteorology, University of Freiburg, Freiburg, Germany, ³Department of Rheumatology, Immunology and Allergology, Inselspital, University Hospital Bern, Bern, Switzerland
Background/Purpose: Sarcoidosis is a multisystemic granulomatous disorder of unknown origin. The central role of macrophages and granuloma formation, the predominant involvement of lung and skin,…
Abstract Number: 381 • 2019 ACR/ARP Annual Meeting
Effect of Vitamin D Supplementation on Calcium Levels in Patients with Sarcoidosis: A Retrospective Analysis
Christopher Overton¹, Trang Le ¹, Thomas Iden ¹, Aamer Syed ¹, Markos Kashiouris ¹ and Huzaefah Syed ¹, ¹VCU Medical Center, Richmond, VA
Background/Purpose: Hypercalcemia is seen in 2-30% of patients with sarcoidosis and is caused by the overproduction of Vitamin D (VitD) 1,25OH (calcitriol) by macrophages within…
Abstract Number: 382 • 2019 ACR/ARP Annual Meeting
Neurofilament Light Chain Levels in Cerebrospinal Fluid and Plasma in Neurosarcoidosis
Keld-Erik Byg¹, Tobias Sejbaek ², Helle Nielsen ³, Zsolt Illes ⁴, Jonna Skov Madsen ⁵, Dorte Olsen ⁶ and Torkell Ellingsen ¹, ¹Department of Rheumatology, Odense University Hospital, Denmark, Odense, Syddanmark, Denmark, ²Department of Neurology, Odense University Hospital; Department of Clinical Research, University of Southern Denmark, Denmark, Odense, Syddanmark, Denmark, ³Department of Neurology, Odense University Hospital, Department of Clinical Research, University of Southern Denmark, Denmark, Odense, Syddanmark, Denmark, ⁴Department of Neurology, Odense University Hospital, Department of Clinical Research, University of Southern Denmark, Denmark, Odense, Midtjylland, Denmark, ⁵Department of Biochemistry and Immunology, Lillebaelt Hospital, Vejle, Department of Regional Health Research, University of Southern Denmark, Denmark, Vejle, Syddanmark, Denmark, ⁶Department of Biochemistry and Immunology, Lillebaelt Hospital, Vejle, Denmark., Vejle, Syddanmark, Denmark
Background/Purpose: Neurofilament Light Chain (NFL) is an emerging biomarker that is specific for neuronal and axonal damage/degeneration but unspecific regarding the origin of destruction. NFL…
Abstract Number: 383 • 2019 ACR/ARP Annual Meeting
Retroperitoneal Fibrosis- a Single Center Experience
Mert Oztas¹, Emir Cerme ², Izzet Altun ³ and Serdal Ugurlu ⁴, ¹Istanbul University-Cerrahpasa,Department of Medicine, Division of Rheumatology, Istanbul, Turkey, ²Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Istanbul, Turkey, ³Mayo Clinic, Scottsdale, AZ, ⁴Istanbul University - Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, istanbul, Turkey
Background/Purpose: Idiopathic retroperitoneal fibrosis (iRPF) is a rare, chronic, progressive disorder of unknown etiology and characterized by the presence of inflammatory and fibrous retroperitoneal tissue…
Abstract Number: 384 • 2019 ACR/ARP Annual Meeting
Prevalence and Predictors of Fibrosis in Rheumatological Patients on Therapy and Risk Factors for Chronic Liver Disease
Connie Lam ¹, Stephen Bloom ² and Alberta Hoi³, ¹School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia, ²Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia, ³School of Clinical Sciences, Monash University, Meloburne, Victoria, Australia
Background/Purpose: The assessment of liver stiffness using liver elastography (Fibroscan) has facilitated early diagnosis of hepatic fibrosis in patients with chronic liver disease, but its…
Abstract Number: 385 • 2019 ACR/ARP Annual Meeting
Distinctive Clinical Features and Biomarkers of Connective Tissue Disease Associated Interstitial Lung Disease
Sang Wan Chung¹, So-Yun Lee ¹, Sang-Hoon Lee ¹, Seung-Jae Hong ¹ and Yeon-Ah Lee ¹, ¹School of Medicine, Kyung Hee University, seoul, Republic of Korea
Background/Purpose: The connective tissue diseases (CTD) are a group of rheumatologic diseases characterized by inflammation and immune-mediated organ damage including interstitial lung disease (ILD). The…
Abstract Number: 386 • 2019 ACR/ARP Annual Meeting
Idiopathic Granulomatous Mastitis: The Role of Rheumatologists in Treating This Rare Cause of Breast Pain
Sarah Ringsted¹ and Marcia Friedman ¹, ¹Oregon Health and Science University, Portland, OR
Background/Purpose: Idiopathic granulomatous mastitis (IGM) is an inflammatory breast disease occurring primarily in young to middle-aged women (1, 2). IGM typically presents with a tender,…
Abstract Number: 387 • 2019 ACR/ARP Annual Meeting
Early Mortality in IgG4-Related Disease
Rachel Wallwork¹, Tyler Harkness ¹, Xiaoqing Fu ¹, Cory Perugino ¹, Hyon K. Choi ², John Stone ³ and Zachary Wallace ¹, ¹Massachusetts General Hospital, Boston, ²Massachusetts General Hospital, Boston, MA, ³Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA
Background/Purpose: IgG4-related disease (IgG4-RD) is a fibroinflammatory disorder characterized by tumefactive lesions that can occur in nearly any organ or anatomic site. Manifestations can include…
Abstract Number: 388 • 2019 ACR/ARP Annual Meeting
Treating Statin-induced Anti-HMGCR Myopathy with Normal Muscle Strength: A New Window of Opportunity
Alain Meyer¹, Yves Troyanov ², Julie Drouin ³, Josiane Bourre-Tessier ⁴, Genevieve Oligny-Longpre ⁵, Océane Landon-Cardinal ⁶, Baptiste Hervier ⁷, Sabrina Hoa ⁸, Anne-Marie Mansour ⁹, Eric Rich ⁴, Jean-Richard Goulet ⁴, Sandra Chartrand ¹⁰, Marie Hudson ¹¹, Jessica Nehme ⁹, Jean-Paul Makhzoum ¹², Farah Zarka ⁹, Sara Hussein ¹³, Vincent Morin ¹⁴, Edith Villeneuve ¹⁵, Jean-Pierre Raynauld ¹⁶, Marianne Landry ¹⁷, Erin O'Ferrall ¹⁸, Jose Ferreira ¹⁹, Benjamin Ellezam ²⁰, Jason Karamchandani ¹⁸, Sandrine Larue ²¹, Rami Massie ¹⁸, Catherine Isabelle ²¹, isabelle Deschênes ⁵, Valérie Leclair ²², Helene Couture ²³, Ira Targoff ²⁴, Marvin Fritzler ²⁵ and Jean-Luc Senecal ⁴, ¹Centre de Reference des Maladies Autoimmunes Rares, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ²Division of Rheumatology, Department of Medicine, Hôpital du Sacre-Coeur de Montreal, Montreal, QC, Canada, ³Centre hospitalier regional de Trois-Rivieres, Trois-Rivieres, QC, Canada, ⁴Centre hospitalier de l'Universite de Montreal, Montreal, QC, Canada, ⁵Hôpital du Haut-Richelieu, Saint-Jean-sur-Richelieu, QC, Canada, ⁶Division of Rheumatology, Centre hospitalier de l'Université de Montréal; Department of Medicine, Université de Montréal, Montreal, QC, Canada, ⁷Hopital Pitie-Salpetriere, Paris, France, ⁸University of Montreal, Montreal, QC, Canada, ⁹Hôpital du Sacre-Coeur de Montreal, Montreal, QC, Canada, ¹⁰Hôpital Maisonneuve-Rosemont, Montreal, QC, Canada, ¹¹Jewish General Hospital, Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, QC, Canada, ¹²Vasculitis Clinic, Hopital du Sacre-Coeur de Montreal, Montreal, QC, Canada, ¹³Centre hospitalier regional de Lanaudiere, Saint-Charles-Borromée, QC, Canada, ¹⁴Universite Laval, Quebec, QC, Canada, ¹⁵Institut de Recherche en Rhumatologie de Montréal, Montreal, QC, Canada, ¹⁶Institut de Rhumatologie de Montréal, Montreal, QC, Canada, ¹⁷Hôpital LaSalle, Montreal, QC, Canada, ¹⁸Montreal Neurological Institute, Montreal, QC, Canada, ¹⁹Hopital Maisonneuve-Rosemont, Montreal, QC, Canada, ²⁰Centre hospitalier universitaire Sainte-Justine, Montreal, QC, Canada, ²¹Hôpital Charles-Le Moyne, Greenfield Park, QC, Canada, ²²Division of Rheumatology, Department of Medicine, Jewish General Hospital; Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Montreal, QC, Canada, ²³Hôpital Enfant-Jesus, Quebec, QC, Canada, ²⁴University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²⁵Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Background/Purpose: Anti-HMGCR myopathy has recently been defined as a subset of immune-mediated necrotizing myopathies characterized by proximal muscle weakness, elevated CK levels and the presence…

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