Abstracts Archive - Page 115 of 2425 - ACR Meeting Abstracts

Abstract Number: 1400 • ACR Convergence 2024
Disease Modifying Anti-rheumatic Drug Use and Association with Survival in Patients with Rheumatoid Arthritis and Newly Diagnosed Lung Cancer
Varun Nandakumar¹, Aaron Baraff², Alexander Peterson², Nicholas Smith³, Jennifer Barton⁴, Ann O'Hare², Christopher Li⁵, Noel Weiss³ and Namrata Singh⁶, ¹AIIMS, New Delhi, Delhi, India, ²VA PUGET SOUND SEATTLE, Seattle, WA, ³University of Washington, Seattle, WA, ⁴VA Portland Health Care System/OHSU, Portland, OR, ⁵University of Washington, Seattle, ⁶University of Washington, Bellevue, WA
Background/Purpose: Despite the significant therapeutic benefits of various disease modifying anti-rheumatic drugs (DMARDs) in RA, concerns remain regarding their safety, particularly their potential impact on…
Abstract Number: 1374 • ACR Convergence 2024
Exploring Two Decades of Therapeutic Challenges: A Monocentric Experience in Rheumatoid Arthritis Patients Battling Cancer
Roba Ghossan¹, Elodie Portier², OLIVIER FOGEL³, Sophie Hecquet¹, Astrid Dauchez¹, Omar AL TABAA⁴, Marion THOMAS⁵, Julia Herrou¹, Yannick Allanore⁶ and Jérôme Avouac⁷, ¹COCHIN HOSPITAL, PARIS, France, ²Cochin Hospital, Bry sur Marne, France, ³AP-HP, Paris, France, ⁴APHP - Cochin Hospital, Paris, France, ⁵APHP, Paris, France, ⁶Université Paris Cité, Paris, France, ⁷Rheumatology A Department, Hôpital Cochin, AP-HP Centre - Université Paris Cité, Paris, France
Background/Purpose: Managing inflammatory arthritis patients on biologics with a history of cancer remains a complex task in daily rheumatology practice and requires a thoughtful, individualized…
Abstract Number: 1426 • ACR Convergence 2024
Single Cell RNA-Seq Characterization of Circulating Immune Cells in Sjogren’s Syndrome: Comparison to SLE and Rheumatoid Arhtritis
Alejandro Gomez-Gomez¹, yolanda Guillen², Paloma Vela Casasempere³, María Paula álvarez Hernández⁴, Ignacio Brana Abascal⁵, Mónica Fernández Castro⁶, Maria López Lasanta¹, José María Pego-Reigosa⁷, Carlos Marras⁸, María García-Villanueva⁹, Francisco Blanco¹⁰, Patricia Carreira¹¹, Carolina Perez-Garcia¹², Íñigo Rúa-Figueroa¹³, Hugo F Avalos bogado¹, Natalia Boix Martí¹, Eric Kirkegaard-Biosca¹⁴, iago álvarez Sáez¹⁵, Nuria Palau¹⁶, Raül Tortosa¹⁶, Jesús Tornero Molina¹⁷, Antonio Fernandez Nebro¹⁸, Jaime Calvo-Alén¹⁹, Juan Cañete²⁰, Damiana Alvarez-Errico², Ernest Choy²¹, Holger Heyn²², Antonio Julia²³, Sara Marsal barril¹ and Jose Luis Andreu²⁴, and on behalf of SSAD and DocTIS consortia, ¹Hospital Universitari Vall d´Hebron, Rheumatology, Barcelona, Spain, ²Imidomics, Inc, Barcelona, Spain, ³Hospital General Universitario de Alicante , Rheumatology, Alicante, Spain, ⁴Hospital universitario de la Princesa. IIS-Princesa, Rheumatology, Madrid, Madrid, Spain, ⁵Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain, ⁶Hospital Universitario Puerta de Hierro Majadahonda., Madrid, Madrid, Spain, ⁷Galicia Health Service (SERGAS), Vigo, Spain, ⁸Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Murcia, Spain, ⁹Hospital Ramón y Cajal, MADRID, Madrid, Spain, ¹⁰Complejo Hospitalario Universitario de A Coruña , Rheumatology, A Coruña, Spain, ¹¹Hospital Universitario 12 de Octubre, Madrid, Madrid, Spain, ¹²Hospital del Mar, Barcelona, Spain, ¹³Department of Rheumatology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas GC, Spain, ¹⁴Hospital Universitari Vall d´Hebron, Ophtalmology, Barcelona, Spain, ¹⁵Hospital Universitari Vall d´Hebron, Maxillofacial Surgery, Barcelona, Spain, ¹⁶Vall d´Hebron Hospital Research Institute, Rheumatology, Barcelona, Spain, ¹⁷Sociedad Española de Reumatologia, Rheumatology, Madrid, Spain, ¹⁸Hospital Regional Universitario Carlos Haya , Rheumatology, Málaga, Spain, ¹⁹Department of Rheumatology, Hospital Araba, Vitoria, Pais Vasco, Spain, ²⁰Hospital Clinic an IDIBAPS, Barcelona, Spain, ²¹Cardiff University School of Medicine, Cardiff, United Kingdom, ²²Centre for Genomic Regulation (CNAG-CRG), National Centre for Genomic Analysis, Barcelona, Spain, ²³Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²⁴Hospital Universitario Puerta de Hierro Majadahonda., Majadahonda, Spain
Background/Purpose: Primary Sjögren’s Syndrome (pSS) shares with SLE and RA features including their predominance in women, immunological characteristics and genetic risk background. Hence, to dissect…
Abstract Number: 1449 • ACR Convergence 2024
Evaluating Spine Structural Damage on a Single CT in Patients with Ankylosing Spondylitis, and According to the Presence of Skin Psoriasis
Andrea MENNINI¹, Damien Loeuille², Isabelle Chary-Valckenaere³, Caroline Morizot⁴ and Marie LAFFAIRE¹, ¹CHRU Nancy, Nancy, France, ²Phd, Nancy Vandoeuvre, Lorraine, France, ³Nancy University Hospital, Vandœuvre-lès-Nancy, Lorraine, France, ⁴Nancy University hospital, Nancy, France
Background/Purpose: To compare, on Thoraco-Abdomino-Pelvic (TAP) computed tomography (CT), structural spinal involvement of the dorsal and lumbar segments in ankylosing spondylitis with (AS-Pso) and without…
Abstract Number: 1300 • ACR Convergence 2024
Tackling Rheumatology Workforce Shortages with a Case-Based Primary Care Rheumatology Curriculum
Diego Cabrera¹, Betty Hsiao² and Fotios Koumpouras¹, ¹Yale School of Medicine, New Haven, CT, ²Yale-New Haven Medical Center, New Haven, CT
Background/Purpose: Rheumatology is facing an imminent workforce shortage adversely affecting patients’ access to care. Primary care physicians are key stakeholders in the early evaluation and…
Abstract Number: 1317 • ACR Convergence 2024
Serum (1-3)-β-D-Glucan Levels in Juvenile Idiopathic Arthritis
Yasmine LAMROUS, Camille LEGLISE, Audrey VANRENTERGHEM, Taieb CHOUAKI and Djamal-Dine DJEDDI, CHU AMIENS PICARDIE, AMIENS, France
Background/Purpose: Juvenile idiopathic arthritis (JIA) encompasses the most common chronic rheumatologic manifestations in children. It results from the interplay of genetic, environmental, and infectious factors.…
Abstract Number: 1412 • ACR Convergence 2024
Survival and Predictive Markers of Prognosis in Patients with Cancer Occurrence After Sjögren Syndrome: A Long-term Observational Study
Yezi Peng¹, Jiana Chen², Yafei Ren³, Dan Yang², Xiangyi Shen⁴, Xu Jiang⁵ and Huaxia Yang², ¹Department of Rheumatology and Clinical Immunology, National Clinical Research Center for Dermatologic and Immunologic Diseases, the Ministry of Education Key Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Dong Cheng Qu, Beijing, China (People's Republic), ²Department of Rheumatology and Clinical Immunology, National Clinical Research Center for Dermatologic and Immunologic Diseases, the Ministry of Education Key Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ³Department of Rheumatology and immunotogy,Affiliated Hospital of Guilin Medical University,Guilin, China, Guangxi, China (People's Republic), ⁴Tsinghua University, Beijing, China, ⁵National Infrastructure for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Background/Purpose: Patients with Sjögren syndrome (SS) have been reported to have a higher risk of cancer than the general population, and malignancy constitutes one of…
Abstract Number: 1376 • ACR Convergence 2024
Comparison of the Efficacy of DMARDs in Phase 3 Trials of Different Populations Used in FDA Approvals for Rheumatoid Arthritis Since 2010
Catherine Emanuel¹ and Ajay Aggarwal², ¹Aclaris Therapeutics Inc., St Louis, MO, ²Aclaris Therapeutics, Inc., Wellesley, MA
Background/Purpose: Varying mechanisms of action are required to address the needs of rheumatoid arthritis patients with different levels of severity. Since 2010, all new FDA…
Abstract Number: 1432 • ACR Convergence 2024
Diagnostic Performance of Mayor Salivary Gland Ultrasound for Diagnosis of Sjögren’s Syndrome in Routine Clinical Practice
Carmen Raya-Santos¹, José Miguel Senabre², José Antonio Bernal³, Rocío Gallego Campuzano⁴, Lara Pons-Canet², Ana Pons-Bas², Juan Carlos Cortes⁴, Gregorio Santos-Soler⁵ and José Rosas-Gómez de Salazar⁶, ¹Hospital Marina Baixa, Villajoyosa (Alicante), Spain, ²Hospital Marina Baixa, Villajoyosa, Spain, ³Hospital Marina Baixa (Villajoyosa), Alicante, Spain, ⁴Hospital Marina Baixa, Villajoyosa, Comunidad Valenciana, Spain, ⁵Hospital Marina Baixa, Villajoyosa, ⁶Hospital Marina Baixa, PALMA DE MALLORCA, Comunidad Valenciana, Spain
Background/Purpose: Major salivary glands ultrasound (SGU) is a promising tool in the diagnosis of Sjögren syndrome (SS) and has demonstrated good sensitivity and specificity in…
Abstract Number: 1272 • ACR Convergence 2024
Angiopoietin-2 and Soluble Tumor Necrosis Factor Receptor Type II Are Elevated in Treatment Naïve JDM Plasma and Associate with Increased Muscle Disease Activity and Decreased Nailfold Capillary Density
Sophia Matossian¹, Julie Sturza², Megan Mattichak¹, William Brodie¹, Christine Goudsmit¹, Nicholas McClellan¹, J. Michelle Kahlenberg¹, Pei-Suen Tsou¹ and Jessica Turnier³, ¹University of Michigan, Ann Arbor, MI, ²Michigan Medicine Biostatistics and Data Management, Ann Arbor, MI, ³University of Michigan, Saline, MI
Background/Purpose: Juvenile Dermatomyositis (JDM) is an autoimmune disease characterized by vasculopathy in skin and muscle, where endothelial cell (EC) dysfunction is thought to contribute to…
Abstract Number: 1439 • ACR Convergence 2024
Risk of Hip and Spine Fractures in Axial Spondyloarthritis Is Associated with Treatment Class
Devin Driscoll¹, Navya George², S. Reza Jafarzadeh³, Christine Peloquin³, Jean Liew³ and Maureen Dubreuil⁴, ¹Boston Medical Center, Boston, MA, ²Boston University Medical Center Internal Medicine Residency Program, Boston, MA, ³Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁴Section of Rheumatology, Boston University School of Medicine, Boston, MA
Background/Purpose: Individuals with axial spondyloarthritis (axSpA) have a risk of fracture that is nearly double that of the general population, possibly related to chronic inflammation.…
Abstract Number: 1421 • ACR Convergence 2024
Differential Impact of B-cell Targeted Monotherapy and Combination Regimen on the Peripheral Blood Transcriptome of Adults with Active Sjögren Disease
Coziana Ciurtin¹, Lucia Martin-Gutierrez¹, John Casement², Kyle Thompson³, Fai Ng⁴, Andre van Maurik⁵ and Elizabeth Jury¹, ¹University College London, London, United Kingdom, ²Newcastle University, Newcastle, United Kingdom, ³Newcastle University, Newcastle, England, United Kingdom, ⁴Newcastle University, Newcastle upon Tyne, England, United Kingdom, ⁵Precision Medicine, GlaxoSmithKline, Stevenage, United Kingdom
Background/Purpose: Sjögren disease (SD) is characterised by B-cell hyperactivity associated with increased levels of B-lymphocyte stimulator (BlyS), but there are no effective biologic treatments for…
Abstract Number: 1390 • ACR Convergence 2024
One-year Real World Evidence Outcomes from the Cohort RADIUS (Real-world Analysis of Upadacitinib in Rheumatoid Arthritis Patients for Improved Understanding and Safety)
Luis Gomez-Lechon Quiros¹, José Miguel Sequí-Sabater², Amalia Rueda³, Costas Torrijo Nerea⁴, Carlos Valera-Ribera⁵, Juan Miguel López-Gómez⁶ and Antonio Alvarez-Cienfuegos⁷, ¹Hospital Francesc de Borja, Valéncia, Spain, ²La Ribera University Hospital, Rheumatology Department, Gandía, Comunidad Valenciana, Spain, ³Hospital General de Valencia, VALENCIA, Comunidad Valenciana, Spain, ⁴Generalitat valenciana, Valencia, Spain, ⁵Hospital Doctor Peset, Valéncia, Comunidad Valenciana, Spain, ⁶Conselleria de Sanitat/Hospital Universitario de Elda, Elda, Comunidad Valenciana, Spain, ⁷Conselleria de Sanitat/Hospital de la Vega Baja, Orihuela, Comunidad Valenciana, Spain
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory disease that affects the joints and other parts of the musculoskeletal system. Early diagnosis and initiation of…
Abstract Number: 1431 • ACR Convergence 2024
Computational Systems Biology Approach to Unveil Molecular Interactions in Sjogren’s Disease Pathogenesis
Sacha E Silva Saffar¹, Jacques-Eric Gottenberg², Michele Bombardieri³, Divi Cornec⁴, Jacques-Olivier Pers⁴, Marta Alarcon-Riquelme⁵, Philippe Moigeon⁶, Michael Barnes⁷, Sandra Ng⁸, Wan Fai Ng⁹, Xavier Mariette¹⁰, Gaetane Nocturne¹⁰ and Anna Niaraki¹¹, ¹University Paris Saclay, Le Kremlin Bicetre, France, ²Rheumatology Department, Strasbourg University Hospital,, Strasbourg, France, ³Centre for Experimental Medicine and Rheumatology, The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ⁴University of Brest, Brest, France, ⁵Fundación Progreso y Salud, Andalusian Government, Granada, Spain, ⁶Servier Laboratories, France, Gif sur Yvette, France, ⁷William Harvey Research institute, Centre for Translational Bioinformatics, London, United Kingdom, ⁸Centre for Translational Bioinformatics, William Harvey Research Institute, London, United Kingdom, ⁹Department of Rheumatology, Newcastle University, & HRB Clinical Research Facility, University College Cork, Newcastle upon Tyne, United Kingdom, ¹⁰Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin Bicetre, France, ¹¹University of Toulouse, Toulouse, France

Background/Purpose: Sjögren's disease (SjD) presents an unmet medical challenge as there is currently no cure. Despite advances in understanding the immunopathogenesis of SjD, there is…
Abstract Number: 1447 • ACR Convergence 2024
The Frequency of Diffuse Idiopathic Skeletal Hyperostosis (DISH) in Spondyloarthritis in Comparison to Age and Sex-matched Controls and Impact of SpA on Onset Age of DISH
Ummugulsum Gazel¹, Nicole Hryciw², Baljot Chahal³, Seyyid Bilal Acikgoz⁴, Gizem Ayan⁵, Zaid Jibri³, Marcos Loreto Sampaio³ and Sibel Aydin⁶, ¹University of Ottawa, Ottawa, ON, Canada, ²University of Ottawa, Ottawa, Canada, ³University of Ottawa, Radiology, Ottawa, Canada, ⁴University of Ottawa, Rheumatology, Ottawa, ON, Canada, ⁵University of Ottawa, Rheumatology, Ankara, Turkey, ⁶University of Ottawa - Ottawa, Ottawa, ON, Canada
Background/Purpose: Although diffuse idiopathic skeletal hyperostosis (DISH) is classically defined in the thoracic spine and the elderly population, there are case reports on the overlap…

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