Abstracts Archive - Page 1144 of 2425 - ACR Meeting Abstracts

Abstract Number: 2092 • 2018 ACR/ARHP Annual Meeting
Glucocorticoid-Induced Leucine Zipper (GILZ) Is a Novel Checkpoint Regulator of Type I Interferon (IFN) Production in SLE
Champa Nataraja¹, Eric Morand¹, Jacinta Lee¹, Taylah Bennett¹, Jacqueline Flynn¹, James Harris¹ and Sarah Jones², ¹Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia, ²School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia
Background/Purpose: Glucocorticoids (GC) remain the frontline treatment in Systemic Lupus Erythematosus (SLE) despite their predictable metabolic adverse effects. Type I interferons (IFN), produced by TLR7…
Abstract Number: 2093 • 2018 ACR/ARHP Annual Meeting
Glucocorticoid-Induced Leucine Zipper (GILZ) Deficiency Worsens Autoimmunity in the Lyn-Deficient Murine Model of Lupus By Disinhibiting the Type I Interferon (IFN) Pathway
Champa Nataraja¹, Eric Morand¹, Jacinta Lee¹, Taylah Bennett¹, Jacqueline Flynn¹, James Harris¹ and Sarah Jones², ¹Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia, ²School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease associated with B cell hyperactivity driven by dysregulated type I IFN. Lyn-deficient mice develop lupus-like…
Abstract Number: 2094 • 2018 ACR/ARHP Annual Meeting
Examining T Cell Exhaustion in Murine Systemic Lupus Erythematosus
Jeremy Tilstra¹, Lyndsay Avery², Ashley Menk², Rachael Gordon², Shuchi Smita³, Lawrence Kane³, Maria Chikina², Greg Delgoffe³ and Mark Shlomchik⁴, ¹Rheumatology, Univ of Pittsburgh Medical Center, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Department of Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: While T cells are important for the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis, little is known about how T cells function…
Abstract Number: 2095 • 2018 ACR/ARHP Annual Meeting
Neutralizing CXCL13 Attenuates Neuropsychiatric Disease in Lupus-Prone Mice
Michelle Huang¹, Ariel Stock² and Chaim Putterman³, ¹Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, ²Albert Einstein College of Medicine, Bronx, NY, ³Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Despite the many lupus patients affected by neuropsychiatric signs and symptoms, the pathogenesis of neuropsychiatric disease in SLE remains unclear. MRL-lpr/lpr mice, a classic…
Abstract Number: 2096 • 2018 ACR/ARHP Annual Meeting
Ectonucleotidase CD73 Suppresses Autoantibody Production and Arterial Vasculopathy in Murine Lupus
Ramadan A. Ali¹, Nicole R. Pearce¹, Srilakshmi Yalavarthi¹, Kevin B. Atkins¹, Alex A. Gandhi¹, Yogendra Kanthi¹ and Jason S. Knight², ¹University of Michigan, Ann Arbor, MI, ²., University of Michigan, Ann Arbor, MI
Background/Purpose: CD73 is a surface nucleotidase that extends into the extracellular space where it generates adenosine from AMP. By regulating a cell’s “purinergic halo,” CD73…
Abstract Number: 2097 • 2018 ACR/ARHP Annual Meeting
Monotherapy with Filgotinib, a JAK1-Selective Inhibitor, Reduces Disease Severity and Alters Immune Cell Subsets in the NZB/W F1 Murine Model of Lupus
Pei Han¹, Christopher Pohlmeyer¹, Ching Shang¹, Zhihua Cui², David Lopez³, Astrid Clarke², Randall Jones², Nevena Mollova³, Igor Mikaelian⁴, David Newstrom³, Shiva Zaboli³, Allyson Shauf³ and Julie Di Paolo⁵, ¹Immunology and Inflammation, Gilead Sciences, Foster City, CA, ²Gilead Sciences, Seattle, WA, ³Gilead Sciences, Foster City, CA, ⁴Biology Core Support, Gilead Sciences, Foster City, CA, ⁵Immunology and Inflammation Biology, Gilead Sciences, Inc., Foster City, CA
Background/Purpose: SLE is a heterogeneous autoimmune disease characterized by immune system hyper-activation leading to the production of autoantibodies and immune attack on multiple organs including…
Abstract Number: 2098 • 2018 ACR/ARHP Annual Meeting
NRF2 Downregulates Inflammation and Protects Against Autoimmune Lung Disease in Experimental Lupus
Shuhong Han¹, Haoyang Zhuang¹, Pui Lee², Lijun Yang³ and Westley Reeves^1,4, ¹Medicine, University of Florida, Gainesville, FL, ²Harvard Medical School, Boston, MA, ³Pathology, Immunology and laboratory medicine, University of Florida, Gainesville, FL, ⁴Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL
Background/Purpose: The transcription factor nuclear factor erythroid 2-related factor (Nrf2) is a master regulator of genes involved in cellular defense against oxidative and electrophilic stresses.…
Abstract Number: 2099 • 2018 ACR/ARHP Annual Meeting
Bruton’s Tyrosine Kinase (BTK) Inhibition Modulates Multiple Cell Types Instrumental in the Pathogenesis of Lupus Nephritis
Samantha Chalmers¹, Sayra Garcia¹, Elliott Klein², Jay S. Fine², Gerald Nabozny³, Meera Ramanujam² and Chaim Putterman⁴, ¹Albert Einstein College of Medicine, Bronx, NY, ²Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ³[email protected], Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁴Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY
Background/Purpose: Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus (SLE) that adds substantial morbidity and mortality. Passive transfer of pre-formed nephritogenic antibodies…
Abstract Number: 2100 • 2018 ACR/ARHP Annual Meeting
Topical Endocannabinoid Administration Protects MRL-Lpr/Lpr Mice from Cutaneous Lupus Erythematosus
Samantha Chalmers¹, Sayra Garcia¹, Andrew Draganski¹, Jessica Doerner², Adam Friedman³, Joel Friedman¹ and Chaim Putterman⁴, ¹Albert Einstein College of Medicine, Bronx, NY, ²University of Pennsylvania, Philadelphia, PA, ³Dermatology, GW School of Medicine and Health Sciences, Washington, DC, ⁴Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY
Background/Purpose: Cutaneous lupus erythematosus (CLE) affects ~75% of SLE patients and has a profound impact on quality of life. While the morbidity from CLE is…
Abstract Number: 2101 • 2018 ACR/ARHP Annual Meeting
UV-Induced Skin Inflammation Is Exacerbated in Lupus-Prone Ro60 Knockout Female Mice with Interferon Priming
Masaoki Kawasumi¹, Daiki Rokunohe¹, Xizhang Sun², Lena Tanaka², Sladjana Skopelja-Gardner³, Edward Chiou², Anne Davidson⁴, Sandra L. Wolin⁵ and Keith B. Elkon², ¹Medicine/Dermatology, University of Washington, Seattle, WA, ²Medicine/Rheumatology, University of Washington, Seattle, WA, ³University of Washington, Seattle, WA, ⁴Feinstein Institute for Medical Research, Manhasset, NY, ⁵National Cancer Institute, Frederick, MD
Background/Purpose: Photosensitivity is a major symptom of lupus, and excessive sunlight can cause skin rashes and flares of disease activity in systemic lupus erythematosus (SLE).…
Abstract Number: 2102 • 2018 ACR/ARHP Annual Meeting
Hyaluronic Acid Synthesis Inhibition Blocks Nephritis and Extends Lifespan in Mice Prone to Lupus
Abel Suarez-Fueyo¹, Seung-Ki Kwok², Kayaho Maeda³ and George C Tsokos⁴, ¹Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, Boston, MA, ²Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul., Seoul, Korea, Republic of (South), ³Rheumatology, Department of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, Boston, MA, ⁴Division of Rheumatology, Department of Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, Boston, MA
Background/Purpose: Hyaluronic acid (HA) is a component of the extracellular matrix and is known to be involved in cancer biology. Although evidence suggests that HA…
Abstract Number: 2103 • 2018 ACR/ARHP Annual Meeting
Using a Drosophila Model to Unravel the Genetic Complexity of Systemic Lupus Erythematosus
Nathan Mortimer, Mary Fischer, Ashley Waring and Victoria DeMichel, School of Biological Sciences, Illinois State University, Normal, IL
Background/Purpose: The objective of our research is to understand the genetic architecture and molecular mechanisms that contribute to the development and progression of the autoimmune…
Abstract Number: 2104 • 2018 ACR/ARHP Annual Meeting
Glomerular and Tubular Transcriptional Profiles Reveal Gene Clusters Specific for Different Stages of Glomerulonephritis in NZM2328 Mice
Hongyang Wang¹, Nick Geraci², Prathyusha Bachali², Brian Kegerreis³, Michelle Catalina², Erika Hubbard², Sun-sang Sung⁴, Felicia Gaskin⁵, Amrie Grammer², Peter Lipsky² and Shu Man Fu⁶, ¹Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA, ²AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA, ³AMPELBioSolutions and RILITE Research Institute, Charlottesville, VA, ⁴Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia School of Medicine, Charlottesville, VA, ⁵Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, ⁶Department of Medicine, University of Virginia, Charlottesville, VA
Background/Purpose: NZM2328 mice spontaneously develop glomerulonephritis (GN) and females commonly progress to renal failure. Our previous study showed that acute GN (aGN) and chronic GN…
Abstract Number: 2105 • 2018 ACR/ARHP Annual Meeting
Genetic Analysis of a Drosophila Systemic Lupus Erythematosus Model Reveals Lupus Susceptibility Genes
Pooja KR, Brooklynne Thielen, Xavier Hernandez and Nathan Mortimer, School of Biological Sciences, Illinois State University, Normal, IL
Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder with various immunological abnormalities and a diverse range of clinical symptoms. In contrast to the…
Abstract Number: 2106 • 2018 ACR/ARHP Annual Meeting
Angiotensin-Converting Enzyme Inhibitors Prevent Spatial Memory Impairment in a Mouse Model of Neuropsychiatric Lupus through LAIR1-Mediated Inhibition of Microglial Activation
Nina Kello¹, Jacquelyn Nestor², Tomas Huerta³, Czeslawa Kowal², Elham Nasiri³, Patricio T. Huerta⁴, Bruce Volpe⁵ and Betty Diamond⁶, ¹Rheumatology, Northwell Health, Donald and Barbara Zucker School of Medicine, Manhasset, NY, ²Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, ³Feinstein Institute for Medical Research, Manhasset, NY, ⁴Feinstein Institue for Medical Research, Manhasset, NY, ⁵Biomedical Sciences, The Feinstein Institute for Medical Research, Manhasset, NY, ⁶The Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Cognitive dysfunction affects up to 90% of patients with systemic lupus erythematosus (SLE), however it is grossly under-recognized, the pathogenesis is poorly understood and…

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