Abstracts Archive - Page 1143 of 2425 - ACR Meeting Abstracts

Abstract Number: 2077 • 2018 ACR/ARHP Annual Meeting
Pathological Osteogenesis and Inflammation in Experimental Spondyloarthritis Are Associated with Aberrant Type H Blood Vessels and Development of High Endothelial Venules Accompanied By Ectopic Lymphoid Structures in Bone Marrow
Merlijn Kaaij¹, Jan Piet van Hamburg², George Kollias³, Dominique Baeten¹, Leonie van Duivenvoorde¹ and Sander W. Tas², ¹Department of Clinical Immunology & Rheumatology and Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Background/Purpose: Spondyloarthritis (SpA) is characterized by pathological osteogenesis, inflammation and extensive angiogenesis in inflamed tissues. TNF plays a central role in SpA pathology and transgenic…
Abstract Number: 2078 • 2018 ACR/ARHP Annual Meeting
Induction of Netosis in Ankylosing Spondylitis: Association to Disease Pathogenesis and Modulation By Anti-Tnfα Therapy
Patricia Ruiz-Limon¹, M. Carmen Castro-Villegas², Chary Lopez-Pedrera³, Rafaela Ortega-Castro⁴, Maria Carmen Abalos-Aguilera¹, Nuria Barbarroja⁴, Carlos Perez-Sanchez⁴, Ivan Arias de la Rosa¹, Alejandro Ibáñez-Costa³, Alejandra Maria Patiño-Trives³, Daniel Espejo-Peralbo¹, Pilar Font-Ugalde⁴, Jose Antonio Gonzalez-Reyes⁵, Jose Manuel Villalba⁵, Clementina López-Medina⁴, Alejandro Escudero-Contreras¹, Eduardo Collantes-Estévez⁴ and Yolanda Jiménez-Gómez⁴, ¹Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ³IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁵Departamento de Biologia Celular, Fisiologia e Inmunología, University of Córdoba, Cordoba, Spain
Background/Purpose: NETosis has been suggested to play a central role in several rheumatology diseases. Nevertheless, this process, and its modulation in therapeutic response has not…
Abstract Number: 2079 • 2018 ACR/ARHP Annual Meeting
Dysbiosis of Gut Microbiomes in Ankylosing Spondylitis
Chen Zhou¹, Xuan Zhang² and Xiao Xinyue¹, ¹Peking Union Medical College Hospital, Beijing, China, ²Rheumatology, Peking Union Medical College Hospital, Beijing, China
Background/Purpose: Ankylosing spondylitis (AS) is a common chronic, systemic, inflammatory disease. Gut microbiome has been reported to play an important role in the homeostasis of…
Abstract Number: 2080 • 2018 ACR/ARHP Annual Meeting
Plasmatic Glycoprotein and Lipoprotein Nuclear Magnetic Resonance Profiles Associated with Psoriatic Arthritis
Antonio Julià¹, Jose A Pinto-Tasende², Jordi Gratacós³, Rubén Queiro⁴, Carlos Alberto Montilla-Morales⁵, Juan Carlos Torre-Alonso⁶, Jose Javier Perez Venegas⁷, Antonio Fernandez-Nebro⁸, Emília Fernández⁹, Santiago Muñoz-Fernández¹⁰, Carlos M Gonzalez¹¹, Daniel Roig¹², Pedro Zarco¹³, Alba Erra¹⁴, Jesus Rodriguez¹⁵, Santos Castañeda¹⁶, Esteban Rubio-Romero¹⁷, Georgina Salvador¹⁸, Cesar Diaz-Torné¹⁹, Ricardo Blanco²⁰, Alfredo Willisch²¹, José Antonio Mosquera²², Paloma Vela²³, Jesús Tornero²⁴, Simón Sánchez-Fernández²⁵, Hector Corominas²⁶, Julio Ramírez²⁷, María López-Lasanta¹, Raül Tortosa¹, Núria Palau¹, Juan D. Cañete²⁸ and Sara Marsal¹, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain, ³Rheumatology Department, Hospital Parc Taulí, Sabadell (Barcelona), Spain, ⁴Rheum-Derm Unit, Hospital Universitario Central de Asturias, Oviedo, Spain, ⁵Hospital Clínico Universitario de Salamanca. Spain, Salamanca, Spain, ⁶Unit Rheumatology, Hospital Monte Naranco, Oviedo, Spain, ⁷Rheumatology, Hospital de Jerez de la Frontera, Jerez de la Frontera, Spain, ⁸UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga Departamento de Medicina y Dermatología, Universidad de Málaga, MÁLAGA, Spain, ⁹Hospital Universitario Infanta Sofía, Madrid, Spain, ¹⁰Hospital Universitario Infanta Sofia. Madrid. Spain, Mardid, Spain, ¹¹Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ¹²Rheumatology Service, Hospital Universitari de Bellvitge, Hospitalet de Llobregat- Barcelona, Spain, ¹³H Fundación Alcorcón, Alcorcón, Spain, ¹⁴Rheumatology Department, Hospital Sant Rafael, Barcelona, Spain, ¹⁵Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain, ¹⁶Hospital Universitario La Princesa, IIS-Princesa, Madrid, Spain, ¹⁷Hospital Universitario Virgen del Rocío. Sevilla. Spain, Sevilla, Spain, ¹⁸Rheumatology Unit., Hospital Mutua de Terrassa. Barcelona, Barcelona, Spain, ¹⁹Rheumatology Department, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, ²⁰Rheumatology Department,, Hospital Marqués de Valdecilla, Santander, Spain, ²¹Complexo Hospitalario de Ourense, Ourense, Spain, ²²Complejo Hospitalario Provincial de Pontevedra, Pontevedra, Spain, ²³Hospital General Universitario de Alicante, Alicante, Spain, ²⁴Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, ²⁵Rheumatology Department, Hospital General La Mancha Centro, Ciudad Real, Spain, ²⁶Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, ²⁷Rheumatology, Hospital Clínic de Barcelona, Barcelona, Spain, ²⁸Rheumatology Deparment, Hospital Clinic and IDIBAPS, Barcelona, Spain, Barcelona, Spain
Background/Purpose: Psoriatic arthritis (PsA) is an autoimmune disease characterized by the chronic inflammation of the skin and joints. Inflammatory processes translate into changes of the…
Abstract Number: 2081 • 2018 ACR/ARHP Annual Meeting
Dysregulated MiR-125a Promotes Joint Angiogenesis in Psoriatic Arthritis through Altered Bioenergetics
Sarah M. Wade¹, Nil Ohnesorge², Hayley Mc-Loughlin¹, Monika Biniecka¹, Trudy McGarry³, Breandán Kennedy⁴, Douglas J. Veale² and Ursula Fearon³, ¹Department of Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ²Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, ³Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ⁴Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin, Ireland
Background/Purpose: Psoriatic arthritis (PsA) is characterised by an early vascular phase essential for pannus growth, immune responses and disease progression. Recently, numerous studies have highlighted…
Abstract Number: 2082 • 2018 ACR/ARHP Annual Meeting
ERAP1 Deficiency Partially Relieves HLA-B27-Induced ER Stress and IL-23 Expression, but Does Not Restore Dendritic Cell Function in Experimental Spondyloarthritis
Tri Tran¹, Vance Holt², Tejpal Gill¹, Joshua R. Bennett², Joel Taurog³ and Robert Colbert⁴, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Dept Int Med-Rheum Dis Div, University of Texas Southwestern Medical Center, Dallas, TX, ⁴National Institute of Arthritis and Musculuskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Preliminary results suggest that endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) deficiency partially protects HLA-B27/human b2m transgenic (B27-Tg) rats from spondyloarthritis (SpA) as evidenced by…
Abstract Number: 2083 • 2018 ACR/ARHP Annual Meeting
Epistasis between HLA-B27 and ERAP1 Affects Gut Microbial Dysbiosis and Arthritis in Experimental Spondyloarthritis
Tejpal Gill¹, Tri Tran¹, Stephen R. Brooks² and Robert Colbert³, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Biodata Mining and Discovery Section, Office of Science and Technology, NIAMS/NIH, Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Common variants in endoplasmic reticulum (ER)-associated aminopeptidase-1 (ERAP1) affect susceptibility to spondyloarthritis (SpA) in HLA-B27-positive human subjects, with loss-of-function/expression conferring protection. Using HLA-B27/human b2-microglobulin…
Abstract Number: 2084 • 2018 ACR/ARHP Annual Meeting
Targeting the Voltage-Gated K+ Channels: T Cell Targeted Therapies for Spondyloarthritis
Siba P. Raychaudhuri¹, Smriti K. Raychaudhuri² and Heike Wulff³, ¹Rheumatology Section, Sacramento Veterans Affairs Medical Center, Sacramento, CA, ²Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA, ³Pharmacology, School of Medicine, University of California Davis, Davis, CA
Background/Purpose: TCR (T cell receptor) engagement triggers intracellular Ca++ influx through voltage-independent Ca2+ channels. This crucial Ca2+-influx is only possible by a counterbalancing K+ efflux…
Abstract Number: 2085 • 2018 ACR/ARHP Annual Meeting
Response Gene to Complement-32 Promotes Kidney Damage in Immune Complex –Mediated Glomerulonephritis
Anamaria Talpos-Caia^1,2, Vinh Nguyen^2,3, Alexandru Tatomir^3,4, Sun-sang Sung⁵, John Papadimitriou⁶, Sergei Atamas^2,3, Irina G. Luzina^2,3, Simona Rednic¹, Horea Rus^3,4 and Violeta Rus^2,3, ¹Rheumatology, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania, ²Medicine, Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD, ³Research Service, Veteran Affairs Medical Center, Baltimore, MD, ⁴Neurology, University of Maryland School of Medicine, Baltimore, MD, ⁵Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia School of Medicine, Charlottesville, VA, ⁶Pathology, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Response Gene to Complement (RGC)-32 is a cell cycle regulator widely expressed in normal tissues including brain, kidney, spleen, thymus, multiple tumors and in…
Abstract Number: 2086 • 2018 ACR/ARHP Annual Meeting
4-Phenylbutyric Acid Mediates Therapeutic Effect in Systemic Lupus Erythematosus: Observations in an Experimental Murine Lupus Model
Yunjung Choi¹, Ji-hyun Jung², Eun-Kyeong Lee², Myeung Su Lee³, Changhoon Lee⁴ and Wan-Hee Yoo⁵, ¹Division of Rheumatology, Department of Internal Medicine, Research Institute of Clinical Medicine of chonbuk national university-Biomedical Research Institute of chonbuk national university hospital, jeonju, Korea, Republic of (South), ²Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea, Republic of (South), ³Department of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South), ⁵Division of Rheumatology, Department of Internal Medicine, Research Institute of Clinical Medicine of chonbuk national university-Biomedical Research Institute of chonbuk national university hospital, Jeonju, Korea, Republic of (South)
Background/Purpose: The purpose of the present study was to investigate whether ER stress inhibition by 4-phenylbutyric acid (4-PBA) ameliorates lupus manifestations in an experimental lupus…
Abstract Number: 2087 • 2018 ACR/ARHP Annual Meeting
Kidney Tissue Damage in Mice with Single and Combined Abnormalities in Complement, Interferon and Apoptotic Cell Clearance
Sladjana Skopelja-Gardner¹, YuFeng Peng², Payton Hermanson², Lucrezia Colonna², Xizhang Sun³, Lena Tanaka⁴, Anne Davidson⁵, David Salant⁶ and Keith B. Elkon⁷, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ²Division of Rheumatology, University of Washington, Seattle, WA, ³Rheumatology, University of Washington, Seattle, WA, ⁴Medicine/Rheumatology, University of Washington, Seattle, WA, ⁵Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ⁶Boston University, Boston, MA, ⁷University of Washington, Seattle, WA
Background/Purpose: Lupus nephritis (LN) affects ~70% of systemic lupus erythematosus (SLE) patients and is one of the main contributors to morbidity and mortality. While defective…
Abstract Number: 2088 • 2018 ACR/ARHP Annual Meeting
Human TLR8 at the Interface between Innate and Adaptive Immunity in Systemic Lupus Erythematosus
Naomi I. Maria¹, Megan Woods², Shani Martinez¹, Chirag Raparia², Weiqing Huang² and Anne Davidson², ¹Center for Autoimmunnity, Musculoskeletal & Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ²Center for Autoimmunity, Musculoskeletal & Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Infiltrating macrophages are one of the hallmarks of renal inflammation and kidney damage in lupus nephritis (LN). Surprisingly overexpression of TLR8, but not other…
Abstract Number: 2089 • 2018 ACR/ARHP Annual Meeting
The Differential Impact of the Abrogation of the Costimulatory Molecule CD137 Ligand on Renal and Cerebral Manifestations in C57BL/6.Faslpr-/- mice
Anselm Mak¹, Bhushan Dharmadhikari², Lik Wei Wong², Saji Kumar Sreedharan² and Herbert Schwarz², ¹Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, ²Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Background/Purpose: Costimulatory molecules which mediate cross-talks between leukocytes, have been identified to play a pathogenetic pivotal role in systemic lupus erythematosus (SLE). Abrogation of the…
Abstract Number: 2090 • 2018 ACR/ARHP Annual Meeting
Identification of a Role for Monocytes in Murine Lupus Associated Diffuse Alveolar Hemorrhage By Mass Cytometry
Nathan Nelson-Maney¹, Pui Lee², Anais Levescot³, Yuelong Huang⁴ and Peter Nigrovic⁵, ¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ²Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, boston, MA, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a life-threatening pulmonary complication of systemic lupus erythematosus. The inciting pathology is thought to be pulmonary capillaritis but the…
Abstract Number: 2091 • 2018 ACR/ARHP Annual Meeting
Mucosal-Associated Invariant T (MAIT) Cells As a Potential Therapeutic Target for Systemic Lupus Erythematosus
Goh Murayama¹, Asako Chiba², Atsushi Nomura³, Hirofumi Amano¹, Ken Yamaji¹, Naoto Tamura¹ and Sachiko Miyake^4,5, ¹Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Juntendo Univ Sch of Med, Juntendo University School of Medicine, Tokyo, Japan, ³JUNTENDO UNIVERSITY SCHOOL OF MEDICINE, Tokyo, Japan, ⁴Division of Immunology/NCNP, Natl Institute of Neuroscience, Kodaira Tokyo, Japan, ⁵Immunology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate T cells that are restricted by the nonpolymorphic MHC-related molecule-1 (MR1) and express a semi-invariant TCRα chain:…

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