Abstract Number: 59 • 2019 ACR/ARP Annual Meeting
Evaluation of Potential Mechanisms Underlying the Safety Observations of Filgotinib in Clinical Studies in RA
Background/Purpose: Inhibition of the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway have demonstrated efficacy in immune-mediated diseases and haves been identified as therapeutic…Abstract Number: 60 • 2019 ACR/ARP Annual Meeting
mTORC1-phosphorylated CXCR3+memory B Cells and Their Potential as a New Mode of Action of TNF Inhibitors in RA
Background/Purpose: B cells play a crucial role through producing autoantibodies and activating osteoclasts in synovium in rheumatoid arthritis (RA). Recently “Immunometabolism” attract much attention, and…Abstract Number: 61 • 2019 ACR/ARP Annual Meeting
Lyn-Deficient Murine Lupus Is Exacerbated by Glucocorticoid-Induced Leucine Zipper (GILZ) Deficiency
Background/Purpose: Lyn-deficient mice develop hyperactive B cells, excess IL-6 production, and nephritis. Mice deficient in glucocorticoid-induced leucine zipper (GILZ), an intracellular protein involved in glucocorticoid…Abstract Number: 62 • 2019 ACR/ARP Annual Meeting
Human Gingiva-derived Mesenchymal Stem Cells Are Therapeutic in Lupus Nephritis Through Targeting of CD39-CD73 Signaling Pathway
Background/Purpose: Cell specific and cytokine targeted therapeutics have underperformed in systemic lupus erythematosus (SLE) in spite of numerous targets examined and clinical trials conducted. Mesenchymal…Abstract Number: 63 • 2019 ACR/ARP Annual Meeting
The Role of the Intestinal Microbiota in Lupus Nephritis
Background/Purpose: The bacterial gut microbiota (GM) exerts substantial influence over the host immune system and dysbiosis of this microbial community has been associated with end-organ…Abstract Number: 64 • 2019 ACR/ARP Annual Meeting
Rab4A Controls mTOR Pathway Activation, Pro-inflammatory Lineage Development, and Disease Pathogenesis in Lupus-prone Mice
Background/Purpose: Mouse models of SLE have been indispensable tools for studying disease pathogenesis; however, each model only recapitulates limited aspects of lupus. SLE1.2.3. (TC) mice…Abstract Number: 65 • 2019 ACR/ARP Annual Meeting
CD6 Modulation Ameliorates Skin and Kidney Disease in a Spontaneous Murine Model of SLE
Background/Purpose: T cells are an important contributor the pathogenesis of SLE and its various end organ manifestations. Thus, they present themselves as potential therapeutic targets;…Abstract Number: 66 • 2019 ACR/ARP Annual Meeting
Amelioration of Immune Complex-Mediated Glomerulonephritis by CD6 Modulation
Background/Purpose: CD6 is a co-stimulatory receptor on T cells, that binds to activated leukocyte cell adhesion molecule (ALCAM), a ligand expressed on antigen presentation cells…Abstract Number: 67 • 2019 ACR/ARP Annual Meeting
Dermal Lymphatic Dysfunction Is Associated with Disease Activity in the MRL/lpr Lupus Model
Background/Purpose: Lymphatic vessels are important in limiting the extent and duration of peripheral immune response, both by transporting cellular debris, inflammatory cells and excess interstitial…Abstract Number: 68 • 2019 ACR/ARP Annual Meeting
Inactivation of Transaldolase and HRES-1/Rab4 Predisposes to Hepatitis in a Mouse Model of Systemic Lupus Erythematosus
Background/Purpose: Deficiency of transaldolase (TAL) in systemic lupus erythematosus (SLE) predisposes to oxidative stress mediated autoimmune hepatitis[1, 2]. Along with TAL, HRES-1/Rab4 (Rab4A), a small…Abstract Number: 69 • 2019 ACR/ARP Annual Meeting
Treatment of Lupus-prone MRL-lpr Mice with the Mitochondrial Antioxidant MitoQ
Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by a type I Interferon (IFN-I) gene signature in peripheral blood lymphocytes (PBL), which contain enlarged mitochondria and…Abstract Number: 70 • 2019 ACR/ARP Annual Meeting
Angiotensin Receptor Blockers Prevent Loss of Dendritic Complexity in a Lupus Mouse Model of Cognitive Impairment
Background/Purpose: Cognitive dysfunction affects the majority of patients with systemic lupus erythematosus (SLE), however it is grossly under-recognized, the pathogenesis is poorly understood, and no…Abstract Number: 71 • 2019 ACR/ARP Annual Meeting
Inhibition of Nuclear Pore Export Ameliorates Lupus via Modulation of Plasma Cell Generation and Survival
Background/Purpose: A major challenge in lupus is the elimination of autoreactive plasma cells, which amplify inflammation at peripheral sites via deposition of autoantibody-self antigen complexes.…Abstract Number: 72 • 2019 ACR/ARP Annual Meeting
The Single-cell Transcriptomic Landscape of NZB/W Murine Lupus at Early and Late Stages of Disease
Background/Purpose: Lupus nephritis is a complex and heterogeneous disease characterized by infiltrating immune cells in damaged kidney tissue. While mouse models have enabled mechanistic studies…Abstract Number: 73 • 2019 ACR/ARP Annual Meeting
Potent Anti-neutrophil Properties of the Natural Compound 6-Gingerol in Models of Lupus and Antiphospholipid Syndrome
Background/Purpose: 6-gingerol, the major bioactive compound of ginger root, is known to have anti-inflammatory and anti-oxidative effects. Indeed, ginger has been employed for millennia as…
ACR Meeting Abstracts