Abstracts Archive - Page 1126 of 2425 - ACR Meeting Abstracts

Abstract Number: 1821 • 2018 ACR/ARHP Annual Meeting
Filgotinib, an Oral, Selective Janus Kinase 1 Inhibitor, Is Effective in Psoriatic Arthritis Patients with an Inadequate Response to Conventional Disease-Modifying Anti-Rheumatic Drugs: Results from a Randomized, Placebo-Controlled, Phase 2 Study
Philip J. Mease¹, Dafna D Gladman², Filip van Den Bosch³, Anna Rychlewska-Hanczewska⁴, Anna Dudek⁵, Chantal Tasset⁶, Luc Meuleners⁶, Pille Harrison⁷, Robin Besuyen⁶, Rebecca Kunder⁸, Neelufar Mozaffarian⁸, Laura C. Coates⁹ and Philip Helliwell¹⁰, ¹Swedish Medical Centre and University of Washington, United States of America, Seattle, WA, ²Department of Medicine, Toronto Psoriatic Arthritis Research Program, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Department of Rheumatology, University of Ghent, Ghent, Belgium, Ghent, Belgium, ⁴ai centrum medyczne sp.z o.o.sp.k., Poznan, Poland, Poznan, Poland, ⁵Centrum Medyczne AMED, Warszawa, Poland, Warszawa, Poland, ⁶Galapagos NV, Mechelen, Belgium, Mechelen, Belgium, ⁷Galapagos NV, Mechelen, Belgium, ⁸Gilead Sciences, Inc., Foster City, CA, ⁹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ¹⁰Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, UK, Leeds, United Kingdom
Background/Purpose: Filgotinib (FIL) is an orally administered, selective Janus Kinase 1 (JAK1) inhibitor in development for inflammatory diseases. The efficacy and safety of FIL was…
Abstract Number: 1822 • 2018 ACR/ARHP Annual Meeting
RNA-Sequencing of Mouse and Human Synovial Fibroblasts Reveals Fibroblast Subset-Specific Responses to Inflammation
Anqi Gao¹, Kevin Wei², Ilya Korsunsky³ and Michael Brenner⁴, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: In rheumatoid arthritis (RA), synovial fibroblasts secrete inflammatory cytokines, degrade cartilage and mediate bone destruction. We have previously identified three synovial fibroblasts subsets with…
Abstract Number: 1823 • 2018 ACR/ARHP Annual Meeting
Loss of Synovial Tissue Resident Macrophages Permits Monocyte to Macrophage Differentiation and Inflammation in Hupo Mice
Qi Quan Huang¹, Renee E. Doyle², Alexander Misharin³, Shang-Yang Chen⁴, Deborah R. Winter⁵ and Richard M. Pope², ¹Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/pulmonary, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, chicago, IL, ⁵Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: We established a mouse model (HUPO) by deletion of Flip in CD11c+ cells that spontaneously develops erosive inflammatory arthritis resembling rheumatoid arthritis (RA). Since…
Abstract Number: 1824 • 2018 ACR/ARHP Annual Meeting
Osteoclast Derived-Autotaxin, a Distinguishing Factor for Inflammatory Bone Loss
Olivier Peyruchaud¹, Sacha Flammier¹, Fanny Bourguillault¹, Francois Duboeuf¹, Gabor Tigyi², Irma Machuca-Gayet¹ and Fabienne Coury¹, ¹INSERM UMR1033, Lyon, France, ²Department of Physiology, University of Tennessee, Memphis, TN
Background/Purpose: Rheumatoid arthritis (RA) patients in sustained clinical remission or low disease activity may continue to accrue periarticular bone erosions despite control of inflammation. Osteoclasts…
Abstract Number: 1825 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Associated Haploinsufficiency in PTPN2 Enhances Severity of IL-17 Mediated Autoimmune Arthritis
Mattias N. D. Svensson¹, Karen M. Doody², Shen Yang³, Dennis J. Wu⁴, Cristiano Sacchetti⁵, Isabelle Aubry⁶, Piotr Mydel⁷, Mitchell Kronenberg⁸, Michel L. Tremblay⁹ and Nunzio Bottini², ¹Department of Medicine, University of California San Diego, La Jolla, CA, ²Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Medicine, University of California San Diego, La Jolla, CA, ⁴University of California San Diego, San Diego, CA, ⁵Rheumatology, University of California San Diego, La Jolla, CA, ⁶Biochemistry, McGill University, Montreal, QC, Canada, ⁷University of Bergen, Bergen, Norway, ⁸Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁹Biochemistry, McGill University, Montréal, QC, Canada
Background/Purpose: Genetic polymorphisms at the PTPN2 locus, which encodes the tyrosine phosphatase TC-PTP, cause reduced gene expression and are linked to rheumatoid arthritis (RA). PTPN2…
Abstract Number: 1826 • 2018 ACR/ARHP Annual Meeting
From Cancer to Autoimmunity : A New Model of Rheumatoid Arthritis Emerging from a Constitutional Genetic Approach Used in Low Penetrance Cancers
Geraldine Falgarone^1,2, Morad El Bouchtaoui³, Marcio Do Cruzeiro⁴, Christophe Leboeuf^5,6,7, Irmine Loisel-Ferreira^5,6, Carèle Frédonie⁷, Chrystophe Ferreira⁸, Rachida Ait El Far⁵, Marc Espié⁹, Bruno Cassinat¹⁰, Jean-Jacques Kiladjian¹¹, Jean-Paul Feugeas^12,13, Anne Janin^5,6,14 and Guilhem Bousquet^2,5,15, ¹HUPSSD, Avicenne Hospital, Rheumatology, APHP, Bobigny, France, ²Paris 13 University, SMBH, Bobigny, France, ³INSERM UMR-S 1165, PARIS, France, ⁴Plateforme de Recombinaison Homologue, Institut Cochin, INSERM U1016, Paris, France, ⁵INSERM UMR-S 1165, Paris, France, ⁶Université Paris Diderot, Paris, France, ⁷INSERM U944, Paris, France, ⁸Plateforme ANIMA5, Université Paris Descartes, Paris, France, ⁹Centre des Maladies du Sein, APHP, Hôpital Saint-Louis, Paris, France, ¹⁰Laboratoire de BIologie Cellulaire, APHP, Hôpital Saint-Louis, Paris, France, ¹¹Centre d'Inverstigation Clinique, APHP, Hôpital Saint-Louis, Paris, France, ¹²INSERM U1137, Paris, France, ¹³Département de Biologie, Université Franche-Comté, Besançon, France, ¹⁴Service de Pathologie, APHP, Hôpital Saint-Louis, Paris, France, ¹⁵Service d'Oncologie médicale, APHP, Hôpital Avicenne, Bobigny, France
Background/Purpose: High-speed technologies for genome sequencing have completely changed the study of disease genetics, but with limited knowledge of the functional value of most genetic…
Abstract Number: 1827 • 2018 ACR/ARHP Annual Meeting
Genetic Ablation of Phd Finger Protein 19 Gene Promotes Autoimmune Arthritis in Mice
Tibor T. Glant¹, Timea Ocskó², Daniel M. Tóth¹, Adrienn Markovics¹ and Tibor A. Rauch¹, ¹Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Orthopedic Surgery, Rush University Medical Center, Chicago, IL
Background/Purpose: Understanding the genetic and epigenetic background of rheumatoid arthritis (RA) is complex since multiple genes and environmental factors are involved. By conducting congenic mapping…
Abstract Number: 1828 • 2018 ACR/ARHP Annual Meeting
Gut-Joint T Cell Trafficking in a Model of Bacteria-Driven Murine IBD-Spa
Eric Norman¹, Adam Lefferts¹ and Kristine A Kuhn^1,2, ¹Rheumatology, University of Colorado Denver, Aurora, CO, ²Mucosal Inflammation Program, University of Colorado Denver, Aurora, CO
Background/Purpose: Significant bacterial dysbiosis occurs in individuals with IBD and SpA, and individuals with SpA have evidence of circulating intestinal-derived cells, lending credence to the…
Abstract Number: 1829 • 2018 ACR/ARHP Annual Meeting
Perturbations of the Gut Fungal and Bacterial Microbiome with Biologic Therapy in Spondyloarthritis
Julia Manasson¹, Lu Yang², Gary E. Solomon¹, Soumya M. Reddy¹, Parvathy V. Girija¹, Andrea L. Neimann³, Leopoldo N. Segal⁴, Carles Ubeda⁵, Jose C. Clemente⁶ and Jose U. Scher⁷, ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²New York University School of Medicine, New York, NY, ³Department of Dermatology, New York University School of Medicine, New York, NY, ⁴Department of Medicine, Division of Pulmonary and Critical Care, New York University School of Medicine, New York City, NY, ⁵Institute for Research in Public Health (FISABIO), Valencia, Spain, ⁶Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, ⁷New York University School of Medicine, New York, NY
Background/Purpose: The microbiome serves a number of important functions, including modulation of the immune system and protection from pathogenic microorganisms1. Many autoimmune diseases have been…
Abstract Number: 1830 • 2018 ACR/ARHP Annual Meeting
Role of BMP2 in Entheseal Bone Formation in Inflammatory Arthritis
Yukiko Maeda¹, Jozsef Karman² and Ellen M. Gravallese³, ¹Medicine, University of Massachusetts Medical School, Worcester, MA, ²Abbvie Bioresearch Center, Worcester, MA, ³Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Spondyloarthritis (SpA) is common, with a prevalence of ~1% in the United States. Patients with SpA suffer from pain and disability due to inflammation…
Abstract Number: 1831 • 2018 ACR/ARHP Annual Meeting
Intestinal Inflammatory Regulation in Murine and Human Spondyloarthropathy Requires High-Affinity T Cell Receptor-Zeta Chain-Associated Protein (ZAP)70-Mediated Runt-Related Transcription Factor (Runx)3 Activity
Zaied Ahmed Bhuyan¹, M. Arifur Rahman², Muralidhara Maradana¹, Ahmed Mehdi³, Giuliana Guggino⁴, Paul Leo⁵, Linda Rehaume¹, Matthew Brown⁵, Francesco Ciccia⁴ and Ranjeny Thomas¹, ¹The University of Queensland Diamantina Institute, Brisbane, Australia, ²Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ³Diamantina Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ⁴Rheumatology Unit, University of Palermo, Palermo, Italy, ⁵Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia
Background/Purpose: Loss of function RUNX3 variants are associated with ankylosing spondylitis (AS) risk but the mechanism is unknown. Disturbances in immune regulation, intestinal microbial dysbiosis…
Abstract Number: 1832 • 2018 ACR/ARHP Annual Meeting
Proteomic and Transcriptomic Profiling of Cells in Ankylosing Spondylitis Patients Identifies a Novel, Synovial-Resident CD8+ T Cell
Zoya Qaiyum¹, Eric Gracey², Yuchen Yao² and Robert D Inman³, ¹Department of Immunology, University of Toronto, Toronto, ON, Canada, ²Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada
Background/Purpose: Current data suggests that immune events in the gut may impact on joint inflammation in ankylosing spondylitis (AS) but what directs cells in the…
Abstract Number: 1833 • 2018 ACR/ARHP Annual Meeting
The Vδ2 Subset of Γδt-Cells Are Present at Healthy Human Enthesis and Have Transcriptional and Functional Characteristics Consistent with a Capacity for IL- 17A Production in Response to IL-23
Richard Cuthbert¹, Evangelos M. Fragkakis¹, Charlie Bridgewood¹, Robert Dunsmuir², Abdulla Watad³, Abhay Rao², Almas Khan², Helena Marzo-Ortega⁴, Darren Newton⁵ and Dennis McGonagle¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Department of Spinal Surgery, National Health Service, Leeds, United Kingdom, ³Department of Internal Medicine 'B', Sheba Medical Center, Ramat Gan, Ramat Gan, Israel, ⁴NIHR LBRC, LTHT and LIRMM, University of Leeds, Leeds, United Kingdom, ⁵Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
Background/Purpose: Recent mouse studies of SpA pathogenesis have suggested that γδT-cells accumulate at entheseal regions in an IL-23 overexpression model and that these cells are…
Abstract Number: 1834 • 2018 ACR/ARHP Annual Meeting
Sleep Apnea and Fibromyalgia: Data from the Cleveland Clinic Fibromyalgia Registry
Carmen E. Gota¹, Nilamba Jhala², Sahar Kaouk³, Yaseen Kinanah⁴ and William Wilke⁵, ¹Education, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, ²Internal Medicine, Cleveland Clinic, Cleveland, OH, ³John Carroll University, University Heights, OH, ⁴Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH, ⁵Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH
Background/Purpose: Up to 50% of sleep apnea (SA) patients have fibromyalgia (FM). Little is known about the prevalence and associations of SA and FM, and…
Abstract Number: 1835 • 2018 ACR/ARHP Annual Meeting
Diagnosis of Fibromyalgia: Disagreement between Fibromyalgia Criteria and Clinician-Based Fibromyalgia Diagnosis in a University Clinic
Sachin Srinivasan¹, Juan Schmukler², Shakeel Jamal³, Isabel Castrejón², Kathryn A Gibson⁴, Winfried Häuser⁵, Theodore Pincus² and Frederick Wolfe⁶, ¹Internal Medicine, University of Kansas School of Medicine, Wichita, KS, ²Division of Rheumatology, Rush University Medical Center, Chicago, IL, ³Rheumatology, Rush University, Chicago, IL, ⁴Ingham Institute, Liverpool Hospital University of New South Wales, Liverpool, Australia, ⁵Department of Psychosomatic Medicine and Psychotherapy, Technische Universität München, Munich, Germany, ⁶FORWARD, The National Databank for Rheumatic Diseases, Wichita, KS
Background/Purpose: Recent studies have suggested that fibromyalgia is inaccurately diagnosed in the community, and that approximately 75% of persons reporting a physician diagnosis of fibromyalgia…

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