Abstracts Archive - Page 1126 of 2607 - ACR Meeting Abstracts

Abstract Number: 2790 • 2019 ACR/ARP Annual Meeting
Platelet Mediates Neutrophil Extracellular Traps Formation via TLR Signaling in ANCA-associated Vasculitis
Kotaro Matsumoto¹, Hidekata Yasuoka ², Katsuya Suzuki ¹ and Tsutomu Takeuchi ¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Fujita Health University School of Medicine, Shinjuku-ku, Aichi, Japan
Background/Purpose: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease that affects small- to medium-sized blood vessels and causes vascular inflammation and multiple organ…
Abstract Number: 2791 • 2019 ACR/ARP Annual Meeting
Treatment Response Criteria for Anti-neutrophil Cytoplasmic Antibodies (ANCA)-vasculitis: Results of a Scoping Review
Sara Monti¹, Kaitlin Quinn ², Robin Christensen ³, Alfred Mahr ⁴, Christian Pagnoux ⁵, Carol Langford ⁶, David Jayne ⁷, Peter Merkel ⁸ and Gunnar Tomasson ⁹, ¹University of Pavia, Pavia, Italy, ²Georgetown University Hospital/National Institutes of Health, Washington, DC, ³Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital & Department of Rheumatology, Institute of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark, ⁴Hospital Saint-Louis, University Paris Diderot, Paris, France, ⁵Mount Sinai Hospital and University Health Network, Toronto, ON, Canada, ⁶Cleveland Clinic, Cleveland, OH, ⁷Vasculitis and Lupus Clinic, Addenbrooke’s Hospital, University of Cambridge, UK, Cambridge, United Kingdom, ⁸University of Pennsylvania, Philadelphia, PA, ⁹Faculty of Medicine, University of Iceland and Landpitali University Hospital, Reykjavik, Iceland
Background/Purpose: A comprehensive assessment of outcome measures to assess response to treatment in ANCA-associated vasculitis (AAV) is necessary to implement.Methods: We performed a scoping review…
Abstract Number: 2792 • 2019 ACR/ARP Annual Meeting
The Need for Personalized, Non-Pharmacological Intervention Programmes in Autoimmune Connective Tissue Disorders: Results of a EULAR-Funded Scoping Review with a Nested, Descriptive Meta-Analysis
Valentin Ritschl¹, Ricardo Ferreira ², Rúben Fernandes ², Eduardo Santos ², Essi Juutila ³, Erika Mosor ¹, Kim Fligelstone ⁴, Helena Gaspar ⁵, Linda Schraven ⁶, Judy Ammerlaan ⁷, Georg Stummvoll ⁸, Maria João Salvador ², Janet Poole ⁹, Cornelia van den Ende ¹⁰, Carina Boström ¹¹ and Tanja Stamm ¹, ¹Medical University of Vienna, Vienna, Austria, ²Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, ³Metropolia University of Applied Sciences, Helsinki, Finland, ⁴Federation of European Scleroderma Associations, Tournai, Belgium, ⁵Portuguese League Against Rheumatic Diseases, Portugal, Portugal, ⁶Federation of European Scleroderma Associations, Sweden, Sweden, ⁷University Medical Centre, Utrecht, Netherlands, ⁸Klinikum Malcherhof Baden, Baden, Austria, ⁹University of New Mexico, Albuquerque, NM, ¹⁰Sint Maartenskliniek Nijmegen, Nijmegen, Netherlands, ¹¹Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Autoimmune Connective Tissue Disorders (CTDs), including Mixed Connective Tissue Disorders (MCTD), systemic sclerosis (SSc) and systemic lupus erythematous (SLE) can lead to Raynaud phenomenon,…
Abstract Number: 2793 • 2019 ACR/ARP Annual Meeting
Methotrexate Intolerance: A Qualitative Descriptive Study of the Adult Rheumatoid Arthritis Patients’ Perspectives
Elizabeth Salt¹, Mary Kay Rayens ², Leslie Crofford ³ and Jamie Studts ², ¹University of Kentucky, Lexington, KY, ²University of Kentucky, Lexington, ³Vanderbilt University, Nashville
Background/Purpose: An estimated 11% to 33% of persons taking methotrexate for rheumatoid arthritis (RA) are reported to be at least moderately intolerant to this medication.…
Abstract Number: 2794 • 2019 ACR/ARP Annual Meeting
Predictors of Incident and Worsening Lumbar Spine Degeneration: The Johnston County Osteoarthritis Project
Adam Goode¹, Rebecca Cleveland ², David Hu ³, Steven George ⁴, Virginia Byers Kraus ⁵, Todd Schwartz ⁶, Richard Gracely ⁷, Louis DeFrate ⁸, Joanne Jordan ⁹ and Yvonne Golightly ¹⁰, ¹Duke University, Department of Orthopedic Surgery, Duke Clinical Research Institute, and Department of Population Health Sciences, Durham, NC, ²Thurston Arthritis Research Center, Chapel Hill, NC, ³Thurston Arthritis Center, University of North Carolina - Chapel Hill, Chapel Hill, NC, ⁴Duke University, Department of Orthopedic Surgery and Duke Clinical Research Institute, Durham, NC, ⁵Duke University, Department of Orthopedic Surgery, Duke Molecular Physiology Laboratory, Durham, NC, ⁶University of North Carolina at Chapel Hill Department of Biostatistics, Chapel Hill, NC, ⁷Department of Endodontics, Adams School of Dentistry, University of North Carolina, Chapel Hill, Chapel Hill, NC, ⁸Duke University, Department of Orthopedic Surgery, Department of Mechanical Engineering and Materials Science and Department of Biomedical Engineering, Durhham, NC, ⁹University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ¹⁰University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC
Background/Purpose: Our aim was to determine whether demographics, clinical characteristics or appendicular joint osteoarthritis predict the incidence and worsening of lumbar spine disc space narrowing…
Abstract Number: 2795 • 2019 ACR/ARP Annual Meeting
Patterns of Ambulatory Health Care Utilization and Medication Adherence Among Transition-Age Youth with Systemic Lupus Erythematosus
Joyce Chang¹, Andrea Knight ² and Erica Lawson ³, ¹Children's Hospital of Philadelphia, Philadelphia, PA, ²Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ³University of California San Francisco Benioff Children’s Hospital, San Francisco, CA
Background/Purpose: Youth with child-onset systemic lupus erythematosus (SLE) transitioning from pediatric to adult health care systems may be at higher risk for poor outcomes than…
Abstract Number: 2796 • 2019 ACR/ARP Annual Meeting
The Association Between Omega-3 Supplementation and Disease Activity in a Rheumatoid Arthritis (RA) Observational Cohort
Adel Andemeskel¹, Vivi Feathers ¹, Christine Iannaccone ¹, Jing Cui ¹ and Nancy Shadick ¹, ¹Brigham and Women's Hospital, Boston, MA
Background/Purpose: Omega-3 supplementation is one of a few complementary and alternative medicine (CAM) therapies that has shown promise in improving RA symptoms through small, randomized…
Abstract Number: 2797 • 2019 ACR/ARP Annual Meeting
Exploring Possible Predictors of Physical Activity in Knee Replacement Patients
Brandy Tanenbaum ¹, Aileen Davis², Deborah Kennedy ³ and Junaid Bhatti ⁴, ¹Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ²Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Sunnybrook Health Sciences Centre - Holland Bone and Joint Program, Toronto, ON, Canada, ⁴Institute of Clinical Evaluative Studies, Toronto, ON, Canada
Background/Purpose: Following total knee replacement (TKR), patients do not achieve recommended physical activity for overall health. The implications of physical inactivity on individuals and the…
Abstract Number: 2798 • 2019 ACR/ARP Annual Meeting
Trajectories of Opioid Filling Patterns After Total Knee Replacement
Chandrasekar Gopalakrishnan ¹, Jessica Franklin ², Yinzhu Jin ³, Daniel Solomon ⁴, Jeffrey Katz ⁵, Yvonne Lee ⁶, Patricia Franklin ⁶, Joyce Lii ², Rishi Desai ⁷ and Seoyoung C. Kim³, ¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Harvard Medical School, Boston, ³Brigham and Women’s Hospital and Harvard Medical School, Boston, ⁴Brigham and Women´s Hospital, Div. of Rheumatology, Immunology and Allergy, Boston, MA, ⁵Brigham and Women's Hospital/Harvard Medical School, Boston, ⁶Northwestern University Feinberg School of Medicine, Chicago, ⁷Brigham and Women's hospital, Boston
Background/Purpose: Patients undergoing total knee replacement (TKR) are at increased risk of persistent opioid use and opioid dependence. Group-based trajectory models can identify clusters of…
Abstract Number: 2799 • 2019 ACR/ARP Annual Meeting
Does Early Anterior Cruciate Ligament Reconstruction Prevent Further Meniscal Damage? Secondary Analysis of a Randomized Controlled Trial
Barbara Snoeker ¹, Frank Roemer ², Aleksandra Turkiewicz ¹, Stefan Lohmander ³, Richard Frobell ¹ and Martin Englund¹, ¹Lund University, Lund, Sweden, ²University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden, Lund, Sweden
Background/Purpose: It has been suggested that recurrent instability episodes in a non-reconstructed anterior cruciate ligament (ACL) injured knee increase the risk for an incident meniscal…
Abstract Number: 2800 • 2019 ACR/ARP Annual Meeting
Five Year Structural Changes in Patients with Meniscal Tear and Osteoarthritis from an RCT of Arthroscopic Partial Meniscectomy vs. Physical Therapy
Swastina Shrestha¹, Jeffrey Katz ², Elena Losina ³ and Jamie Collins ⁴, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital/Harvard Medical School, Boston, ³Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston
Background/Purpose: Meniscal tear is an independent risk factor of structural progression in OA; Arthroscopic partial meniscectomy (APM) is also associated with progression, though it is…
Abstract Number: 2801 • 2019 ACR/ARP Annual Meeting
Optimal Threshold of Walking Speed Predictive of Mortality Risk over 9 Years in Knee Osteoarthritis: Data from Osteoarthritis Initiative
Hiral Master¹, Tuhina Neogi ², Lavalley Michael ³, Louise Thoma ⁴, Meredith Christiansen ⁵, Dana Voinier ⁵, Lauren Neely ⁵, Jason Jakiela ⁵ and Daniel White ¹, ¹University of Delaware, Newark, DE, ²Boston University School of Medicine, Boston, MA, ³Boston University, Boston, ⁴University of North Carolina at Chapel Hill, Newark, ⁵University of Delaware, Newark
Background/Purpose: Knee osteoarthritis (OA) is associated with mortality, and walking difficulty is known to mediate this relationship. However, little is known about what specific aspects…
Abstract Number: 2802 • 2019 ACR/ARP Annual Meeting
High Intensity Interval Training for Knee Osteoarthritis: A Pilot Study
Yvonne Golightly¹, Carolina Alvarez ², Malia Blue ³, Kelli Allen ³, Amanda Nelson ³ and Abbie Smith-Ryan ³, ¹University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, ²University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ³University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Physical activity reduces pain and increases physical function in people with knee osteoarthritis (OA), but few achieve recommended levels of physical activity because of…
Abstract Number: 2803 • 2019 ACR/ARP Annual Meeting
Efficacy of a 3-Month Wearable-enabled Physical Activity Counselling Program for People with Knee Osteoarthritis
Hui Xie ¹, Linda Li², Na Lu ³, Diane Gromala ⁴, Chris Shaw ⁴, Catherine L. Backman ⁵, Johnathan Tam ⁶, Noonan Gregory ⁷, J. Antonio Avina-Zubieta ⁸, Alison Hoens ², Anne Townsend ⁹ and Lynne Feehan ², ¹Arthritis Research Canada and Simon Fraser University, Vancouver, BC, Canada, ²University of British Columbia, Vancouver, BC, Canada, ³Arthritis Research Canada, Vancouver, BC, Canada, ⁴Simon Fraser University, Surrey, BC, Canada, ⁵University of British Columbia, Vancouver, Canada, ⁶Arthritis Research Canada, Richmond, BC, Canada, ⁷Vancouver General Hospital, Vancouver, BC, Canada, ⁸Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada, ⁹Lancaster University, Lancaster, United Kingdom
Background/Purpose: Current guidelines emphasize an active lifestyle in the management of knee osteoarthritis (OA), but up to 90% of OA patients are inactive. We previously…
Abstract Number: 2804 • 2019 ACR/ARP Annual Meeting
Neutrophil Passage Through the Megakaryocyte Cytoplasm via Emperipolesis Modulates Neutrophil Migration
Pierre Cunin¹, Alexandra Wactor ², Li Guo ³, Andrew Weyrich ³, Éric Boilard ⁴ and Peter Nigrovic ⁵, ¹Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, ³Program in Molecular Medicine and Department of Internal Medicine, University of Utah, Salt Lake City, ⁴Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Québec – Université Laval, Québec, Qc, Canada, Québec, QC, Canada, ⁵Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA ; Department of Medicine, Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA., Boston
Background/Purpose: Emperipolesis (EP) is a little-understood phenomenon referring to the presence neutrophils within megakaryocytes (MKs). We developed methods to study EP in vitro and in…

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