Abstracts Archive - Page 1124 of 2607 - ACR Meeting Abstracts

Abstract Number: 2760 • 2019 ACR/ARP Annual Meeting
A Phase 2 Double-Blind Clinical Trial to Examine the Comparative Effects on Osteoarthritic Knee Pain of CGS-200-1 (1% Capsaicin Topical Liquid), CGS-200-5 (5% Capsaicin Topical Liquid), and CGS-200-0 (Vehicle, No Capsaicin)
Michael Billard ¹, John Todhunter ¹, Margaret Fleming ¹, Tim Warneke¹, Yuhui Qiu ², Nhu Ly ², William Aronstein ² and William Moore ¹, ¹Vizuri Health Sciences, LLC, Columbia, MD, ²CTI Clinical Trial & Consulting, Covington, KY
Background/Purpose: There is considerable unmet medical need for an osteoarthritic knee pain (OAKP) treatment that does not require regular daily use, does not carry gastrointestinal…
Abstract Number: 2761 • 2019 ACR/ARP Annual Meeting
Cartilage Thickness Modification with Sprifermin in Knee Osteoarthritis Patients Translates into Symptomatic Improvement over Placebo in Patients at Risk of Further Structural and Symptomatic Progression: Post-Hoc Analysis of a Phase II Trial
Hans Guehring¹, Jeffrey Kraines ², Flavie Moreau ², Benjamin Daelken ¹, Christoph Ladel ¹, Wolfgang Wirth ³, Philip G Conaghan ⁴, Felix Eckstein ⁵ and Marc C. Hochberg ⁶, ¹Merck KGaA, Darmstadt, Germany, ²EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ³Paracelsus Medical University, Salzbury, Austria, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, ⁵Paracelsus Medical University, Salzburg, Austria, ⁶University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Results from the 5-year Phase II FORWARD study showed significant dose-dependent modification of total femorotibial joint (TFTJ) cartilage thickness change with sprifermin at 2…
Abstract Number: 2762 • 2019 ACR/ARP Annual Meeting
The Preparation and Recovery Experience from Total Knee Replacement of Patients with Osteoarthritis: A Qualitative Study
Iris Navarro-Millan¹, Sarah Young ², Geyanne Lui ¹, Marianna Frey ³, Janey Peterson ¹, Susan Goodman ⁴, Monika Safford ¹ and Lisa Mandl ⁵, ¹Weill Cornell Medicine, New York, ²Binghamton University, Binghamton, ³Hospital for Special Surgery, New York, NY, New York, ⁴Hospital For Special Surgery/Weill Cornell Medicine, New York, NY, ⁵Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, New York, NY
Background/Purpose: Up to 30% of patients may have persistent pain post-total knee arthroplasty (TKA). One possible approach to improve these outcomes is to optimize muscle…
Abstract Number: 2763 • 2019 ACR/ARP Annual Meeting
What Disease Do You Have? – Assessment and Predictors of Accurate Illness Naming in Rheumatology
Jacob Meindertsma¹, Kara Harrison ¹, Nicholas Lucchesi ¹ and Adam Carlson ¹, ¹University of Virginia, Charlottesville, VA
Background/Purpose: Shared decision making remains central to the effective treatment of many rheumatologic conditions and is most appropriate when the patient and physician agree on…
Abstract Number: 2764 • 2019 ACR/ARP Annual Meeting
Medication Necessity and Concerns Beliefs Are Distinct, Interactive Predictors of Treatment Adherence in Rheumatoid Arthritis
George Karpouzas¹, Elizabeth Hernandez ², Lorena Ruiz ³, Vibeke Strand ⁴ and Sarah Ormseth ¹, ¹Harbor-UCLA Medical Center and Los Angeles Biomedical Institute, Torrance, CA, ²Harbor-UCLA and Los Angeles Biomedical Institute, Torrance, CA, ³Harbor-UCLA andLos Angeles Biomedical Research Institute, Torrance, ⁴Division of Immunology/Rheumatology, Stanford University, Stanford, CA
Background/Purpose: Medication adherence is instrumental for the successful management of rheumatoid arthritis (RA) to a goal of remission. Awareness of medication necessity and concerns regarding…
Abstract Number: 2765 • 2019 ACR/ARP Annual Meeting
Assessing the Impact of Digital Health Coaching on Quality Adjusted Life Years, Symptom Severity and Disease Activity in Patients with Rheumatoid Arthritis
Matt Allsion¹, Michael McMorris ², Dhiren Patel ² and B Stephen Burton ³, ¹Pack Health, Birmigham, AL, ²Pack Health, Birmingham, ³Pack Health, Birmingham, AL
Background/Purpose: Rheumatoid arthritis (RA) is the most common autoimmune inflammatory arthritis in adults. RA has a significant negative impact on the ability to perform daily…
Abstract Number: 2766 • 2019 ACR/ARP Annual Meeting
Patient Preferences for Attributes of Treatments for Chronic Pain Associated with Osteoarthritis Pain and Chronic Low Back Pain That Differentiate Nerve-Growth Factor Inhibitors, Nonsteroidal Anti-inflammatory Drugs, and Opioids in the United States: A Discrete-Choice Experiment
Dennis Turk ¹, Marco Boeri², Lucy Abraham ³, Brett Hauber ⁴, Joanna Atkinson ³, Andrew Bushmakin ⁵, Joseph Cappelleri ⁵, Leo Russo ⁶, Lars Viktrup ⁷ and David Walsh ⁸, ¹University of Washington, Seattle, ²RTI Health Solutions, Belfast, Northern Ireland, United Kingdom, ³Pfizer, LTD, Surrey, England, United Kingdom, ⁴RTI Health Solutions, Research Triangle Park, NC, ⁵Pfizer Inc, Groton, CT, ⁶Pfizer, Inc., Collegeville, PA, ⁷Eli Lilly and Company, Indianapolis, IN, ⁸Sherwood Forest Hospitals NHS Foundation Trust, Nottingham, United Kingdom
Background/Purpose: Monoclonal antibodies that inhibit nerve growth factor (NGF-abs) may offer an alternative to current nonsteroidal anti-inflammatory drug (NSAID) and opioid treatments for osteoarthritis (OA)…
Abstract Number: 2767 • 2019 ACR/ARP Annual Meeting
Importance of Discussing RA Treatment Goals: Patients Report Providers Seldom Discuss Treatment Goals and Outcomes Improve When Goals Are Discussed
Kelly O'Neill¹, Cynthia Crowson ², Dana Symons ³, Pamela Sinicrope ⁴, Elena Myasoedova ⁴, Martha Bock ⁴, Jon Tilburt ⁴ and John Davis ⁴, ¹Rheumatoid Patient Foundation, Inc., Winter Springs, FL, ²Mayo Clinic Rochester, Rochester, ³Rheumatoid Patient Foundation, Inc., Rockford, MI, ⁴Mayo Clinic, Rochester, MN
Background/Purpose: Treat-to-target is a guiding principle in the management of rheumatoid arthritis (RA), and randomized clinical trials demonstrate its value in improving outcomes. However, implementation…
Abstract Number: 2768 • 2019 ACR/ARP Annual Meeting
Changes in B Cell Profile as a Marker of Clinical Remission to TNF Inhibitors in Patients with Rheumatoid Arthritis
Borja Hernández-Breijo¹, Israel Nieto-Gañán ², Cristina Sobrino ³, Victoria Navarro-Compán ⁴, Ana Martínez-Feito ⁵, Carlota García-Hoz ⁶, Paloma Lapuente-Suanzes ², javier Bachiller ³, Gema Bonilla ⁷, Cristina Pijoán-Moratalla ³, Garbiñe Roy ², Mónica Vázquez Díaz ³, Alejandro Balsa ⁷, Luisa María Villar ², Dora Pascual-Salcedo ¹, Eulalia Rodríguez-Martín ² and Chamaida Plasencia ⁷, ¹Immuno-Rheumatology Research Group, IdiPAZ. La Paz University Hospital, Madrid, Spain, ²Immunology Department, Ramón y Cajal University Hospital & IRYCIS, Madrid, Spain, ³Rheumatology Department, Ramón y Cajal University Hospital & IRYCIS, Madrid, Spain, ⁴University Hospital La Paz, IdiPaz, Madrid, Spain, ⁵Immuno-Rheumatology Research Group, IdiPAZ & Immunology Department. La Paz University Hospital, MADRID, Spain, ⁶Immunology Department, Ramón y Cajal University Hospital & IRYCIS, Madrid, ⁷Immuno-Rheumatology Research Group, IdiPaz & Rheumatology Department. La Paz University Hospital, Madrid, Spain
Background/Purpose: According to the EULAR recommendations, the therapeutic objective in patients with rheumatoid arthritis (RA) should be remission. Biological therapies, as TNF inhibitors (TNFi), have…
Abstract Number: 2769 • 2019 ACR/ARP Annual Meeting
The Pre-Treatment Gut Microbiome Predicts Early Response to Methotrexate in Rheumatoid Arthritis
Sandrine Isaac ¹, Alejandro Artacho ¹, Renuka Nayak ², Steven B. Abramson ³, Margaret Alexander ², Imhoi Koo ⁴, Pamela Rosenthal ⁵, Peter Izmirly ⁶, Andrew Patterson ⁷, Antonio Pineda ⁸, Leonor Puchades-Carrasco ⁸, Peter Turnbaugh ², Carles Ubeda ⁹ and Jose Scher¹⁰, ¹FISABIO, Valencia, Spain, ²UCSF, San Francisco, ³NYU School of Medicine and NYU Langone Orthopedic Hospital, New York City, NY, ⁴Pennsylvania State University; Penn State · Huck Institutes of Life Sciences, University Park, PA, ⁵NYU Langone Orhopedic Hospital, New York, ⁶NYU School of Medicine, New York, ⁷Penn State, University Park, PA, ⁸Centro de Investigación Príncipe Felipe/Instituto de Investigación Sanitaria La Fe, Valencia, Spain, ⁹Centro Superior de Investigación en Salud Pública - FISABIO, Valencia, Spain, ¹⁰New York University School of Medicine, New York, NY
Background/Purpose: Early treatment initiation in rheumatoid arthritis (RA) is fundamental to avoid chronic joint destruction and disability. Despite remarkable advances in RA therapeutics, oral methotrexate…
Abstract Number: 2770 • 2019 ACR/ARP Annual Meeting
Towards the Lowest Efficacious Dose (ToLEDo): Results of a Multicenter Non-Inferiority Randomized Open-Label Controlled Trial Assessing Tocilizumab or Abatacept Injection Spacing in Rheumatoid Arthritis Patients in Remission
Joanna Kedra¹, Philippe Dieudé ², Hubert Marotte ³, Alexandre Lafourcade ⁴, Emilie Ducourau ⁵, Thierry Schaeverbeke ⁶, Aleth Perdriger ⁷, Martin SOUBRIER ⁸, Jacques Morel ⁹, Arnaud Constantin ¹⁰, Emmanuelle Dernis ¹¹, Valérie Royant ¹², Jean-Hugues Salmon ¹³, Thao Pham ¹⁴, Jacques-Eric Gottenberg ¹⁵, Edouard Pertuiset ¹⁶, Maxime Dougados ¹⁷, Valérie Devauchelle Pensec ¹⁸, Philippe Gaudin ¹⁹, gregoire Cormier ²⁰, Philippe Goupille ²¹, Xavier Mariette ²², Francis Berenbaum ²³, Didier Alcaix ²⁴, Sid-Ahmed Rouidi ²⁵, Jean-Marie Berthelot ²⁶, Agnès Monnier ²⁷, Christine Piroth ²⁸, Frédéric Lioté ²⁹, Vincent Goeb ³⁰, Cécile Gaujoux-Viala ³¹, Isabelle Chary-Valckenaere ³², David Hajage ⁴, Florence Tubach ³³ and Bruno Fautrel ³⁴, ¹Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), UMR S1136, Paris France, Paris, France, ²Rheumatology, Bichat Hospital, APHP, Paris;, Paris, France, ³University Hospital, St Etienne, France, ⁴Biostatistics, Public Health and Medical Information department, Pitié-Salpêtrière Hospital, AP-HP, Paris, France, Paris, France, ⁵Rheumatology Department, CHR Orléans, Orléans, France, ⁶FHU ACRONIM, Department of Rheumatology, Centre Hospitalier Universitaire, Bordeaux, France, Bordeaux, France, ⁷Rheumatology department, Rennes University Hospital, France, Rennes, France, ⁸CHU Gabriel Montpied, Clermont Ferrand, Auvergne, France, ⁹CHU MONTPELLIER, MONTPELLIER, France, ¹⁰Hôpital Pierre-Paul Riquet, Toulouse, France, ¹¹Rheumatology Department, Le Mans Central Hospital, Le Mans, France, ¹²Rheumatology Department, Chartres Hospital, Chartres, France, ¹³Rheumatology, Reims University Hospital, Reims, Reims, France, ¹⁴Aix-Marseille University, CHU Marseille, department of Rheumatology, 13,000 Marseille, France, Marseille, France, ¹⁵Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ¹⁶Rheumatology Department, Pontoise Hospital, Pontoise, France, Pontoise, France, ¹⁷Cochin Hospital, Paris, France, ¹⁸University Hospital of Brest, Brest, France, ¹⁹Rheumatology Department, CHU Grenoble Alpes Hôpital Sud and GREPI - Université Grenoble Alpes, EA7408, Grenoble - Echirolles, France, ²⁰CHD Vendée, La Roche sur Yon, France, ²¹Tours University-Hospital, Tours, France, Tours, France, ²²Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, ²³Sorbonne Université-Inserm CDR Saint-Antoine, AP-HP, Paris, France, ²⁴Rheumatology Department, Le Havre Hospital, Le Havre, ²⁵Rheumatology Department, Dreux, France, ²⁶University Hospital, Nantes, France, ²⁷Internal Medicine Department, CH Côte Basque, Bayonne, France, ²⁸Rheumatology Department, Dijon Hospital, Dijon, France, ²⁹Rheumatology Department, Lariboisiere Hospital, AP-HP, Paris, France, Paris, France, ³⁰Rheumatology Department, Amiens University Hospital, Amiens, France, ³¹Nîmes University Hospital, Nîmes, France, ³²Centre Hospitalier Universitaire de Nancy, VANDOEUVRE, France, ³³Pitié Salpétrière University-Hospital, Paris, Ile-de-France, France, ³⁴Pitié-Salpêtrière Hospital, Department of Rheumatology, AP-HP, Sorbonne University, UPMC university, Paris, Ile-de-France, France
Background/Purpose: Biologic Disease Modifying Anti-Rheumatic Drugs (bDMARD) tapering is proposed by clinical practice guidelines in rheumatoid arthritis (RA) patients in sustained remission. However, no randomized…
Abstract Number: 2771 • 2019 ACR/ARP Annual Meeting
A Phase I, Randomized, Double-blind, Placebo-controlled, Single Center, Single-dose Escalation to Investigate the Safety, Tolerability, and Pharmacodynamics of Subcutaneously Administered DEN-181 in Adult Patients with ACPA+ Rheumatoid Arthritis on Stable Methotrexate
Amee Sonigra ¹, Hendrik Nel ², Nishta Ramnoruth ², Meghna Talekar ², Joanne Tesiram ³, Frederik Stuurman ⁴, Lavinia Proctor ⁵, Helen Roberts ⁶, Robin Thurmond ⁷, Phillip Vecchio ³, Ian Gourley ⁸, Mark Rigby ⁹, Nathan Felix ¹⁰, Stephane Becart ¹¹, Kim Campbell ¹² and Ranjeny Thomas², ¹Princess Alexandra Hospital, Woolloongabba, Queensland, Australia, ²University of Queensland, Woolloongabba, Australia, ³Princess Alexandra Hospital, Woolloongabba, Australia, ⁴Centre for Human Drug Research, Leiden, Netherlands, ⁵Dendright, Woolloongabba, Australia, ⁶Dendright, Woolloongabba, Queensland, Australia, ⁷Janssen Research & Development, La Jolla, CA, ⁸Janssen Research & Development, Springhouse, ⁹Janssen Research & Development, La Jolla, ¹⁰Janssen R&D, Spring House, PA, ¹¹Janssen R&D, La Jolla, CA, ¹²Janssen Research & Development, LLC, Spring House, PA
Background/Purpose: Antigen-specific immunological tolerance strategies leverage the natural process of antigen presentation by dendritic cells (DCs) to regulate pathogenic T cells and B cells. We…
Abstract Number: 2772 • 2019 ACR/ARP Annual Meeting
Clinical and Biological Changes in Rheumatoid Arthritis Patients Exposed to an Anti-inflammatory Diet
francesca cedola¹, Roxana Coras ², Marta Fernandez-Bustamante ³, Meritxell Agusti-Perez ³, Maram Al-Harthi ³, Susan Lee ³, Abha Singh ³, Choi Soo ³, Kathy Nguyen ³, Oswald Quehenberger ³, Tatyana Shekhtman ³, Shahrokh Golshan ³ and Monica Guma ⁴, ¹University of California San Diego, Rome, Italy, ². Department of Medicine, School of Medicine. University of California, San Diego, ³University of California San Diego, san diego, ⁴Department of Medicine, School of Medicine. University of California San Diego, La Jolla, United States
Background/Purpose: RA patients often inquire about dietary interventions to improve disease control, as they perceive quick changes in pain and/or swelling after consumption of certain…
Abstract Number: 2773 • 2019 ACR/ARP Annual Meeting
Individually Tailored Predictions of Flare Probability for Rheumatoid Arthritis Patients on Biologic DMARDs Based on Machine Learning Stacking Meta-Classifier
Asmir Vodencarevic ¹, David Simon ², Fabian Hartmann ², Michaela Reiser ², Axel Hueber ², Koray Tascilar ³, Arnd Kleyer ⁴, Marcus Zimmermann-Rittereiser ¹ and Georg Schett⁵, ¹Siemens Healthcare GmbH, Erlangen, Bayern, Germany, ²Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Bayern, Germany, ³Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany, Erlangen, Bayern, Germany, ⁴Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, ⁵Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Tapering or stopping conventional and biologic DMARDs in patients with rheumatoid arthritis (RA) in stable remission may be feasible in a subset of patients…
Abstract Number: 2774 • 2019 ACR/ARP Annual Meeting
Cluster-based Spondyloarthritis Phenotypes Defined at Baseline Are Predictive of Different Severity Outcomes at 5-Year in the DESIR Cohort
Félicie Costantino ¹, Philippe Aegerter ², Anna Moltó ³, Georg Schett ⁴, Maxime Breban ⁵ and Maria-Antonietta D'Agostino⁶, ¹UMR1173, INSERM/Versailles-Saint Quentin University, France Ambroise Paré Hospital (AP-HP) Department of Rheumatology, Boulogne-Billancourt, France, Boulogne Billancourt, France, ²Public Health Department - GIRCI IdF - INSERM/Versailles-Saint Quentin University, France, Versailles, France, ³Paris Descartes University, Cochin Hospital, Rheumatology department, Paris, France, ⁴Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany, ⁵UMR1173, INSERM/Versailles-Saint Quentin University, France Ambroise Paré Hospital (AP-HP) Department of Rheumatology, Boulogne-Billancourt, France, Boulogne Billancourt, ⁶UMR1173, INSERM/Versailles-Saint Quentin University, France Ambroise Paré Hospital (AP-HP) Department of Rheumatology, Boulogne Billancourt, France
Background/Purpose: The course of axial spondyloarthritis (SpA) is heterogeneous and remains to be better defined. DESIR is a longitudinal French cohort of early undifferentiated axial…

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