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  • Abstract Number: 1791 • 2018 ACR/ARHP Annual Meeting

    Efficacy of Apremilast for Oral Ulcers Associated with Active Behçet’s Syndrome in a Phase III Study: A Prespecified Analysis By Baseline Patient Demographics and Disease Characteristics

    Gulen Hatemi1, Alfred Mahr2, Mitsuhiro Takeno3, Do-Young Kim4, Melike Melikoglu1, Sue Cheng5, Shannon McCue5, Maria Paris5, Mindy Chen5 and Yusuf Yazici6, 1Istanbul University Cerrahpasa Medical School, Istanbul, Turkey, 2Hospital Saint-Louis, University Paris Diderot, Paris, France, 3Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 4Yonsei University College of Medicine and Severance Hospital, Seoul, Korea, Republic of (South), 5Celgene Corporation, Summit, NJ, 6New York University School of Medicine, New York, NY

    Background/Purpose: Behçet’s syndrome is a chronic, multi-system inflammatory disorder characterized by recurrent oral ulcers (OU) that can be disabling and negatively affect quality of life.…
  • Abstract Number: 1792 • 2018 ACR/ARHP Annual Meeting

    Work Productivity Is Impaired in Patients with Behcet’s Syndrome

    Nergis Serin1, Yesim Ozguler1, Sinem Nihal Esatoglu1, Vedat Hamuryudan1 and Gulen Hatemi2, 1Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 2Istanbul University Cerrahpasa Medical School, Istanbul, Turkey

    Background/Purpose: Behcet’s syndrome (BS) is most active during young adulthood and working years, thus affecting productivity. Work disability was previously reported especially among BS patients…
  • Abstract Number: 1793 • 2018 ACR/ARHP Annual Meeting

    The Omeract Core Domain Set for Clinical Trials in Behçet’s Syndrome

    Gulen Hatemi1, Alexa Meara2, Yesim Ozguler3, Haner Direskeneli4, Alfred Mahr5, Beverly Shea6, Esen Cam7, Ahmet Gül8, Yusuf Yazici9, Peter Tugwell10, Hasan Yazici11 and Peter A. Merkel12, 1Istanbul University Cerrahpasa Medical School, Istanbul, Turkey, 2Internal Medicine/Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 3Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 4Rheumatology, Marmara University, School of Medicine Hospital, Istabul, Turkey, 5Hôpital Saint-Louis (Hôpitaux Universitaires Saint-Louis), Paris, France, 6Bruyere Research Institute, Ottawa, ON, Canada, 7The Univeristy of Istanbul, Istanbul, Turkey, 8Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 9New York University School of Medicine, New York, NY, 10Center For Global Health, Institute of Population Hlth, Ottawa, ON, Canada, 11Division of Rheumatology,, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 12Division of Rheumatology and the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: There is an unmet need for reliable, validated, and widely-accepted outcome measures for clinical trials in Behçet’s syndrome (BS). The Outcome Measures in Rheumatology…
  • Abstract Number: 1794 • 2018 ACR/ARHP Annual Meeting

    Venous Vessel Wall Thickness in Lower Extremity Is Increased in Male Behcet’s Disease Patients

    Fatma Alibaz-Oner1, Rabia Ergelen2, Aydan Mutiş3, Zeynep Erturk1, Ruslan Asadov4, Tulin Ergun5 and Haner Direskeneli6, 1Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, 2Marmara University School of Medicine, Radiology, ISTANBUL, Turkey, 3Marmara University, School of Medicine, Rheumatology, ISTANBUL, Turkey, 4Marmara University School of Medicine, Radiology, Istanbul, Turkey, 5Marmara University, School of Medicine, Dermatology, Istanbul, Turkey, 6Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey

    Background/Purpose: Vascular involvement is seen in up to 40% of the patients with Behcet's Disease (BD), especially in young males and is one of the…
  • Abstract Number: 1795 • 2018 ACR/ARHP Annual Meeting

    New Major Organ Involvement Is Lower in Young Male Behçet’s Patients Compared to Retrospective Series: Five-Year Results of a Prospective Cohort

    Fatma Alibaz-Oner1, Belgin Aldag2, Emrah Karatay3, Gonca Mumcu4, Tulin Ergun5 and Haner Direskeneli6, 1Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, 2Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey, 3Radiology, Marmara University, School of Medicine, Istanbul, Turkey, 4Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, 5Marmara University, School of Medicine, Dermatology, Istanbul, Turkey, 6Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey

    Background/Purpose: Major organ involvement such as vascular or ocular disease, especially in young males, is one of the main causes of mortality and morbidity in…
  • Abstract Number: 1796 • 2018 ACR/ARHP Annual Meeting

    Retrospective Analysis of Initial Presentation Findings of Behcet’s Syndrome throughout 4 Decades

    Elif Dincses1, Yesim Ozguler2, Didar Ucar3, Yilmaz Ozyazgan4, Serdal Ugurlu2, Gulen Hatemi2, Melike Melikoglu2, Sebahattin Yurdakul2, Hasan Yazici5 and Emire Seyahi2, 1Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, İstanbul, Turkey, 2Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 3Ophthalmology, Istanbul University, Cerrahpasa Medical Faculty, Department of Ophthalmology, Istanbul, Turkey, 4Istanbul University, Cerrahpasa Medical Faculty, Department of Ophthalmology, Istanbul, Turkey, 5Istanbul Academic Hospital, Istanbul, Turkey

    Background/Purpose: There is some evidence that incident Behcet’s syndrome (BS) might be becoming less severe (1, 2). We compared clinical findings at presentation of BS…
  • Abstract Number: 1797 • 2018 ACR/ARHP Annual Meeting

    An Update on Pulmonary Artery Involvement in Behcet’s Syndrome: More Pulmonary Artery Thrombotic Disease and a Better Outcome

    Yesim Ozguler1, Elif Dincses2, Selim Bakan3, Gulen Hatemi1, Melike Melikoglu1, Sebahattin Yurdakul1, Hasan Yazici1 and Emire Seyahi1, 1Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 2Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, İstanbul, Turkey, 3Istanbul University, Cerrahpasa Medical Faculty, Department of Radiology, ISTANBUL, Turkey

    Background/Purpose: Pulmonary artery involvement (PAI) is the most common form of arterial involvement in Behçet’s syndrome (BS). A previous survey (1) by our group had…
  • Abstract Number: 1798 • 2018 ACR/ARHP Annual Meeting

    Leg Ulcers in Behçet’s Syndrome: An Observational Survey in 24 Patients

    Yesim Ozguler1, Zekayi Kutlubay2, Atilla Süleyman Dikici3, Melike Melikoglu1, Cem Mat2, Hasan Yazici1 and Emire Seyahi1, 1Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 2Istanbul University, Cerrahpasa Medical Faculty, Department of Dermatology, Istanbul, Turkey, 3Radiolgy, Istanbul University, Cerrahpasa Medical Faculty, Department of Radiology, Istanbul, Turkey

     Background/Purpose: Formal experience with leg ulcers in Behcet’s syndrome (BS) is limited. It is a relatively rare complication that can be seen during the course…
  • Abstract Number: 1799 • 2018 ACR/ARHP Annual Meeting

    Increased Vein Wall Thickness in Behçet’s Syndrome

    Migena Gjoni1, Serkan Akbaş2, Emine Şebnem Durmaz2, Atilla Süleyman Dikici2, İsmail Mihmanlı2, Hasan Yazici3 and Emire Seyahi4, 1Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Istanbul, Turkey, 2Radiolgy, Istanbul University, Cerrahpasa Medical Faculty, Department of Radiology, Istanbul, Turkey, 3Istanbul Academic Hospital, Istanbul, Turkey, 4Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey

    Background/Purpose: Lower extremity vein thrombosis (LEVT) is the key feature of vascular involvement in Behçet’s syndrome (BS).Vein wall thickness (VWT) is proposed to be a…
  • Abstract Number: 1800 • 2018 ACR/ARHP Annual Meeting

    A Declining Trend in Frequency of Secondary Amyloidosis in Behçet’s Syndrome

    Guzin Karatemiz1, Sinem Nihal Esatoglu1, Yesim Ozguler1, Sebahattin Yurdakul1, Vedat Hamuryudan1, Melike Melikoglu1, Izzet Fresko1, Emire Seyahi1, Serdal Ugurlu1, Huri Ozdogan1, Hasan Yazici2 and Gulen Hatemi1, 1Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 2Istanbul Academic Hospital, Istanbul, Turkey

    Background/Purpose: A decline in the frequency of AA amyloidosis secondary to RA and infectious diseases has been reported. This is probably due to more effective…
  • Abstract Number: 1801 • 2018 ACR/ARHP Annual Meeting

    Factors Associated with Damage Progression in Behçet’s Syndrome Uveitis

    Yilmaz Ozyazgan1, Didar Ucar2, Mustafa Erdogan3, Yesim Ozguler3, Gulen Hatemi4, Sebahattin Yurdakul3, Vedat Hamuryudan3, Izzet Fresko3, Melike Melikoglu5, Emire Seyahi3, Serdal Ugurlu3 and Hasan Yazici6, 1Istanbul University, Cerrahpasa Medical Faculty, Department of Ophthalmology, Istanbul, Turkey, 2Ophthalmology, Istanbul University, Cerrahpasa Medical Faculty, Department of Ophthalmology, Istanbul, Turkey, 3Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 4Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 5Istanbul University Cerrahpasa Medical School, Istanbul, Turkey, 6Division of Rheumatology,, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey

    Background/Purpose: Uveitis in Behçet’s syndrome (BS) follows a recurrent disease course with inflammatory exacerbations causing damage in the uvea, retina and optic nerve even with…
  • Abstract Number: 1802 • 2018 ACR/ARHP Annual Meeting

    Behcet’s Disease in the Southwestern United States

    Maheswari Muruganandam1 and Noelle Rolle2, 1Rheumatology, University of New Mexico Health Sciences Center, ALBUQUERQUE, NM, 2Rheumatology, University Of New Mexico Health Sciences Center, ALBUQUERQUE, NM

    Background/Purpose: Behcet’s disease (BD) in the US is estimated to have a prevalence of 5.2-6.6 per 100,000 populations which is similar to that of European…
  • Abstract Number: 1803 • 2018 ACR/ARHP Annual Meeting

    Assessment of Severity and Risk Factors of Post-Thrombotic Syndrome in Vascular Behçet Disease: Muticentered Retrospective Study

    Aysun Aksoy1, Seda Çolak2, Burcu Yagız3, Belkıs Nihan Coşkun4, Ahmet Omma5, Naile Bolca6, Rabia Ergelen7, Haner Direskeneli8 and Fatma Alibaz-Oner1, 1Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, 2Rheumatology, Numune Training and Research Hospital, ankara, Turkey, 3Rheumatology, Uludag University, School of Medicine, Bursa, Turkey, 4Rheumatology, Uludag University Faculty of Medicine, Bursa, Turkey, 5Numune Training and Research Hospital, ankara, Turkey, 6Radiology, Uludag University, School of Medicine, Bursa, Turkey, 7Marmara University School of Medicine, Radiology, ISTANBUL, Turkey, 8Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey

    Background/Purpose: Vascular involvement is seen in about one third of patients with Behçet Disease(BD). DVT(deep venous thrombosis) is the most common form of vascular Behçet…
  • Abstract Number: 1804 • 2018 ACR/ARHP Annual Meeting

    Optimization Protocol for Adalimumab Treatment in Refractory Uveitis Due to Behçet’s Disease

    José Luis Martín-Varillas1, Belén Atienza-Mateo1, Vanesa Calvo-Río2, Diana Prieto Peña2, Monica Calderón Goercke2, Eva Peña Sainz-Pardo3, Emma Beltrán4, Juan Sánchez Bursón Sr.5, M. Victoria Hernández6, Alfredo Adan7, Marina Mesquida7, Marisa Hernández8, Elia Valls-Pascual9, Lucía Martínez-Costa9, Agusti Sellas-Fernandez10, Miguel Cordero-Coma11, Manuel Díaz-Llopis12, Roberto Gallego12, David Salom12, Norberto Ortego Centeno13, Jose L. García Serrano14, José-Luis Callejas-Rubio15, Jose M Herreras16, Angel Garcia-Aparicio17, Olga Maíz18, Ana Blanco19, Ignacio Torre-Salaberri20, David Diaz-Valle21, Esperanza Pato Cour22, Elena Aurrecoechea23, Miguel A. Caracuel24, Fernando Gamero25, Enrique Minguez26, Carmen Carrasco-Cubero27, Alejandro Olivé-Marqués28, Oscar Ruiz Moreno29, Javier Manero29, Julio Vázquez30, Santiago Muñoz Fernandez31, Myriam Gandía32, Esteban Rubio-Romero33, Francisco Toyos34, Francisco Javier López Longo35, Joan Miquel Nolla36, Marcelino Revenga Martínez37, Javier Loricera3, Rosalía Demetrio-Pablo3, Enar Pons1, José Luis Hernández3, Miguel Angel González-Gay3 and Ricardo Blanco1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 2Rheumatology, Rheumatology. Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 3Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 4Rheumatology, Hospital del Mar. Barcelona. Spain, Barcelona, Spain, 5Rheumatology, Hospital de Valme. Sevilla. Spain, Sevilla, Spain, 6Rheumatology, Hospital Clinic. Barcelona. Spain, Barcelona, Spain, 7Hospital Clinic. Barcelona. Spain, Barcelona, Spain, 8Ophthalmology, Hospital General Universitario de Valencia. Spain, Valencia, Spain, 9Hospital Universitario Doctor Peset. Valencia. Spain, Valencia, Spain, 10Vall d'Hebron Hospital Research Institute, Barcelona, Spain, 11Ophthalmology, Hospital de León. Spain, León, Spain, 12Hospital Universitario La Fe. Valencia. Spain, Valencia, Spain, 13Medicine Department, Hospital Universitario San Cecilio. Granada. Spain, Granada, Spain, 14Ophthalmology, Hospital Universitario San Cecilio. Granada. Spain, Granada, Spain, 15Hospital Universitario San Cecilio. Granada. Spain, Granada, Spain, 16Ophthalmology, Hospital Universitario, IOBA. Valladolid. Spain, Valladolid, Spain, 17Rheumatology, Hospital de Toledo. Toledo. Spain, Toledo, Spain, 18Hospital Universitario Donostia. San Sebastian. Spain, San Sebastián, Spain, 19Ophtamology, Hospital Universitario Donostia. San Sebastian. Spain, San Sebastian, Spain, 20Rheumatology, Hospital Universitario de Basurto. Bilbao. Spain, Bilbao, Spain, 21Hospital Clínico San Carlos. Madrid. Spain, Madrid, Spain, 22Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 23Rheumatology, Hospital de Sierrallana, Torrelavega. Cantabria. Spain, Torrelavega, Spain, 24Hospital de Córdoba, Córdoba, Spain., Córdoba, Spain, 25Rheumatology, Hospital San Pedro Alcántara. Cáceres. Spain, Cáceres, Spain, 26Ophthalmology, Hospital Clínico de Zaragoza. Spain, Zaragoza, Spain, 27Hospital de Mérida. Spain, Mérida, Spain, 28Rheumatology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 29Ophthalmology and Rheumatology, Hospital Miguel Servet. Zaragoza. Spain, Zaragoza, Spain, 30Rheumatology, Hospital de Ferrol. La Coruña. Spain, La Coruña, Spain, 31Hospital Universitario Infanta Sofía. Madrid. Spain, San Sebastián de los Reyes (Madrid), Spain, 32Rheumatology, Hospital Puerta del Mar. Cádiz. Spain, Cádiz, Spain, 33Hospital Universitario Virgen del Rocío. Sevilla. Spain, Sevilla, Spain, 34Rheumatology, Hospital Universitario Virgen de la Macarena, Sevilla, Spain, 35Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain, 36Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 37Hospital Universitario Ramón y Cajal. Madrid. Spain, Madrid, Spain

    Background/Purpose: Uveitis is the most common ocular manifestation in Behçet Disease (BD), which can cause irreversible blindness. Once the efficacy, safety and cost-effectiveness of Adalimumab…
  • Abstract Number: 1805 • 2018 ACR/ARHP Annual Meeting

    Strong Association of HLA-DRB1*0901 with Japanese Patients with Chronic Progressive Neuro-Behçet’s Disease

    Hirotoshi Kikuchi1, Takafumi Tomizuka1, Takahiro Itamiya1, Kurumi Asako1, Tamiko Yanagida1, Hajime Kono2 and Shunsei Hirohata3, 1Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 2Teikyo University School of Medicine, Department of Internal Medicine, Tokyo, Japan, 3Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan

    Background/Purpose: Central nervous system involvement is one of the most serious complications in Behçetfs disease (BD). This condition is referred to as neuro-BD (NB) and…
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