ACR Meeting Abstracts

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  • Abstract Number: 1731 • 2018 ACR/ARHP Annual Meeting

    Vertebral Fracture Prevalence and Measurement of the Scanographic Bone Attenuation Coefficient on CT-Scan in 70 Patients with Systemic Scleroderma

    Marine FAUNY1, Elodie BAUER2, Eliane ALBUISSON3, Julia Perrier-Cornet1, Joelle DEIBENER4, Francois CHABOT5, Damien MANDRY6, Olivier HUTTIN7, Isabelle Chary-Valckenaere8 and Damien Loeuille2, 1Rheumatology, University Hospital of Nancy, VANDOEUVRE LES NANCY, France, 2Rheumatology, University Hospital of Nancy, NANCY, France, 3University Hospital of Nancy, Nancy, France, 4Internal Medicine, University Hospital of Nancy, NANCY, France, 5Pneumology, University Hospital of Nancy, NANCY, France, 6Radiology, University Hospital of Nancy, NANCY, France, 7Cardiology, University Hospital of Nancy, NANCY, France, 8Rheumatology, CHRU Nancy, Vandoeuvres les Nancy, France

    Background/Purpose: Osteoporosis screening is not systematic in sclerodermic patients but some studies demonstrated a similar risk between rheumatoid arthritis and systemic scleroderma [1,2,3]. Thoracic and/or…
  • Abstract Number: 1732 • 2018 ACR/ARHP Annual Meeting

    Alterations of Body Composition in Patients with Systemic Scleroderma Are Associated with Disease Activity, Physical Activity and Serum Levels of Inflammatory Cytokines

    Sabina Oreska1,2, Maja Spiritovic1,3, Petr Cesak4, Michal Cesak5, Hana Storkanova1,2, Hana Smucrova1, Barbora Hermankova1,3, Barbora Sumova1,2, Olga Ruzickova1,6, Herman F Mann1,7, Karel Pavelka1,2, Ladislav Šenolt1,2, Jiri Vencovsky1,8, Radim Becvar1,2 and Michal Tomcik1,2, 1Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 2Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 3Department of Physiotherapy, Faculty of Physical Education and Sports, Charles University, Prague, Czech Republic, Prague, Czech Republic, 4Body Composition Laboratory, Faculty of Physical Education and Sports, Charles University, Prague, Czech Republic, Prague, Czech Republic, 5Faculty of Physical Education and Sports, Charles University, Prague, Czech Republic, Prague, Czech Republic, 6Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 7First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 8Department Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Fibrosis of the skin and visceral organs, especially digestive tract, and musculoskeletal involvement in systemic sclerosis (SSc) can have a negative impact on body…
  • Abstract Number: 1733 • 2018 ACR/ARHP Annual Meeting

    Should We Perform Exercise Echocardiogram As a Screening Test for Pulmonary Arterial Hypertension (PAH) for All Systemic Sclerosis (SSc) Patients?

    Luis Valdés1, Consuelo Orihuela-Sandoval2, Liliana Muñoz-Hernández3, Miguel Ayala-León2, José Luís Hernández-Oropeza4, Sergio Adán Benavides Suárez5, Alexia Esquinca-González5, Pablo Hernández-Reyes2 and Tatiana S. Rodriguez-Reyna5, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán., Mexico City, Mexico, 2Cardiology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 3Endocrinology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 4Cardio-neumology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 5Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: Prevalence of pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) is 8-12%, and 3-year survival rate is 47-56%. Rest echocardiogram is used to screen…
  • Abstract Number: 1734 • 2018 ACR/ARHP Annual Meeting

    Association of Short-Term Longitudinal Changes in Clinical and Physiologic Variables with Overall Survival in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD)

    Vincent Sobanski1, Jeska de Vries-Bouwstra2, Anna-Maria Hoffmann-Vold3, Dörte Huscher4, Margarida Alves5, Marco Matucci-Cerinic6, Gabriela Riemekasten7, Mengtao Li8, Gabriele Valentini9, László Czirják10, Otylia Kowal-Bielecka11, Yannick Allanore12, Nils Schoof5 and Oliver Distler13, 1Department of Internal Medicine and Clinical Immunology, University of Lille, Lille, France, 2Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Oslo University Hospital, Oslo, Norway, 4Charité – Universitaetsmedizin Berlin and Berlin Institute of Health, Berlin, Germany, 5Boehringer Ingelheim International GmbH, Ingelheim, Germany, 6Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 7Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany, 8Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 9Department of Rheumatology, Second University of Naples, Napoli, Italy, 10Department of Rheumatology and Immunology, University of Pécs, Pécs, Hungary, 11Department of Rheumatology and Internal Medicine, Medical University of Białystok, Białystok, Poland, 12Cochin Hospital, Paris Descartes University, Paris, France, Paris, France, 13Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Interstitial lung disease (ILD) is one of the leading causes of morbidity and mortality in patients with SSc. However, the impact of changes in…
  • Abstract Number: 1735 • 2018 ACR/ARHP Annual Meeting

    Diagnostic Accuracy of MR Angiography in a Cohort with Systemic Sclerosis Compared to Other Rheumatic Diseases with Acral Hypoperfusion

    Diana Dan1,2, Simon Saner1, Andrea D. Gloor1,3, Harald Bonel4, Jennifer L. Cullmann4 and Peter M. Villiger1, 1Department of Rheumatology, Immunology and Allergology, Inselspital, University Hospital of Bern, Bern, Switzerland, 2Service of Rheumatology, Lausanne University Hospital, Lausanne, Switzerland, 3Dermatology, Inselspital, University Hospital of Bern, Bern, Switzerland, 4Institute of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital of Bern, Bern, Switzerland

    Background/Purpose: Vasculopathy is a major feature of systemic sclerosis (SSc). It leads to intimal proliferation and adventitial fibrosis of small and large arterial blood vessels.…
  • Abstract Number: 1736 • 2018 ACR/ARHP Annual Meeting

    Incidence and Risk Factors for Gangrene in Patients with Systemic Sclerosis from the Eustar Cohort

    Carina Mihai1,2, Oliver Distler1, Ana Maria Gheorghiu2,3, Paul Iulian Constantin2, Rucsandra Dobrota1,2, Suzana Jordan4, Vanessa Smith5, Eric Hachulla6, Joerg C. Henes7, Elise Siegert8, Serena Vettori9, Ulf Müller-Ladner10, Marco Matucci-Cerinic11 and Yannick Allanore12, 1Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, 3Internal Medicine and Rheumatology, Carol Davila University of Medicine and Pharmacy, Cantacuzino Hospital, Bucharest, Romania, 4Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 5Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, 6Department of Internal Medicine and Clinical Immunology, Hôpital Claude Huriez, University of Lille, Lille, France, 7Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, 8Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, 9Rheumatology Unit, Department of Internal and Experimental Medicine University of Campania "Luigi Vanvitelli", Napoli, Italy, 10Dept. of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University Giessen, Germany, Bad Nauheim, Germany, 11Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 12Cochin Hospital, Paris Descartes University, Paris, France, Paris, France

    Background/Purpose: In patients with systemic sclerosis (SSc), peripheral vasculopathy can promote critical ischemia and gangrene that are very severe complications with potential life-threatening consequences. Recently…
  • Abstract Number: 1737 • 2018 ACR/ARHP Annual Meeting

    Multiplexed Autoantibody Profiles in a Systemic Sclerosis Clinical Trial Comparing Autologous Hematopoietic Stem Cell Transplantation and Cyclophosphamide

    Paul J. Utz1 and Burcu Ayoglu2, 1Medicine, Stanford University School of Medicine, Stanford, CA, 2Medicine, Stanford University, STANFORD, CA

     Background/Purpose: In a randomized, open-label, phase II clinical trial (SCOT, Scleroderma: Cyclophosphamide or Transplantation)1, subjects were randomly assigned to treatment with myeloablative CD34+ selected autologous…
  • Abstract Number: 1738 • 2018 ACR/ARHP Annual Meeting

    Detect Outperforms Echocardiography Based Screening Guidelines for Early Detection of Systemic Sclerosis Associated Pulmonary Arterial Hypertension

    Amber Young1, Victor M. Moles2,3, Vivek Nagaraja1, Dharshan Vummidi4, Scott H. Visovatti3, Vallerie McLaughlin3 and Dinesh Khanna1, 1Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, 2Hospital Jose Maria Cullen, Santa Fe, Argentina, 3Division of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 4Department of Radiology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Pulmonary arterial hypertension (PAH) is a leading cause of mortality in patients with systemic sclerosis (SSc). Active screening can detect SSc-PAH earlier and may…
  • Abstract Number: 1739 • 2018 ACR/ARHP Annual Meeting

    What Do Patient Reported Outcomes for Routine Monitoring of Gastrointestinal Tract Symptoms in a Systemic Sclerosis Center Tell Us about Clinical Features of Potential Small Intestinal Bacterial Overgrowth?

    Jessica Zhu1, Craig Gale2, Joshua Biber3, Mandana Nikpour4, Murray Baron5 and Tracy M. Frech6, 1School of Medicine, University of Utah, Salt Lake City, UT, 2Bioinformatics, University of Utah, Salt Lake City, UT, 3University of Utah, Salt Lake City, UT, 4The University of Melbourne, Melbourne, Australia, Melbourne, Australia, 5Department of Medicine, McGill University, Montreal, QC, Canada, 6Division of Rheumatology, University of Utah, Salt Lake City, UT

    Background/Purpose: The implementation of patient reported outcome measures (PROMs) is increasingly recognized as a critical aspect of clinical practice.  The use of gastrointestinal (GI) PROMs…
  • Abstract Number: 1740 • 2018 ACR/ARHP Annual Meeting

    Effectiveness and Safety of Tocilizumab for the Treatment of Refractory Systemic Sclerosis Associated Interstitial Lung Disease: A Case Series

    Judit Lluch1, Ivan Castellvi2, J Alegre3, Pablo Juárez1, Joan Miquel Nolla1 and Francisco Javier Narváez4, 1Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 2Rheumatology, Hospital Santa Creu i San Pau, Barcelona, Spain, 3Rheumatology, Hospital Universitario Doctor Peset. Valencia. Spain, Valencia, Spain, 4Rheumatology Department, Hospital Universitario de Bellvitge, Idibell, Barcelona, Spain

    Background/Purpose: To evaluate the efficacy and safety of TCZ as as a rescue therapy in patients with refractory scleroderma-associated interstitial lung disease (SSc-ILD). Methods: We…
  • Abstract Number: 1741 • 2018 ACR/ARHP Annual Meeting

    Disease Duration and Autoantibodies Predict Distinct Skin Score Trajectories in Diffuse Cutaneous Systemic Sclerosis

    Svetlana I. Nihtyanova1, Alper Sari2, Voon H. Ong3 and Christopher P. Denton4, 1Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 2Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 3Division of Medicine, University College London, London, United Kingdom, 4University College London, London, United Kingdom

    Background/Purpose: Although severity of skin involvement and change in skin thickness over time vary substantially between patients with diffuse cutaneous systemic sclerosis (dcSSc), for the…
  • Abstract Number: 1742 • 2018 ACR/ARHP Annual Meeting

    Disease-Specific Autoantibodies Associate with Remarkably Different Risk of Development of Significant Lung Fibrosis in Systemic Sclerosis

    Svetlana I. Nihtyanova1, Alper Sari2, Anna Leslie3, Voon H. Ong4 and Christopher P. Denton5, 1Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 2Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 3Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, 4Division of Medicine, University College London, London, United Kingdom, 5University College London, London, United Kingdom

    Background/Purpose: Pulmonary fibrosis (PF) is a leading cause of disease-related death in SSc patients. Some studies suggest that the timing of PF development differs between…
  • Abstract Number: 1743 • 2018 ACR/ARHP Annual Meeting

    Serum Markers Potentially Associated with PAH in Systemic Sclerosis; A Targeted Screening Approach

    Anders Heiervang Tennøe1, Håvard Fretheim2, Oyvind Midtvedt2, Torhild Garen2, Thor Ueland3, Pål Aukrust2, Arne K Andreassen2, Einar Gude2, Øyvind Molberg2 and Anna-Maria Hoffmann-Vold2, 1Rheumatology, Oslo University Hospital, Oslo, Norway, 2Oslo University Hospital, Oslo, Norway, 3Research Institute of Internal Medicine Research, Oslo University Hospital, Oslo, Norway

    Background/Purpose: Pulmonary arterial hypertension (PAH) is a feared complication in systemic sclerosis (SSc). Detection of PAH at a preclinical stage is important as early diagnosis…
  • Abstract Number: 1744 • 2018 ACR/ARHP Annual Meeting

    Prognostic Value of Right Heart Involvement in Systemic Sclerosis:Not Only Pulmonary Arterial Hypertension

    Luna Gargani1, Cosimo Bruni2, Antonella Moreo3, Laura Belloli3, Silvia Bellando-Randone2, Oscar Massimiliano Epis3, Francesco Ferrara4, Olga Vriz5, Eduardo Bossone6, Petar M. Seferovic7, Daniel E. Furst8 and Marco Matucci-Cerinic9, 1Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche (CNR), Pisa, Italy, 2Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Firenze, Italy, 3Niguarda Ca’ Granda Hospital, Milan, Italy, 4"Cava de' Tirreni and Amalfi Coast", University Hospital, Salerno, Italy, 5King Faisal Hospital, Riyadh, Saudi Arabia, 6Cardarelli Hospital, Naples, Italy, 7Department of Cardiology, , Clinical Center of Serbia and Belgrade University School of Medicine, Belgrade, Serbia, 8University of California Los Angeles, Los Angeles, CA, 9Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

    Background/Purpose: In SSc, cardiac dysfunction is associated with poor prognosis. Right ventricular involvement is frequently secondary to PAH. Echocardiography is the routine imaging tool to…
  • Abstract Number: 1745 • 2018 ACR/ARHP Annual Meeting

    Efficacy of Eosinophilic Granulomatosis with Polyangiitis (Churg–Strauss) Treatments According to the Type of Manifestations Based on Analysis of 376 Patients

    Matthias Papo1, Giacomo Emmi2, Franco Schiavon3, Matthieu Groh4, Maria-Letizia Urban2, Chiara Marvisi5, Jean-Emmanuel Kahn4, Alberto Sinico6, Maxime Samson7, Pascal Cohen1, Xavier Puéchal1, Luc Mouthon1, Loïc Guillevin1, Augusto Vaglio5 and Benjamin Terrier8, 1Department of Internal Medicine, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, 2Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 3Operative Unit of Rheumatology, Department of Medicine DIMED, University of Padova, Padova, Italy, 4Service de Médecine Interne, Centre de Référence des Syndromes Hyperéosinophiliques-CEREO, Hôpital Foch, Université Versailles–Saint-Quentin-en-Yvelines, Suresnes, France, 5Nephrology Unit, Parma University Hospital, Parma, Italy, 6UOS di Immunologia Clinica e UOC di Nefrologia, Azienda Ospedaliera San Carlo Borromeo, Milan, Italy, 7Department of Internal Medicine and Clinical Immunology, François-Mitterrand Teaching Hospital, University of Bourgogne-Franche-Comté, Dijon, France, 8Department of Internal Medicine, Centre de Référence pour les Maladies Auto-immunes Rares, Paris, France, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

    Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) (Churg–Strauss) is a small-vessel necrotizing vasculitis characterized by blood and tissue eosinophilia and asthma. Glucocorticoids (GCs) represent the cornerstone…
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