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  • Abstract Number: 1566 • 2018 ACR/ARHP Annual Meeting

    Prevalence and Prognosis of Interstitial Lung Disease in a Large Cohort of Chinese Primary Sjögren’s Syndrome Patients

    Hui Gao1,2, Xuewu Zhang1, Jing He3, Jing Zhang4, Ye Sun5 and Zhan-Guo Li1, 1Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 2Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China, 3Rheumatology, Peking University People's Hospital, Beijing, China, 4Peking University International Hospital, Beijing, China, 5Department of Radiology, Peking University People's Hospital, Beijing, China

    Background/Purpose: To determine the prevalence and identify the prognosis associated with pulmonary involvement in pSS patients. Methods: A total of 1341 hospitalized patients (853 with…
  • Abstract Number: 1567 • 2018 ACR/ARHP Annual Meeting

    The Risk Factors and Prognosis of Interstitial Lung Disease Associated with Primary Sjogren’s Syndrome: A Multi-Center Cohort Study

    Ziwei Liu1, Mengtao Li2, Qian Wang1, Yan Zhao3, Dong Xu1 and Xiaofeng Zeng4, 1Peking Union Medical College Hospital, Beijing, China, 2Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 3Rheumatology, Peking Union Medical College Hospital, Beijing, China, 4Rheumatology, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: The present study aimed to investigate the risk factors and prognosis of primary Sjogren’s syndrome-associated interstitial lung disease (pSS-ILD). Methods: Data were retrospectively collected…
  • Abstract Number: 1568 • 2018 ACR/ARHP Annual Meeting

    Azathioprine and Mycophenolate for Management of Sjögren’s Syndrome-Related Interstitial Lung Disease: A Retrospective Cohort Study

    Barkha Amlani1, Umang Barvalia2, Ghada Metwally Ahmed Elsayed3, Jeffrey P. Kanne4, Zhanhai Li5 and Sara S. McCoy6, 1Rheumatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, 2Pulmonary And Critical Care, university of wisconsin Hospital and clinics, Madison, WI, 3Rheumatology, University of Wisconsin Hospital and clinics, Madison, WI, 4Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, 5University of Wisconsin School of Medicine and Public Health, Madison, WI, 6Department of Medicine, Rheumatology Division, University of Wisconsin School of Medicine and Public Health, Madison, WI

    Background/Purpose: Interstitial lung disease (ILD) is a common extraglandular manifestation of Sjögren’s syndrome (SS).  There is a paucity of literature on the management of SS-ILD.…
  • Abstract Number: 1569 • 2018 ACR/ARHP Annual Meeting

    Diagnostic Performance of Labial Salivary Gland Biosy, Serological and Clinical Data in Sjogrens Syndrome. in Argentinian Multicenter

    Janet Flores1, Diego Baenas2, Maria Jezabel Haye Salinas3, Soledad Retamozo4, Juan Pablo Pirola5, Nadia Benzaquén3, Nadia Riscanevo6, María Flavia Ceballos7, Ana C. Alvarez3, Verónica Saurit8, Alejandro Alvarellos9, Priscila Serravalle10, Alberto Ortiz11, Sergio Paira11 and Francisco Caeiro5, 1Rheumatology Unit, Hospital privado Universitario de Córdoba, Cordoba, Argentina, 2Reumatologia, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, 3Rheumatology, Rheumatology Unit, Hospital Privado Universitario de Córdoba, Córdoba, Argentina, 4Sociedad Argentina de Reumatologia, Córdoba, Argentina, 5Rheumatology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, 6Rheumatology, Rheumatology Unit, Hospital privado Universitario de Córdoba, Cordoba, Argentina, 7Rheumatology, Rheumatology Unit, Hospital privado Universitario de Córdoba., Cordoba, Argentina, 8Hospital Privado Centro Médico de Córdoba, Cordoba, Argentina, 9Rheumatology, Rheumatology Unit, Hospital Privado Universitario de Córdoba, Cordoba, Argentina, 10Hospital Cullen, Santa Fe, Argentina, 11Reumatologia, Hospital J M Cullen, Santa Fe, Argentina

    Background/Purpose:Labial salivary gland biopsy (LSGB) is a safe and minimally invasive procedure used in the diagnostic evaluation of Sjogren’s Syndrome (SS). The objectives of this…
  • Abstract Number: 1570 • 2018 ACR/ARHP Annual Meeting

    Clinical Utility of a Second Minor Salivary Gland Biopsy in Patients with Suspected Sjögren’s Syndrome: A Retrospective Cohort Study

    Thibaud Depinoy1, Valérie Devauchelle-Pensec2, Sandrine Jousse-Joulin3, Thierry Marhadour1, Dewi Guellec3, Pascale Marcorelles1, Jacques-Olivier Pers2, Alain Saraux3 and Divi Cornec4, 1CHU Brest, Brest, France, 2U1227, Université de Brest, Inserm, Labex IGO, CHU de Brest, Brest, France, 3Rheumatology, CHU Brest, Brest, France, 4Rheumatology and UMR1227, Lymphocytes B et Autoimmunité, CHU Brest, Brest, France

    Background/Purpose: To determine whether the repetition of minor salivary gland biopsy (MSGB) has a clinical diagnostic utility in patients with suspicion of primary Sjögren’s syndrome…
  • Abstract Number: 1571 • 2018 ACR/ARHP Annual Meeting

    RNA Sequencing Detection of Gene Dysregulation in Epithelial Cells Sorted from Salivary Gland Tissue Reveals Interesting Pathways Involved in Primary Sjögren’s Syndrome Pathophysiology

    Elodie Rivière1,2, Nicolas Tchitchek1, Gaetane Nocturne1,3, Juliette Pascaud1, Alexandre Virone1, Saida Boudaoud1, Alice Thai4, Normand Allaire4, Bernd Jagla5, Michael Mingueneau4 and Xavier Mariette1,3, 1Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre & Fontenay aux Roses, France, 2Arthritis Fondation Courtin, Paris, France, 3Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, 4Immunology Research, Biogen, Cambridge, MA, 5Biomarker Discovery Platform UTechS CB, Hub de Bioinformatique et biostatistique C3IB, Institut Pasteur, Paris, France

    Background/Purpose: Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder characterized by lymphocytic infiltrates and destruction of the salivary glands. Several lines of evidence support…
  • Abstract Number: 1572 • 2018 ACR/ARHP Annual Meeting

    Salivary Flow Rates and Oral Health Related Quality of Life Are Associated with Ultrasonographic Scoring of the Major Salivary Glands in Sjogren Syndrome

    Yasemin Yalçınkaya1, Gonca Mumcu2, Filiz Ture Ozdemir3, Zeynep Erturk1, Ali Ugur Unal1, Pamir Atagunduz4, Haner Direskeneli5 and Nevsun Inanc6,7, 1Department of Internal Medicine, Division of Rheumatology, Marmara University, Istanbul, Turkey, 2Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, 3Marmara University, School of Medicine, Department of Immunology, Istanbul, Turkey, 4Department Internal Medicine, Division of Rheumatology, Marmara University,, Istanbul, Turkey, 5Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 6Marmara University, Istanbul, Turkey, 7Departement of İnternal Medicine, Division of Rheumatology, Marmara University, Istanbul, Turkey

    Background/Purpose:  Ultrasonography (USG) of major salivary glands (SG-USG) as a non-invasive method is widely used to evaluate salivary gland involvement in Sjogren’s syndrome (SjS). Since…
  • Abstract Number: 1573 • 2018 ACR/ARHP Annual Meeting

    Salivary Dysbiosis Correlates with Clinical Status of Anti-Ro Positive Mothers of Children with Neonatal Lupus

    Robert M. Clancy1, Carl Langefeld2, Hannah C. Ainsworth3, Martin Blaser4, Peter M. Izmirly5, Corey Lacher1, Miranda C Marion6, Mala Masson1, Gregg Silverman7 and Jill P. Buyon1, 1NYU School of Medicine, New York, NY, 2Wake Forest School of Medicine, Winston-Salem, NC, 3Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 4Director of the NYU Human Microbiome Program, NYU School of Medicine, New York, NY, 5Rheumatology, NYU School of Medicine, New York, NY, 6Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC, 7Dept of Medicine, NYU School of Medicine, New York, NY

    Background/Purpose: Neonatal lupus is linked to the presence of circulating anti-Ro antibodies in the mother. These antibodies are present in asymptomatic individuals, who in a…
  • Abstract Number: 1574 • 2018 ACR/ARHP Annual Meeting

    Autoantibodies Present in Saliva from Sjogren’s Syndrome and Non-Sjogren’s Sicca Patients Are Not Detectible in Serum

    Kristi A. Koelsch1,2,3, Joshua Cavett3,4, Kenneth Smith3, Jacen Maier-Moore5, Astrid Rasmussen3, David M. Lewis6, Lida Radfar7, Biji T. Kurien2,4,8, Judith A. James3,9, Kathy L. Sivils10, A. Darise Farris11 and R. Hal Scofield2,11,12, 1Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Okalahoma City, OK, 2U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, 3Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 5Clinical Laboratory Science, University of Texas at El Paso, El Paso, TX, 6Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, 7Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, 8Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 9University of Oklahoma Health Sciences Center, Oklahoma City, OK, 10Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma, OK, 11Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 12Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: There is evidence for B cell involvement in the pathogenesis of Sjögren’s syndrome by the presence of autoantigen-specific B cells. Autoantibodies toward Ro/SSA and…
  • Abstract Number: 1575 • 2018 ACR/ARHP Annual Meeting

    The Association between Salivary Gland Ultrasonography and Clinical Manifestation in Patients with Early Primary Sjögren’s Syndrome

    Yen-Fu Chen1 and Yao-Fan Fang2, 1Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 2Chang-Gung Memorial Hospital, Taoyuan city, Taiwan

    Background/Purpose: To investigate the clinical manifestations in patients with early primary Sjögren¡¦s syndrome based on different severity score under salivary gland ultrasonography.Methods: We enrolled 44…
  • Abstract Number: 1576 • 2018 ACR/ARHP Annual Meeting

    Soluble Semaphorin 4D/CD100 Is Increased in the Saliva of Sjögren’s Syndrome

    Shin Eui Kang1, Jeong Seok Lee2, Ji Soo Park1, Ji Hye Lee2, Jeong Yeon Kim1, Hyun Jung Yoo2, Yun Jong Lee3, Eun Young Lee4, Eun Bong Lee2 and Yeong Wook Song1,5, 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), 3Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Korea, Republic of (South), 4Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), 5Rheumatology, Seoul National University Hospital, Seoul, Korea, Republic of (South)

    Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration in exocrine organs with dry mouth and dry eyes. Semaphorin 4D (SEMA4D) /…
  • Abstract Number: 1577 • 2018 ACR/ARHP Annual Meeting

    Soluble Siglec-5 Is a Novel Salivary Biomarker for Primary Sjogren’s Syndrome

    Jennifer Lee1, Hong-Ki Min2, Ji-Won Kim3, Seung-Ki Kwok4 and Sung-Hwan Park5, 1Rheumatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 3Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 4Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul., Seoul, Korea, Republic of (South), 5Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)

    Background/Purpose: Despite advances in the understanding of the pathogenesis, disease-specific biomarkers have not been included in the classification criteria for Primary Sjogren's syndrome (pSS). Based…
  • Abstract Number: 1578 • 2018 ACR/ARHP Annual Meeting

    Exercise Increases Aerobic Capacity in Primary Sjögren´s Syndrome: A Randomized Controlled Trial

    Ana Beatriz Andreo Garcia, MD1, Virginia Fernandes Moça Trevisani2, Luciana Dardin3 and Paulo Alexandre Minali4, 1Evidence-based Health, UNIFESP, São Paulo, Brazil, São Paulo, Brazil, 2UNIFESP, Sao Paulo, Brazil, San Paulo, Brazil, 3Emergency Medicine and Evidence-Based Medicine Department, UNIFESP, São Paulo Brazil, SÃO PAULO, Brazil, 4UNIFESP, São Paulo, Brazil, São Paulo, Brazil

    Background/Purpose: Recent studies have shown increased cardiovascular risk in patients with primary Sjögren's syndrome (pSS). As physical exercise is one of the pillars in primary…
  • Abstract Number: 1579 • 2018 ACR/ARHP Annual Meeting

    Sjögren’s Syndrome Is Associated with Reduced Sex Hormone Exposure: A Case-Control Study

    Sara S. McCoy1, Emmanuel Sampene2 and Alan N. Baer3, 1Department of Medicine, Rheumatology Division, University of Wisconsin School of Medicine and Public Health, Madison, WI, 2Biostatistics, University of Wisconsin School of Medicine and Public Health, Madison, WI, 3Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Sjögren’s Syndrome (SS) is an autoimmune disease with female predominance and frequent perimenopausal onset, indicating a potential pathogenic role for sex hormones.  The goal…
  • Abstract Number: 1580 • 2018 ACR/ARHP Annual Meeting

    Persistent Serological Activity in Primary Sjögren’s Syndrome

    Jorge Lopez-Morales, Daniel Cortes-Muñoz and Gabriela Hernandez-Molina, Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, Mexico

    Background/Purpose: To assess presence of persistent serological activity and its association with clinical outcomes in a cohort of patients with primary Sjögren’s syndrome (pSS). Methods:…
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