ACR Meeting Abstracts

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  • Abstract Number: 1536 • 2018 ACR/ARHP Annual Meeting

    Mean Platelet Volume Changes with Baricitinib Indicate Reduced New Platelet Production in Baricitinib-Treated Rheumatoid Arthritis Patients

    Jon T. Giles1, Michael T. Nurmohamed2, Henry M. Rinder3, Venkatesh Krishnan4, Brenda J. Crowe4, Chadi Saifan4 and Thomas Dörner5, 1Columbia University, New York, NY, 2VU University Medical Center, Amsterdam, Netherlands, 3Yale University School of Medicine, New Haven, CT, 4Eli Lilly and Company, Indianapolis, IN, 5Charité Universitätsmedizin Berlin and Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany

    Background/Purpose: Transient increases in circulating platelets were observed in patients with RA treated with baricitinib, an oral selective Janus kinase 1/2 inhibitor, approved for the…
  • Abstract Number: 1537 • 2018 ACR/ARHP Annual Meeting

    Frequency and Duration of Early Non-Serious Adverse Events in Rheumatoid Arthritis Patients Treated with Tofacitinib 5 Mg Twice Daily As Monotherapy and Combination Therapy

    Ara Dikranian1, Jürgen Wollenhaupt2, Valderilio F Azevedo3, Louis Bessette4, David Gold5, Jose L Rivas6, Harry Shi7, Lisy Wang8, John Woolcott7, Andrea Shapiro9 and Peter Nash10, 1Cabrillo Center for Rheumatic Disease, San Diego, CA, 2Schön Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, 3Universidade Federal do Paraná, Curitiba, Brazil, 4Laval University, Kirkland, QC, Canada, 5Pfizer Canada, Montreal, QC, Canada, 6Pfizer SLU, Madrid, Spain, 7Pfizer Inc, Collegeville, PA, 8Pfizer Inc, Groton, CT, 9Pfizer Inc, Peapack, NJ, 10University of Queensland, Brisbane, Australia

    Background/Purpose: Tolerability remains ill-defined in clinical trials and most commonly refers to non-serious adverse events (AEs) that may impact patient (pt) satisfaction and adherence to…
  • Abstract Number: 1538 • 2018 ACR/ARHP Annual Meeting

    Moderate Adverse Drug Reactions Due to Disease Modifying Drugs in a Cohort of Patients with Incident Rheumatoid Arthritis

    Lydia A Alcazar1, Dalifer Freites Núñez1, Isabel Hernández-Rodríguez2, Judit Font Urgelles2, Pia Mercedes Lois2, Benjamín Fernández-Gutiérrez2, Juan A Jover Jover1 and Zulema Rosales Rosado1,2, 1Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain, 2Rheumatology, Hospital Clínico San Carlos, Madrid, Spain

    Background/Purpose: In rheumatology, we are aware of the possibility to develop adverse drug reactions (ADR) to the widely used Disease Modifying Drugs (DMARD). We are…
  • Abstract Number: 1539 • 2018 ACR/ARHP Annual Meeting

    Safety of Methotrexate and Leflunomide Combination Therapy in the Treatment of Rheumatoid Arthritis

    María Badilla1, Nicia Moldenhauer2, Diego Neira3, Luis Muñoz4 and Oscar Neira1, 1Rheumatology Section., Hospital del Salvador, Universidad de Chile., Santiago, Chile, 2Rheumatology Section, Hospital del Salvador, Universidad de Chile, Santiago, Chile, 3Internal Medicine Departament, Hospital del Salvador, Universidad de Chile, Santiago, Chile, 4Pharmacy Department, Hospital del Salvador, Santiago, Chile

    Background/Purpose: Best treatment of Rheumatoid Arthritis (RA) requires to begin early, with a tight control, including nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, disease-modifying antirheumatic drugs (DMARDs)…
  • Abstract Number: 1540 • 2018 ACR/ARHP Annual Meeting

    Validation of Hepatic Fibrosis Markers in People with Rheumatoid Arthritis on Methotrexate

    Debbie Olsson-White1, John Olynyk2,3, Warren Raymond4,5, Shereen Paramalingam1,5 and Helen Keen1,6, 1Rheumatology, Fiona Stanley Hospital, Murdoch, Australia, 2Gastroenterology and Hepatology, Fiona Stanley Hospital, Murdoch, Australia, 3School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia, 4Rheumatology, Sir Charles Gairdner Hospital, Nedlands, Australia, 5University of Western Australia, Crawley, Australia, 6University of Western Australia, Perth, Australia

    Background/Purpose: MTX is the cornerstone of treatment of RA. A relatively rare side effect is liver fibrosis and cirrhosis, the incidence in patients on long-term…
  • Abstract Number: 1541 • 2018 ACR/ARHP Annual Meeting

    The Safety Profile of Iguratimod in Real Clinical Practice: Analysis of 491 Patients with Rheumatoid Arthritis

    Yukihiko Ikeda1, Ryo Rokutanda1, Sho Fukui1, Haruki Sawada2, Mitsuru Watanabe3, Ayako Koido3, Yuko Kataoka1, Rui Kawato4, Haruyuki Yanaoka5, Masei Suda6, Yuri Ohara7, Hiromichi Tamaki1, Hisanori Shimizu6, Tokutaro Tsuda1, Ken-ichi Yamaguchi8, Mitsumasa Kishimoto1 and Masato Okada1, 1Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, 2Immuno-rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, 3Immune-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, 4Immuno rheumatology center, St. Luke's International Hospital, Tokyo, Japan, 5St. Luke's International Hospital, Tokyo, Japan, 6Immuno-Rheumatology Center, St luke's International hospital, Tokyo, Japan, 7Allergy & Rheumatology, St. Luke's International Hospital, Tokyo, Japan, 8Allergy and Rheumatology, St. Luke's International Hospital, Tokyo, Japan

    The retention rate and safty profile of iguratimod in real clinical practice: Analysis of 456 patients with Rheumatoid arthritis. Abstract Background/Purpose: Iguratimod is one of…
  • Abstract Number: 1542 • 2018 ACR/ARHP Annual Meeting

    Real-World Data from a Post-Approval Safety Surveillance Study of Tofacitinib Vs Biologic Dmards and Conventional Synthetic Dmards: Five-Year Results from a US-Based Rheumatoid Arthritis Registry

    Joel Kremer1, Laura C. Cappelli2, Carol J. Etzel3, Jeffrey Greenberg3, Jamie Geier4, Ann Madsen4, Connie Chen4, Alina Onofrei3, Christine J Barr3, Dimitrios A. Pappas3, Kimberly J Dandreo3, Andrea Shapiro5, Carol A Connell6 and Arthur Kavanaugh7, 1Albany Medical College and the Center for Rheumatology, Albany, NY, 2Johns Hopkins University, Baltimore, MD, 3Corrona LLC, Waltham, MA, 4Pfizer Inc, New York, NY, 5Pfizer Inc, Peapack, NJ, 6Pfizer Inc, Groton, CT, 7University of California, San Diego School of Medicine, La Jolla, San Diego, CA

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. A prospective observational 5-year study, embedded within the US Corrona RA registry,…
  • Abstract Number: 1543 • 2018 ACR/ARHP Annual Meeting

    The Efficacy, Safety and Adherence of Biologicbiological Disease-Modifying Anti Rheumatic Drugs, Infliximab, Tocilizumab and Abatacept, in Elderly Patients with Rheumatoid Arthritis

    Takuma Tsuzuki Wada1, Yu Funakubo Asanuma2, Mayumi Matsuda3, Hiroaki Yazawa2, Yoshinobu Nakao4, Noritsune Kozu5 and Toshihide Mimura2, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine,, Saitama Medical University, Saitama, Japan, 2Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 3Department of Rheumatology and Applied Immunology, Saitama Medical University, Saitama, Japan, 4Department of Rheumatology, Saga University Hospital, Saga, Japan, 5Kozu Orthopedic Clinic, Yachiyo, Japan

    Background/Purpose: Elderly patients with rheumatoid arthritis (RA) have declined physical performances and increased various complications. We are concerned about decrease of efficacy and increase of…
  • Abstract Number: 1544 • 2018 ACR/ARHP Annual Meeting

    Tofacitinib Safety and Efficacy in the Treatment of Rheumatoid Arthritis in a Central/Eastern European Subpopulation

    Jiri Vencovsky1, Janusz Badurski2, Šárka Forejtová1, Olga Lukáčová3, Mykola Stanislavchuk4, Daniela Yaneva-Bichovska5, Harry Shi6, Radu Vasilescu7, Tatjana Lukic8 and Martin Kabina9, 1Institute of Rheumatology, Prague, Czech Republic, 2Centre of Osteoporosis and Osteoarticular Diseases, Bialystok, Poland, 3National Institute for Rheumatic Diseases, Piešťany, Slovakia, 4Vinnytsia Regional Clinical Hospital, Vinnytsia, Ukraine, 5Medical Centre Synexus, Sofia, Bulgaria, 6Pfizer Inc, Collegeville, PA, 7Pfizer Regional Medical Europe, Brussels, Belgium, 8Pfizer Inc, New York, NY, 9Pfizer Innovative Health, Prague, Czech Republic

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. This post hoc analysis assessed tofacitinib safety and efficacy in the Central…
  • Abstract Number: 1545 • 2018 ACR/ARHP Annual Meeting

    Exploring the Effects of Depressive Symptoms on the Efficacy of Sarilumab and Improvements in Health-Related Quality of Life

    Vibeke Strand1, Erin Mangan2, Owen Hagino3, Jonathan Sadeh4, Susan Boklage2 and Toshio Kimura2, 1Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, 2Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 3Sanofi Genzyme, Bridgewater, NJ, 4Sanofi, Bridgewater, NJ

    Background/Purpose: The pro-inflammatory cytokine IL-6 has been found to play a critical role in mood disorders, with symptoms such as anxiety and depression having implications…
  • Abstract Number: 1546 • 2018 ACR/ARHP Annual Meeting

    Efficacy and Safety of Corticosteroids in Rheumatoid Arthritis: Systematic Literature Review and Practical Recommendations

    Raimon Sanmartí1, Jesús Tornero Molina2, Francisco Javier Narváez3, Alejandro Muñoz4, Elena Garmendia5, Ana M. Ortiz Garcia6, Miguel A. Abad7, Patricia Moya8, Maria Lourdes Mateo9, Delia Reina10, Juan Salvatierra Osorio11, Sergio Rodriguez12, Ana Rubial Escribano13, Natalia Palmou-Fontana14 and Jaime Calvo-Alén15, 1Rheumatology Service, Hospital Clínic de Barcelona, Barcelona, Spain, 2Rheumatology Unit, Hospital de Guadalajara, Guadalajara, Spain, 3Rheumatology Department, Hospital Universitario de Bellvitge, Idibell, Barcelona, Spain, 4Rheumatology, Hospital Universitario Virgen del Rocío, Sevilla, Spain, 5Rheumatology, Hospital Universitario Cruces. Barakaldo. Spain, Barakaldo, Spain, 6Rheumatology, Rheumatology Service, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, 7FEA Reumatología, Hospital Virgen del Puerto, Cáceres, Spain, 8Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, 9Rheumatology, Hospital Germans Trias i Pujol, Badalona, Spain, 10Rheumatology, Hospital Moises Broggi, Sant Joan Despí, Spain, 11Complejo Hospitalario Universitario de Granada, Granada, Spain, 12Rheumatology, Hospital Universitario Virgen de Valme, Sevilla, Spain, 13Rheumatology, Hospital Alfredo Espinosa, Urduliz, Spain, 14Hospital Universitario Marqués de Valdecilla, IDIVAL. Universidad of Cantabria, Santander, Spain, 15Rheumatology Department, Hospital Universitario Araba. Vitoria-Gasteiz, Alava, Spain

    Background/Purpose: Corticosteroids are effective in rheumatoid arthritis (RA) patients but their adverse events limit their use. The aim of this study was to: 1) To…
  • Abstract Number: 1547 • 2018 ACR/ARHP Annual Meeting

    Impact of Obesity on Drug Survival of Tofacitinib in Patients with Rheumatoid Arthritis: Analysis from the Turkbio Registry

    Hakan Babaoglu1, Berna Goker1, Nevsun İnanç2, Merih Birlik3, Suleyman Serdar Koca4, Ayse Cefle5, Ediz Dalkiliç6, Abdurrahman Tufan1, Sema Yilmaz7, Soner Senel8, Servet Akar9, Nurullah Akkoc10, Fatos Onen3 and Ummugulsum Gazel11, 1Internal Medicine-Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey, 2Rheumatology, Marmara University faculty of Medicine, İstanbul, Turkey, 3Rheumatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey, 4Rheumatology, Firat University Faculty of Medicine, Elazığ, Turkey, 5Rheumatology, Kocaeli University, Faculty of Medicine, Kocaeli, Turkey, 6Department of Internal Medicine, Division of Rheumatology, Uludağ University Faculty of Medicine, Bursa, Turkey, 7Department of Rheumatology, Selcuk University School of Medicine, Konya, Turkey, 8Rheumatology, Kayseri Erciyes University, Faculty of Medicine, Kayseri, Turkey, 9Department of Internal Medicine, Division of Rheumatology,, Izmir Katip Çelebi University Faculty of Medicine, Izmir, Turkey, 10Rheumatology, İzmir, Turkey, İzmir, Turkey, 11Rheumatology, Marmara University faculty of Medicine, Istanbul, Turkey

    Background/Purpose: Several previous reports suggest that obesity impairs the effectiveness and drug survival of anti-TNF-α agents in rheumatoid arthritis (RA). The aim of the study…
  • Abstract Number: 1548 • 2018 ACR/ARHP Annual Meeting

    Favorable Effect of Hydroxychloroquine in Patients with Rheumatoid Arthritis and Diabetes or Impaired Glucose Control

    Farhana Polara, Mohmed Imran Gora and Shante Hinson, Internal Medicine, Lincoln Medical and Mental hospital, Bronx, NY

    Background/Purpose: Hydroxychloroquine (HCQ) is widely prescribed for patients with Rheumatoid Arthritis (RA) and Systemic Lupus Erythromatus (SLE). It is fairly well tolerated with multiple well…
  • Abstract Number: 1549 • 2018 ACR/ARHP Annual Meeting

    Comparison of Adverse Events and Survival of Treatment in Patients with Rheumatoid Arthritis Receiving Combined Treatment of Methotrexate and Leflunomide Versus Those Receiving Biological Therapy

    Magdalena Cavalieri1, Roger Rolon Campuzano1, Emilce E Schneeberger2, Fernando Dal Pra3, Dafne Capelusnik4, Carolina Ayelen Isnardi5, Marina Natalia Fornaro6 and Gustavo Citera7, 1Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Buenos Aires, Argentina, 2Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 3Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 4Reumatology, Instituto de Rehabilitación Psicofísica, Argentina, CABA, Argentina, 5Reumatology, Instituto de Rehabilitación Psicofísica, CABA, Argentina, 6Section of Rheumatology, Instituto de Rehabilitación Psicofísica, buenos aires, Argentina, 7Rheumatology Section, Instituto de Rehabilitación Psicofísica, CABA, Argentina

    Background/Purpose: According to clinical practice guidelines for patients with rheumatoid arthritis (RA), after failure to a c-DMARD (conventional disease modifying antirheumatic drug) can be chosen…
  • Abstract Number: 1550 • 2018 ACR/ARHP Annual Meeting

    Improvement of HbA1c in Patients with Rheumatoid Arthritis and Diabetes Type 2 during Treatment with Tocilizumab

    Christof Specker1, Annette Alberding2, Martin Aringer3, Gerd R. Burmester4, Jan-Paul Flacke5, Michael Hofmann6, Peter Kaestner7, Herbert Kellner8, Frank Moosig9, Maren Sieburg10, Hans-Peter Tony11 and Gerhard Fliedner12, 1Rheumatology and Clinical Immunology, Universitätsklinikum Essen, Essen, Germany, 2Internal Rheumatology, Krankenhaus St. Josef, Wuppertal, Germany, 3Medicine III, University Medical Center and Faculty of Medicine TU Dresden, Dresden, Germany, 4Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany, 5Rheumatology, Roche Pharma AG, Grenzach-Wyhlen, Germany, 6Rheumatology, Chugai Pharma Europe Ltd., Frankfurt, Germany, 7Rheumatology, Ambulantes Rheumazentrum, Erfurt, Germany, 8Ambulantes Rheumazentrum, Erfurt, Germany, 9Rheumatology Center Schleswig-Holstein Mitte, Neumuenster, Germany, 10Rheumatologische Gemeinschaftspraxis, Magdeburg, Germany, 11Rheumatology/Immunology, Medizinische Klinik II, Universitätsklinik, Würzburg, Germany, 12Rheumatological Practice, Osnabrueck, Germany

    Background/Purpose: Interleukin 6 (IL-6) and C-reactive protein (CRP) are independent risk factors for type 2 diabetes mellitus [1], and IL-6 plays a role in insulin…
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