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  • Abstract Number: 2189 • 2019 ACR/ARP Annual Meeting

    Reference Curves for the Knee Injury and Osteoarthritis Outcome Score in the Middle-aged Dutch Population

    Marieke Loef1, Féline PB Kroon 1, Stephan Böhringer 1, Frits R Rosendaal 1 and Margreet Kloppenburg 1, 1Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands

    Background/Purpose: The Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire is a widely used patient-reported outcome tool, developed to evaluate short- and long-term knee symptoms…
  • Abstract Number: 2190 • 2019 ACR/ARP Annual Meeting

    Multi-vendor Multi-site T1ρ and T2 Quantification of Knee Cartilage

    Jeehun Kim 1, Kenji Mamoto 2, Richard Lartey 1, Kaipin Xu 1, Matthew Tanaka 3, Emma Bahroos 3, Carl Winalski 2, Thomas Link 3, Peter Hardy 4, Qi Peng 5, Angie Botto-van Bemden 6, Kecheng Liu 7, Robert Peters 8, Can Wu 9 and Xiaojuan Li10, 1Program of Advanced Musculoskeletal Imaging, Cleveland Clinic Foundation, Cleveland, 2Cleveland Clinic Foundation, Cleveland, 3University of California, San Francisco, San Francisco, 4University of Kentucky, Lexington, 5Albert Einstein College of Medicine, New York City, 6Arthritis Foundation, Atlanta, 7Siemens Medical Solution Inc, Malvern, 8GE Healthcare, Milwaukee, 9Philips Healthcare, Andover, 10Program of Advanced Musculoskeletal Imaging, Cleveland Clinic Foundation, Cleveland, OH

    Background/Purpose: Osteoarthritis (OA) is a degenerative joint disease characterized by deterioration of articular cartilage in the joints. MRI T1ρ and T2 relaxation times have been…
  • Abstract Number: 2191 • 2019 ACR/ARP Annual Meeting

    Construct Validity of OMERACT Ultrasound Knee Scores with Pain, Other Symptoms, Radiographic and MRI Findings

    Win Min Oo1, James Linklater 2, Kimberly Bennell 3, Shirley Yu 1, Xia Wang 1, Vicky Duong 1 and David Hunter 1, 1Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Australia, Sydney, New South Wales, Australia, 2Department of Musculoskeletal Imaging, Castlereagh Sports Imaging Center, St. Leonards, Sydney, Australia, Sydney, New South Wales, Australia, 3Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, Faculty of Medicine Dentistry & Health Sciences, The University of Melbourne, Melbourne, VIC, Australia., Parkville, Victoria, Australia

    Background/Purpose: To investigate the construct validity of Outcome Measures in Rheumatology (OMERACT) ultrasound scores for knee osteoarthritis (OA) with pain, other symptoms, and OA severity…
  • Abstract Number: 2192 • 2019 ACR/ARP Annual Meeting

    Stabilization of Patellar Bone-Shape Correlates Significantly with Reduced Knee Pain Frequency After IA TPX-100 in Subjects with Bilateral Patellofemoral OA

    Dawn McGuire1, Michael Bowes 2, Alan Brett 2, Neil Segal 3, Meghan Miller 4, David Rosen 4 and Yoshinari Kumagai 4, 1OrthoTrophix, Orinda, CA, 2Imorphics, Manchester, England, United Kingdom, 3University of Kansas Medical Center, Kansas City, KS, 4OrthoTrophix, Oakland, CA

    Background/Purpose: Based on data from the Osteoarthritis Initiative (OAI), MRI-based analyses of bone shape changes in the knee predict symptomatic and radiographic progression of knee…
  • Abstract Number: 2193 • 2019 ACR/ARP Annual Meeting

    “If It Was Unicorn Dust I’d Have It Again.” Patient Experiences of Hip Osteoarthritis and Treatments in the Hip Injection Trial

    Clare Jinks 1, Ashley Hawarden 1, Edward Roddy2, Zoe Paskins 3, Christian Mallen 4 and Melanie Holden 5, 1Research Institute for Primary Care and Health Sciences, Keele University, Keele, England, United Kingdom, 2Research Institute for Primary Care and Health Sciences and Keele Clinical Trials Unit, Keele, United Kingdom, 3Research Institute for Primary Care and Health Sciences, Keele University, Keele, United Kingdom, 4Research Institute for Primary Care and Health Sciences, Keele University, UK, Keele, United Kingdom, 5Research Institute for Primary Care and Health Sciences and Keele CTU, Keele University, Keele, England, United Kingdom

    Background/Purpose: Evidence of the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited and conflicting. The HIT trial compared the clinical effectiveness of…
  • Abstract Number: 2194 • 2019 ACR/ARP Annual Meeting

    Surgical and Medical Weight Loss Threshold Dictates Decreases in Knee Osteoarthritis Pain but Not Reductions in Inflammatory Biomarkers

    Fernando Bomfim1, Shannon Chen 1, Stephen Zak 2, Taylor Jazrawi 1, Madeline Kundler 2, Vivienne Qie 2, Laura Peralta 2, Jose Aleman 2, Christine Ren-Fielding 2, Holly Lofton 2, Jyoti Patel 2, Mukundan Attur 3, Steven B. Abramson 3 and Jonathan Samuels 1, 1NYU Langone Health, New York, 2NYU Langone Health, New York, NY, 3NYU School of Medicine and NYU Langone Orthopedic Hospital, New York City, NY

    Background/Purpose: Weight loss in obese patients can reduce knee osteoarthritis (OA) pain, even when physical therapy and intra-articular injections have failed. The impacts of either…
  • Abstract Number: 2195 • 2019 ACR/ARP Annual Meeting

    BMI Has Minimal Effect on Reduction of Symptoms in Patients with Osteoarthritis of the Knee Treated with Diclofenac 1% Gel

    Joel A. Block1, Bharat Patel 2 and Sandy Yacoub Garas 3, 1Rush University Medical Center, Chicago, IL, 2GlaxoSmithKline Consumer Healthcare, Weybridge, United Kingdom, 3GlaxoSmithKline Consumer Healthcare, Warren, NJ

    Background/Purpose: Clinical trials demonstrate that diclofenac sodium gel 1% (DSG 1%), a topical NSAID, provides significantly better pain relief than vehicle placebo for patients with…
  • Abstract Number: 2196 • 2019 ACR/ARP Annual Meeting

    Machine Learning Defines the Relationship Between Structural Knee Osteoarthritis and Patient-Important Outcomes: An 8-year Study of 47,858 Knee MRIs from the Osteoarthritis Initiative (OAI)

    Michael Bowes1, Katherine Kacena 2, Oras Alabas 3, Alan Brett 1, Bright Dube 4, Neil Bodick 5 and Philip G Conaghan 6, 1Imorphics, Manchester, England, United Kingdom, 2BioBridges, Wellesley Hills, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, 4University of Leeds, LEEDS, England, United Kingdom, 5Flexion Therapeutics, Burlington, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom

    Background/Purpose: Osteoarthritis (OA) is a slowly progressing disease which may be asymptomatic for many years. Therapy development has been hampered by poor understanding of both…
  • Abstract Number: 2197 • 2019 ACR/ARP Annual Meeting

    Clinically Relevant Improvements in Knee Osteoarthritis Pain with Diclofenac Sodium Gel 1%

    Marc C. Hochberg1, Bharat Patel 2, Sandy Yacoub Garas 3 and Roy Altman 4, 1University of Maryland School of Medicine, Baltimore, MD, 2GlaxoSmithKline Consumer Healthcare, Weybridge, United Kingdom, 3GlaxoSmithKline Consumer Healthcare, Warren, NJ, 4University of California, Los Angeles

    Background/Purpose: Topical agents are recommended for the initial treatment of patients with knee osteoarthritis (OA). Diclofenac sodium gel 1% (DSG 1%), a topical nonsteroidal anti-inflammatory…
  • Abstract Number: 2198 • 2019 ACR/ARP Annual Meeting

    Severe Acute Localized Reactions Following Intra-Articular Hyaluronic Acid Injections in Knee Osteoarthritis

    Kevin Ong1, Maria Runa 1, Wilson Ngai 2, Zhimin Xiao 3, Edmund Lau 4 and Roy Altman 5, 1Exponent, Inc., Philadelphia, 2Sanofi, U.S. Medical Affairs, Bridgewater, 3Sanofi US, Cambridge, 4Exponent, Inc., Menlo Park, 5University of California, Los Angeles

    Background/Purpose: Some concerns have been raised about subsequent severe acute localized reactions (SALR) (flares, pseudoseptic reactions, etc.) following hyaluronic acid (HA) injections for pain relief…
  • Abstract Number: 2199 • 2019 ACR/ARP Annual Meeting

    Is There an Association of Serum LDL, HDL and Total Cholesterol with the Development of Knee Osteoarthritis?

    Jessica Barlow1, Xianbang Sun 2, Michael Nevitt 3, James Torner 4, Beth Lewis 5, Nirupa Matthan 6, Alice Lichtenstein 6 and David Felson 7, 1Boston University School of Medicine, Department of Rheumatology, Boston, MA, 2Boston University School of Medicine, Boston, MA, 3University of California at San Francisco, San Francisco, CA, 4University of Iowa at Iowa City, Iowa City, 5University of Alabama at Birmingham, Birmingham, AL, 6Tufts University, Boston, MA, 7Boston University School of Medicine, Department of Rheumatology, Boston

    Background/Purpose: Recent data have suggested an association between elevated serum cholesterol levels, particularly low density lipoprotein (LDL), and the development of osteoarthritis (OA).  Within the…
  • Abstract Number: 2200 • 2019 ACR/ARP Annual Meeting

    Magnetic Resonance Imaging of Knee Joint Protection Following an Intra-Articular Injection of Lipid-Based Dexamethasone Sodium Phosphate Sustained Release Formulation on Subjects with Knee Osteoarthritis

    Sheue-Fang Shih1, Carl Brown 1, Tien-Tzu Tai 1 and Wing Chuang 1, 1Taiwan Liposome Company, Ltd., Taipei, Taiwan (Republic of China)

    Background/Purpose: The most commonly used intra-articular (IA) corticosteroid for osteoarthritis (OA) is triamcinolone acetonide (TA), but its potential chondrotoxicity restricts injection frequency to 3-4 injections…
  • Abstract Number: 2201 • 2019 ACR/ARP Annual Meeting

    Developing a Comprehensive Patient-Specific Disease Progression Prediction Model for Knee Osteoarthritis Using Machine/Deep Learning Methods

    Afshin Jamshidi 1, Mickael Leclercq 2, Jean-Pierre Pelletier 3, Aurèlie Labbe 4, François Abram 5, Arnaud Droit 6 and Johanne Martel-Pelletier7, 1University of Montreal Hospital Research Centre (CRCHUM); Laval University Hospital Research Centre, Québec, QC, Canada, 2Laval University Hospital Research Centre, q, QC, Canada, 3University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, 4Department of Decision Sciences, HEC Montréal, Montreal, QC, Canada, 5ArthroLab Inc., Montreal, QC, Canada, 6Laval University Hospital Research Centre, Québec, QC, Canada, 7University of Montreal Hospital Research Centre (CRCHUM), Montreal, Canada

    Background/Purpose: Current assessment of knee osteoarthritis (OA) is primarily based on a patient’s personal and familial history, clinical features, and on radiographies. However, such information…
  • Abstract Number: 2202 • 2019 ACR/ARP Annual Meeting

    Trends in Prescribing of NSAIDs and Opioids Among Osteoarthritis Patients in British Columbia, Canada, 1998-2014

    Jacek Kopec1, Jolanda Cibere 2, Na Lu 3, Hui Xie 4, J. Antonio Avina-Zubieta 1 and John Esdaile 5, 1Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada, 2Arthritis Research Canada and the University of British Columbia, Vancouver, Canada, 3Arthritis Research Canada, Vancouver, BC, Canada, 4Arthritis Research Canada and Simon Fraser University, Vancouver, BC, Canada, 5Arthritis Research Canada and the University of British Columbia, Richmond, BC, Canada

    Background/Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) and opioids are commonly prescribed for patients with osteoarthritis (OA). However, both types of medication are associated with serious side…
  • Abstract Number: 2203 • 2019 ACR/ARP Annual Meeting

    Impact of Hypothetical Changes in the Use of Analgesics on the Burden of Osteoarthritis: A Population-based Microsimulation Study

    Jacek Kopec1, Eric Sayre 2, Anya Okhmatovskaia 3, Jolanda Cibere 4, Linda Li 5, Nick Bansback 6, Hubert Wong 5 and John Esdaile 7, 1Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada, 2Arthritis Research Canada, Vancouver, BC, Canada, 3McGill University, Montreal, QC, Canada, 4Arthritis Research Canada and the University of British Columbia, Vancouver, Canada, 5University of British Columbia, Vancouver, BC, Canada, 6University of British Columbia, Vancouver, Canada, 7Arthritis Research Canada and the University of British Columbia, Richmond, BC, Canada

    Background/Purpose: Analgesics are the cornerstone of medical treatment of osteoarthritis (OA) but are associated with serious side effects. A more optimal use of analgesics in…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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