Abstracts Archive - Page 1083 of 2607 - ACR Meeting Abstracts

Abstract Number: 2144 • 2019 ACR/ARP Annual Meeting
Musculoskeletal Immune-Related Adverse Events After Immune Checkpoint Inhibitor Therapy: Single Center Experience
Didem Saygin¹, Melissa Bastacky ¹, Gerard Mascara ¹, Timothy L Brenner ¹, Chester Oddis ¹, Siamak Moghadam-Kia ¹, Dana Ascherman ¹, Diwakar Davar ¹ and Rohit Aggarwal ¹, ¹University of Pittsburgh Medical Center, Pittsburgh, PA
Background/Purpose: Immune checkpoint inhibitors (ICI) are new anti-cancer agents used for lung cancer, melanoma, renal cell and urothelial carcinoma, and head and neck cancers. They…
Abstract Number: 2145 • 2019 ACR/ARP Annual Meeting
Long-term Safety of Tildrakizumab in Patients with Moderate-to-Severe Plaque Psoriasis: Incidence of Severe Infections Through 3 Years (148 Weeks) from 2 Phase 3 Trials
Diamant Thaçi ¹, Kristian Reich ², Jo Lydie Lambert ³, Lars Iversen ⁴, Andrea Peserico ⁵, Ignasi Pau-Charles ⁶, Andrew Blauvelt⁷ and Christopher Griffiths ⁸, ¹Institute and Comprehensive Center for Inflammation Medicine, University of Lübeck, Lübeck, Germany, Lübeck, Germany, ²University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Skinflammation®, Hamburg, Germany; Dermatologikum Berlin, Berlin, Germany, Hamburg, Germany, ³Department of Dermatology, Ghent University Hospital, Ghent, Belgium, Ghent, Belgium, ⁴Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark, Aarhus, Denmark, ⁵Clinica Dermatologica, Department of Medicine-DIMED University of Padua, Padua, Italy, Padua, Italy, ⁶Almirall R&D, Barcelona, Spain, Barcelona, Spain, ⁷Oregon Medical Research Center, Portland, OR, USA, Portland, OR, ⁸Centre for Dermatology Research, The University of Manchester, Manchester, UK, Manchester, United Kingdom
Background/Purpose: Tildrakizumab (TIL) is a high-affinity anti–interleukin-23p19 monoclonal antibody approved for the treatment of moderate-to-severe plaque psoriasis. The objective of this study was to evaluate…
Abstract Number: 2146 • 2019 ACR/ARP Annual Meeting
Complications of Immune Checkpoint Inhibitor Therapy in Patients with and Without Pre-existing Rheumatologic Disease
Emily Carroll¹, Amanda Leiter ², Danielle Brooks ¹, Jennifer Ben Shimol ³, Elliot Eisenberg ¹, Matthew Galsky ⁴, Emily Gallagher ⁵ and Margrit Wiesendanger ³, ¹Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, ²Division of Endocrinology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, ³Division of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, ⁴Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, ⁵Division of Endocrinology, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York
Background/Purpose: Immune checkpoint inhibitors (ICIs) are effective therapies in the treatment of many cancers, but their use has been linked with immune-related adverse events (irAEs).…
Abstract Number: 2147 • 2019 ACR/ARP Annual Meeting
Musculoskeletal Ultrasound Enhances the Evaluation of Checkpoint Inhibitor Associated Musculoskeletal Immune Related Adverse Events
Mazen Nasrallah¹, Sara Schoenfeld ², Mark Matza ¹, Donald Lawrence ², Justine Cohen ², Meghan Mooradian ², Kerry Reynolds ², Ryan Sullivan ² and Minna Kohler ², ¹Massachusetts General Hospital, Boston, ²MGH, Boston
Background/Purpose: Cancer immunotherapy with monoclonal antibodies that antagonize molecular checkpoint pathways in immune activation, the PD-1/PDL1 axis and CTLA-4, have revolutionized the treatment of solid…
Abstract Number: 2148 • 2019 ACR/ARP Annual Meeting
Muscle Involvement Revealed by 18F-PET-CT in Polymyalgia Rheumatica
Daniel WENDLING¹, Maxime SONDAG ², Nicolas GIRAUD ², Mickael CHOUK ², Hatem Boulahdour ², Clément PRATI ² and Frank VERHOEVEN ³, ¹Rheumatology, University Teaching Hospital (CHRU), Besançon, France, ²University Teaching Hospital (CHRU), Besançon, France, ³CHU Besancon, BESANCON, France
Background/Purpose: Imaging techniques in polymyalgia rheumatica (PMR) have revealed mainly bursitis, tenosynovitis, capsulitis and enthesitis. This is also the case for 18F-FDG-PET-CT. This technique, which…
Abstract Number: 2149 • 2019 ACR/ARP Annual Meeting
Principal Components Analysis as a Tool to Identify Lesional Skin Patterns in Cutaneous Lupus Erythematosus
Smriti Prasad¹, Justin Raman ¹, Motolani Ogunsanya ² and Benjamin Chong ³, ¹University of Texas Southwestern Medical Center, Dallas, ²OU College of Pharmacy, Oklahoma City, ³University of Texas Southwestern, Dallas
Background/Purpose: Cutaneous lupus erythematosus (CLE) has multiple subtypes that account for a broad range of presentations. The preferential locations of skin lesions have only been…
Abstract Number: 2150 • 2019 ACR/ARP Annual Meeting
Frequency of Polyautoimmunity in a Tertiary Hospital
Elena Grau García¹, José Ivorra Cortés ¹, Jorge Juan Fragio Gil ¹, Roxana Gonzalez Mazarío ¹, Marta de la Rubia Navarro ¹, Cristóbal Pavez Perales ¹, Cristina Alcañiz Escandell ¹, Inmaculada Chalmeta Verdejo ¹, Luis González Puig ¹, Isabel Martínez Cordellat ¹, Rosa Negueroles Albuixech ¹, José Eloy Oller Rodríguez ², Francisco Miguel Ortiz-Sanjuán ¹, Elvira Vicens Bernabeu ¹, Carmen Nájera Herranz ¹, Inés Cánovas Olmos ¹, Samuel Leal Rodriguez ¹ and José Andrés Román Ivorra ¹, ¹Rheumatology Department. HUP La Fe, Valencia, Comunidad Valenciana, Spain, ²Rheumatology Department. HUP La Fe, v, Comunidad Valenciana, Spain
Background/Purpose: Polyautoimmunity (PAI) is the presence of more than one Autoimmune Disease (AID) in one patient. PAI have been reported in different AIDs as systemic…
Abstract Number: 2151 • 2019 ACR/ARP Annual Meeting
Patient Reported Outcomes and Factors Predicting Clinical Disease Activity in Patients with Immune-Checkpoint Inhibitor Inflammatory Arthritis
Caoilfhionn Connolly¹, Tawnie Braaten ¹, Ami Shah ¹, Clifton Bingham ² and Laura Cappelli ², ¹Johns Hopkins Hospital, Baltimore, MD, ²Johns Hopkins University, Baltimore, MD
Background/Purpose: Immune checkpoint inhibitors (ICIs) enhance anti-tumor immunity by stimulating a patient’s immune system to fight cancer. ICIs have demonstrated unprecedented response rates in a…
Abstract Number: 2152 • 2019 ACR/ARP Annual Meeting
Safety of Immune Checkpoint Inhibitors in Patients Treated for Cancer with Pre-existing Autoimmune Diseases
Aneet Kaur ¹, Umang Swami ¹, Munazza Fatima ¹, Meredith Ginn ¹, Jill Stein ¹, Yubo Gao ¹, Yousef Zakharia ¹ and Namrata Singh², ¹University of Iowa Hospitals and clinics, Iowa city, IA, ²University of Iowa, Iowa City
Background/Purpose: Patients with pre-existing autoimmune diseases (AID) have been traditionally excluded from clinical trials of immune checkpoint inhibitors (ICI), so the data on risk of…
Abstract Number: 2153 • 2019 ACR/ARP Annual Meeting
Ocular Scleral Pathology and Relationship with Autoimmune Diseases: Study of 101 Patients from a Single Universitary Centre
Lara Sanchez-Bilbao¹, Iñigo Gonzalez-Mazon ², Mónica Calderón-Goercke ³, DIANA PRIETO- PENA ², Jose Luis Martín-Varillas ¹, Belén Atienza-Mateo ¹, Rosalia Demetrio ⁴, Miguel A Gonzalez-Gay ¹ and Ricardo Blanco ¹, ¹Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Spain, ²Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, ³Hospital Marqués de Valdecilla, Santander, Cantabria, Spain, ⁴Hospital Universitario Marqués de Valdecilla, Santander, Spain
Background/Purpose: Ocular scleral pathology may be associated with autoimmune diseases. Our aim was to assess a) the epidemiological and clinical features and b) the relationship…
Abstract Number: 2154 • 2019 ACR/ARP Annual Meeting
Role of Insulin Resistance and Inflammation on Resting Energy Expenditure in Patients with Rheumatoid Arthritis
Beatriz Hanaoka¹ and Barbara Gower ², ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham
Background/Purpose: In patients with rheumatoid arthritis(RA), elevated resting energy expenditure(REE) is associated with rheumatoid cachexia and protein catabolism driven by pro-inflammatory cytokines. IR is also…
Abstract Number: 2155 • 2019 ACR/ARP Annual Meeting
The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3-Year-Prospective Study from a Referral Center of Lung Transplantation
Sara Remuzgo-Martínez¹, Diana Prieto-Peña ², Mónica Calderón-Goercke ², Victor Manuel Mora Cuesta ³, David Iturbe Fernández ¹, Sonia M. Fernández Rozas ³, Jose Manuel Cifrian Martínez ³ and Miguel Angel González-Gay ⁴, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ²Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL; and Rheumatology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain, Santander, Spain, ³Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL; and Pneumology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain, Santander, Spain, ⁴Universidad de Cantabria and IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain
Background/Purpose: Interstitial lung disease (ILD) occurs in approximately 15% of patients with autoimmune diseases (AD) [1]. Its presence is associated with an increased risk of…
Abstract Number: 2156 • 2019 ACR/ARP Annual Meeting
Expanding the Phenotypic and Genotypic Spectrum in Yao Syndrome
Qingping Yao¹ and Apostolos Kontzias ¹, ¹Stony Brook University, Stony Brook, NY
Background/Purpose: Yao syndrome (YAOS, OMIM 617321), formerly termed nucleotide-binding, oligomerization domain 2(NOD2)-associated autoinflammatory disease, has become increasingly recognized. The disease has been reported in America,…
Abstract Number: 2157 • 2019 ACR/ARP Annual Meeting
Checkpoint Inhibitor-Associated Arthritis: Phenotype, Steroid Dose, Serology and Survival
Karmela Kim Chan ¹, Aidan Tirpack ¹, Caroline Benson ¹, Gregory Vitone ¹, Jackie Finik ², Vivian Bykerk ³, Susan Goodman ⁴, Laura Donlin ⁵, Deepak Rao ⁶ and Anne Bass⁴, ¹Hospital For Special Surgery, New York, ²Hospital for Special Surgery, New York, NY, New York, NY, ³Hospital for Special Surgery, New York City, NY, ⁴Hospital For Special Surgery/Weill Cornell Medicine, New York, NY, ⁵Hospital For Special Surgery, New York, NY, ⁶Brigham and Women's Hospital, Boston, MA
Background/Purpose: Previous studies suggest that steroid dose1and rheumatoid factor positivity2 impact cancer survival in checkpoint inhibitor (CI)-treated patients (with CI-associated hypophysitis, and in all-comers with non-small…
Abstract Number: 2158 • 2019 ACR/ARP Annual Meeting
Rheumatic Immune Related Adverse Events Associated with Cancer Immunotherapy: A Nationwide Multi-centre Canadian Cohort from the Canadian Research Group of Rheumatology in Immuno-oncology (CanRIO)
Janet Roberts¹, Daniel Ennis ², Marie Hudson ³, Carrie Ye ⁴, Alexandra Saltman ⁵, Sabrina Hoa ⁶, Janet Pope ⁷, Megan Himmel ², Nancy Maltez ⁸, Aurore Fifi-Mah ⁹, Annaliese Tisseverasinghe ¹⁰, Robert Rottapel ¹¹, Karam Al Jumaily ¹², Christina Ly ¹³, Liliana Cartagena ¹⁴ and Shahin Jamal ¹⁵, ¹Dalhousie University, Halifax, NS, Canada, ²University of Toronto, Toronto, ON, Canada, ³Jewish General Hospital, Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, QC, Canada, ⁴University of Alberta, Edmonton, AB, Canada, ⁵University of Toronto, Mount Sinai Hospital and Princess Margaret Cancer Centre, Toronto, ON, Canada, ⁶University of Montreal, Montreal, QC, Canada, ⁷Western University, London, ON, Canada, ⁸University of Ottawa, Ottawa, ON, Canada, ⁹University of Calgary, Calgary, AB, Canada, ¹⁰University of Manitoba, Winnipeg, MB, Canada, ¹¹University of Toronto, Toronto, Canada, ¹²University of Alberta, edmonton, Canada, ¹³McGill University, Montreal, Canada, ¹⁴Arthritis Research Canada, Vancouver, Canada, ¹⁵University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy by harnessing the immune system to fight cancer. They are associated with the development of autoimmune…

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