Abstracts Archive - Page 1076 of 2425 - ACR Meeting Abstracts

Abstract Number: 1071 • 2018 ACR/ARHP Annual Meeting
Protective Role of the Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Rs2495477 Polymorphism in Patients with Rheumatoid Arthritis
Sara Remuzgo-Martínez¹, Fernanda Genre¹, Verónica Pulito-Cueto¹, Alfonso Corrales¹, Javier Llorca², Verónica Mijares¹, Leticia Lera-Gómez¹, Virginia Portilla¹, Iván Ferraz-Amaro³, Santos Castañeda⁴, Oreste Gualillo⁵, Javier Martín⁶, Ricardo Blanco¹, Raquel Lopez-Mejías¹ and Miguel Angel González-Gay⁷, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ²Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, Santander, Spain, ³Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain, Tenerife, Spain, ⁴Rheumatology Department, Hospital Universitario La Princesa, IIS-Princesa, Madrid, Spain, Madrid, Spain, ⁵SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), The NEIRID Group (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Santiago University Clinical Hospital, Santiago de Compostela, Spain, Santiago de Compostela, Spain, ⁶Instituto de Parasitología y Biomedicina "López-Neyra", CSIC, PTS Granada, Granada, Spain, Granada, Spain, ⁷Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL and School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain
Background/Purpose: RA is associated with the development of cardiovascular (CV) disease and subclinical atherosclerosis, which leads to an increased risk of CV mortality in RA…
Abstract Number: 1072 • 2018 ACR/ARHP Annual Meeting
Fibrin-Triggered Chondrosynovial Adhesion As a Novel Mechanism of Cartilage Damage in Rheumatoid Arthritis
Sonia Nasi¹, Jay Degen², Nathalie Busso³, Alexander So⁴ and Thomas Hügle⁵, ¹1 Service of Rheumatology, DAL, Lausanne University Hospital (CHUV), University of Lausanne, Switzerland., epalinges, Switzerland, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Rheumatology, University Hospital Lausanne (CHUV), epalinges, Switzerland, ⁴University of Lausanne, Lausanne, Switzerland, ⁵Rheumatology, University Hospital Lausanne (CHUV), Lausanne, Switzerland
Background/Purpose: Pannus infiltration and inflammatory cytokines are the main responsible factors for cartilage damage in rheumatoid arthritis (RA). Moreover, the crosstalk between inflammation and coagulation…
Abstract Number: 1073 • 2018 ACR/ARHP Annual Meeting
Connective Tissue Growth Factor Associates with Angiogenesis through Notch-1 Activation in Rheumatoid Arthritis
Kazuhisa Nozawa¹, Takuya Hirai², Hiroshi Tsushima², Ken Yamaji³, Naoto Tamura³ and Iwao Sekigawa⁴, ¹2-1-1 Hongo Bunkyo-ku, Juntendo University, Tokyo, Japan, ²Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan, ³Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Institute for Environment and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan
Background/Purpose: Aberrant angiogenesis has been considered as one of important factors for pathogenesis of rheumatoid arthritis (RA). Several angiogenetic mediators are reported to be massively…
Abstract Number: 1074 • 2018 ACR/ARHP Annual Meeting
Distinct Metabolic Profile in the Urine of Rheumatoid Arthritis Patients:a Possible Link to Arthritis Phenotypes
JungHee Koh¹, Yune-Jung Park², Hong-Ki Min³, Moon Young Kim⁴, Seung-Ah Yoo⁵, Chul-Soo Cho⁶ and Wan-Uk Kim⁷, ¹Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea, Republic of (South), ²Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Gyeonggido, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine,College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁵The Catholic University of Korea, Center for Integrative Rheumatoid Transcriptomics and Dynamics, seoul, Korea, Republic of (South), ⁶Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁷Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, seoul, Korea, Republic of (South)
Background/Purpose: A great deal of recent attention has been directed at a possible link between intestinal microbial metabolism and inflammation. Metabolites represent the intermediate products…
Abstract Number: 1075 • 2018 ACR/ARHP Annual Meeting
Automated Multiparameter Microscopy and Image Analysis: Next Generation Synovial Tissue Histology
William Murray-Brown¹, Helen Weedon¹, Amanda Aloia², Susan Lester³, Susanna Proudman⁴, Malcolm D. Smith⁵, Jenny Walker¹ and Mihir D Wechalekar^1,3, ¹Rheumatology, Flinders University, Adelaide, Australia, ²Cellular Imaging, Flinders University, Adelaide, Australia, ³Royal Adelaide Hospital, Adelaide, Australia, ⁴Royal Adelaide Hospital, Rheumatology Unit and University of Adelaide, Discipline of Medicine, Adelaide, Australia, ⁵Rheumotology, Flinders University, Adelaide, Australia
Background/Purpose: Currently, histological assessment of synovial tissue (ST) in Rheumatoid Arthritis (RA) is hampered by 3 main factors: 1) tissue is a finite resource, 2)…
Abstract Number: 1076 • 2018 ACR/ARHP Annual Meeting
Phospholipase C-eta2, As a C2 Domain-Containing Protein, Regulate Aggressiveness of Fibroblast‐like Synoviocytes and Ameliorate Arthritis in Experimental Animal Models of Rheumatoid Arthritis
Mingyo Kim, Hyun Min Jeon, Hae Sook Noh, Sang Mi Yi and Sang-Il Lee, Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea, Republic of (South)
Background/Purpose: The C2 domain is a Ca2+-dependent membrane-targeting motif found in many cellular proteins involved in signal transduction or inflammatory pathway. However, the effects of…
Abstract Number: 1077 • 2018 ACR/ARHP Annual Meeting
Identification of Biomarkers Involved in the Resolution Phase of Inflammation: Specialized Pro-Resolving Mediator Receptors Expression in Rheumatoid Arthritis
Simone Perniola¹, Liliana Dinoia¹, Nunzia Lacarpia¹, Dorotea Natuzzi¹, Rita Bizzoca¹ and Florenzo Iannone², ¹Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy, ²D.E.T.O., Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy
Background/Purpose: Inflammation is part of the complex biological response of body tissues to harmful stimuli, involving immune cells, blood vessels, and molecular mediators. At the…
Abstract Number: 1078 • 2018 ACR/ARHP Annual Meeting
Standardization of Synovial Biopsies Procedures across Centers: A Consensus Initiative Using a Delphi Survey
Aurélie Najm^1,2, Benoît Le Goff MD PhD^3,4, Carl Orr⁵, Rogier Thurlings⁶, Juan D. Cañete⁷, Frances Humby⁸, Stefano Alivernini⁹, Søren Andreas Just¹⁰, Vasco C. Romão¹¹, Veit Krenn¹², Ulf Müller-Ladner¹³, Olga Addimanda¹⁴, Antonio Manzo¹⁵, Sander W. Tas¹⁶, Patrick Durez¹⁷, Laurent Meric de Bellefon¹⁷, Maria Stoenoiu¹⁸, Vibeke Strand¹⁹, Mihir D Wechalekar²⁰, João E. Fonseca²¹, Bernard R. Lauwerys²² and Douglas J. Veale²³, ¹INSERM U1238 University of medicine, PHY-OS Laboratory, Nantes, France, ²Department of Rheumatology, Nantes University Hospital, Nantes, France, ³Rheumatology, Nantes University Hospital, Nantes, France, ⁴UNR1238 University of medicine, PHY-OS Laboratory, Nantes, France, ⁵Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, ⁶Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁷Rheumatology Deparment, Hospital Clinic and IDIBAPS, Barcelona, Spain, Barcelona, Spain, ⁸Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁹Division of Rheumatology - Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, ¹⁰Department of Rheumatology, Department of Rheumatology, Odense University Hospital, Odense, Denmark, Odense, Denmark, ¹¹Rheumatology Department, Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHLN, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, ¹²Zytologie und Molekulare Diagnostik, MVZ-Zentrum für Histologie, Trier, Germany, ¹³Dept. of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University Giessen, Germany, Bad Nauheim, Germany, ¹⁴Medicine & Rheumatology Unit, Rizzoli Orthopaedic Institute, Bologna, ., Italy, ¹⁵Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of Pavia, Pavia, Italy, ¹⁶Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ¹⁷Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ¹⁸Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Bruxelles, Belgium, ¹⁹Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, ²⁰Royal Adelaide Hospital, Adelaide, Australia, ²¹Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHLN, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, ²²Department of Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ²³Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland
Background/Purpose: Synovial biopsies are increasingly performed in both clinical setting and translational research. Synovial tissue analysis role in prediction of response to treatment is to…
Abstract Number: 1079 • 2018 ACR/ARHP Annual Meeting
Plasma Metabolomic Analysis Combined with Transcriptome Data Has Revealed the Importance of Amino Acids Homeostasis in SLE Pathogenesis
Yukiko Iwasaki¹, Yusuke Takeshima^1,2, Mineto Ota^1,2, Yasuo Nagafuchi¹, Shuji Sumitomo¹, Akari Suzuki³, Yuta Kochi³, Tomohisa Okamura^1,2, Ichirou Miki⁴, Kazuhiro Sakurada⁴, Shigeo Koyasu⁴, Kazuhiko Yamamoto^1,3 and Keishi Fujio¹, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Functional Genomics and Immunological Diseases, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan, ³Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ⁴Medical Sciences Innovation Hub Program, Cluster for Science and Technology Hub, RIKEN, Yokohama, Japan
Background/Purpose: Recently, many reports on immune metabolism have been accumulated and metabolic changes are now considered to be a key factor for controlling immune cell…
Abstract Number: 1080 • 2018 ACR/ARHP Annual Meeting
Hypomethylation of STAT1 and HLA-DRB1 in CD8+ T Cells Is Associated with Type-I Interferon-Dependent HLA-DRB1 Overexpression and Activation of Autologous CD4+ T Cells in Systemic Lupus Erythematosus
Shaylynn Miller¹, Patrick Coit¹, Elizabeth Gensterblum-Miller¹, Paul Renauer^1,2, Nathan Kilian^1,3, Mark Schonfeld¹, Pei-Suen Tsou¹ and Amr H Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Department of Genetics, Yale University, New Haven, CT, ³Medical School, Georgetown University, Washington, DC
Background/Purpose: Systemic lupus erythematosus is a chronic autoimmune disease characterized by epigenetic dysregulation, and increased autoantibody and type-I interferon (IFN) production. The goal of this…
Abstract Number: 1081 • 2018 ACR/ARHP Annual Meeting
Associations between Daily Alcohol Intake and SLE-Related Cytokines and Chemokines U.S. Female Nurses without SLE
Cianna Leatherwood¹, Xinyi Liu¹, Susan Malspeis², Andrea Roberts³, Jeffrey A. Sparks¹, Elizabeth Karlson¹, Candace H. Feldman¹, Judith A. James⁴, Laura Kubzansky⁵ and Karen Costenbader¹, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Harvard T.H. Chan School of Public Health, Boston, MA, ⁴OMRF & OUHSC, Oklahoma City, OK, ⁵Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA
Background/Purpose: Low or no alcohol intake (0-5 gm/day or <0.5 drinks/day) has been associated with increased SLE risk among women. Several cytokines and chemokines are…
Abstract Number: 1082 • 2018 ACR/ARHP Annual Meeting
Peripheral Blood CD11c+ CD21- Age-Associated B Cells (ABCs) in Human Systemic Lupus Erythematosus Are Associated with Innate Type III Interferon and Disease Activity
Jennifer L. Barnas, Lin Gao, Mary O'Connell, Jennifer Albrecht, Nida Meednu, R. John Looney and Jennifer Anolik, Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by an interferon-stimulated gene (ISG) signature typically attributed to interferon (IFN)-α. However, ISGs can be induced by other…
Abstract Number: 1083 • 2018 ACR/ARHP Annual Meeting
Changes of Innate Lymphoid Cells in Peripheral Blood of Patients with Systemic Lupus Erythematosus and Its Correlations with Clinical Markers
Hui Chu, Xiaomei Li, zhen Tan, ruolan Wu, Xiangpei Li, xuan Fang, xu Zhen and Guosheng Wang, The first affiliated hospital of university of Science and Technology of China, Hefei, China
Background/Purpose: Innate Lymphoid Cells (ILCs) are a novel group of innate immune cells, according to the cytokine profile, they were divided into three major subsets:…
Abstract Number: 1084 • 2018 ACR/ARHP Annual Meeting
Dysfunction of the DNASE1L3 Pathway and Antigen Accumulation in Lupus Nephritis
Johannes Hartl¹, Robert M. Clancy¹, Peter M. Izmirly², H. Michael Belmont¹, Nicole Kaiden³, Nicole Bornkamp³, Vanja Sisirak¹, Benjamin Sally¹, Jill P. Buyon¹ and Boris Reizis¹, ¹NYU School of Medicine, New York, NY, ²Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ³Medicine, NYU School of Medicine, New York, NY
Background/Purpose: DNASE1L3 is a unique secreted DNase that is capable of degrading DNA complexed with proteins and/or encapsulated in membranes, such as chromatin within microparticles…
Abstract Number: 1085 • 2018 ACR/ARHP Annual Meeting
Natural Gingerols Inhibit Neutrophil Extracellular Trap Release Elicited By Lupus Autoantibodies
Ramadan A. Ali¹ and Jason S. Knight², ¹University of Michigan, Ann Arbor, MI, ²., University of Michigan, Ann Arbor, MI
Background/Purpose: Recent studies have revealed a role for neutrophils in the pathogenesis of lupus and antiphospholipid syndrome (APS). Indeed, neutrophils are activated by various disease-relevant…

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