Abstract Number: 1041 • 2018 ACR/ARHP Annual Meeting
The Anti-Adamts-5 Nanobody®, M6495, Protects Against Cartilage Breakdown in Cartilage and Synovial Joint Tissue Explant Models
Background/Purpose: Osteoarthritis (OA) is associated with cartilage breakdown, where degradation of aggrecan by ADAMTS-5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) is thought to…Abstract Number: 1042 • 2018 ACR/ARHP Annual Meeting
Development of a Neo-Epitope Specific Assay for Serological Assessment of Type X Collagen Degradation and Its Potential Diagnostic Value for Knee Osteoarthritis
Background/Purpose: Phenotypic changes of chondrocytes toward hypertrophy might be fundamental in the pathogenesis of OA, of which type X collagen is a well-known marker. The…Abstract Number: 1043 • 2018 ACR/ARHP Annual Meeting
Computational Analysis of Potential Self-Antigens in Osteoarthritis
Background/Purpose: Recent work in a subpopulation of individuals with osteoarthritis (OA) suggests that T cells are (1) responding to auto-antigenic stimuli (e.g. peptidoglycan epitopes), (2)…Abstract Number: 1044 • 2018 ACR/ARHP Annual Meeting
Alendronate-CGS21680 Conjugates Prevent Bone Erosion in a Murine Osteolysis Model
Background/Purpose: The most common cause of total joint replacement revision surgeries is loosening of the implant due to loss of bone around the prosthesis. Wear…Abstract Number: 1045 • 2018 ACR/ARHP Annual Meeting
The Coll2-1 Peptide of Collagen Type II: A New Actor of Synovitis in Osteoarthritis
Background/Purpose: We evaluated the inflammatory effect of Coll2-1 peptide in osteoarthritic synoviocytes and rats by comparing peptide-induced inflammatory reaction with the one induced by bovine…Abstract Number: 1046 • 2018 ACR/ARHP Annual Meeting
Distinct Balance of TNF-α/IL-10 in Circulating and Infiltrating CD163+ Macrophages between Rapidly and Slowly Progressive Symptomatic Knee Osteoarthritis
Background/Purpose: There is a subtype of osteoarthritis (OA), which shows higher level of inflammation and higher risk of disease progression. In the current study, we…Abstract Number: 1047 • 2018 ACR/ARHP Annual Meeting
Signaling at Adenosine A2A Receptor (A2aR) in Osteoblasts; Crosstalk with Wnt/ β-Catenin Signaling Pathway
Background/Purpose: The Wnt/β-catenin signaling pathway plays a key role in regulating bone formation and maintaining bone hemostasis. Wnt activates a pathway that leads to stabilization…Abstract Number: 1048 • 2018 ACR/ARHP Annual Meeting
Identification of Novel Molecules with Senolytic and Autophagy Activity As Osteoarthritis Therapeutics
Background/Purpose: Disease-modifying treatments for Osteoarthritis (OA) are not available. Aging-related features such as failure of homeostasis mechanisms, including autophagy, cause extracellular matrix damage, chondrocyte senescence…Abstract Number: 1049 • 2018 ACR/ARHP Annual Meeting
Optical Biomarkers for the Early Diagnosis of Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is a rheumatic disease characterized by articular cartilage degradation. On its early stages, OA is asymptomatic and its current gold-standard diagnosis (X-Rays),…Abstract Number: 1050 • 2018 ACR/ARHP Annual Meeting
Pharmacokinetic and pharmacodynamic modelling of the novel anti-ADAMTS-5 nanobody M6495 using the neo-epitope ARGS as a biomarker
Background/Purpose: The anti-ADAMTS-5 Nanobody®, M6495, is a first-in-class, highly selective, bifunctional Nanobody® and a potent inhibitor of ADAMTS-5, with the potential to be the first…Abstract Number: 1051 • 2018 ACR/ARHP Annual Meeting
Hoxd Genes Regulate Arthritis-Relevant Pathways
Background/Purpose: Gene expression and functions of synovial fibroblasts (SF) differ profoundly between distinct joints. This might lead to site-specific activation of arthritis-relevant pathways with implications…Abstract Number: 1052 • 2018 ACR/ARHP Annual Meeting
Detection of Precursors of RANK- Osteoclast-like Cells (Olcs) in Peripheral Blood and Olcs in Bone Tissue from Rheumatoid Arthritis Patients
Background/Purpose: Proinflammatory cytokines play an important role in bone destruction in rheumatoid arthritis (RA), as inferred by the efficacy of biologics. Previously, we reported that…Abstract Number: 1053 • 2018 ACR/ARHP Annual Meeting
Synovial Inflammation Identifies Patients Clusters in Osteoarthritis
Background/Purpose: Synovial membrane inflammation is common in osteoarthritis (OA). Inflammation may be present at all disease stages, increases the risk of cartilage injury, and is…Abstract Number: 1054 • 2018 ACR/ARHP Annual Meeting
Study of the Metabolic Effect of MSCs on Their Chondroprotective and Regenerative Properties: Modulating Their Metabolism to Improve Their Therapeutic Potential for the Treatment of Osteoarthritis
Background/Purpose: Mesenchymal Stem Cells (MSCs) are stromal multipotent cells with wide regenerative and immunomodulatory properties and have been proposed as a powerful therapeutic tool. Among…Abstract Number: 1055 • 2018 ACR/ARHP Annual Meeting
The TLR-4 Inhibitor 6-Shogaol As a Treatment in Osteoarthritis Trough the Modulation of Chondrocyte Hypertrophy and Matrix Calcification
Background/Purpose: Osteoarthritis (OA) is a complex joint disease characterized by a progressive loss of articular cartilage (AC) and synovial inflammation. The latest theories of OA…
ACR Meeting Abstracts