Abstract Number: 1978 • 2019 ACR/ARP Annual Meeting
HSP90AA1, a Chaperone-mediated Autophagy Mediator, Is a Biomarker of Joint Damage in Osteoarthritis
Background/Purpose: In osteoarthritis (OA) defects in Autophagy are evident and precede joint damage. Therefore, identifying biomarkers associated with autophagy defects could facilitate the development of…Abstract Number: 1979 • 2019 ACR/ARP Annual Meeting
What Is the Pathogenic Meaning of Chondrocyte Hypertrophy in Osteoarthritis? Effect of Evc Deletion Through Hedgehog Signaling
Background/Purpose: Osteoarthritis (OA) is mainly characterized by the progressive damage of articular cartilage, where chondrocytes acquire a hypertrophic-like phenotype. Indian Hedgehog levels are increased in…Abstract Number: 1980 • 2019 ACR/ARP Annual Meeting
Disorganization of Chondrocyte Columns in the Growth Plate During Experimental Osteoarthritis in Mice
Background/Purpose: Osteoarthritis (OA) is a biomechanical joint disease mainly affecting articular cartilage and subchondral bone. A great variety of animal models, especially mice, are used…Abstract Number: 1981 • 2019 ACR/ARP Annual Meeting
Functional Differences Between Osteoclasts and Osteoclast-like Cells Differentiated from Peripheral Blood Mononuclear Cells in Patients with Rheumatoid Arthritis
Background/Purpose: Osteoclasts (OCs) are giant multinucleated cells formed from precursors of the monocyte/macrophage lineage and are believe to play a major role in the bone…Abstract Number: 1982 • 2019 ACR/ARP Annual Meeting
Senescent Synoviocytes in Knee Osteoarthritis Correlate with Disease Biomarkers, Synovitis, and Knee Pain
Background/Purpose: Background/Purpose: Cellular senescence is a natural state in which a cell permanently halts division through upregulation of a set of intracellular proteins including p16INK4A…Abstract Number: 1983 • 2019 ACR/ARP Annual Meeting
Preclinical Evaluation of Targeting TGF-beta Signaling and Senescence in ex Vivo Models of Human Knee and Spine Osteoarthritis
Background/Purpose: The absence of effective disease-modifying drugs remains an important unmet need in the treatment of osteoarthritis. In recent years, novel pharmacological treatments including targeting…Abstract Number: 1984 • 2019 ACR/ARP Annual Meeting
Alendronate-CGS21680 Conjugates Prevent Bone Erosion in a Murine Osteolysis Model but Not in A2A KO Mice
Background/Purpose: Implant loosening due to loss of bone is the most common cause of total joint replacement revision surgeries. One of the main cause of…Abstract Number: 1985 • 2019 ACR/ARP Annual Meeting
Divergent Mononuclear Cell Participation and Cytokine Release Profiles Define Hip and Knee Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is a progressive joint disease driven by a blend of inflammatory and biomechanical processes. Studies using human samples to understand inflammatory mechanisms…Abstract Number: 1986 • 2019 ACR/ARP Annual Meeting
Insights into Osteoarthritis Progression by Gene Expression and miRNA Profiling of Mesenchymal Stromal Cells from Medial and Lateral Femoral Condyles
Background/Purpose: Bone marrow multipotential stromal cells (MSC) are widely used in clinical trials to treat bone and cartilage diseases. However, there is limited information on…Abstract Number: 1987 • 2019 ACR/ARP Annual Meeting
CCN3 Regulates Macrophage Function in MSU-induced Inflammation
Background/Purpose: Gout is the most common metabolic disease in which monosodium urate (MSU) crystals form and deposit in the joints and soft tissues of patients.…Abstract Number: 1988 • 2019 ACR/ARP Annual Meeting
Establishing an in Vitro Model of Hand Osteoarthritis by Generating Induced Pluripotent Stem Cells (iPSc) That Carry Single Nucleotide Polymorphisms Associated with Hand Osteoarthritis Risk
Background/Purpose: Knowledge and research results in the field of hand osteoarthritis (hOA) are currently limited, mainly due to the unavailability of tissue samples to develop…Abstract Number: 1989 • 2019 ACR/ARP Annual Meeting
Netrin-1 and Its Receptor Unc5B Mediates Tenofovir Induced Bone Loss and Dipyridamole, an Agent That Blocks Adenosine Transporter, Is Able to Modulate the Signal
Background/Purpose: Osteopenia and fragility fractures have been associated with HIV infection. Tenofovir, a common antiviral in HIV treatment, also leads to increases in bone catabolism…Abstract Number: 1990 • 2019 ACR/ARP Annual Meeting
Tenofovir Modulates Semaphorin 4D Signaling and Regulates Bone Homeostasis, Which Can Be Counteracted by Dipyridamole and Adenosine A2A Receptor
Background/Purpose: Semaphorins (Sema) are a family of proteins associated with neuronal development and guidance. Sema4D/CD100 was first identified as a regulator of immune response in…Abstract Number: 1991 • 2019 ACR/ARP Annual Meeting
Inhibition of CD44 Intracellular Domain Production Suppresses Bovine Articular Chondrocyte De-differentiation Induced by Excessive Mechanical Stress Loading
Background/Purpose: CD44 fragmentation is enhanced in chondrocytes of osteoarthritis (OA) patients. Excessive mechanical stress loading is a risk factor for OA, but the molecular mechanism…Abstract Number: 1992 • 2019 ACR/ARP Annual Meeting
Adenosine A2A Receptor (A2AR) Stimulation Mitigates Mitochondrial Inflammaging, Enhances Mitochondrial Metabolism and Reduces Reactive Oxygen Species-Mediated Mitochondrial Injury In Vitro and In Vivo in Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 10% of the US population and one of the contributing factors in OA…
ACR Meeting Abstracts