Abstract Number: 936 • 2018 ACR/ARHP Annual Meeting
Selective Deficiency of Serine Arginine-Rich Splicing Factor 1 (SRSF1) in T Lymphocytes Leads to mTORC1 Activation, Treg Dysfunction and Systemic Autoimmune Disease
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) exhibit defects in signaling and cytokine production, and aberrant numbers and/or function of regulatory T…Abstract Number: 937 • 2018 ACR/ARHP Annual Meeting
Evidence of a Common Microglial Signature in Models of ‘Neuropsychiatric Symptoms of Systemic Lupus Erythematosus’
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune syndrome affecting multiple organs, including the brain. More than 60% of patients experience neuropsychiatric symptoms of…Abstract Number: 938 • 2018 ACR/ARHP Annual Meeting
Dermal Lymphatic Dysfunction and Photosensitivity in the MRL/Lpr Lupus Model
Background/Purpose: Proper function of lymphatic vessels is needed to limit the magnitude and duration of tissue inflammation. Chronic inflammatory states such as obesity and psoriasis…Abstract Number: 939 • 2018 ACR/ARHP Annual Meeting
Rab4A Protects from Lupus Nephritis By Limiting Germinal Center Formation and Pro-Inflammatory Expression of GLUT1 and Integrin By Renal Epithelial Cells
Background/Purpose: Lupus nephritis is most common cause of mortality and morbidity in systemic lupus erythematosus (SLE) patients and 60% of SLE patients develops lupus nephritis.…Abstract Number: 940 • 2018 ACR/ARHP Annual Meeting
Inactivated Influenza Vaccine Prevents Respiratory Infections and Improves All-Cause and Cause-Specific Mortality in Immunosuppressed People with Autoimmune Rheumatic Diseases: Propensity Score Adjusted Cohort Study Using Data from Clinical Practice Research Datalink
Background/Purpose: To assess the effectiveness of inactivated influenza vaccine (IIV) in preventing influenza like illness (ILI), lower respiratory tract infection (LRTI), pneumonia, chronic obstructive pulmonary…Abstract Number: 941 • 2018 ACR/ARHP Annual Meeting
Causal Inference Methods for the Effect of Rheumatoid Arthritis on Mortality Independent of Lifestyle and Clinical Factors before and after RA Diagnosis
Background/Purpose: RA is associated with increased total, cardiovascular, and respiratory mortality compared to the general population. This excess RA mortality may be mediated through lifestyle,…Abstract Number: 942 • 2018 ACR/ARHP Annual Meeting
Risk of Serious Infections in Tocilizumab Versus TNF Inhibitor Initiators in Patients with RA: A Multi-Database Cohort Study
Background/Purpose: While biologics are known to be associated with risk of serious infections, data on head-to-head comparison of different biologic drugs for the risk of…Abstract Number: 943 • 2018 ACR/ARHP Annual Meeting
Risk of Prostate Cancer in US Veterans with Rheumatoid Arthritis
Background/Purpose: Patients with rheumatoid arthritis (RA) are at a small, but significantly increased risk of cancer compared with the general population. This risk varies by…Abstract Number: 944 • 2018 ACR/ARHP Annual Meeting
Gout: A Potential Risk Factor for Uveitis in the Older Adults?
Background/Purpose: Elevated intraocular levels of these pro-inflammatory cytokines and systemic levels of C-reactive protein are seen in uveitis, which leads to 30,000 new cases of…Abstract Number: 945 • 2018 ACR/ARHP Annual Meeting
Pain, Functional Limitations and Physical Activity Participation Trajectories in Patients with Symptomatic Knee and Hip Osteoarthritis: A Multi-Trajectory Analysis
Background/Purpose: The aims of this study were to identify homogeneous subgroups of knee and/or hip osteoarthritis (OA) patients with distinct trajectories of the combination of…Abstract Number: 946 • 2018 ACR/ARHP Annual Meeting
Short-Term Safety of Fractional-Dose Yellow Fever Vaccination in Autoimmune Rheumatic Diseases and Kinetics of White Blood Cells
Background/Purpose: Brazil faced a new yellow fever (YFV) outbreak that reached the state of Sao Paulo in December 2016. The fractional dose was used in…Abstract Number: 947 • 2018 ACR/ARHP Annual Meeting
Clinical Characteristics and Outcome after Treatment of a National Cohort of PCR-Positive Lyme Arthritis
Background/Purpose: Lyme arthritis (LA) is a disseminated Borrelia infection whom prevalence is lower in Europe than in the USA, probably because of difference in Borrelia…Abstract Number: 948 • 2018 ACR/ARHP Annual Meeting
Effects of Antiretroviral Therapy with Tenofovir and Other Antiretroviral Drugs on the Inflammatory State and Bone Remodeling on Newly Diagnosed HIV-Patients at Basal and 3 Months after Starting Treatment
Background/Purpose: Bone alterations have been observed in the course of HIV infection, with a notable decreases in bone mineral density (BMD) and fractures due to…Abstract Number: 949 • 2018 ACR/ARHP Annual Meeting
Long-Term Rheumatic and Musculoskeletal Disorders Associated to Ebola Virus Infection
Background/Purpose: Between December 2013 and April 2016, the largest epidemic of Ebola virus disease (EVD) to date generated more than 28,000 cases and more than…Abstract Number: 950 • 2018 ACR/ARHP Annual Meeting
Ultrasonographic Examinations Show Highly Prevalent Abnormalities of Hamstring Tendons in Lyme Arthritis Patients
Background/Purpose: Lyme arthritis (LA), the most common late manifestation of Lyme disease, usually occurs months to up to 2 years after the initial infection. Joint…
ACR Meeting Abstracts