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  • Abstract Number: 1888 • 2019 ACR/ARP Annual Meeting

    Serum Calprotectin Is a Prognostic Marker for Drug-Free Remission in RA

    Emma de Moel1, Jürgen Rech 2, Michael Mahler 3, Johannes Roth 4, Anne Schouffoer 5, Karel Ronday 6, Thomas Huizinga 5, CF Allaart 7, René Toes 5, Georg Schett 8 and Diane van der Woude 1, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany, 3Inova Diagnostics, San Diego, CA, 4University of Muenster, Muenster, Germany, 5Leiden University Medical Center, Leiden, Netherlands, 6Haga Ziekenhuis, The Hague, Netherlands, 7Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, 8Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: The ability to accurately predict whether RA patients will flare following DMARD-tapering would open doors in clinical decision-making for achieving drug-free remission (DFR). Calprotectin…
  • Abstract Number: 1889 • 2019 ACR/ARP Annual Meeting

    Biomarkers of Clinical Relapse and Radiological Progression in Patients with Rheumatoid Arthritis in Remission: Observational Study of 5 Years of Follow-up

    Julio Ramirez1, Andrea Cuervo Aguilera 2, Raquel Celis 3, Virginia Ruiz-Esquide 3, Raul Castellanos-Moreira 4, Jose Gomez-Puerta 5, Raimon Sanmarti 5 and Juan Cañete 5, 1Hospital Clinic, Barcelona, Spain, Barcelona, Spain, 2Hospital Clínic Barcelona, Spain, Barcelona, Spain, 3Hospital Clínic, Barcelona, Spain, 4Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Catalonia, Spain, 5Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Spain

    Background/Purpose: To search biomarkers of clinical relapse and radiological progression in patients with RA in clinical remissionMethods: RA patients in clinical remission (defined as DAS28-ESR…
  • Abstract Number: 1890 • 2019 ACR/ARP Annual Meeting

    Methotrexate Adverse Events in a Randomized Double-Blind Placebo-Controlled Trial:Results from the Cardiovascular Inflammation Reduction Trial (CIRT)

    Daniel Solomon1, Robert Glynn 2, Elizabeth Karlson 3, Fengxin Lu 3, Cassandra Corrigan 3, Joshua Colls 3, Chang Xu 3, Jean MacFadyen 3, Medha Barbhaiya 4, Nancy Berliner 3, Paul Dellaripa 3, Brendan Everett 3, Sara Hammond 3, Meredith Murray 3, Deepak Rao 3, Susan Ritter 5, Anna Rutherford 5, Jeffrey Sparks 3, Jacklyn Stratton 5, Dong Suh 3, Sara K. Tedeschi 6, Kathleen Vanni 3, Nina Paynter 5 and Paul Ridker 5, 1Brigham and Women´s Hospital, Div. of Rheumatology, Immunology and Allergy, Boston, MA, 2Harvard Medical School - Boston, MA, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 5Brigham and Women's Hospital, Boston, 6Brigham and Women's Hospital, Div. of Rheumatology, Immunology and Allergy, Boston, MA

    Background/Purpose: Prior observational studies have estimated the risk of adverse events with low dose methotrexate (MTX). However, prior randomized controlled trials (RCT) were too small…
  • Abstract Number: 1891 • 2019 ACR/ARP Annual Meeting

    Hydroxychloroquine Use Is Associated with a Lower Risk of Major Adverse Cardiovascular Events in Medicare Recipients with Rheumatoid Arthritis

    Priyanka Iyer 1, Yubo Gao 2, Saket Girotra 2, Jeffrey Curtis 3, Mary Vaughan-Sarrazin 4 and Namrata Singh4, 1University of Iowa, Iowa City, IA, 2University of Iowa Hospitals and Clinics, Iowa city, IA, 3University of Alabama at Birmingham, Birmingham, AL, 4University of Iowa, Iowa City

    Background/Purpose: Hydroxychloroquine (HCQ) has known immunomodulatory effects and mechanistic actions that may provide cardioprotective effects. To date, cardiovascular (CV) outcomes in elderly patients receiving HCQ…
  • Abstract Number: 1892 • 2019 ACR/ARP Annual Meeting

    Association Between Rheumatoid Arthritis Treatment and the Risk of Death or Readmission After Major Surgery

    Michael George1, Joshua Baker 2, Kevin Winthrop 3, Lang Chen 4, Qufei Wu 2, Fenglong Xie 5 and Jeffrey Curtis 4, 1University of Pennsylvania, Philadelphia, 2University of Pennsylvania, Philadelphia, PA, 3Oregon Health and Science University, Portland, OR, 4University of Alabama at Birmingham, Birmingham, AL, 5University of Alabama at Birmingham, Birmingham

    Background/Purpose: The impact of immunosuppression on post-operative outcomes in rheumatoid arthritis (RA) has primarily been studied in patients undergoing joint replacement surgery. We aimed to…
  • Abstract Number: 1893 • 2019 ACR/ARP Annual Meeting

    Statin Exposure Moderates the Effects of Chronic Inflammation on Coronary Atherosclerosis Progression and Cardiovascular Events in Rheumatoid Arthritis

    George Karpouzas1, Sarah Ormseth 1, Elizabeth Hernandez 2 and Matthew Budoff 1, 1Harbor-UCLA Medical Center and Los Angeles Biomedical Institute, Torrance, CA, 2Harbor-UCLA and Los Angeles Biomedical Institute, Torrance, CA

    Background/Purpose: Chronic inflammation yields higher risk of cardiovascular events (CVE) in patients with rheumatoid arthritis (RA). We recently reported that occult atherosclerosis burden on coronary…
  • Abstract Number: 1894 • 2019 ACR/ARP Annual Meeting

    Risk of Venous Thromboembolism in Rheumatoid Arthritis Patients Initiating Biologic and Non-biologic DMARDs, a Population-based Study

    Lingyi Li1, Na Lu 1, Diane Lacaille 2, Hui Xie 3, John Esdaile 4 and J. Antonio Avina-Zubieta 5, 1Arthritis Research Canada, Vancouver, BC, Canada, 2Arthritis Research Canada and University of British Columbia, Vancouver, BC, Canada, 3Arthritis Research Canada and Simon Fraser University, Vancouver, BC, Canada, 4Arthritis Research Canada and the University of British Columbia, Richmond, BC, Canada, 5Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada

    Background/Purpose: Patients with rheumatoid arthritis (RA) have an increased risk of venous thromboembolism (VTE, which includes pulmonary embolism [PE] and deep vein thrombosis [DVT]) compared…
  • Abstract Number: 1895 • 2019 ACR/ARP Annual Meeting

    Biologics Prevent Cardiovascular Events in Rheumatoid Arthritis by Inhibiting Non-calcified Coronary Plaque Progression and Stabilizing Vulnerable Plaques

    George Karpouzas1, Sarah Ormseth 1, Elizabeth Hernandez 2 and Matthew Budoff 1, 1Harbor-UCLA Medical Center and Los Angeles Biomedical Institute, Torrance, CA, 2Harbor-UCLA and Los Angeles Biomedical Institute, Torrance, CA

    Background/Purpose: Biologic disease-modifying antirheumatic drugs (bDMARDs) may decrease cardiovascular events (CVE) in Rheumatoid arthritis (RA). We here evaluated whether bDMARDs reduce long-term CVE risk in…
  • Abstract Number: 1896 • 2019 ACR/ARP Annual Meeting

    Breastfeeding in Women with Rheumatic Diseases

    Naira Ikram1, Amanda Eudy 1 and Megan Clowse 1, 1Duke University, Durham

    Background/Purpose: For many women, breastfeeding is a central aspect of motherhood, but many worry that their rheumatic disease or treatment will interfere. Fortunately, most anti-rheumatic…
  • Abstract Number: 1897 • 2019 ACR/ARP Annual Meeting

    Sexual Function and Health-related Quality of Life in Male Patients with Systemic Lupus Erythematosus, the Untold Story

    Martín Valdez-López1, Jonathan Campos-Guzmán 1, Ana Barrera-Vargas 2, Samuel Govea-Peláez 1, Diana Gómez-Martín 1, Jorge Alcocer-Varela 1, Eduardo Aguirre-Aguilar 1, Diana Padilla-Ortíz 3 and Javier Merayo-Chalico 1, 1Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico City, Distrito Federal, Mexico, 2Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico City, Mexico, 3Universidad De La Sabana, Bogotá, Cundinamarca, Colombia

    Background/Purpose: Although SLE is uncommon in men, the disease is usually more severe and requires more aggressive immunosuppression in male patients. There are multiple studies…
  • Abstract Number: 1898 • 2019 ACR/ARP Annual Meeting

    Rheumatoid Arthritis in Pregnancy and Offspring School Performance. a Danish Nationwide Register-Based Study

    Signe Knudsen1, Julia Simard 2, Jakob Christensen 3, Thomas Lauersen 4, Bent Deleuran 5 and Bodil Bech 1, 1Department of Public Health, Aarhus University, Aarhus, Denmark, Aarhus, Denmark, 2Stanford University School of Medicine, Palo Alto, CA, 3Department of Neurology, Aarhus University Hospital & The National Center for Register-based Research, Aarhus University, Denmark, Aarhus, Denmark, 4The National Center for Register-based Research, Department of Economics and Business Economics, Business and Social Science, Aarhus University, Aarhus, Denmark, Aarhus, Denmark, 5Department of Biomedicine; Department of Rheumatology, Aarhus University, Aarhus, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) during pregnancy is a risk factor for several adverse pregnancy and child outcomes. Studies have found higher incidences of neurological and…
  • Abstract Number: 1899 • 2019 ACR/ARP Annual Meeting

    sFlt-1, PlGF and VEGF in the Differential Diagnosis Between Active SLE Nephritis During Pregnancy and Preeclampsia

    Guilherme De Jesus1, Marcela Lacerda 1, Bruna Rodrigues 1, Flavia dos Santos 1, Adriana Nascimento 1, Luis Cristóvão Porto 1, Nilson Ramires de Jesús 1, Roger Levy 2 and Evandro Klumb 1, 1Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, 2GlaxoSmithKline, Upper Providence, PA

    Background/Purpose: Pregnancy in patients with SLE is associated with significant morbidity and mortality. SLE activity during pregnancy, specifically nephritis, makes the differential diagnosis with preeclampsia…
  • Abstract Number: 1900 • 2019 ACR/ARP Annual Meeting

    Assessing Commercial Titers of anti-Ro60 and Ro52 Antibodies to Risk Stratify Surveillance of Anti-Ro/SSA Antibody Positive Pregnancies

    Kimberly Robins 1, Rohit Bhan1, Catherine Trad 1, Rebecca Cohen 1, Miao Chang 1, Benjamin Wainwright 1, Mala Masson 1, Shilpi Mehta-Lee 1, Peter Izmirly 1, Robert Clancy 1, Bettina Cuneo 2 and Jill Buyon 1, 1NYU School of Medicine, New York, 2Children's Hospital Colorado, Aurora

    Background/Purpose: Pregnancy counseling of all anti-Ro positive women includes advice regarding the development of congenital heart block (CHB), albeit the risk is only 2% for…
  • Abstract Number: 1901 • 2019 ACR/ARP Annual Meeting

    Serious Infections in Offspring Exposed in Utero to Non-TNFi Biologics and Tofacitinib

    Evelyne Vinet1, Yvan St-Pierre 1, Cristiano S. Moura 1, Jeffrey Curtis 2 and Sasha Bernatsky 3, 1McGill University Health Centre, Montreal, QC, Canada, 2University of Alabama at Birmingham, Birmingham, AL, 3Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: During pregnancy, maternal circulating immunoglobulins G (IgG) are actively transported across the placenta through their Fc portion. Thus, TNFi and other biologics harbouring an Fc…
  • Abstract Number: 1902 • 2019 ACR/ARP Annual Meeting

    Systems Biology in 874 Patients with Primary Sjögren’s Syndrome Indicates the Predominant Role of Interferon Alpha Compared to Interferon Gamma, Its Association with Systemic Complications, and a New Aspect of the Genetic Contribution of HLA

    Pierre Bost 1, Xavier Mariette 2, Vincent Bondet 3, Alba Llibre 1, Céline Posseme 3, Bruno Charbit 3, Christian Thorball 4, Roland Jonsson 5, Chris Lessard 6, Renaud Felten 7, Fai Ng 8, K Silvis 9, Lucienne Chatenoud 10, Hélène Dumortier 11, Jacques Fellay 4, Karl A Brostadt 12, Silke Appel 5, Jessica R Tarn 8, Lluis Quintana-Murci 3, Michael Minguenau 13, Nicolas Meyer 14, Darragh Duffy 1, Benno Schwikowski 1 and Jacques-Eric Gottenberg15, 1PASTEUR, PARIS, France, 2Université Paris-Sud, Paris, France, Paris, Centre, France, 3PASTEUR, PARIS, Centre, France, 4School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 5University of Bergen, Bergen, Norway, 6ORMF, Oklahoma City, 7Strasbourg Unviersity Hospital, Strasbourg, Alsace, France, 8Newcastle Hospital, Newcastle, United Kingdom, 9ORMF, Oklahoma, 10Necker Hospital, Paris, France, 11IBMC, Strasbourg, Alsace, France, 12Universiy of Bergen, Bergen, Norway, 13Biogen, Boston, 14Strasbourg University Hospital, STRASBOURG, France, 15Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France

    Background/Purpose: Primary Sjögren’s syndrome (pSS) is the second most frequent systemic autoimmune disease affecting 0.1% of the general population. No specific immunomodulatory drug has demonstrated…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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