Abstracts Archive - Page 1060 of 2425 - ACR Meeting Abstracts

Abstract Number: 831 • 2018 ACR/ARHP Annual Meeting
No More HCV RNA in Serum and Cryoprecipitate in Patients with Persisting HCV-Cryoglobulinemia Vasculitis after Daa-Induced Sustained Virological Response
Patrice Cacoub¹, Eve Todesco², Pascale Ghillani-Dalbin³, Lucile Musset³ and David Saadoun⁴, ¹Internal Medicine Department, University Hospital “Pitié-Salpêtrière”, “Pierre et Marie Curie Paris VI” University, Paris, France, Paris, France, ²Virology Pitie Salpetriere hospital, Paris, France, ³Immunobiology department Pitie Salpetriere Hospital, Paris, France, ⁴Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), F-75005, Paris, France; INSERM, UMR_S 959, F-75013, Paris, France; CNRS, FRE3632, F-75005, Paris, France; AP-HP, Groupe Hospitalier, Paris, France
No more HCV RNA in Serum and Cryoprecipitate in Patients with Persisting HCV-Cryoglobulinemia Vasculitis after DAA-induced Sustained Virological ResponseBackground/Purpose: In addition to high antiviral efficacy,…
Abstract Number: 832 • 2018 ACR/ARHP Annual Meeting
Immunoglobuline a Vasculitis: Comparison between Pediatric and Adult Population
Martin Brom¹, Ignacio Javier Gandino², Marina Scolnik³, Valeria Scaglioni³, Maria Britos⁴, Carmen De Cunto⁴ and Enrique R Soriano³, ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ²Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Argentina., Buenos Aires, Argentina, ³Rheumatology Unit, Internal Medicine Service. Hospital Italiano Buenos Aires. Argentina, Buenos Aires, Argentina, ⁴Pediatric Rheumatology, Hospital Italiano De Buenos Aires, Buenos Aires, Argentina
Background/Purpose: Immunoglobuline A (IgA) Vasculitis, formerly known as Henoch-Schönlein purpura, is a small-vessel leukocytoclastic vasculitis due to deposition of IgA1, a subclass of IgA. Although…
Abstract Number: 833 • 2018 ACR/ARHP Annual Meeting
11 Patients with Relapsing Polychondritis Presenting with Severe Airways Disease in One Centre in UK
Shirish Dubey¹, Grace Pink², Asad Ali², Nicholas Hart³, Patrick Murphy⁴, Joanne Shakespeare⁵, Colin Gelder⁶, Chris Taylor² and David D'Cruz⁷, ¹Rheumatology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, ²Respiratory medicine, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, ³Respiratory medicine, St Thomas' Hospital, London, United Kingdom, ⁴Lane Fox Respiratory Unit, St Thomas' Hospital, London, United Kingdom, ⁵Respiratory physiology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, ⁶University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, ⁷Louise Coote Lupus Unit, Guy's and St. Thomas' Hospital, London, United Kingdom
Background/Purpose: Relapsing polychondritis (RP) is a multi-system disease characterised by episodes of progressive inflammation and subsequent degeneration of cartilage and connective tissue throughout the body.…
Abstract Number: 834 • 2018 ACR/ARHP Annual Meeting
Clinical Characteristics of IgA Vasculitis in Children and Adults: A Retrospective Cohort Study
Michel Villatoro-Villar¹, Cynthia S. Crowson^1,2, Kenneth J. Warrington³, Ashima Makol¹, Steven R. Ytterberg³ and Matthew J. Koster¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic, Rochester, MN, ³Rheumatology, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN
Background/Purpose: Differences in both presentation and outcome based on age of diagnosis have been described in patients with IgA vasculitis (IgAV) but data are limited…
Abstract Number: 835 • 2018 ACR/ARHP Annual Meeting
WITHDRAWN
Abstract Number: 836 • 2018 ACR/ARHP Annual Meeting
Genetic Risk Score Prediction in Ankylosing Spondylitis
Zhixiu Li¹, Erika De Guzman¹, Jessica Harris¹, Nurullah Akkoc², Mahdi Mahmoudi³, Maxime Breban⁴, Chung-Tei Chou⁵, Michael Weisman⁶, Lianne S. Gensler⁷, Michael Ward⁸, Mohammad H. Rahbar⁹, Laura A. Diekman¹⁰, Tae-Hwan Kim¹¹, Paul Leo¹, John D. Reveille¹⁰, Paul Wordsworth¹², Matthew Brown¹ and Huji Xu¹³, ¹Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ²Rheumatology, İzmir, Turkey, İzmir, Turkey, ³Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran, Tehran, Iran (Islamic Republic of), ⁴Hôpital Ambroise Paré, Assistance Publique-Hôpitaux de Paris, Boulogne, France, Boulogne, France, ⁵Division of Allergy-Immunology-Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Taipei, Taiwan, ⁶Cedars-Sinai Medical Center, Los Angeles, CA, USA, Los Angeles, CA, ⁷University of California San Francisco, San Francisco, CA, ⁸National Institutes of Health, Bethesda, MD, USA, Bethesda, MD, ⁹Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, ¹⁰Rheumatology, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, ¹¹Rheumatology, The Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea, Seoul, Korea, Republic of (South), ¹²Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, Oxford, United Kingdom, ¹³School of Clinical Medicine, Tsinghua University, Beijing, China, Beijing, China
Background/Purpose: The diagnosis of ankylosing spondylitis (AS) is delayed by on average 8–11 years after the onset of symptoms, and there is increasing evidence that…
Abstract Number: 837 • 2018 ACR/ARHP Annual Meeting
Efficacy of High-Dose Versus Standard-Dose Influenza Vaccine in Seropositive Rheumatoid Arthritis Patients
Ines Colmegna¹, Mariana Useche², Katherine Rodriguez³, Marie Hudson⁴, Sasha Bernatsky⁵, Hacene Nedjar³, Elham Rahme⁶ and Brian Ward⁷, ¹The Research Institute of the McGill University Health Centre, Division of Rheumatology, Department of Medicine, McGill University, Montreal, Quebec, Canada, Montreal, QC, Canada, ²Medicine, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ³The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁴Division of Rheumatology, Jewish General Hospital, Lady Davis Institute for Medical Research, Montreal, QC, Canada, ⁵Divisions of Rheumatology and Clinical Epidemiology, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁶Epidemiology, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁷Infectious Diseases, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Rheumatoid arthritis (RA) patients have 2.75 fold increased risk of influenza and influenza-related illness than age-matched healthy controls. For this reason, RA patients are…
Abstract Number: 838 • 2018 ACR/ARHP Annual Meeting
Efficacy and Safety of Combined Immunosuppressive Therapy with High-Dose Glucocorticoid, Tacrolimus, and Cyclophosphamide in Interstitial Lung Disease Accompanied By Anti-MDA5-Positive Dermatomyositis -a Multicenter Prospective Study –
Hideaki Tsuji¹, Ran Nakashima¹, Yoshitaka Imura², Masato Yagita², Hajime Yoshifuji¹, Shintaro Hirata³, Takaki Nojima³, Eiji Sugiyama⁴, Kazuhiro Hatta⁵, Yoshio Taguchi⁶, Masaki Katayama⁷, Shuji Akizuki¹, Kosaku Murakami¹, Motomu Hashimoto⁸, Masao Tanaka⁸, Koichiro Ohmura¹ and Tsuneyo Mimori⁹, ¹Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Department of Clinical Immunology and Rheumatology, The Tazuke-Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan, ³Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan, ⁴Department of Clinical Immunology and Rheumatology, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan, ⁵Department of General Medicine, Tenri Hospital, Tenri, Japan, ⁶Department of Respiratory Medicine, Tenri Hospital, Tenri, Japan, ⁷Department of Rheumatology and Clinical Immunology, Osaka Red Cross Hospital, Osaka, Japan, ⁸Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁹Department of Rheumatology and Clinical Immunology, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Background/Purpose: Interstitial lung disease (ILD) accompanied by anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis (DM) is often rapidly progressive and associated with poor life prognosis in…
Abstract Number: 839 • 2018 ACR/ARHP Annual Meeting
Fibromyalgia Is Identified in Routine Care on Indices Derived from an MDHAQ (MultiDimensional Health Assessment Questionnaire) with Robust Agreement with 2011 Revised Fibromyalgia Criteria Questionnaire
Juan Schmukler, Jacquelin R. Chua, Mariam Riad, Isabel Castrejón and Theodore Pincus, Division of Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Fibromyalgia (FM) generally is easily diagnosed, but maybe complex, particularly in patients who meet criteria for other rheumatic diseases. FM criteria have been revised…
Abstract Number: 840 • 2018 ACR/ARHP Annual Meeting
The CCL21/CCR7 Axis Drives Vascular, Inflammatory and Destructive Remodeling in Rheumatoid Arthritis
Katrien Van Raemdonck^1,2, Karol Palasiewicz^1,2, Sadiq Umar^1,2 and Shiva Shahrara², ¹Jesse Brown VA Medical Center, Chicago, IL, ²Medicine, Division of Rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The synovial tissue of rheumatoid arthritis (RA) patients exhibits abundant expression of CCL21, produced excessively by RA fibroblasts and macrophages. While CCR7 mediates CCL21-driven…
Abstract Number: 841 • 2018 ACR/ARHP Annual Meeting
TNFR2 Inactivation Reduces Psoriatic Inflammation in Mice Via Down-Regulating Dendritic Cell Expansion and Inhibiting IL-23/IL-17 Pathways
Unnikrishnan M Chandrasekharan¹, Jennifer Harvey², Vandana Rai³, Chad Braley⁴, MacKenzie Lee³, Jason Hsieh³, Ritika Jaini⁵, Anthony Fernandez⁶, Paul DiCorleto⁷ and M. Elaine Husni⁸, ¹Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH, ²Department of Cellular and Molecular, Cleveland Clinic, Cleveland, OH, ³Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH, ⁴Department of Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, ⁵Cleveland Clinic, Cleveland, OH, ⁶Dermatology and Pathology, Cleveland Clinic, Cleveland, OH, ⁷Division of Research and Sponsored Programs, Kent State, kent, OH, ⁸Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH
Background/Purpose: Tumor necrosis factor-a (TNF), a potent proinflammatory cytokine, activates two receptors: TNFR1 and TNFR2. Anti-TNF biological agents neutralize TNF, thus preventing both TNFR1 and…
Abstract Number: 842 • 2018 ACR/ARHP Annual Meeting
Interleukin 17 Receptor D (IL-17RD) Is Regulated By Pro-Inflammatory Cytokines and Plays a Role in the Development of Collagen-Induced Arthritis
M Molendijk¹, A Otten-Mus², P Asmawidjaja³, Dominique Baeten⁴ and Erik Lubberts⁵, ¹Rheumatology, Erasmus MC, Rotterdam, Netherlands, ²Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Rheumatology and Clinical Immunology, AMC, Amsterdam, Netherlands, ⁵Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose: Interleukin-17 Receptor D (IL-17RD) otherwise known as similar expression of fibroblast growth factor genes (SEF) is often described as an inhibitor of multiple signaling…
Abstract Number: 843 • 2018 ACR/ARHP Annual Meeting
Localization of the Voltage-Gated Sodium Channel 1.7 in Peripheral Monocytes Contributes to Activation of BAFF Signaling in Monocytes of Patients with Primary Sjögren’s Syndrome
Keiko Yoshimoto, Yumi Ikeda, Katsuya Suzuki and Tsutomu Takeuchi, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: In our previous study, we have reported that IL-6 production was robustly increased in BAFF-stimulated peripheral monocytes of patients with primary Sjögren’s syndrome (pSS)…
Abstract Number: 844 • 2018 ACR/ARHP Annual Meeting
Differential Roles of Tnfα-TNFR1 and Tnfα-TNFR2 in the Differentiation and Function of Induced CD4+Foxp3+ Treg Cells in Autoimmune Diseases
SONGGUO ZHENG¹, Su-juan Yang², Julie Wang¹ and Rayford June¹, ¹Medicine, Milton S. Hershey Medical School at Penn State University, HERSHEY, PA, ²Medicine, The Third Affiliated Hospital at Sun Yat-sen University, Guangzhou, China
Background/Purpose: Tumor Necrosis Factor (TNF) α exerts it pro-inflammatory or anti-inflammatory function. This study hypothesizes that TNFα has multi-function through binding the different receptor 1…
Abstract Number: 845 • 2018 ACR/ARHP Annual Meeting
New Insights in Lupus Dermatitis: Differential Regulation and Roles of Tissue-Resident Dendritic Cell Subsets in the Pathogenesis of Autoimmune Skin Inflammation
Ram R. Singh, Miguel-Angel Gutierrez, Peter Kim, Darshan Randhawa, Rachael Philips, Jennifer K. King and Anna Eriksson, Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA
Background/Purpose: Acquired or self antigens in tissues are taken to lymphoid organs to elicit protective immunity or tolerance, respectively. This is accomplished by dendritic cells…

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