Abstracts Archive - Page 1059 of 2607 - ACR Meeting Abstracts

Abstract Number: 1783 • 2019 ACR/ARP Annual Meeting
Reversible Dysregulation of Renal Circadian Rhythm in Lupus Nephritis
Rakesh Mishra ¹, Ramalingam Bethunaickan ¹, Celine Berthier ², Zhengzi Yi ³, Joshua Strohl ¹, Patricio Huerta ¹, Weijia Zhang ⁴ and Anne Davidson⁵, ¹Feinstein Institute for Medical Research, manhasset, NY, ²University of Michigan, Ann Arbor, MI, ³Mount Sinai School of Medicine, New York, ⁴Mount Sinai School of Medicine, New York, NY, ⁵Feinstein Institutes for Medical Research, Manhasset
Background/Purpose: Circadian rhythm is a universal phenomenon that governs homeostasis of overall organism functioning as well as of individual organs. Circadian regulation of homeostatic functions…
Abstract Number: 1784 • 2019 ACR/ARP Annual Meeting
Single Cell Analysis of Renal Myeloid Cells from NZB/WF1 Mice with Lupus Nephritis Reveals Multiple Subsets with Altered Functions
Rakesh Mishra ¹, Celine Berthier ², Heather Geiger ³, Weijia Zhang ⁴ and Anne Davidson⁵, ¹Feinstein Institute for Medical Research, manhasset, NY, ²University of Michigan, Ann Arbor, MI, ³New York Genome Center, New York, NY, ⁴Mount Sinai School of Medicine, New York, NY, ⁵Feinstein Institutes for Medical Research, Manhasset
Background/Purpose: Renal infiltration with macrophages and dendritic cells is associated with poor prognosis in humans with lupus nephritis (LN). However, the precise pathogenic and/or protective…
Abstract Number: 1785 • 2019 ACR/ARP Annual Meeting
The Pathogenic Potential of Choroid Plexus T Cells in Neuropsychiatric Lupus
Erica Moore¹, Michelle Huang ¹, Cara Reynolds ¹ and Chaim Putterman ², ¹Albert Einstein College of Medicine, Bronx, NY, ²Albert Einstein College of Medicine, New York, NY
Background/Purpose: The pathogenesis of neuropsychiatric Systemic Lupus Erythematosus (NPSLE) is incompletely understood, but is considered to be complex and multifactorial. Additionally, there is a wide…
Abstract Number: 1786 • 2019 ACR/ARP Annual Meeting
Surrogate Pathways of Complement Activation in Novel Polygenic SLE-like Models of Kidney Injury
Sladjana Skopelja-Gardner¹, Xizhang Sun ², Yufeng Peng ², Lucrezia Colonna ², Payton Hermanson ², Lena Tanaka ², Joyce Tai ², David Salant ³ and Keith Elkon ², ¹University of Washington, Seattle, WA, ²University of Washington, Seattle, ³Boston University, Boston
Background/Purpose: Lupus nephritis (LN) is a major contributor to morbidity and mortality in systemic lupus erythematosus (SLE). Defective clearance of apoptotic cells (AC), autoantibodies, and…
Abstract Number: 1787 • 2019 ACR/ARP Annual Meeting
The Glucocorticoid-Induced Protein GILZ Represent a Checkpoint in the IFN Program in SLE
Eric Morand¹, Champa Nataraja ¹, Melissa Northcott ¹, Wendy Dankers ¹, Jacqueline Flynn ¹, Wendy Zhu ¹, Taylah Bennett ¹, Mehnaz Pervin ¹, Brendan Russ ¹, James Harris ¹ and Sarah Jones ¹, ¹Monash University, Melbourne, Victoria, Australia
Background/Purpose: Given the primacy of Type I interferon (IFN) pathways in SLE pathogenesis, and the near-ubiquity of glucocorticoid (GC) use in SLE treatment, clarifying the…
Abstract Number: 1788 • 2019 ACR/ARP Annual Meeting
Anti-neutrophil Extracellular Trap (NET) Autoantibodies in Primary Antiphospholipid Syndrome
Yu Zuo¹, Srilakshmi Yalavarthi ², Kelsey Gockman ², David Karp ³, Quan-Zhen Li ⁴ and Jason Knight ⁵, ¹University of Texas Southwestern, Dallas, TX, ²University of Michigan, Ann Arbor, MI, ³UTSouthwestern Medical Center, Dallas, TX, ⁴Department of Immunology & Internal Medicine/University of Texas Southwestern Medical Center, Charleston, ⁵Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI
Background/Purpose: Neutrophil extracellular traps (NETs) are prothrombotic tangles of chromatin and microbicidal proteins ejected from neutrophils in response to a variety of stimuli. In antiphospholipid…
Abstract Number: 1789 • 2019 ACR/ARP Annual Meeting
Defibrotide Inhibits Antiphospholipid Antibody-Mediated NET Release and Endothelial Cell Activation
Ramadan Ali¹, Hui Shi ¹, Srilakshmi Yalavarthi ¹ and Jason Knight ², ¹University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI
Background/Purpose: Defibrotide is a mixture of phosphodiester oligonucleotides derived from porcine intestinal mucosa, currently approved for treatment of hepatic sinusoidal obstruction syndrome. Defibrotide has been…
Abstract Number: 1790 • 2019 ACR/ARP Annual Meeting
The Epidemiology of the Antiphospholipid Syndrome in the UK, 1990 – 2016
Mia Rodziewicz¹, David D'Cruz ², Martin Gulliford ³ and Nisha Hazra ³, ¹The Louise Coote Lupus Unit, Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom, ²The Louise Coote Lupus Unit, Guy's Hospital, London, England, United Kingdom, ³School of Population Health and Environmental Sciences, King’s College London, London, United Kingdom
Background/Purpose: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterised by recurrent vascular thrombosis and/or pregnancy morbidity in the presence of persistently positive antiphospholipid autoantibodies.…
Abstract Number: 1791 • 2019 ACR/ARP Annual Meeting
Antiphospholipid Antibody Profile Stability over Time: Prospective Results from AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (“Registry”)
Elena Gkrouzman¹, Ecem Sevim ², Jackie Finik ³, Danieli Andrade ⁴, Vittorio Pengo ⁵, Savino Sciascia ⁶, Maria Tektonidou ⁷, Amaia Ugarte ⁸, Cecilia Chighizola ⁹, H Michael Belmont ¹⁰, Laura Pérez Sánchez ¹¹, Lanlan Ji ¹², Paul Fortin ¹³, Maria Efthymiou ¹⁴, Guilherme De Jesus ¹⁵, David Branch ¹⁶, Cecilia Nalli ¹⁷, Michelle Petri ¹⁸, Ricard Cervera ¹⁹, Esther Rodriguez ²⁰, Jason Knight ²¹, Tatsuya Atsumi ²², Rohan Willis ²³, Maria Laura Bertolaccini ²⁴, Hannah Cohen ¹⁴, Jacob Rand ²⁵, Doruk Erkan ¹ and On Behalf Of APS ACTION ²⁶, ¹Hospital for Special Surgery, New York City, ²Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery, New York, NY, New York, NY, ⁴Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil, ⁵Azienda Ospedaliera of Padova, University of Padova, Padova, Italy, ⁶Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Torino, Italy, ⁷First Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece, ⁸Hospital Universitario Cruces, University of the Basque Country Autoimmune Diseases Research Unit, Department of Internal M edicine, BioCruces Health, Biscay, Spain, ⁹Rheumatology, Istituto Auxologico Italiano, University of Milan, Milan, Italy, ¹⁰NYU Langone Health, New York, NY, ¹¹IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ¹²Peking University First Hospital, Beijing, China (People's Republic), ¹³Division de Rhumatologie, Département de Médecine, CHU de Québec – Université Laval, Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Québec – Université Laval, Canada, Quebec, QC, Canada, ¹⁴University College London, London, United Kingdom, ¹⁵Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ¹⁶University of Utah Health Sciences Center, Salt Lake City, UT, ¹⁷Rheumatology and Clinical Immunology, Spedali Civili, Brescia, Italy, Brescia, Italy, ¹⁸Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁹Hospital Clinic of Barcelona, Barcelona, Spain, ²⁰Hospital Universitario 12 de Octubre, Madrid, Spain, ²¹Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, ²²Hokkaido University, Sapporo, Japan, ²³Antiphospholipid Standardization Laboratory, University of Texas Medical Branch, Galveston, TX, ²⁴King's College London, London, United Kingdom, ²⁵Weill Cornell Medicine, New York, ²⁶APS ACTION, New York, NY
Background/Purpose: APS ACTION "Registry" was created to study long-term outcomes in persistently antiphospholipid antibody (aPL)-positive patients with and without other systemic autoimmune diseases. Our primary…
Abstract Number: 1792 • 2019 ACR/ARP Annual Meeting
Cognitive Dysfunction (CD) and Serum Levels of Brain-Derived Neurotrophic Factor (BDNF) in Primary Antiphospholipid Syndrome (PAPS)
Renata Rosa¹, Michelle Remião Ugolini-Lopes ², Ana Paula Gandara ², Kenia Campanholo ², Livia Dutra ³ and Danieli Andrade ⁴, ¹Faculdade de Medicina da Universidade de São Paulo (USP), Brazil., São Paulo, Sao Paulo, Brazil, ²Faculdade de Medicina da Universidade de São Paulo (USP), Brazil., São Paulo, Brazil, ³Escola Paulista de Medicina (EPM), Brazil, São Paulo, Brazil, ⁴Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil
Background/Purpose: Cognition dysfunction (CD) is a poorly understood non-stroke central neurologic manifestation of antiphospholipid syndrome, whose diagnosis involves a specific neuropsychological (NP) evaluation. Brain-derived neurotrophic…
Abstract Number: 1793 • 2019 ACR/ARP Annual Meeting
Descriptive Analysis of Biopsy-proven Antiphospholipid Antibody-associated Nephropathy Patients Included in the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (“Registry”)
Maxime Taghavi¹, Medha Barbhaiya ², Maria Tektonidou ³, Paul Fortin ⁴, Danieli Andrade ⁵, Jason Knight ⁶, Bahar Artim-Esen ⁷, Tatsuya Atsumi ⁸, Hannah Cohen ⁹, Lanlan Ji ¹⁰, Savino Sciascia ¹¹, Surya Seshan ¹², Doruk Erkan ¹³ and on Behalf of APS ACTION ¹⁴, ¹Brugmann Hospital, Brugmann, Belgium, ²Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ³First Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece, ⁴Division de Rhumatologie, Département de Médecine, CHU de Québec – Université Laval, Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Québec – Université Laval, Canada, Quebec, QC, Canada, ⁵Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil, ⁶Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, ⁷Istanbul University School of Medicine, Istanbul, Turkey, ⁸Hokkaido University, Sapporo, Japan, ⁹University College London, London, United Kingdom, ¹⁰Peking University First Hospital, Beijing, China (People's Republic), ¹¹Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Torino, Italy, ¹²Weill Cornell Medicine, New York, ¹³Hospital for Special Surgery, New York City, ¹⁴Hospital for Special Surgery, New York
Background/Purpose: Antiphospholipid antibody (aPL) nephropathy is a distinct entity that can be challenging to recognize and treat; it remains unknown if uniform pathologic criteria are…
Abstract Number: 1794 • 2019 ACR/ARP Annual Meeting
An Evaluation of Burnout Among U.S. Rheumatology Fellows: A National Survey
Jenna McGoldrick¹, Diego Molina-Ochoa ¹, Pascale Schwab ¹, Samuel Edwards ² and Jennifer Barton ², ¹OHSU, Portland, OR, ²VA Portland Health Care System & Oregon Health & Science University, Portland, OR
Background/Purpose: Physician and trainee retention is critical given the significant projected workforce shortage of rheumatologists. While previous studies have reported significant burnout among physicians and…
Abstract Number: 1795 • 2019 ACR/ARP Annual Meeting
Education of Rheumatology Faculty: Evaluation of an Interactive Team Based Approach versus Traditional Didactic Teaching
Alysia Kwiatkowski¹, Najia Shakoor ¹, Andrew Ruthberg ¹, Joel A. Block ¹ and Sonali Khandelwal ¹, ¹Rush University Medical Center, Chicago, IL
Background/Purpose: Medical schools have been moving from traditional teaching to interactive approaches. Team-based learning (TBL) is a conceptual model that focuses on learner engagement, and…
Abstract Number: 1796 • 2019 ACR/ARP Annual Meeting
Identifying Educational Themes and Knowledge Gaps Through Analysis of Electronic Consultation (eConsult) Communication Between Primary Care Physicians and Rheumatologists
Ruchi Jain¹, Anna Broder ² and Sharon Rikin ¹, ¹Montefiore Medical Center, Bronx, ²Rheumatology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Despite advancements in management of rheumatologic diseases, barriers still exist for timely access to care. Electronic consultation (eConsult) use has increased in response to…
Abstract Number: 1797 • 2019 ACR/ARP Annual Meeting
Rheumatology Mechanism Madness: A Pilot Collaborative Learning Activity for Rheumatology Trainees
David Leverenz¹ and Lisa Criscione-Schreiber ², ¹Duke University, Durham, NC, ²Duke University, Durham
Background/Purpose: The Community of Inquiry (CoI) is a framework to understand how a group of individuals learns together and includes concepts of social, teaching, and…

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