Abstracts Archive - Page 1058 of 2607 - ACR Meeting Abstracts

Abstract Number: 1768 • 2019 ACR/ARP Annual Meeting
A First-in-class Selective and Potent IRAK4 Degrader Demonstrates Robust in Vitro and in Vivo Inhibition of TLR/IL-1R Activation and Inflammation
Veronica Campbell¹, Joseph Kelleher ¹, Jesse Chen ¹, Jared Gollob ², Nan Ji ², Christine Klaus ², Christine Loh ², Michelle mayo ², Alice McDonald ², Haojing Rong ², Scott Rusin ², Kirti Sharma ², Matt Weiss ², Karen Yuan ², Duncan Walker ², Xiaozhang Zheng ², Anthony Slavin ² and Nello Mainolfi ², ¹Kymera Therapeutics, cambridge, MA, ²Kymera Therapeutics, Cambridge
Background/Purpose: IL-1R/TLR activation plays a central role in the pathophysiology of multiple autoimmune and inflammatory diseases driven by the IL-1 family of cytokines and by…
Abstract Number: 1769 • 2019 ACR/ARP Annual Meeting
Myosin Regulation of TNF Receptor 2 Signaling May Contribute to Anti-TNF Therapy Response
Unnikrishnan M Chandrasekharan¹, Jennifer Harvey ², Mackenzie Dunlap ², Marcia Leon Rabanal ², Vandana Rai ² and M. Elaine Husni ³, ¹Cleveland clinic foundation, Cleveland, OH, ²Cleveland clinic, Cleveland, ³Department of Rheumatologic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH
Background/Purpose: Background/Purpose:Anti-TNF agents have revolutionized the clinical outcomes of patients with rheumatoid and psoriatic diseases. However, up to 40% of patients do not respond or…
Abstract Number: 1770 • 2019 ACR/ARP Annual Meeting
Experimental Rheumatoid Joint Ameliorated by CRISPR Interference Targeting Long Non-coding RNA H19 Through Wnt Signaling Inactivation
Chrong-Reen Wang¹, Shih-Yao Chen ¹, Yu-Chi Chou ², Chao-Liang Wu ³, Yu-Ting Lo ¹ and Ai-Li Shiau ⁴, ¹National Cheng Kung University Hospital, Tainan, Taiwan (Republic of China), ²Genomics Research Center, Academia Sinica, Taipei, Taiwan (Republic of China), ³National Cheng Kung University Medical College, Tainan, Taiwan (Republic of China), ⁴National Cheng Kung University Medical College, Tainan, Taiwan (Republic of China)
Background/Purpose: Long non-coding RNAs (lncRNAs) participate in the rheumatoid arthritis (RA) pathogenesis. The aim of this study was to examine the lncRNA H19 and HOTAIR…
Abstract Number: 1771 • 2019 ACR/ARP Annual Meeting
MyD88 S209R Enhances Inflammation in Mouse Models of Arthritis
Sufia Bakshi¹, Anders Lindstedt ², Malika Waschmann ³, Wanxia Tsai ¹, Robert Colbert ⁴ and Keith Sikora ¹, ¹National Institutes of Health, Bethesda, MD, ²NIH, Bethesda, MD, ³Oregon Health and Science University, Portland, OR, ⁴Pediatric Clinical Trials Unit, Pediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD
Background/Purpose: MyD88 is a critical adaptor protein that connects Toll-like and IL-1 receptor signaling to activation of NF-kB. We previously reported a heterozygous de novo gain-of-function mutation in MYD88 (S222R)…
Abstract Number: 1772 • 2019 ACR/ARP Annual Meeting
Chronotherapy Using Baricitinib Attenuates Collagen-induced Arthritis in Mice
Arisa Yaekura¹, Kanta Morii ², Yuto Oketani ³, Ikumi Okumura ², Kenta Kaneshiro ⁴, Kohsuke Yoshida ², Yoshiko Kawasaki ⁵, Nao Shibanuma ⁵, Yoshitada Sakai ⁶ and Akira Hashiramoto ², ¹Kobe University Graduate School of Health Sciences, Kawanishi, Hyogo, Japan, ²Kobe University Graduate School of Health Sciences, Kobe, Hyogo, Japan, ³Kobe University Graduate School of Health Sciences, Himeji, Hyogo, Japan, ⁴Kobe University Graduate School of Health Sciences, Osaka, Osaka, Japan, ⁵Kobe Kaisei Hospital, Kobe, Hyogo, Japan, ⁶Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
Background/Purpose: Diurnal variations are observed in symptoms of rheumatoid arthritis (RA). Among them, “morning stiffness of joints” is closely reflects the daily medical condition of…
Abstract Number: 1773 • 2019 ACR/ARP Annual Meeting
The Card9-Neutrophil Signaling Axis Is Critical to Induction of Th17-Mediated Arthritis in SKG Mice
Ruth Napier¹, Ellen Lee ¹, Emily Vance ¹, Beatitude Steffen ², Shimon Sakaguchi ³ and Holly Rosenzweig ⁴, ¹Oregon Health & Science University and Portland VA Hospital, Portland, OR, ²Oregon Health & Science University and Portland VA Hospital, Portland, ³Osaka University, Osaka, Japan, ⁴Oregon Health & Science University and Portland VA Hospital, Oregon
Background/Purpose: Caspase recruitment domain-containing protein 9 (CARD9) is an adaptor protein downstream of C-type lectin receptor signaling within myeloid cells. CARD9 is critical for anti-fungal immunity;…
Abstract Number: 1774 • 2019 ACR/ARP Annual Meeting
Potential Involvement of OX40 Expressing Tfh Cells on Regulation of Autoantibody Sialylation in Experimental and Rheumatoid Arthritis
Izumi Kurata¹, Isao Matsumoto ¹, Natsuko Mikami ¹, Ayako Ohyama ¹, Atsumu Osada ¹, Yuya Kondo ¹, Hiroto Tsuboi ¹ and Takayuki Sumida ¹, ¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Recently, IL-23-Th17 cells axis and hyposialylation of antibodies were proved to be linked to experimental and rheumatoid arthritis. However it remains uncertain how Tfh,…
Abstract Number: 1775 • 2019 ACR/ARP Annual Meeting
Cholesterol Sequestering in Macrophages Contributes to the Lipid Paradox in Chronic Arthritis
Sandra Pérez-Baos¹, Junko Arakawa ², Raquel Largo ¹, Katsunori Ikewaki ² and Gabriel Herrero-Beaumont ¹, ¹IIS-Fundación Jiménez Díaz, Madrid, Madrid, Spain, ²National Defense Medical College, Tokorozawa, Saitama, Japan
Background/Purpose: Patients with active rheumatoid arthritis (RA) have increased cardiovascular mortality, paradoxically associated with reduced circulating lipid levels. Several disease-modifying antirheumatic drugs (DMARDs), such as…
Abstract Number: 1776 • 2019 ACR/ARP Annual Meeting
Causal Effect of TNF-α, IL-12p70, IL-17 Levels on the Risk of Psoriatic Arthritis: A Mendelian Randomization Study
Dongze WU¹, Priscilla Wong ¹, Steven H.M. Lam ¹, Isaac T. Cheng ¹, Edmund K. Li ¹, Ling Qin ¹ and Lai-Shan Tam ¹, ¹The Chinese University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: Biologic agents targeting cytokines including TNF-α, IL-12p70 and IL-17 have been proven to be very effective in treating psoriatic arthritis (PsA). Nonetheless, whether these…
Abstract Number: 1777 • 2019 ACR/ARP Annual Meeting
The Deubiquitinase TRABID Is a Potential Therapeutic Target in Spondyloarthritis
Daniele Mauro¹, Federica Macaluso ², Alessandra Nerviani ³, Marie-Astrid Boutet ³, Aroldo Rizzo ⁴, Riccardo Alessandro ², Giuliana Guggino ², Costantino Pitzalis ³ and Francesco Ciccia ⁵, ¹Centre for Experimental Medicine & Rheumatology, Queen Mary University of London, London, England, United Kingdom, ²University of Palermo, Italy, Palermo, Italy, ³Centre for Experimental Medicine & Rheumatology, Queen Mary University of London, London, United Kingdom, ⁴Pathology Unit, Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello, Palermo, Italy., Palermo, Italy, ⁵University of Campania L. Vanvitelli, Naples, Italy
Background/Purpose: Interleukin 12 (IL-12) and 23 (IL-23) may play a pivotal role in the pathogenesis of inflammatory diseases, including Spondyloarthritis (SpA). In mice, the deubiquitinase…
Abstract Number: 1778 • 2019 ACR/ARP Annual Meeting
Entheseal CD90+ SOX9+ Cartilage-like Cells Initiate Spinal Ankylosis in Ankylosing Spondylitis
Sungsin Jo¹, Young Lim Lee ¹, Tae-Han Lee ¹, Ye-Soo Park ² and Tae-Hwan Kim ¹, ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ²Department of Orthopedic Surgery, Hanyang University Medical Center, Guri Hospital,, Guri, Republic of Korea
Background/Purpose: Enthesitis is characterized by inflammation at the interface where tendon or ligament attaches to the bone and is a representative symptom of ankylosing spondylitis(AS).…
Abstract Number: 1779 • 2019 ACR/ARP Annual Meeting
CLEC5A/MDL-1 Is Critical for Inflammatory Arthritis and Skin Inflammation
Cuong Nguyen¹, Dai Hui ¹, Ran Gu ¹, Trevor Chan ², Alina Marleev ³, Emanual Maverakis ³, Vijay Kuchroo ⁴, Shie-Liang Hsieh ⁵, Ilias Tagkopoulos ², Christopher Ritchlin ⁶ and Iannis Adamopoulos ¹, ¹Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Sacramento, CA, ²University of California, Davis, Department of Computer Science, California, USA, Davis, CA, ³Department of Dermatology, School of Medicine, UCD, Sacramento, California, USA., Sacramento, CA, ⁴Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, MA, USA, Boston, MA, ⁵Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, Taiwan, Taipei, Taiwan (Republic of China), ⁶Division of Allergy, Immunology and Rheumatology, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, Rochester, NY
Background/Purpose: Interleukin-23 (IL-23) and its cognate receptor interleukin-23R (IL-23R):IL-12Rβ1 plays a critical role in the pathogenesis of autoimmune diseases including psoriasis and psoriatic arthritis. Although…
Abstract Number: 1780 • 2019 ACR/ARP Annual Meeting
Microbiome in Offspring of Ankylosing Spondylitis Patients
Matthew Stoll¹, Kimberly DeQuattro ², Zhixiu Li ³, Henna Sawhney ⁴, Maria Castillo ⁴, Pamela F. Weiss ⁵, Peter Nigrovic ⁶, Lynn Punaro ⁷, Kenneth Schikler ⁸, Barbara Edelheit ⁹, John Reveille ¹⁰, Matthew Brown ³ and Lianne Gensler ¹¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of California, San Francisco, San Francisco, CA, ³Queensland University of Technology, Queensland, Australia, ⁴University of California in San Francisco, San Francisco, CA, ⁵Children's Hospital of Philadelphia, Philadelphia, PA, ⁶Boston Children's Hospital, Boston, MA, ⁷Texas Scottish Rite Hospital, Dallas, TX, ⁸University of Kentucky, Louisville, KY, ⁹Connecticut Children's Medical Center, Hartford, CT, ¹⁰University of Texas McGovern Medical School, Houston, ¹¹University San Francisco California, San Francisco, CA
Background/Purpose: Spondyloarthritis (SpA) results from the interplay between genetic and environmental factors. An emerging factor is the human intestinal microbiota, which multiple studies in children…
Abstract Number: 1781 • 2019 ACR/ARP Annual Meeting
Cytokine Dependence of Enthesis-resident Lymphocytes in Murine Spondyloarthritis
Mederbek Matmusaev ¹, Emma Haley¹, Imtiyaz Hossain ¹ and Joerg Ermann ¹, ¹Brigham and Women's Hospital, Boston
Background/Purpose: Enthesis-resident CD4-CD8- double-negative (DN) T cells have been implicated in the pathogenesis of spondyloarthritis. Overexpression of IL-23 in adult mice activates these cells to…
Abstract Number: 1782 • 2019 ACR/ARP Annual Meeting
A Human SLE Variant NCF1-R90H Drives Lupus-like Kidney Disease in a Pristane-induced Murine Lupus Model
Lin-Yu Geng¹, Ivan Molano ², Ling-Xiao Xu ³, Qing Sun ¹, Phillip Ruiz ⁴, Quan-Zhen Li ⁵, Gary Gilkeson ⁶ and Betty Tsao ⁷, ¹Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston, SC, ²Division of Rheumatology & Immunology/Medical University of South Carolina, Charelston, ³Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charelston, SC, ⁴Department of Surgery/University of Miami School of Medicine, Charleston, ⁵Department of Immunology & Internal Medicine/University of Texas Southwestern Medical Center, Charleston, ⁶Division of Rheumatology & Immunology/Ralph H. Johnson VA Medical Center/Medical University of South Carolina, Charleston, SC, ⁷Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston
Background/Purpose: We previously identify a p.Arg90His (p.R90H) substitution encoded in phagocyte neutrophil cytosolic factor (NCF1) as a novel risk variant for SLE, with decreased and…

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