Abstracts Archive - Page 1058 of 2425 - ACR Meeting Abstracts

Abstract Number: 801 • 2018 ACR/ARHP Annual Meeting
Cardiac Autonomic Modulation at Rest and during Orthostatic Stress in Systemic Sclerosis Patients
Adriana Severino¹, Gabriel Dias Rodrigues², Chiara Bellocchi¹, Eleonora Tobaldini^3,4, Nicola Montano^3,4 and Lorenzo Beretta¹, ¹Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ²Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University, Niterói, Brazil, ³Department of Internal Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ⁴Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Background/Purpose: Autonomic dysfunction is a marker of myocardial involvement in systemic sclerosis (SSc) and heart rate variability (HRV) is impaired in SSc patients (1). The…
Abstract Number: 802 • 2018 ACR/ARHP Annual Meeting
Prognostic Significance of Bicaudal D2 Antibodies in Sistemic Sclerosis (SSc) Patients
Giulia Segatto¹, Chiara Bellocchi², Gaia Montanelli¹, Silvia Casas³, Karl Norvell⁴, Michelle Amino³, Fabrece Roup⁴, Michael Mahler⁴ and Lorenzo Beretta², ¹Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy, ²Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ³Inova Diagnostics, San Diego, CA, ⁴Research and Development, Inova Diagnostics, San Diego, CA
Background/Purpose: Antibodies (Ab) toward Bicaudal D homolog 2 (BlCD2) can be found in 25% of Systemic Sclerosis (SSc) sera, mostly in association with anti-centromere (ACA)…
Abstract Number: 803 • 2018 ACR/ARHP Annual Meeting
Treating Interstitial Lung Disease and Skin Involvement in Systemic Sclerosis with Oral Versus Intravenous Cyclophosphamide: Preliminary Efficacy and Safety Data from 2 Randomized Clinical Trials and 1 Registry
Cosimo Bruni¹, Donald P. Tashkin², Virginia D. Steen³, Yannick Allanore⁴, Oliver Distler⁵, Jonathan Grotts⁶, Marco Matucci-Cerinic⁷ and Daniel E. Furst⁸, ¹Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Firenze, Italy, ²University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ³Rheumatology, MedStar Georgetown University Hospital, Washington, DC, ⁴Cochin Hospital, Paris Descartes University, Paris, France, Paris, France, ⁵Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁶Biostatistics, University of California Los Angeles, Los Angeles, CA, ⁷Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, ⁸University of California Los Angeles, Los Angeles, CA
Background/Purpose: Two randomized controlled trials showed modest but significant effects for oral (po) CYC ( superior to placebo and equal to mycophenolate mofetil). A number…
Abstract Number: 804 • 2018 ACR/ARHP Annual Meeting
Prevalence of Echocardiographic Abnormalities in Patients with Systemic Sclerosis
Judit Lluch¹, Francisco Javier Narváez², Pablo Juárez¹ and Joan Miquel Nolla¹, ¹Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ²Rheumatology Department, Hospital Universitario de Bellvitge, Idibell, Barcelona, Spain
Background/Purpose: To determine the prevalence of echocardiographic abnormalities and to identify associated clinical and laboratory features in a large systemic sclerosis (SSc) cohort. Methods: The…
Abstract Number: 805 • 2018 ACR/ARHP Annual Meeting
Diastolic Dysfunction in Scleroderma: An Investigation into Associated Risk Factors and Impact on Survival
Alicia M. Hinze^1,2, Laura K. Hummers¹, Fredrick M. Wigley¹, Monica Mukherjee³ and Ami A. Shah¹, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Division of Rheumatology, Mayo Clinic, Rochester, MN, ³Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Scleroderma heart disease often goes unrecognized until severe clinical manifestations are present. Diastolic dysfunction (DD) may identify patients at risk for cardiac complications by…
Abstract Number: 806 • 2018 ACR/ARHP Annual Meeting
Estradiol Levels Are Elevated in Older Men with Diffuse Cutaneous SSc and Are Associated with Decreased Survival
DeAnna Baker Frost¹, Bethany J Wolf², Christine Peoples³, Katherine Silver⁴, Maureen Laffoon⁵, Thomas A. Medsger Jr.^3,6 and Carol A. Feghali-Bostwick⁴, ¹Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ²Public Health Sciences, Medical University of South Carolina, Charleston, SC, ³Department of Medicine, University of Pittsburgh, Division of Rheumatology and Clinical Immunology, Pittsburgh, PA, ⁴Department of Medicine, Medical University of South Carolina, Division of Rheumatology and Immunology, Charleston, SC, ⁵Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁶Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by excessive extracellular matrix deposition (ECM), leading to dermal and internal organ fibrosis. As in other…
Abstract Number: 807 • 2018 ACR/ARHP Annual Meeting
The Effects of DNA Methylation on Differential Expression in Dermal Fibroblasts from African-American Patients with Systemic Sclerosis
DeAnna Baker Frost¹, Willian da Silveira², Ilia Atanelishvili³, Robert C. Wilson⁴, E. Starr Hazard², Jim C. Oates⁵, Galina S. Bogatkevich³, Carol A. Feghali-Bostwick⁶, Gary Hardiman⁷ and Paula S. Ramos⁸, ¹Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ²Center for Genomic Medicine, Medical University of South Carolina, Charleston, SC, ³Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁴Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, ⁵Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine, Medical University of South Carolina, Division of Rheumatology and Immunology, Charleston, SC, ⁷Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁸Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC
Background/Purpose: The etiology and reasons underlying the ethnic disparities in systemic sclerosis (SSc) remain unknown. African-Americans (AA) are disproportionally affected by SSc, yet dramatically underrepresented…
Abstract Number: 808 • 2018 ACR/ARHP Annual Meeting
Mean Number of Nailfold Capillaries Is Associated with Disease Activity at 6 Months Follow-up in Systemic Sclerosis Patients
Ana Maria Gheorghiu¹, Raida Oneata², Alexandra Radu¹, Anca Briceag¹, Cristiana Draganescu¹, Cristina Vrancianu¹, Stefania Magda³, Tudor Constantinescu⁴, Alina Soare⁵, Rucsandra Dobrota⁶, Ioan Ancuta⁷, Claudia Ciofu⁷, Liviu Macovei⁷, Mihaela Milicescu⁷, Mariana Sasu⁷, Alexandra Enuica⁸, Octavian Linte⁸, Gheorghe Stan⁸, Brindus Comanescu⁸, Teodor Necsoiu⁸, Mihai Bojinca¹, Victor Stoica⁷ and Carina Mihai^7,9, ¹Internal Medicine and Rheumatology, Carol Davila University of Medicine and Pharmacy, Cantacuzino Hospital, Bucharest, Romania, ²Internal Medicine and Rheumatology Department, Carol Davila University of Medicine and Pharmacy, Cantacuzino Hospital, Bucharest, Romania, ³Cardiology Department, University Emergency Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, ⁴Marius Nasta National Pneumology Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, ⁵Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁶Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, ⁷Carol Davila University of Medicine and Pharmacy, Cantacuzino Hospital, Bucharest, Romania, ⁸Optoelectronica, Bucharest, Romania, ⁹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Nailfold capillaroscopy (NFC) is essential in the evaluation and classification of systemic sclerosis (SSc). The mean number of capillaries is considered a promising tool…
Abstract Number: 809 • 2018 ACR/ARHP Annual Meeting
The Lymphangiogenetic Factors VEGF-C, CCL21 and Ang-2 Are Associated with Pulmonary Arterial Hypertension in Systemic Sclerosis
Henriette Didriksen¹, Håvard Fretheim¹, Vyacheslav Palchevskiy², Arne K Andreassen¹, Torhild Garen¹, Oyvind Midtvedt¹, Einar Gude¹, John A Belperio³, Øyvind Molberg¹ and Anna-Maria Hoffmann-Vold¹, ¹Oslo University Hospital, Oslo, Norway, ²University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ³University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Systemic sclerosis (SSc) is characterized by abnormalities in vascular pathways and lymphatic vessels with pulmonary hypertension as a major complication. Vascular endothelial growth factor…
Abstract Number: 810 • 2018 ACR/ARHP Annual Meeting
Sexual Dysfunction in Women with Systemic Sclerosis
Marina Soledad Dalpiaz¹, Juan Argüello², Maria Florencia Rodriguez³, Marta Mamani⁴, Anastasia Secco⁵, Natalia Tamborenea², Eduardo Kerzberg⁶, Sandra Fabiana Montoya⁶, Carolina Aimo⁶, Fernando Manuel Villalobos⁶, Eliana Rebeca Serrano⁷, Maria Elena Crespo Espindola⁸ and Ana Lía Gervilla Galan⁹, ¹Hospital Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Argentina, ²Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ³Reumatologia, Hospital Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Argentina, ⁴Rheumatology Department, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁵Rheumatology Section, Hospital Bernardino Rivadavia, CABA, Argentina, ⁶Hospital General de Agudos José María Ramos Mejía, BUENOS AIRES, Argentina, ⁷Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, ⁸Reumatologia, Hospital Señor del Milagro, Salta, Argentina, ⁹Hospital San Roque, San Salvador de Jujuy, Argentina
Background/Purpose: Impaired sexual function is common among women with chronic illnesses, including Systemic Sclerosis (SSc). Studies of sexual functioning among women with SSc have concluded…
Abstract Number: 811 • 2018 ACR/ARHP Annual Meeting
Identification of Risk Factors for Gastric Antral Vascular Ectasia (GAVE) Among Systemic Sclerosis Patients
Naomi Serling-Boyd¹, Shufeng Li², David Fiorentino², Laren Becker³, Nielsen Fernandez-Becker³, John Clarke⁴ and Lorinda Chung^5,6, ¹Medicine, Stanford University School of Medicine, Stanford, CA, ²Dermatology, Stanford University School of Medicine, Stanford, CA, ³Gastroenterology, Stanford University School of Medicine, Palo Alto, CA, ⁴Gastroenterology, Stanford University School of Medicine, Stanford, CA, ⁵VA Palo Alto Health Care System, Palo Alto, CA, ⁶Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA
Background/Purpose: Gastric Antral Vascular Ectasia (GAVE) is a vascular manifestation of systemic sclerosis (SSc) characterized by erythematous streaks and longitudinal rugal folds in the stomach…
Abstract Number: 812 • 2018 ACR/ARHP Annual Meeting
Inflammatory Stays Inflammatory: A Subgroup of Systemic Sclerosis Characterized By High Morbidity and Inflammatory Resistance to Cyclophosphamide
Aleksey Mitev¹, Daria Feldmann¹, Moritz Binder², Kim Möller³, Anna-Maria Kanne¹, Thomas Hügle⁴, Peter M. Villiger⁵, Reinhard Voll⁶, Stephanie Finzel¹ and Florian Kollert⁷, ¹Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ²Department of Internal Medicine, Mayo Clinic, Rochester, MN, ³Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁴Rheumatology, University Hospital Lausanne (CHUV), Lausanne, Switzerland, ⁵Rheumatology and Clin Immunol, Bern, Switzerland, ⁶Clinic for Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ⁷Department of Rheumatology, Immunology, and Allergology, Inselspital, University Hospital Bern, Bern, Switzerland
Background/Purpose: Elevated levels of C-reactive protein (CRP) in systemic sclerosis (SSc) have been linked to early inflammatory stages of the disease. This study has been…
Abstract Number: 813 • 2018 ACR/ARHP Annual Meeting
Prevalence of Gastroesophageal Disease in Systemic Sclerosis and Its Impact on Lung Disease: Fact or Fiction
Tasneam Shagroni¹, David Lin², Jeremy Wang², Isela Valera³, Aly M Aly⁴, Philip J. Clements², Daniel E. Furst², Rajan Saggar⁵, Jeffrey Conklin⁶ and Suzanne Kafaja², ¹Rheumatology, University of California Los Angeles, Los Angeles, CA, ²University of California Los Angeles, Los Angeles, CA, ³Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, UCLA, Los Angeles, CA, ⁴Alexandria University Faculty of Medicine, Alexandria, Egypt, ⁵UCLA, Los Angeles, CA, ⁶Medicine, University of California Los Angeles, Los Angeles, CA
Background/Purpose: Systemic sclerosis (SSc) patients frequently have upper gastrointestinal (GI) symptoms, with GI involvement being the leading cause of morbidity. Meanwhile, interstitial lung disease (ILD)…
Abstract Number: 814 • 2018 ACR/ARHP Annual Meeting
NON Diffuse SSc, Peripheral Neuropathy, Concomitant Sjogren Syndrome and ANTI-RNA Polymerase III Represent Risk Factors for the Higher Frequency of Cancer in a Large Single Cohort of Patients with Systemic Sclerosis
Ana Paula Luppino-Assad¹, Adriana Bortoluzzo², Henrique Carriço da Silva³, Danieli Andrade⁴ and Percival Sampaio-Barros⁴, ¹Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., sao paulo, Brazil, ²c Instituto Insper de Educação e Pesquisa, São Paulo, SP, Brasil, sao paulo, Brazil, ³Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., SAO PAULO, Brazil, ⁴Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., São Paulo, Brazil
Background/Purpose: A higher prevalence of cancer has been described in patients with systemic sclerosis (SSc), but the magnitude of this risk and the type of…
Abstract Number: 815 • 2018 ACR/ARHP Annual Meeting
Classic and Atypical Polymyalgia Rheumatica, Are Different Syndromes? Study of 93 Patients with PET/CT from a Single Center
Diana Prieto Peña¹, Monica Calderón Goercke¹, Javier Loricera², Isabel Martínez-Rodríguez³, Ignacio Banzo³, Belén Atienza-Mateo⁴, José Luis Martín-Varillas⁴, Vanesa Calvo-Río¹, Carmen Gonzalez Vela⁵, Miguel Angel González-Gay², José Luis Hernández² and Ricardo Blanco⁴, ¹Rheumatology, Rheumatology. Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ²Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ³Nuclear Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ⁴Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ⁵Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain
Background/Purpose: Polymyalgia rheumatica (PMR) is a common inflammatory rheumatic disease of the elderly whose diagnosis is usually based on clinical, analytical and ultrasound findings. However,…

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