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  • Abstract Number: 711 • 2018 ACR/ARHP Annual Meeting

    Recurrence of Lupus Nephritis in Renal Transplant Recipients

    Debendra Pattanaik1, Joseph Green2, Manish Talwar3, Miklos Molnar3 and Syed Hasan Raza1, 1Rheumatology, University of Tennessee Health Science Center, Memphis, TN, 2rheumatology, University of Tennessee Health Science Center, memphis, TN, 3University of Tennessee Health Science Center, Memphis, TN

    Background/Purpose: Recurrence of lupus nephritis in the graft is a concern in lupus patients with end stage renal disease who undergo renal transplantation. The recurrence…
  • Abstract Number: 712 • 2018 ACR/ARHP Annual Meeting

    Higher Prednisolone Dose during Treatment of Tuberculosis Correlates with Mortality during Tuberculosis Treatment in Systemic Lupus Erythematosus Patients: A Retrospective Cohort Study

    Chiao-Feng Cheng, Cheng-Hsun Lu, Song-Chou Hsieh and Ko-Jen Li, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

    Background/Purpose: Tuberculosis (TB) has complex interplay with systemic lupus erythematosus (SLE). In addition, SLE, corticosteroid, and immunosuppressants are associated with TB infection. However, the prognostic…
  • Abstract Number: 713 • 2018 ACR/ARHP Annual Meeting

    Soluble ST2 and CXCL-10 May Serve As Biomarkers of Diastolic Dysfunction in SLE and Correlate with Disease Activity and Damage

    Udi Chorin1, Aviram Hochstadt1, David Levartovsky2, Irena Litinsky3, Ofir Elalouf4, Ari Polachek5, Ilana Kaufman6, Uri Arad7, Valerie Aloush7, Sara Borok Lev-Ran8, Irena Wigler7, Jonathan Wollman7, Dan Caspi2, Yael Lahat2, Or Carmi2, Shlomo Berliner9, Ori Elkayam7, Yan Topilsky1 and Daphna Paran2, 1Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 2Rheumatology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 3Rheumatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 4Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 5Rheumatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv Univrsity, Tel Aviv, Israel, 6Rheumatology, Tel-Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 7Rheumatology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel, 8Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel AViv, Israel, 9Internal Medicine E, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    Background/Purpose: Subclinical myocardial dysfunction has been reported to occur earlyin SLE. The pathogenesis and prognosis of this finding is not clear. The study aims to…
  • Abstract Number: 714 • 2018 ACR/ARHP Annual Meeting

    A Predictive Clinical-Immunological Index for Infections Unveils Novel Innate and Adaptive Immunity Abnormalities As Key Risk Factors for Infections in a Cohort of Patients with Systemic Lupus Erythematosus

    Diana Gómez-Martín1,2, Jiram Torres-Ruíz3, Nancy R Mejía-Domínguez4, Guillermo Juárez-Vega5, Javier Merayo-Chalico3, Ana Barrera-Vargas3 and Jorge Alcocer-Varela1, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico city, Mexico, 3Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City, Mexico, 4Bioinformatics, Biostatistics and Computational Biology Unit, Red de Apoyo a la Investigación. Coordinación de la Investigación Científica, Universidad Nacional Autónoma de México, Mexico, Mexico, 5Flow Cytometry Unit, Red de Apoyo a la Investigación. Coordinación de la Investigación Científica, Universidad Nacional Autónoma de México, Mexico, Mexico

    Background/Purpose: Patients with systemic lupus erythematosus (SLE) have multiple innate and adaptive immune response abnormalities. It is unknown whether they play a key role in…
  • Abstract Number: 715 • 2018 ACR/ARHP Annual Meeting

    Septic Shock Among Patients with Systemic Lupus Erythematosus: Short and Long-Term Outcome and Cost. Analysis of the French Nationwide Database

    Arthur Mageau1, Karim Sacre2, Anne Perozziello1, Stephane Ruckly1, Claire Dupuis1, Lila Bouadma1, Thomas Papo1 and Jean Francois Timsit1, 1Université Paris-Diderot, Paris, France, 2Bichat Hospital, Paris Diderot University, Paris, France

    Background/Purpose: Infection is a leading cause of death and ICU admission in systemic lupus erythematosus (SLE) patients. Our aim was to investigate the outcome and…
  • Abstract Number: 716 • 2018 ACR/ARHP Annual Meeting

    Soluble CD163 Is a Biomarker Associated with Accelerated Carotid Atheroma in SLE Patients at Otherwise Low Risk for Cardiovascular Disease

    Clemence David1, Gillian Divard1, Rachid Abbas1, Brigitte Escoubet1, Marie-Paule Chauveheid1, Diane Rouzaud1, Anne Boutten1, Thomas Papo1, Monique Dehoux1 and Karim Sacre2, 1Université Paris-Diderot, Paris, France, 2Bichat Hospital, Paris Diderot University, Paris, France

    Background/Purpose: Our study aimed to determine whether sCD163, a soluble macrophage marker upregulated in numerous inflammatory disorders, might be predictive of accelerated atherosclerosis associated with…
  • Abstract Number: 717 • 2018 ACR/ARHP Annual Meeting

    The Burden of Chronic Kidney Disease in Systemic Lupus Erythematosus (SLE): A Nationwide Epidemiologic Study

    Arthur Mageau1, Jean Francois Timsit1, Anne Perozziello1, Stephane Ruckly1, Claire Dupuis1, Lila Bouadma1, Thomas Papo1 and Karim Sacre2, 1Université Paris-Diderot, Paris, France, 2Bichat Hospital, Paris Diderot University, Paris, France

    Background/Purpose: Lupus nephritis occurs in about 50% of SLE patients. We aimed to analyze the impact of chronic kidney disease (CKD) on major clinical outcomes…
  • Abstract Number: 718 • 2018 ACR/ARHP Annual Meeting

    Assessing Dyspnea in Patients with Systemic Lupus Erythematosus

    Chia-Chi J. Lee1, Lindsy J. Forbess2, Daniel J. Wallace2, Caroline Jefferies2 and Mariko Ishimori3, 1Cedars-Sinai Medical Center, Los Angeles, CA, 2Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 3Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA

    Background/Purpose: Lungs can be affected in up to 50% of systemic lupus erythematosus (SLE) patients. Our aim was to assess the prevalence and degree of…
  • Abstract Number: 719 • 2018 ACR/ARHP Annual Meeting

    Men and Sexual Function: An Overlooked Issue in Systemic Lupus Erythematosus

    Jonathan Campos-Guzmán1, Ana Barrera-Vargas1, Diana Gómez-Martín2, Jorge Alcocer-Varela2, Samuel Govea-Peláez1, Miguel Angel Gómez-Sámano3, Daniel Cuevas-Ramos3, Diana Marcela Padilla-Ortíz4 and Javier Merayo-Chalico1, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 3Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 4Universidad de la Sabana, Bogotá, Colombia

    Background/Purpose: Whereas SLE is uncommon in men, the disease is usually more severe and requires more aggressive immunosuppression in male patients. There are multiple studies…
  • Abstract Number: 720 • 2018 ACR/ARHP Annual Meeting

    Interkeukin-6 Level in Cerebrospinal Fluid As a Biomarker for Systemic Lupus Erythematosus Patients with Longitudinally Extensive Transverse Myelitis like Neuromyelitis Optica Spectrum Disease

    Yasuhiro Hasegawa1, Yoshiyuki Arinuma1, Kazuma Ino1, Takumi Muramatsu1, Junichi Kondo1, Yu Matsueda1, Takayuki Hoshiyama1, Toshihiro Tono1, Tatsuhiko Wada1, Tatsuo Nagai2 and Sumiaki Tanaka1, 1Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, 2Kitasato University, Department of Rheumatology and Infectious Diseases, Sagamihara, Japan

    Background/Purpose: Demyelinating syndrome in NPSLE includes the wide range of lesions similar to multiple sclerosis (MS). Recently, the diagnostic criteria for neuromyelitis optica spectrum disease…
  • Abstract Number: 721 • 2018 ACR/ARHP Annual Meeting

    The Burden of Renal Arteriosclerosis in Lupus Nephritis: A Cohort Study Examining Prevalence and Predictors of Renal Arteriosclerosis

    Shivani Garg1, Sarah Panzer2, Mike Semanik3 and Christie M. Bartels4, 1Rheumatology/ Medicine, University of Wisconsin - Madison, Fitchburg, WI, 2Nephrology/ Medicine, University of Wisconsin, Madison, WI, 3Nephrology/ Pediatrics, University of Wisconsin, Madison, WI, 4Rheumatology/Medicine, University of Wisconsin - Madison, Madison, WI

    Background/Purpose: Cardiovascular disease (CVD) is significantly accelerated in young systemic lupus erythematous (SLE) patients including those with lupus nephritis (LN). Despite literature suggesting that renal…
  • Abstract Number: 722 • 2018 ACR/ARHP Annual Meeting

    Increased Blood Pressure Visit-to-Visit Variability in Patients with Systemic Lupus Erythematosus: Association with Inflammation, Comorbidities and Increased Mortality

    Tyler Reese1, Alyson Dickson1, Jacquelyn E. Neal2, Jocelyn S. Gandelman3, Omair A. Khan2, April Barnado4, William Dupont2, C. Michael Stein1 and Cecilia P. Chung1, 1Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 2Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, 3Vanderbilt University School of Medicine, Nashville, TN, 4Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Patients with systemic lupus erythematosus (SLE) have increased mortality compared to the general population. As outcomes related to disease control have improved, this mortality…
  • Abstract Number: 723 • 2018 ACR/ARHP Annual Meeting

    Patient-Reported Cognitive Screen Does Not Identify Cognitive Sub-Domains: Exploration of the Subscale Structure of the Perceived Deficits Questionnaire in a Systemic Lupus Erythematosus Cohort

    Lisa Engel1, Jiandong Su1, Emily Nalder2, Yael Goverover3, Monique Gignac4, Carmela Tartaglia5, Nicole Anderson1 and Zahi Touma1, 1University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Department of Occupational Science and Occupational Therapy, University of Toronto, Toronto, ON, Canada, 3Department of Occupational Therapy, New York University, New York, NY, 4Instititue for Work and Health, Toronto, ON, Canada, 5University of Toronto, Krembil Neurosciences Centre, Toronto, ON, Canada

    Background/Purpose: Identifying patients with Systemic Lupus Erythematosus related cognitive impairment (SLE-CI) is critical as SLE-CI can negatively affect employment, quality of life, and disease self-management.…
  • Abstract Number: 724 • 2018 ACR/ARHP Annual Meeting

    Are Traditional Biomarkers of Lupus Associated with Renal Pathology in Lupus Nephritis?

    Kelly Liang1, Kimberly P. Liang2, Yaming Li3, Alex Hurd3, Douglas Landsittel4 and Sheldon Bastacky5, 1Medicine, Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA, 2Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 3Biostatistics, University of Pittsburgh, Pittsburgh, PA, 4Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, 5Pathology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Traditional biomarkers for systemic lupus erythematosus (SLE) and lupus nephritis (LN) include serum creatinine (Cr), complement levels (C3/C4), double-stranded DNA antibody (dsDNA), erythrocyte sedimentation…
  • Abstract Number: 725 • 2018 ACR/ARHP Annual Meeting

    Preliminary Population-Based Incidence and Prevalence Estimates of Primary Discoid Lupus and Cutaneous Lupus Erythematosus from the Manhattan Lupus Surveillance Program

    Peter M. Izmirly1, Jill P. Buyon2, H. Michael Belmont3, Sara Sahl4, Isabella Wan5, Jane E. Salmon6, Anca Askanase7, Joan Bathon8, Laura Geraldino-Pardilla7, Yousaf Ali9, Ellen M. Ginzler10, Chaim Putterman11, Caroline Gordon12, Charles G. Helmick13 and Hilary Parton14, 1NYU Langone Health, New York, NY, 2Medicine, New York University School of Medicine, New York, NY, 3Medicine, NYU Langone Health, New York, NY, 4Pediatrics, Harbor-University of California at Los Angeles Medical Center, Torrance, CA, 5Medicine/Rheumatology, New York University School of Medicine, New York, NY, 6Medicine/Rheumatology, Hospital for Special Surgery, New York, NY, 7Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, 8Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, 9Rheumatology, Mount Sinai Medical Center, New York, NY, 10Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY, 11Rheumatology, Albert Einstein College of Medicine, Bronx, NY, 12Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 13Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, 14Bureau of Epidemiology Services, New York City Department of Health and Mental Hygiene, Long Island City, NY

    Background/Purpose: The extant epidemiologic data of primary discoid lupus erythematosus (DLE) and primary cutaneous lupus erythematosus (CLE) remains limited with few published estimates for the…
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