ACR Meeting Abstracts

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  • Abstract Number: 606 • 2018 ACR/ARHP Annual Meeting

    Similiar Efficacy of Tofacinitib on Disease Activity in Rheumatoid Arthritis Patients with and without Previous Biologicals; Results from the Turkbio Regıstry

    Berrin Zengin1, Nevsun Inanc2, Servet Akar3, Gerçek Can1, Ediz Dalkiliç4, Abdurrahman Tufan5, Soner Senel6, Suleyman Serdar Koca7, Handan Yarkan1, Yavuz Pehlivan8, Zeynep Erturk9, Berna Goker5, Haner Direskeneli2, Merih Birlik1, Nurullah Akkoc10 and Fatos Onen1, 1Rheumatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey, 2Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 3Faculty of Medicine, Department of Rheumatology, Izmir Katip Celebi University, Izmir, Turkey, 4Rheumatology, Uludag University Faculty of Medicine, Bursa, Turkey, 5Internal Medicine-Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey, 6Rheumatology, Kayseri Erciyes University, Faculty of Medicine, Kayseri, Turkey, 7Rheumatology, Firat University Faculty of Medicine, Elazığ, Turkey, 8Rheumatology, Uludag University, Faculty of Medicine, Bursa, Turkey, 9Rheumatology, Marmara University Faculty of Medicine, istanbul, Turkey, 10Rheumatology, İzmir, Turkey, İzmir, Turkey

    Background/Purpose: Tofacitinib, a JAK3 inhibitor has been used to treat patients with rheumatoid arthritis (RA) in Turkey since 2015. The aim of this study was…
  • Abstract Number: 607 • 2018 ACR/ARHP Annual Meeting

    Clinical and Functional Response to Tofacitinib and Adalimumab in Patients with Rheumatoid Arthritis: Probability Plot Analysis of Results from the ORAL Strategy Trial

    Tsutomu Takeuchi1, Josef S. Smolen2, Roy Fleischmann3, Noriko Iikuni4, Haiyun Fan5, Koshika Soma6, Ermeg Akylbekova7 and Tomohiro Hirose8, 1Keio University, Tokyo, Japan, 2Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, 3Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX, 4Pfizer Inc, New York, NY, 5Pfizer Inc, Collegeville, PA, 6Pfizer Inc, Groton, CT, 7IQVIA, Durham, NC, 8Pfizer Japan Inc, Tokyo, Japan

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. ORAL Strategy (NCT02187055), a 12-month, global, Phase 3b/4 study, demonstrated that in…
  • Abstract Number: 608 • 2018 ACR/ARHP Annual Meeting

    Half Dose Reduction of Methotrexate in Patient with RA Who Achieved Clinical Remission

    Takeshi Suzuki, Takayasu Ando, Shoshi Shinagawa, Machiko Mizushima, Tomohiko Shibata and Kimito Kawahata, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan

    Background/Purpose: Recently, it is recommended that tapering csDMARDs could be considered If a patient is in persistent remission. However, the methods of tapering csDMARDs including…
  • Abstract Number: 609 • 2018 ACR/ARHP Annual Meeting

    Multi-Biologic Usage in Rheumatoid Arthritis Is Not Infrequent in the Routine Practice

    Alper Sari1, Levent Kilic1, Berkan Armagan1, Abdulsamet Erden2, Gozde Yardımcı1, Ali Akdogan2, Omer Karadag2, Sule Apras Bilgen2, Ihsan Ertenli2 and Sedat Kiraz2, 1Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 2Rheumatology, Hacettepe University, Faculty of Medicine, Ankara, Turkey

    Background/Purpose: Biologic DMARDs (bDMARDs) have proven efficacy in rheumatoid arthritis (RA) however, some patients inadequately response to multiple bDMARDs.  This study aims to determine the…
  • Abstract Number: 610 • 2018 ACR/ARHP Annual Meeting

    4 Years Follow-up of a Cohort of Patients with Rheumatoid Arthritis in Sustained Clinical Remission with Optimization of Biological Therapy

    María Lourdes Ladehesa-Pineda1, M. Carmen Castro-Villegas1, Montserrat Romero Gómez1, Clementina López-Medina2, Laura Pérez Sánchez3, Ignacio Gómez-García4, Pilar Carreto Font5, Alejandro Escudero-Contreras2, Eduardo Collantes-Estévez2 and Pilar Font-Ugalde2, 1Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 2Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 4Rheumatology, Hospital Universitario Reina Sofia, CÓRDOBA, Spain, 5Centro de Salud Tudera de Duero. Área Este de Valladolid, Valladolid. SPAIN, Valladolid, Spain

    Background/Purpose: Once sustained clinical remission is achieved under tratment with biological therapies, the most efficient strategy is optimization. Searching for the lowest effective dose for…
  • Abstract Number: 611 • 2018 ACR/ARHP Annual Meeting

    Influence of Dose Titration of Concomitant Steroid and Methotrexate during Biologic Therapy in Patients with Rheumatoid Arthritis in Daily Practice Based on the IORRA Cohort

    Yoko Shimizu1, Eiichi Tanaka1, Eisuke Inoue1,2, Kumiko Saka1, Eri Sugano1, Naohiro Sugitani1,3, Moeko Ochiai1, Rei Yamaguchi1, Naoki Sugimoto1, Ayako Nakajima1,3, Katsunori Ikari1, Atsuo Taniguchi1 and Hisashi Yamanaka4, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Division of Medical Informatics, St. Marianna University School of Medicine, Kawasaki, Japan, 3Center for Rheumatic Diseases, Mie University Hospital, Tsu city, Japan, 4Institute of Rheumatology, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: After the introduction of Biological Disease-Modifying Anti-Rheumatic-Drugs (bDMARDs) for the treatment of patients with active rheumatoid arthritis (RA), clinical remission has become an achievable…
  • Abstract Number: 612 • 2018 ACR/ARHP Annual Meeting

    Anti-Drug Antibodies Detected By Competitive ELISA Can Predict Treatment Failure in Patients Taking Adalimumab

    Manca Ogrič1, Polona Žigon1, Katja Lakota1,2, Sonja Praprotnik1, David Drobne3,4, Borut Štabuc3,4, Snezna Sodin Semrl1,2 and Saša Čučnik1,5, 1University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia, 2University of Primorska, Faculty of Mathematics, Natural Science and Information Technology, Koper, Slovenia, 3University Medical Centre Ljubljana, Department of Gastroenterology, Ljubljana, Slovenia, 4University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia, 5University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia

    Background/Purpose: A reduced clinical response in patients taking TNF-alpha inhibitors is influenced by their immunogenicity and therefore the importance of therapeutic drug monitoring has been…
  • Abstract Number: 613 • 2018 ACR/ARHP Annual Meeting

    Interim Analysis of Baseline Characteristics and Preferences of Administration Route of Rheumatoid Arthritis Patients Who Are Bio-Naïve or Switched between Advanced RA Treatments; A Multicenter, Prospective, Observational Study

    Haner Direskeneli1, Omer Karadag2, Aşkın Ateş3, Abdurrahman Tufan4, Nevsun Inanc1, Suleyman Serdar Koca5, Gozde Yildirim Cetin6, Servet Akar7, Muhammet Cinar8, Sedat Yılmaz8, Neslihan Yilmaz9, Ediz Dalkiliç10, Cemal Bes11, Zeynep Ozbalkan12, Baris Yilmazer13, Ali Şahin14, Emine Duygu Ersozlu15, Mehmet Engin Tezcan16, Nesrin Şen16, Gokhan Keser17, Ilkan Tansoker18, Fatma Basak Hacibedel19, Kerem Helvacioglu19 and Levent Mert Gunay18, 1Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 2Hacettepe University Faculty of Medicine, Ankara, Turkey, 3Department of Internal Medicine, Division of Rheumatology, Ankara University School of Medicine, Ankara, Turkey, 4Internal Medicine-Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey, 5Rheumatology, Firat University Faculty of Medicine, Elazığ, Turkey, 6Department of Internal Medicine, Division of Rheumatology, Sutcu Imam University, School of Medicine, Kahramanmaras, Turkey, 7Faculty of Medicine, Department of Rheumatology, Izmir Katip Celebi University, Izmir, Turkey, 8Rheumatology Division, Gülhane Training and Research Hospital, Ankara, Turkey, 9Department of Rheumatology, Bilim University Faculty of Medicine, Istanbul, Turkey, 10Rheumatology, Uludag University Faculty of Medicine, Bursa, Turkey, 11Department of Rheumatology, Health Sciences University Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey, 12Rheumatology Division, Ankara Numune Training and Research Hospital, Ankara, Turkey, 13Internal Medicine, Rheumatology Division, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Turkey, 14Department of Rheumatology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey, 15Rheumatology Division, Ministry of Health Adana City Hospital, Adana, Turkey, 16Rheumatology Division, Ministry of Health İstanbul Kartal Training and Research Hospital, Istanbul, Turkey, 17Rheumatology, Ege University Medical Faculty, Izmir, Turkey, 18Medical Department, Pfizer, Istanbul, Turkey, 19Health Economics and Outcomes Research Department, Pfizer, Istanbul, Turkey

    Background/Purpose: To describe the baseline characteristics, patient and physician preferences of rheumatoid arthritis patients treated with biologics or targeted therapies in a real world setting.…
  • Abstract Number: 614 • 2018 ACR/ARHP Annual Meeting

    Disease Activity One Year after Addition of Bucillamine or Sulfasaladine to Methotrexate in Japanese Patients with Rheumatoid Arthritis : Propensity Score Analysis

    Genki Kidoguchi1 and Kenichiro Tokunaga2, 1General internal medicine, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan, 2Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan

    Background/Purpose: Bucillamine (BUC) is a small-molecule disease-modifying antirheumatic drug (DMARD) developed in Japan. The efficacy of combination therapy with BUC and methotrexate (MTX) has been demonstrated…
  • Abstract Number: 615 • 2018 ACR/ARHP Annual Meeting

    The Comparative Observational Study about Efficacy, Safety and Adherence between Tocilizumab and Infliximab in Patients with Rheumatoid Arthritis

    Mayumi Matsuda1, Yu Funakubo Asanuma2, Yoshinobu Nakao3, Hiroaki Yazawa2, Takuma Tsuzuki Wada4, Noritsune Kouzu5 and Toshihide Mimura2, 1Department of Rheumatology and Applied Immunology, Saitama Medical University, Saitama, Japan, 2Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 3Department of Rheumatology, Saga University Hospital, Saga, Japan, 4Department of Rheumatology and Applied Immunology, Faculty of Medicine,, Saitama Medical University, Saitama, Japan, 5Saitama Medical University, Moroyama, Japan

    Background/Purpose: Since 2003 in Japan, biologic agents have become widely used for RA patients in whom csDMARDs were ineffective. Tocilizumab (TCZ) was approved for marketing…
  • Abstract Number: 616 • 2018 ACR/ARHP Annual Meeting

    Supplementation of Methotrexate (MTX) with Ticagrelor Therapy Suppresses Disease Activity in Patients with Moderate to Very Active Ra; Further Evidence That Adenosine and Its Receptors Mediate the Anti-Inflammatory Activity of MTX

    Pamela B. Rosenthal1, Jeffrey S. Berger2 and Bruce N. Cronstein1, 1Rheumatology, New York University School of Medicine, New York, NY, 2Medicine, Division of Cardiology, New York University School of Medicine, New York, NY

    Background/Purpose: Low dose weekly MTX remains the anchor drug for treatment of Rheumatoid Arthritis. The principal mechanism by which MTX suppresses inflammation in Rheumatoid Arthritis…
  • Abstract Number: 617 • 2018 ACR/ARHP Annual Meeting

    Long-Term Outcome of Rituximab in Rheumatoid Arthritis: Real World Experience

    Candice Low1, Richard Conway1, Francis Young2, Eamonn S. Molloy3, Anne Barbara Mongey3, Oliver FitzGerald4, Anthony G. Wilson5, Ursula Fearon6 and Douglas J. Veale1, 1Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, 2Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, 3Saint Vincent's University Hospital, Dublin 4, Ireland, 4Department of Rheumatology, St Vincent's University Hospital and Conway Institute, University College Dublin, Ireland, Dublin, Ireland, 5UCD School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland, 6Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

    Background/Purpose: Rituximab is an effective treatment for rheumatoid arthritis (RA). Data on long-term outcomes following rituximab treatment are limited. The aim of this study was…
  • Abstract Number: 618 • 2018 ACR/ARHP Annual Meeting

    Blood Lymphocytes Subtypes As Biomarkers for Early Identification of Optimal Responders to Anti-TNF Treatment in Rheumatoid Arthritis

    Cristina Sobrino1, Borja Hernández-Breijo2, Israel Gañán-Nieto1, Carlota García-Hoz1, Victoria Navarro-Compán2, Ana Martínez2, Javier Bachiller1, María Gema Bonilla Hernán2, Dora Pascual-Salcedo2, Garbiñe Roy1, Mónica Vázquez1, Alejandro Balsa2, Luisa María Villar1, Chamaida Plasencia2 and Eulalia Rodríguez-Martín1, 1Immuno-Rheumatology research group, IRYCIS. Ramón y Cajal University Hospital, Madrid, Spain, 2Immuno-Rheumatology research group, IdiPaz. La Paz University Hospital, Madrid, Spain

    Background/Purpose: TNF inhibitors (TNFi) are the most common biologicalagents used as disease-modifying treatment in rheumatoid arthritis (RA). Although these drugs have contributed to change the…
  • Abstract Number: 619 • 2018 ACR/ARHP Annual Meeting

    Patterns of Change of a Second Biological Dmard in a Cohort of Patients with Rheumatoid Arthritis

    Roger Rolon Campuzano1, Andrea Lujan Coronel Ale2, Osvaldo Cerda3,4,5, Fernando Dal Pra6, Emilce E Schneeberger7, María de los Angeles Correa3, Marcos G. Rosemffet8, Emilio Buschiazzo9, Rodrigo García Salinas10, Silvia Beatriz Papasidero11, Belén Barrios12, Hernán Maldonado Ficco13 and Gustavo Citera2, 1Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Buenos Aires, Argentina, 2Rheumatology Section, Instituto de Rehabilitación Psicofísica, CABA, Argentina, 3Rheumatology Section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 4Staff, Buenos Aires, Argentina, 5Sociedad Argentina de Reumatologia, CABA, Argentina, 6Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 7Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 8Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 9Rheumatology Section, Hospital Señor del Milagro, Salta, Argentina, 10Rheumatology Section, Hospital Italiano de La Plata, La Plata, Argentina, 11Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Argentina, Buenos Aires, Argentina, 12Rheumatology section, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, 13Rheumatology Section, Hospital San Antonio de Padua, Río Cuarto- Córdoba, Argentina

    Background/Purpose: Evaluate the survival of the 2nd biological disease modifying drug (bDMARD)and to determine the causes of suspension of the 2nd bDMARD. Methods: Patients ≥…
  • Abstract Number: 620 • 2018 ACR/ARHP Annual Meeting

    Efficacy of a Second Tumor Necrosis Factor Inhibitor (TNFi) in the Treatment of Rheumatoid Arthritis (RA)

    Jennifer Reams1, Andrea Berger2, Philip Dunn2, Eva O'Connell3, William Torelli2, Jason Bankert2, Muhammed Bashir2 and Alfred Denio1, 1Rheumatology, Geisinger Medical Center, Danville, PA, 2Geisinger Medical Center, Danville, PA, 3Internal Medicine, Geisinger Medical Center, Danville, PA

    Background/Purpose: The response rate of TNFis in RA is variable and to some extent unpredictable, making treatment decision-making quite complex.  Some insurance carriers require RA…
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