ACR Meeting Abstracts

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  • Abstract Number: 531 • 2018 ACR/ARHP Annual Meeting

    Association of Rheumatoid Arthritis and Other Autoinmune Diseases

    Eliana Rebeca Serrano1, Julia Sosa2, María Paula Kohan2, María Julia Santa Cruz1, María Alejandra Medina1, Diana Silvia Klajn3, Silvia Beatriz Papasidero4, José Ángel Caracciolo1, Mariana Benegas5, Etel Saturansky6, Rosana Quintana7, Bernardo Pons Estel7, Dora Pereira8, Analía Dellepiane9, Rodrigo García Salinas10, María de los Angeles Correa11, Gustavo Citera12, Mónica Sacnun13, Claudia Hartvig14, Julia Demarchi15, Guillermo Bartel15, Andrea Gómez15, Karin Kirmayr16, José Velasco Zamora17, Yamila Chichotky18, María Marta Zalazar19, Oscar Rillo3, Analía Bohr20, Adriana Pérez Dávila21, Hugo Najera22, Anastasia Secco22, Rene Jearmany Chuquimia22, Alejandro Martinez Muñoz23, Emilio Buschiazzo24, Ricardo Vicente Juárez25, Laura Raiti26, Vanesa Cruzat26, Andrea Smichowski27, Gustavo Casado27, David Marcos Zelaya28, Damaris Álvarez28, Eduardo Kerzberg29, Javier Rosa30, Victoria García31, Cinthya Retamozo32, Ana Carolina Costi33, Claudia Pena34 and Hernán Maldonado Ficco35, 1Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, 2Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Argentina, CABA, Argentina, 3Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, CABA, Argentina, 4Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Argentina, Buenos Aires, Argentina, 5Rheumatology Section, Sanatorio Dr. Julio Méndez, Buenos Aires, Argentina, 6Rheumatology Section, Sanatorio Dr. Julio Méndez, CABA, Argentina, 7Rheumatology Section, Sanatorio Parque S.A., Rosario, Argentina, 8Rheumatology Section, Hospital Dr. Ricardo Gutiérrez, Argentina, Buenos Aires, Argentina, 9Rheumatology Section, CEMEC, Casilda-Santa Fe, Argentina, 10Rheumatology Section, Hospital Italiano de La Plata, La Plata, Argentina, 11Rheumatology Section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 12Rheumatology Section, Instituto de Rehabilitación Psicofísica, CABA, Argentina, 13Rheumatology Section, Hospital Provincial de Rosario, Rosario, Argentina, 14Rheumatology Section, Hospital Provincial de Rosario, Rosario-Santa Fe, Argentina, 15Rheumatology Section, Hospital Británico de Buenos Aires, CABA, Argentina, 16Rheumatology Section, Sanatorio San Carlos de Bariloche, Bariloche, Argentina, 17Rheumatology Section, Reumatologia al Sur, Berazategui- Buenos Aires, Argentina, 18Rheumatology Section, Reumatologia al sur, Berazategui- Buenos Aires, Argentina, 19Rheumatology Section, Hospital General de Agudos Dr. Ignacio Pirovano, Buenos Aires, Argentina, 20Rheumatology Section, Hospital de Rehabilitación Manuel Rocca, Buenos Aires, Argentina, 21Rheumatology Section, Hospital de Rehabilitación Manuel Rocca, CABA, Argentina, 22Rheumatology Section, Hospital Bernardino Rivadavia, CABA, Argentina, 23Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, San Miguel- Buenos Aires, Argentina, 24Rheumatology Section, Hospital Señor del Milagro, Salta, Argentina, 25Rheumatology Section, Hospital Señor del Milagro de Salta, Salta, Argentina, 26Rheumatology Section, Clínica Bessone, San Miguel- Buenos Aires, Argentina, 27Rheumatology Section, Hospital Militar Central, CABA, Argentina, 28Rheumatology Section, Hospital General de Agudos José María Ramos Mejía, CABA, Argentina, 29Rheumatology Section, Hospital General de Agudos José María Ramos Mejía, Buenos Aires, Argentina, 30Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Capital Federal, Argentina, 31Rheumatology Section, Hospital Italiano de Buenos Aires, CABA, Argentina, 32Rheumatology Section, Centro Especializado Diabetes y Reumatologia, Orán- Salta, Argentina, 33Rheumatology Section, Hospital Interzonal General de Agudos Gral. José de San Martín, La Plata, Buenos Aires, Argentina, 34Rheumatology Section, Hospital San Martín de La Plata, La Plata- Buenos Aires, Argentina, 35Rheumatology Section, Hospital San Antonio de Padua, Río Cuarto- Córdoba, Argentina

    Background/Purpose: The coexistence of different autoimmune diseases (AID) has been well established in the literature. In our knowledge, there is no study assessing specifically the…
  • Abstract Number: 532 • 2018 ACR/ARHP Annual Meeting

    Relationship between Insulin Sensitivity and Beta Cell Secretion in Non-Diabetic Rheumatoid Arthritis Subjects

    Esmeralda Delgado-Frías1, Beatriz-Segura Tejera2, Raquel Lopez-Mejías3, De Vera-González AM4, Alejandro Jiménez-Sosa5, Jose M Olmos6, José Luis Hernández7, Javier Llorca8,9, Miguel Angel González-Gay3,10,11,12 and Iván Ferraz-Amaro2, 1Division of Rheumatology.Hospital Universitario de Canarias, La Laguna, Spain, 2Division of Rheumatology.Hospital Universitario de Canarias, Tenerife, Spain, 3Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, 4Division of Central Laboratory. Hospital Universitario de Canarias, San Cristobal de La Laguna, Spain, 5Research Unit. Hospital Universitario de Canarias, Tenerife, Spain, 6Division of Internal Medicine. Hospital Universitario Marqués de Valdecilla, IDIVAL.Universidad de Cantabria., Santander, Spain, 7Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 8Division of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, Santander, Spain, 9CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, 10School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain, 11Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL and School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain, 12Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

    Background/Purpose: In non-diabetic healthy individuals insulin secretion and insulin sensitivity are linked by a negative feedback loop characterized by a hyperbolic function. We aimed to…
  • Abstract Number: 533 • 2018 ACR/ARHP Annual Meeting

    Association between Inflammation and Changes in Kidney Function in Patients with Early Rheumatoid Arthritis

    Ganna Prytkova1, Dmytro Rekalov2 and Daryna Nikitina1, 1Rheumatology, Zaporizhzhya Regional Clinical Hospital, Zaporizhzhya, Ukraine, 2Department of Internal Diseases, Zaporizhzhya Regional Clinical Hospital, Zaporizhzhya, Ukraine

    Background/Purpose: One of the most severe visceral manifestations of RA is nephropathy. The key symptoms of renal dysfunction (RD) are microalbuminuria (MA), β-2-microglobulinuria (β-2M), reduced…
  • Abstract Number: 534 • 2018 ACR/ARHP Annual Meeting

    Increased Insulin Resistance and Impaired Beta-Cell Function in Patients with Rheumatoid Arthritis: The Role of Glucocorticoid Therapy?

    Gorica Ristic1, Vesna Subota2, Dejana Stanisavljevic3, Branislava Glisic1, Milan Petronijevic1 and Dusan Stefanovic1, 1Department of Rheumatology and Clinical Immunology, Military Medical Academy, Belgrade, Serbia, 2Institute of Medical Biochemistry, Military Medical Academy, Belgrade, Serbia, 3Institute of Medical Statistics, Belgrade University School of Medicine, Belgrade, Serbia

    Background/Purpose: Increased insulin resistance and impaired β-cell function have been demonstrated in rheumatoid arthritis (RA). The aim of the study was to analyze the association…
  • Abstract Number: 535 • 2018 ACR/ARHP Annual Meeting

    Is There Achilles Tendon Damage in Rheumatoid Arthritis Patients?

    Marina Natalia Fornaro1, Tomas Cazenave2, Maria Celeste Orozco3, María Victoria Martire4, Estela Reyes2, Haydee Schmulevich2, Gustavo Citera5 and Marcos G. Rosemffet3, 1Section of Rheumatology, Instituto de Rehabilitación Psicofísica, buenos aires, Argentina, 2Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 3Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 4Instituto Médico Platense, La Plata, Argentina, 5Rheumatology Section, Instituto de Rehabilitación Psicofísica, CABA, Argentina

    Background/Purpose: Ankle involvement is common in Rheumatoid Arthritis (RA). It has been reported that more than 90 % of patients develop ankle symptoms over the…
  • Abstract Number: 536 • 2018 ACR/ARHP Annual Meeting

    Prevalence and Relative Factors for Frailty in Patients with RA from a Prospective Observational Study

    Masahiro Tada1, Yutaro Yamada2, Koji Mandai3 and Noriaki Hidaka4, 1Orthopaedic Surgery, Osaka City General Hospital, Osaka, Japan, 2Orthopedic surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, 3Orthopaedic surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, 4Orthopaedic surgery, Osaka City General Hospital, Osaka, Japan

    Prevalence and relative factors for frailty in patients with RA from a prospective observational study Background/Purpose: Frailty is defined as degradation of physical and cognition…
  • Abstract Number: 537 • 2018 ACR/ARHP Annual Meeting

    Increased Risk of Incident Chronic Kidney Disease Among Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Cohort Studies

    Patompong Ungprasert1 and Sukit Raksasuk2, 1Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, 2Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Increased Risk of Incident Chronic Kidney Disease among Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis of Cohort Studies AbstractBackground/Purpose: Patients with rheumatoid arthritis (RA)…
  • Abstract Number: 538 • 2018 ACR/ARHP Annual Meeting

    Type 1 Diabetes in RA: Comparison with Type 2 and Its Association with RA Severity and Treatment

    Sofia Pedro1, Gulsen Ozen2 and Kaleb Michaud1,2, 1FORWARD, The National Databank for Rheumatic Diseases, Wichita, KS, 2Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: DMARD treatment for Rheumatoid Arthritis (RA) has been shown to improve the glucose control and reduce the incidence of diabetes, usually assumed to be…
  • Abstract Number: 539 • 2018 ACR/ARHP Annual Meeting

    Thyroid Function in Early Versus Established Rheumatoid Arthritis

    Suad Hannawi1, Issa Al Salmi2 and Haifa Hannawi3, 1Rheumatology Department. Ministry of Health and Prevention, Asst.Prof, Dubai, United Arab Emirates, 2Prof, Muscat, Oman, 3Research Department. Ministry of Health and Prevention, Asst.Prof, Dubai, United Arab Emirates

    Background/Purpose: Thyroid dysfunction is common in rheumatoid arthritis (RA). Subclinical hypothyroidism is the first most common, followed by clinical hypothyroidism. Thyroid dysfunction in RA had…
  • Abstract Number: 540 • 2018 ACR/ARHP Annual Meeting

    Echocardiographic Abnormalities in Rheumatoid Arthritis Patients Compared to Age, Sex and Traditional Cardiovascular Risk Factors Matched Controls

    Suad Hannawi1, Kashif Naeem2, Haifa Hannawi3 and Issa Al Salmi4, 1Rheumatology Department. Ministry of Health and Prevention, Asst.Prof, Dubai, United Arab Emirates, 2Cardiology Department. Ministry of Health and Prevention, Dr, Dubai, United Arab Emirates, 3Research Department. Ministry of Health and Prevention, Asst.Prof, Dubai, United Arab Emirates, 4Prof, Muscat, Oman

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of the joints with several extra-articular features. Cardiovascular disease (CVD) mortality accounts for 40-50% of…
  • Abstract Number: 541 • 2018 ACR/ARHP Annual Meeting

    Prevalence of Sjögren’s Syndrome in Patients with RA Enrolled in a Large Observational US Registry

    Leslie R Harrold1, Ying Shan2, Sabrina Rebello2, Neil Kramer3, Sean E. Connolly4, Evo Alemao4, Sheila Kelly4, Tammy Curtice4, Joel Kremer5 and Elliot Rosenstein3, 1University of Massachusetts, Worcester, MA, 2Corrona, LLC, Southborough, MA, 3Overlook Medical Center, Institute for Rheumatic & Autoimmune Diseases, Summit, NJ, 4Bristol-Myers Squibb, Princeton, NJ, 5Albany Medical College and the Center for Rheumatology, Albany, NY

    Background/Purpose: Sjögren’s syndrome is a known co-existing autoimmune disease in patients with RA, but its prevalence and impact on RA are poorly understood. The aims…
  • Abstract Number: 542 • 2018 ACR/ARHP Annual Meeting

    Incidence and Prevalence of Interstitial Lung Disease in the US Population and in Patients with RA By Anti-Citrullinated Protein Antibody Status

    Evo Alemao1, Roshini Indrakumar2, Aarti Rao2 and Ying Bao1, 1Bristol-Myers Squibb, Princeton, NJ, 2Mu Sigma, Bangalore, India

    Background/Purpose: Interstitial lung disease (ILD) is recognized as the most common pulmonary extra-articular manifestation of RA. The hazard ratio for 30-year risk of ILD in…
  • Abstract Number: 543 • 2018 ACR/ARHP Annual Meeting

    Disease Severity Among Bio-Naive RA Patients on Csdmards

    Leslie R. Harrold1,2, Jenny Griffith3, Heather J Litman4, Hua Feng2, Casey A. Schlacher5 and Joel Kremer6, 1University of Massachusetts Medical School, Worcester, MA, 2Corrona, LLC, Waltham, MA, 3AbbVie, Inc., North Chicago, IL, 4Corrona LLC, Waltham, MA, 5AbbVie Inc., North Chicago, IL, 6Albany Medical College and the Center for Rheumatology, Albany, NY

    Background/Purpose: Conventional synthetic disease-modifying anti-rheumatic drugs (csDMARD) are recommended as the first-line treatment for patients with rheumatoid arthritis (RA). Guidelines recommend escalation of treatment to…
  • Abstract Number: 544 • 2018 ACR/ARHP Annual Meeting

    Does Anti-Citrullinated Protein Antibody Status Modify Treatment Effect of Certain Biologic DMARDs?

    Evo Alemao1, Yedid Elbez2, Yogesh Saini3, Sean E. Connolly1, Aarti Rao3, Christine K Iannaccone4, Michael E Weinblatt4 and Nancy A. Shadick4, 1Bristol-Myers Squibb, Princeton, NJ, 2Excelya, Boulogne-Billancourt, France, 3Mu Sigma, Bangalore, India, 4Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Multiple therapeutic options with different mechanistic actions are available to treat patients (pts) with RA. However, selecting therapies by the characteristics of pts with…
  • Abstract Number: 545 • 2018 ACR/ARHP Annual Meeting

    How to Treat Rheumatoid Arthritis Patients When Methotrexate Has Failed? Results from the Meteor Registry

    Sytske Anne Bergstra1, Lai-Ling Winchow2, Elizabeth Murphy3, Arvind Chopra4, Karen Salomon-Escoto5, João E. Fonseca6, Cornelia F. Allaart1 and Robert B.M. Landewé7, 1Department of Rheumatology, LUMC, Leiden, Netherlands, 2University of the Witwatersrand, Johannesburg, South Africa, 3University Hospital Wishaw, Scotland, Wishaw, United Kingdom, 4Center for Rheumatic Diseases, Pune, India, 5University of Massachusetts Medical School, Rheumatology Center, UMass Memorial Medical Center, Worcester, MA, 6Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHLN, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, 7Amsterdam Rheumatology & Immunology Center | Zuyderland Medical Center, Heerlen, Netherlands

    Background/Purpose: After failure of initial methotrexate (MTX) treatment in rheumatoid arthritis (RA) patients, various treatment options can be considered. To date, evidence about the preferred…
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