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  • Abstract Number: 1498 • 2019 ACR/ARP Annual Meeting

    A Randomized, Placebo-Controlled Study Evaluating the Safety and Efficacy of Secukinumab in US Biologic-Naive Patients with Active Psoriatic Arthritis and Psoriatic Skin Lesions

    Tien Nguyen1, Melvin Churchill 2, Robert Levin 3, Guillermo Valenzuela 4, Joseph Merola 5, Alexis Ogdie 6, Ana-Maria Orbai 7, Jose Scher 8, Arthur Kavanaugh 9, Shital Agawane 10, Farid Kianifard 11, Chauncy Rollins 11 and Olivier Chambenoit 11, 1Department of Dermatology, University of California, Irvine, Irvine, CA, 2Arthritis Center of Nebraska, Lincoln, NE, 3Clinical Research of West Florida, Inc and University of South Florida, Clearwater/Tampa, FL, 4Integral Rheumatology & Immunology Specialists, Plantation, FL, 5Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, 6Department of Medicine and Rheumatology and Department of Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 7Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 8Division of Rheumatology, New York University School of Medicine and NYU Langone Orthopedic Hospital, New York, NY, 9University of California, San Diego School of Medicine, La Jolla, CA, 10Novartis Healthcare Pvt Ltd, Hyderabad, India, 11Novartis Pharmaceuticals Corporation, East Hanover, NJ

    Background/Purpose: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis that often develops in patients (pts) with psoriasis. Secukinumab (SEC) inhibits IL-17A, a key inflammatory cytokine…
  • Abstract Number: 1499 • 2019 ACR/ARP Annual Meeting

    Golimumab Persistence in Biologic Naive and Non-Naive Patients with Axial Spondyloarthritis: Results of the GO PRACTICE Study

    René-Marc Flipo 1, Florence Tubach 2, Jean Ouaniche 3, Philippe Goupille4, Eric Lespessailles 5, Najat Gouyette 6, Naoual Harid 7, Jean-Marie Fayette 8, Philippe Bertin 9 and Bruno Fautrel 10, 1Roger Salengro University-Hospital, Lille , France, Lille, France, 2Pitié Salpétrière University-Hospital, Paris, Ile-de-France, France, 3Private Practice , Toulon, France, Toulon, France, 4Tours University-Hospital, Tours, France, Tours, France, 5Orléans Regional Hospitals, Orléans ,France, Orléans, France, 6MSD France, Courbevoie ,France, Courbevoie, Ile-de-France, France, 7MSD France, Courbevoie, France, Courbevoie, Ile-de-France, France, 8ClinSearch, Malakoff, France, Malakoff, Ile-de-France, France, 9Limoges University-Hospital , Limoges, France, Limoges, France, 10Pitié-Salpêtrière Hospital, Department of Rheumatology, AP-HP, Sorbonne University, UPMC university, Paris, Ile-de-France, France

    Background/Purpose: The pivotal GO AFTER study [1] and the ongoing observational GO BEYOND study investigate GLM efficacy in rheumatoid arthritis (RA) patients who previously received…
  • Abstract Number: 1500 • 2019 ACR/ARP Annual Meeting

    Effectiveness of Switching Between TNF Inhibitors in Patients with Axial Spondyloarthritis: Is the Reason to Switch Relevant?

    Santiago Rodrigues-Manica1, Alexandre Sepriano 2, Fernando Pimentel-Santos 1, Nélia Gouveia 3, Anabela Barcelos 4, Jaime Branco 1, Miguel Bernardes 5, Raquel Miriam-Ferreira 5, Elsa Vieira-Sousa 6, Sofia Barreira 6, Filipe Vinagre 7, Raquel Roque 7, Helena Santos 8, Nathalie Madeira 8, João Rovisco 9, Alexandra Daniel 9 and Sofia Ramiro 10, 1CEDOC, NOVA-Medical School | Hospital Egas Moniz, CHLO, Lisbon, Lisbon, Portugal, 2Leiden University Medical Center, Leiden, Netherlands, 3CEDOC, NOVA-Medical School, Lisbon, Portugal, Lisboa, Portugal, 4Centro Hospitalar Baixo Vouga | iBemed, University of Aveiro, Aveiro, Portugal, 5Rheumatology, Centro Hospitalar de São João, Porto, Portugal, Porto, Portugal, 6Rheumatology and Metabolic Bone Diseases, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, EPE | Rheumatology Research Unit, Instituto de Medicina Molecular - Faculty of Medicine, University of Lisbon, Lisbon Academic Medical Centre, Lisbon, Portugal,, Lisbon, Portugal, 7Rheumatology, Hospital Garcia de Orta, Almada, Portugal, Almada, Portugal, 8Instituto Português de Reumatologia (IPR), Lisbon, Portugal, 9Rheumatology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Coimbra, Portugal, 10Leiden University Medical Center and Zuyderland Medical Centre, Leiden, Netherlands

    Background/Purpose: Over the last years, and mostly due to lack of alternatives, it has been common practice to start a second TNF inhibitor (TNFi) in…
  • Abstract Number: 1501 • 2019 ACR/ARP Annual Meeting

    Ixekizumab: 52-Week Efficacy and Safety in Radiographic Axial Spondyloarthritis Patients with Prior Inadequate Response/Intolerance to Tumor Necrosis Factor Inhibitors

    Maxime Dougados1, Joachim Sieper 2, Xenofon Baraliakos 3, Filip Van den Bosch 4, Walter P. Maksymowych 5, Joerg Ermann 6, Xiaoqi Li 7, Gaia Gallo 8, Hilde Carlier 7 and Lianne Gensler 9, 1Hôpital Cochin, Paris, France, 2Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, 3Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany, Herne, Germany, 4Ghent University Hospital, Ghent, Belgium, 5University of Alberta, Edmonton, AB, Canada, 6Brigham and Women's Hospital, Boston, 7Eli Lilly and Company, Indianapolis, 8Eli Lilly and Company, Indianapolis, IN, 9University San Francisco California, San Francisco, CA

    Background/Purpose: Week 16 results from COAST-W (NCT02696798) showed that ixekizumab (IXE) was superior to placebo (PBO) in improving the signs and symptoms of active radiographic…
  • Abstract Number: 1502 • 2019 ACR/ARP Annual Meeting

    The Effect of Tofacitinib on Residual Pain in Patients with Psoriatic Arthritis

    Maxime Dougados1, Désirée van der Heijde 2, Clifton Bingham 3, Peter Taylor 4, Lara Fallon 5, John Woolcott 6, Yves Brault 7, Lisy Wang 8 and Meriem Kessouri 7, 1Cochin Hospital, Paris, France, 2Leiden University Medical Center, Leiden, Netherlands, 3Johns Hopkins University, Baltimore, MD, 4University of Oxford, Oxford, United Kingdom, 5Pfizer Inc, Montreal, QC, Canada, 6Pfizer Inc, Collegeville, PA, 7Pfizer Inc, Paris, France, 8Pfizer Inc, Groton, CT

    Background/Purpose: Current treatments for PsA have proven effective in reducing patient (pt)-reported pain;1,2 however, residual pain often remains. Tofacitinib is an oral Janus kinase inhibitor…
  • Abstract Number: 1503 • 2019 ACR/ARP Annual Meeting

    Safety Profile of Ixekizumab Treatment in Patients with Moderate-to-Severe Plaque Psoriasis and Psoriatic Arthritis: Integrated Analysis of 18 Clinical Trials

    Mark Genovese1, Hideto Kameda 2, Proton Rahman 3, Juan Cañete 4, Sandra Garces 5, Wen Xu 6, Matthew M. Hufford 5 and Bernard Combe 7, 1Stanford University, Stanford, CA, 2Toho University, Tokyo, Japan, Tokyo, Japan, 3Memorial University, Newfoundland, NL, Canada, 4Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Spain, 5Eli Lilly and Company, Indianapolis, IN, 6Eli Lilly and Company, Indianapolis, 7CHU Montpellier, Montpellier University, Montpellier, France

    Background/Purpose: Ixekizumab (IXE) is a high-affinity monoclonal antibody that specifically targets IL-17A. Pooled safety data from IXE studies in moderate-to-severe plaque psoriasis (PsO) and psoriatic…
  • Abstract Number: 1504 • 2019 ACR/ARP Annual Meeting

    Subcutaneous Secukinumab 150 Mg Provides Rapid and Sustained Relief in Total and Nocturnal Back Pains, Morning Stiffness, and Fatigue in Patients with Active Ankylosing Spondylitis over 4 Years

    Helena Marzo-Ortega1, Corinne Miceli-Richard 2, Sonja Gill 3, Marina Magrey 4, Paula Machado 5, Abhijit Shete 6, Jianyuan Wang 6, Susanne Rohrer 6 and Atul Deodhar 7, 1NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, University of Leeds, Leeds, Leeds, United Kingdom, 2Paris Descartes University, Department of Rheumatology - Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, 3412 – 3075 Hospital Gate, Oakville, Canada, 4Division of Rheumatology, The MetroHealth System and School of Medicine, Case Western Reserve University, Cleveland, OH, 5Novartis Pharmaceuticals Corporation, East Hanover, NJ, 6Novartis Pharma AG, Basel, Switzerland, 7Oregon Health & Science University, Portland, OR

    Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory condition. Pain, stiffness, and fatigue are reported as the most troubling symptoms by 70–80%, 20–40%, and 50–60%…
  • Abstract Number: 1505 • 2019 ACR/ARP Annual Meeting

    Persistence with Etanercept in Patients with Ankylosing Spondylitis or Psoriatic Arthritis in Germany: A Real-World Analysis

    Xenofon Baraliakos1, Denis Poddubnyy 2, Frank Behrens 3, Cinzia Curiale 4, Miriam Tarallo 4, Ana Cristina Hernandez Daly 5, Olaf Behmer 6, Joseph Cappelleri 7, Nicholas Hudson 8 and Christen Gray 8, 1Rheumatology Department, Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, 2Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany, 3Rheumatology Goethe-University Frankfurt & Fraunhofer IME-TMP, Frankfurt, Germany, 4Pfizer Inc., Rome, Italy, 5Pfizer Inc., Athens, Greece, 6Pfizer Inc., Berlin, Germany, 7Pfizer Inc, Groton, CT, 8IQVIA, London, United Kingdom

    Background/Purpose: Ankylosing spondylitis (AS) and psoriatic arthritis (PsA) treatment includes biologics, prescribed on a long-term basis. As persistence data from real-world practice are limited, the…
  • Abstract Number: 1506 • 2019 ACR/ARP Annual Meeting

    Long‑Term Certolizumab Pegol Treatment of Axial Spondyloarthritis Is Associated with Rapid and Sustained Reduction of Active Inflammation and Minimal Structural Changes in the Spine: 4‑Year MRI Results

    Xenofon Baraliakos1, Sebastian Kruse 2, Simone Auteri 3, Natasha de Peyrecave 4, Tommi Nurminen 5, Thomas Kumke 5, Bengt Hoepken 6 and Jürgen Braun 2, 1Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany, Herne, Germany, 2Rheumazentrum Ruhrgebiet/Ruhr University, Herne, Germany, 3UCB Pharma, Brussels, Belgium, 4UCB Pharma, Slough, United Kingdom, 5UCB Pharma, Monheim, Germany, 6UCB Pharma, Monheim am Rhein, Germany

    Background/Purpose: Inflammation of the spine is believed to trigger a repair mechanism that results in syndesmophyte formation in axial spondyloarthritis (axSpA) patients (pts).1 Bone marrow…
  • Abstract Number: 1507 • 2019 ACR/ARP Annual Meeting

    Certolizumab Pegol Improves Work and Household Productivity and Social Participation over 1 Year of Treatment in Patients with Non-Radiographic Axial Spondyloarthritis

    Atul Deodhar1, Lianne Gensler 2, Jonathan Kay 3, Walter P. Maksymowych 4, Nigil Haroon 5, Robert B.M. Landewé 6, Martin Rudwaleit 7, Stephen Hall 8, Lars Bauer 9, Bengt Hoepken 9, Natasha de Peyrecave 10, Thomas Kumke 11 and Désirée van der Heijde 12, 1Oregon Health & Science University, Portland, OR, 2University San Francisco California, San Francisco, CA, 3UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA, 4University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, 5Toronto Western Hospital, Krembil Research Institute, University of Toronto, Toronto, ON, Canada, 6Amsterdam University Medical Center, Amsterdam, Netherlands, 7Klinikum Bielefeld, Charité Berlin, Gent University, Bielefeld, Germany, 8Monash University and Emeritus Research, Melbourne, Australia, 9UCB Pharma, Monheim am Rhein, Germany, 10UCB Pharma, Slough, United Kingdom, 11UCB Pharma, Monheim, Germany, 12Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Patients (pts) with non-radiographic axial spondyloarthritis (nr-axSpA) report substantial impairment of productivity and daily activities due to the burden of their disease, similar to…
  • Abstract Number: 1508 • 2019 ACR/ARP Annual Meeting

    Certolizumab Pegol-Treated Patients with Non-Radiographic Axial Spondyloarthritis Demonstrate Improvements in Sleep Quality and Other Patient Reported Outcomes

    Lianne Gensler 1, Jonathan Kay 2, Walter P. Maksymowych 3, Nigil Haroon 4, Lars Bauer 5, Bengt Hoepken 5, Natasha de Peyrecave 6, Thomas Kumke 7 and Atul Deodhar8, 1University San Francisco California, San Francisco, CA, 2UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA, 3University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, 4Toronto Western Hospital, Krembil Research Institute, University of Toronto, Toronto, ON, Canada, 5UCB Pharma, Monheim am Rhein, Germany, 6UCB Pharma, Slough, United Kingdom, 7UCB Pharma, Monheim, Germany, 8Oregon Health & Science University, Portland, OR

    Background/Purpose: Pain, fatigue, morning stiffness and impaired sleep are some of the main symptoms contributing to reduced quality of life (QoL) in patients (pts) with…
  • Abstract Number: 1509 • 2019 ACR/ARP Annual Meeting

    Impact of Age and Disease Duration on the Response to IL-17A Inhibitor (Secukinumab) Treatment in Ankylosing Spondylitis: Pooled Results from the Phase 3 MEASURE Studies

    Atul Deodhar1, Philip Mease 2, Paula Machado 3, Xiangyi Meng 3, Vibeke Strand 4 and Marina Magrey 5, 1Oregon Health & Science University, Portland, OR, 2Swedish Medical Center/Providence St Joseph Health, and University of Washington, Seattle, WA, 3Novartis Pharmaceuticals Corporation, East Hanover, NJ, 4Division of Immunology/Rheumatology, Stanford University, Stanford, CA, 5Division of Rheumatology, The MetroHealth System and School of Medicine, Case Western Reserve University, Cleveland, OH

    Background/Purpose: Ankylosing spondylitis (AS), a chronic inflammatory disease involving the sacroiliac joints and spine, is associated with pain, stiffness, disability, and reduced quality of life.1,2…
  • Abstract Number: 1510 • 2019 ACR/ARP Annual Meeting

    Ixekizumab Improves Fatigue, Pain, and Sleep up to 52 Weeks in Patients with Radiographic Axial Spondyloarthritis

    Atul Deodhar1, Philip Mease 2, Proton Rahman 3, Victoria Navarro-Compán 4, Vibeke Strand 5, Theresa Hunter 6, David Sandoval 7, Jeffrey Lisse 7, Fangyi Zhao 7 and Helena Marzo-Ortega 8, 1Oregon Health & Science University, Portland, OR, 2Swedish Medical Center/Providence St Joseph Health, and University of Washington, Seattle, WA, 3Memorial University, Newfoundland, NL, Canada, 4University Hospital La Paz, IdiPaz, Madrid, Spain, 5Division of Immunology/Rheumatology, Stanford University, Stanford, CA, 6Eli Lilly and Company, Indianapolis, 7Eli Lilly and Company, Indianapolis, IN, 8NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, University of Leeds, Leeds, Leeds, United Kingdom

    Background/Purpose: Axial spondyloarthritis (axSpA) is an inflammatory condition affecting sacroiliac joints and axial skeleton, characterized by fatigue, spinal pain, and sleep disturbances that negatively affect…
  • Abstract Number: 1511 • 2019 ACR/ARP Annual Meeting

    Drug Survival of Ustekinumab in Psoriatic Arthritis: A Real-World Multicentric Cohort of 252 Patients

    Jean-Guillaume Letarouilly1, Benoit Flachaire 2, Céline Labadie 3, Jérémie Sellam 4, Pascal Richette 5, Philippe Dieudé 6, Pascal Claudepierre 7, Bruno Fautrel 8, Eric Houvenagel 9, Chi Duc Nguyen 10, Marie-Hélène Guyot 11, Nicolas Segaud 12, Frédéric Maury 13, Laurent Marguerie 14, Xavier Deprez 15, Jean-Hugues Salmon 16, Guy Baudens 17, Elisabeth Gervais 18, Isabelle Chary-Valckenaere 19, Pierre Lafforgue 20, Damien Loeuille 21, Christophe Richez 22, Thao Pham 20 and René-Marc Flipo 23, 1University of Lille, CHU Lille, department of rheumatology, 59,000 Lille, France, Lille, Nord-Pas-de-Calais, France, 2Aix-Marseille University, CHU Marseille, department of Rheumatology, 13,000 Marseille, France, Marseille, Provence-Alpes-Cote d'Azur, France, 3Bordeaux University, CHU Bordeaux, department of Rheumatology, 33,000 Bordeaux, France, Bordeaux, Aquitaine, France, 4Service de Rhumatologie, AP-HP Hôpital Saint-Antoine, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, 5Department of Rheumatology, AP-HP Lariboisiere Hospital, Paris, France, 6Rheumatology, Bichat Hospital, APHP, Paris;, Paris, France, 7Rheumatology, CHU Henri Mondor Créteil, Paris, France, 8Pitié-Salpêtrière Hospital, Department of Rheumatology, AP-HP, Sorbonne University, UPMC university, Paris, Ile-de-France, France, 9Rheumatology, Saint Philibert Hospital, Lille Cathololic Institute, Lomme, Lomme, France, 10Rheumatology, Hospital of Béthune, Béthune, Béthune, France, 11Rheumatology, Hospital of Roubaix, Roubaix, Roubaix, France, 12Internal Medicine, Hospital of Armentières, Armentières, Armentières, France, 13Rheumatology, Private Practice, Beuvry, Beuvry, France, 14Rheumatology, Calot Institute, Berck, Berck-sur-Mer, 15Rheumatology, Hospital of Valenciennes, Valenciennes, Valenciennes, France, 16Rheumatology, Reims University Hospital, Reims, Reims, France, 17Rheumatology, Private Practice, Valenciennes, Valenciennes, France, 18CHU de Poitiers, Rheumatology, Poitiers, France, 19Centre Hospitalier Universitaire de Nancy, VANDOEUVRE, France, 20Aix-Marseille University, CHU Marseille, department of Rheumatology, 13,000 Marseille, France, Marseille, France, 21Rheumatology, Nancy University Hospital and and UMR 7365 CNRS-UL IMoPA, Université de Lorraine, VANDOEUVRE, France, 22Pellegrin Hospital, University Hospital of Bordeaux, Bordeaux, France, 23University of Lille, CHU Lille, department of rheumatology, 59,000 Lille, France, Lille, France

    Background/Purpose: Ustekinumab (UST) is a new biological Disease-modifying AntiRheumatic Drug (bDMARD) available in psoriatic arthritis (PsA), targeting respectively IL12-23. Real-world data are missing for this…
  • Abstract Number: 1512 • 2019 ACR/ARP Annual Meeting

    Retention Rates and Response of Anti-TNF Treatments in the Enteropathic Spondylitis: HUR-BIO Real Life Results

    Gozde Kubra Yardımcı 1, Bayram Farisoğulları 1, Alper Sarı 1, Levent Kilic 2, Berkan Armagan 3, Emre Bilgin 1, Ertugrul Cagri Bolek 1, Omer Karadag 4, Ali Akdoğan 1, Şule Apras Bilgen 2, Ali İhsan Ertenli 1, Sedat Kiraz 2 and Umut Kalyoncu5, 1Hacettepe University Vasculitis Centre, Ankara, Turkey, Ankara, Turkey, 2Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, 3Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey., Ankara, Turkey, 4Hacettepe University Vasculitis Centre, Ankara, Turkey / Vasculitis and Lupus Clinic, Addenbrooke’s Hospital, University of Cambridge, UK, Ankara, Turkey, 5Hacettepe University Department of Rheumatology, Ankara, Turkey

    Background/Purpose: Enteropathic spondylitis (eSpA) is younger brother of spondyloarthritis, and the retention rate of biological DMARD in eSpA was not yet clear.  The objective of this study was to…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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