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  • Abstract Number: 470 • 2018 ACR/ARHP Annual Meeting

    Pro-Inflammatory High Density Lipoprotein Function Is Associated with Accelerated Carotid Intimal Medial Thickness Progression in Childhood-Onset SLE

    Jennifer C. Cooper1, Stacy P. Ardoin2, Emily von Scheven3, Laura E. Schanberg4, Brian Skaggs5 and Maureen A. McMahon6, 1Pediatrics, Divison of Rheumatology, University of California, San Francisco, San Francisco, CA, 2Division of Rheumatology, Nationwide Children’s Hospital, Columbus, OH, 3Pediatric Rheumatology, University of California San Francisco, San Francisco, CA, 4Duke University Medical Center, Durham, NC, 5Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 6University of California, Los Angeles, Los Angeles, CA

    Background/Purpose: Patients with childhood-onset(cSLE) are at significantly increased risk of death from cardiovascular disease when they reach early adulthood. The Atherosclerosis Prevention Pediatric Lupus Erythematous…
  • Abstract Number: 471 • 2018 ACR/ARHP Annual Meeting

    Early Signs of Diastolic Impairment in Children with Incident Systemic Lupus Erythematosus

    Joyce C. Chang1,2, Brian R. White3, Matthew D. Elias3, Rui Xiao4, Andrea M. Knight5,6,7, Pamela F. Weiss8,9,10 and Laura M. Mercer-Rosa3,7, 1Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, 3Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, 4Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 5Center for Pediatric Clinical Effectiveness & PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, 6Division of Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, 7Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 8Center for Clinical Epidemiology and Biostastistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 9Division of Rheumatology, Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, 10Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

    Background/Purpose: The timing and etiology of diastolic impairment in pediatric-onset systemic lupus erythematosus (pSLE) are poorly understood, and the role of screening echocardiography remains unclear.…
  • Abstract Number: 472 • 2018 ACR/ARHP Annual Meeting

    Libman Sacks Endocarditis in Pediatric Systemic Lupus Erythematosus: Clinical Features and Complications

    Marla Guzman, Meiqian Ma, B. Anne Eberhard and Joyce Hui-Yuen, Pediatric Rheumatology, Cohen Children's Medical Center, New Hyde Park, NY

    Background/Purpose:        Libman-Sacks endocarditis (LSE) is a rare manifestation of pediatric-onset systemic lupus erythematosus (pSLE). It is difficult to differentiate LSE from infective endocarditis (IE) in immunosuppressed…
  • Abstract Number: 473 • 2018 ACR/ARHP Annual Meeting

    A Weighty Diagnosis: Weight Change and Risk Factors in Early Juvenile Systemic Lupus Erythematosus

    Erin Treemarcki1, Jackie Szymonifka2, Alexa Adams3, Nancy Pan4, Sarah Taber5 and Karen Onel5, 1Hospital for Special Surgery Weill Cornell Medical College, New York, NY, 2Hospital for Special Surgery, New York, NY, 3Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, 4Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 5Pediatric Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY

    Background/Purpose: SLE is a chronic, multisystem autoimmune condition with multiple comorbidities due to inflammation and treatment, including metabolic syndrome, poor cardiac outcome, and poor quality…
  • Abstract Number: 474 • 2018 ACR/ARHP Annual Meeting

    Lupus Impact Tracker (LIT) As a New Tool in Assessing Patient Reported Outcome in Pediatric Lupus

    Suhas Ganguli1, Joyce Hui-Yuen1, Meenakshi Jolly2,3, Jane Cerise4 and B. Anne Eberhard5, 1Pediatric Rheumatology, Cohen Children's Medical Center, Lake Success, NY, 2Rush University Medical Center, Chicago, IL, 3Rheumatology, Rush University Medical Center, Chicago, IL, 4Biostatistics, The Feinstein Institute for Medical Research, Manhasset, NY, 5Pediatric Rheumatology, Cohen Children's Medical Center, New Hyde Park, NY

    Background/Purpose: Patient Reported Outcome (PRO) measures for Quality of Life (QoL) in patients with lupus are useful supplements to the physician-derived indices of disease activity…
  • Abstract Number: 475 • 2018 ACR/ARHP Annual Meeting

    Adolescents’ Perspectives on Living with Childhood-Onset Systemic Lupus Erythematosus

    Onengiya Harry1, Angela C Combs2, Brooke Hater2, Emily Roemisch2, Leslie A. Favier3, Najla Aljaberi4, Aimee W Smith2, Rhyanne McDade2, Lauren Fussner5, Jennifer L. Huggins6, Lori E Crosby2 and Avani C Modi7, 1Pediatric Rheumatology, Cincinnati Childrens' Hospital Medical Center, Cincinnati, OH, 2Behavior Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Pediatric Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 5Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 7Center for Treatment Adherence and Self-Management, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Non-adherence to medical recommendations in childhood-onset systematic lupus erythematosus (cSLE) is estimated to be between 40-50%. For patients with cSLE, non-adherence results in increased…
  • Abstract Number: 476 • 2018 ACR/ARHP Annual Meeting

    A Better Understanding of Childhood Sjögren Syndrome: Evaluation of the 2016 Acr/EULAR Classification Criteria for Use in Diagnosing Sjögren Syndrome in Children

    Matthew Basiaga1, Sara M. Stern2, Jay Mehta3 and Scott Lieberman4, 1University of Washington, Division of Pediatric Rheumatology, Seattle Children's Hospital, Seattle, WA, 2Pediatrics-Rheumatology, University of Utah, Salt Lake City, UT, 3Rheumatology, Children’s Hospital of Philadelphia, Philadelphia, PA, 4Pediatrics (Division of Rheumatology), University of Iowa Stead Family Children's Hospital, Iowa City, IA

    Background/Purpose: Clinical presentation of Sjögren syndrome in children differs from adults: dryness symptoms are more common in adults, while parotitis is more common in children.…
  • Abstract Number: 477 • 2018 ACR/ARHP Annual Meeting

    Early Treatment with Intravenous Pulse Methylprednisolone or Methotrexate Is Associated with Decreased Medication Requirements at 12 and 24 Months in Patients with Juvenile Dermatomyositis: A Propensity Score Analysis

    Takayuki Kishi1,2, Jesse Wilkerson3, Marjo Smith3, Nastaran Bayat1, Michael Henrickson4, Bianca Lang5, Murray Passo6, Frederick W. Miller1, Michael Ward7 and Lisa G. Rider1, 1Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, 2Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan, 3Social & Scientific Systems, Inc., Durham, NC, 4Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5Department of Pediatrics, IWK Health Centre and Dalhousie University, Halifax, NS, Canada, 6Division of Rheumatology PTD, Medical University of South Carolina, Charleston, SC, 7National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

    Background/Purpose: Daily oral prednisone has been the main therapy in juvenile dermatomyositis (JDM), and combination therapy with methotrexate (MTX) introduced soon after diagnosis has been…
  • Abstract Number: 478 • 2018 ACR/ARHP Annual Meeting

    Evidence Based Recommendations for Corticosteroid Tapering/Discontinuation in New Onset Juvenile Dermatomyositis Patients: Results from the Paediatric Rheumatology International Trials Organisation

    Gabriella Giancane1, Claudio Lavarello2, Angela Pistorio2, Francesco Zulian2, Bo Magnusson3, Tadej Avcin2, Fabrizia Corona2, Valeria Gerloni2, Serena Pastore2, Roberto Marini2, Silvana Martino2, Anne Pagnier4, Michel Rodiere2, Christine Soler2, Valda Stanevicha2, Rebecca ten Cate2, Yosef Uziel2, Jelena Vojinovic2, Elena Fueri2, Angelo Ravelli5, Alberto Martini6 and Nicola Ruperto7, 1Clinica Pediatrica - Reumatologia, Istituto Giannina Gaslini, Genoa, Italy, 2Istituto Giannina Gaslini - Clinica Pediatrica e Reumatologia - PRINTO, Genoa, Italy, 3Karolinska University Hospital, Stockholm, Sweden, 4Istituto Giannina Gaslini - Clinica Pediatrica e Reumatologia - PRINTO, Genova, Italy, 5Clinica Pediatrica - Reumatologia, Istituto Giannina Gaslini, Genova, Italy, 6Universita di Genova Pediatria II, Genova, Italy, 7Istituto Giannina Gaslini - Clinica Pediatrica e Reumatologia, Genoa, Italy

    Background/Purpose: At present no clear evidence based guidelines exist to standardize the tapering and discontinuation of corticosteroids (CS) in juvenile dermatomyositis (JDM). Aim of our…
  • Abstract Number: 479 • 2018 ACR/ARHP Annual Meeting

    Intravenous Immunoglobulin in Combination with Intravenous Methylprednisolone in the Treatment of Calcinosis Associated with Juvenile Dermatomyositis (JDM)

    Marc Phillpotts1, Eman Alshaikh1, Yaseen Aleatany1, Olcay Y. Jones2, Gulnara Mamyrova1, Lisa G. Rider3 and Rodolfo Curiel1, 1Department of Medicine, Division of Rheumatology, The George Washington University, Washington, DC, 2Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, 3Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD

    Background/Purpose: Calcinosis is a major complication of JDM and is associated with disability and poor quality of life. There are no known effective treatments for…
  • Abstract Number: 480 • 2018 ACR/ARHP Annual Meeting

    Analyze Myositis with Ultrasound and Exercise (AMUSE) Kids- Initial Analysis of Longitudinal Data

    Laura Tasan1, Emily Brunner2, Judy Squires3, Rohit Aggarwal4, Chester V. Oddis4, Christina K. Zigler5, Kaila Schollaert-Fitch6, Emily Mirizio7 and Kathryn S. Torok2, 1Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 2Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 3Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 4Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh/University of Pittsburgh Medical Center, Pittsburgh, PA, 5University of Pittsburgh Med Ctr, Pittsburgh, PA, 6Pediatric Rheumatology, University of Pittsburgh Med Ctr, Pittsburgh, PA, 7Peds Rheum, University of Pittsburgh Med Ctr, Pittsburgh, PA

    Background/Purpose:  There is an unmet need for more objective disease outcome measures in Juvenile Myositis (JM) patients.  This pilot study sought to test the reliability,…
  • Abstract Number: 481 • 2018 ACR/ARHP Annual Meeting

    Stepping It up: The Use of Physical Activity Monitors As an Outcome Measure in Juvenile Myositis

    Emily Brunner1, Laura Tasan2, Kathryn S. Torok3, Bonny Rockette-Wagner4, Christina K. Zigler5, Kaila Schollaert-Fitch3, Diane Koontz6, Chester V. Oddis7 and Rohit Aggarwal8, 1Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 2Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 3Pediatric Rheumatology, University of Pittsburgh Med Ctr, Pittsburgh, PA, 4University of Pittsburgh Medical Center, Pittsburgh, PA, 5Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA, 6Internal Medicine Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, 7Division of Rheumatology and Clinical Immunology, Department of Medicine, Unviersity of Pittsburgh/University of Pittsburgh Medical Center, Pittsburgh, PA, 8Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh/University of Pittsburgh Medical Center, Pittsburgh, PA

    Background/Purpose: The use of physical activity monitors (PAM), which objectively quantify free-living movement, may enhance assessment of disease activity in juvenile myositis (JM) clinical trials…
  • Abstract Number: 482 • 2018 ACR/ARHP Annual Meeting

    The Association of Short-Term Ultraviolet Radiation Exposure and Calcinosis in Juvenile Dermatomyositis in the Childhood Arthritis & Rheumatology Research Alliance Registry

    Jessica Neely1, Craig S. Long2, Hugh Sturrock3 and Susan Kim4, 1Pediatric Rheumatology, University of California, San Francisco, San Francisco, CA, 2National Oceanic and Atmospheric Administration (NOAA)/Climate Prediction Center, College Park, MD, 3Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 4Pediatric Rheumatology, University of California, San francisco School of Medicine, San Francisco, CA

    Background/Purpose: JDM is an autoimmune systemic vasculopathy characterized by myositis and skin rash.  Some myositis specific antibodies (MSAs) are associated with clinical manifestations in JDM,…
  • Abstract Number: 483 • 2018 ACR/ARHP Annual Meeting

    Correlation between Disease Activity and Hip Score in Patients with Rheumatoid Arthritis after Total Hip Arthroplasty

    Hiroki Wakabayashi1,2, Masahiro Hasegawa3 and Akihiro Sudo4,5, 1Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan, 2Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan, 3Mie University Graduate School of Medicine, Tsu, Japan, 4Department of Orthopaedic surgery, Mie University Graduate School of Medicine, Tsu-city, Japan, 5Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu City, Japan

    Background/Purpose: The Disease Activity Score including 28 joints (DAS28), the Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI) were developed in…
  • Abstract Number: 484 • 2018 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Patients Have Lower Preoperative Expectations but Greater Clinical Improvement after Total Knee Arthroplasty Compared to Osteoarthritis Patients

    Jason Blevins1, Yu-fen Chiu2, Stephen Lyman3, Susan M. Goodman1, Lisa A. Mandl4, Peter K. Sculco5, Mark P. Figgie6 and Alexander McLawhorn2, 1Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, new york, NY, 3Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, 4Rheumatology, Hospital for Special Surgery, New York, NY, 5Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, 6Surgery, Hospital for Special Surgery, New York, NY

     Background/Purpose: Preoperative patient expectations of Total Knee Arthroplasty (TKA) influence postoperative outcomes and satisfaction. Rheumatoid Arthritis (RA) may lower preoperative expectations after TKA compared to…
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