Abstracts Archive - Page 1010 of 2607 - ACR Meeting Abstracts

Abstract Number: 1048 • 2019 ACR/ARP Annual Meeting
Clonally Expanded CD4+ Cytotoxic T Cells, Endothelial Cell Apoptosis and the Pathogenesis of Early Systemic Sclerosis
Takashi Maehara ¹, Cory Perugino², Naoki Kaneko ¹, Hamid Mattoo ³, Jesper Kers ⁴, Hugues Allard-Chamard ⁵, Vinay Mahajan ⁵, Hang Liu ⁵, Samuel Murphy ⁵, Musie Ghebremichael ⁵, Yesim Tuncay ⁵, Emanuel Della Torre ⁶, Lloyd Liang ², Sydney Montesi ⁷, Zachary Wallace ², David Fox ⁸, Robert Lafyatis ⁹, John Stone ¹⁰, Dinesh Khanna ¹¹ and Shiv Pillai ¹², ¹Kyushu University, Fukuoka, Japan, ²Massachusetts General Hospital, Boston, ³Sanofi, Cambridge, ⁴University of Amsterdam, Amsterdam, Netherlands, ⁵Ragon Institute of MGH, MTI and Harvard, Cambridge, ⁶Hospital San Raffaele, milan, Italy, ⁷Massachusetts General Hospital, Boston, MA, ⁸University of Michigan, Ann Arbor, ⁹University of Pittsburgh, Pittsburgh, PA, ¹⁰Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ¹¹Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, ¹²Ragon Institude of MGH, MIT and Harvard, Charlestown, MA
Background/Purpose: The CD4+ T cell subset driving the pathogenesis of systemic sclerosis (SSc) remains poorly understood. Many different CD4+ T cell subsets have been implicated,…
Abstract Number: 1049 • 2019 ACR/ARP Annual Meeting
Induction of a Profibrotic Phenotype in Normal Dermal Fibroblasts by Expression of PIM1 Kinase and Demonstration of Antifibrotic Effects of Inhibition of PIM Kinases in Systemic Sclerosis Dermal Fibroblasts
Danielle Pomante ¹, Sergio Jimenez ² and Sonsoles Piera-Velazquez¹, ¹Thomas Jefferson University, Philadelphia, PA, ²Jefferson Institute of Molecular Medicine and Division of Connective Tissue Diseases, Thomas Jefferson University, Philadelphia, PA, Philadelphia, PA
Background/Purpose: There is an urgent unmet need for effective therapeutic approaches for Systemic Sclerosis (SSc), a systemic autoimmune disease characterized by progressive fibrosis of skin…
Abstract Number: 1050 • 2019 ACR/ARP Annual Meeting
Genome-Wide DNA Methylation Signatures in Classical Monocytes from African Ancestry Patients with Systemic Sclerosis
Peter Allen¹, Jena Wirth ², Nathan Wilson ², Jim Oates ³, Melissa Cunningham ², Devin Absher ⁴ and Paula Ramos ², ¹University of Alabama at Birmingham, Birmingham, AL, ²Medical University of South Carolina, Charleston, ³Division of Rheumatology & Immunology/Medical University of South Carolina, Charleston, SC, ⁴HudsonAlpha Institute for Biotechnology, Huntsville, AL
Background/Purpose: Systemic sclerosis (SSc) is a rare, fibrotic autoimmune disorder characterized by cutaneous and visceral fibrosis, immune dysregulation, and vasculopathy. It disproportionately affects individuals of…
Abstract Number: 1051 • 2019 ACR/ARP Annual Meeting
Identification of Differential Chromatin Accessibility Using ATAC-seq in a Novel 3D Tissue Culture System of Systemic Sclerosis
Tamar Wheeler¹, Ji-Qing Chen ¹, Diana Toledo ¹, Bhaven Mehta ², Yue Wang ², Meredith Brown ¹, Rajan Bhandari ³ and Mengqi Huang ⁴, ¹Dartmouth College, Hanover, ²Geisel School of Medicine at Dartmouth, Hanover, NH, ³Dartmouth College, Lebanon, ⁴Geisel School of Medicine at Dartmouth College, Hanover, NH
Background/Purpose: Although the majority of SSc research has focused on differential gene expression, recent studies havedemonstrated that non-coding epigenetic changes in chromatin accessibility are likely…
Abstract Number: 1052 • 2019 ACR/ARP Annual Meeting
The PPAR Agonist Lanifibranor Protects Against Right Ventricular Hypertrophy in a Mouse Model of Systemic Sclerosis Associated Pulmonary Hypertension
Emma Derrett-Smith ¹, Kristina Clark¹, Shiwen Xu ¹, David Abraham ¹, Olivier Lacombe ², Pierre Broqua ², Jean-Louis Junien ², Irena Konstantinova ² and Christopher Denton ³, ¹University College London, London, United Kingdom, ²Inventiva, Daix, France, ³University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom
Background/Purpose: The TβRIIΔk-fib transgenic mouse model of systemic sclerosis (SSc) develops constitutive structural vasculopathy with vessel wall fibrosis and is susceptible to pulmonary hypertension (PH)…
Abstract Number: 1053 • 2019 ACR/ARP Annual Meeting
Parallel Analysis of Systemic Sclerosis and Keloidal Morphea Skin Biopsies Delineates the Hallmark Profibrotic Gene Expression Profile for Scleroderma in Vivo
Kristina Clark¹, Corrado Campochiaro ¹, Nataliya Gak ¹, Emma Derrett-Smith ¹ and Christopher Denton ², ¹University College London, London, United Kingdom, ²University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom
Background/Purpose: We have examined whole skin biopsy gene expression by RNAseq in a rare subgroup of scleroderma with both systemic sclerosis (SSc) and concurrent keloidal…
Abstract Number: 1054 • 2019 ACR/ARP Annual Meeting
Analysis of Serum Markers Across the Scleroderma Spectrum Shows Subset and Stage Specific Profiles of Fibrogenesis
Kristina Clark¹, Corrado Campochiaro ¹, Katherine Nevin ², Eszter Csomor ², Nicholas Galwey ², Mary Morse ², Nicolas Wisniacki ², Shaun Flint ², Voon Ong ³, Emma Derrett-Smith ¹ and Christopher Denton ⁴, ¹University College London, London, United Kingdom, ²GlaxoSmithKline, Stevenage, United Kingdom, ³UCL Medical School, Royal Free Campus, London, ⁴University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom
Background/Purpose: Systemic sclerosis (SSc) is characterised by autoimmunity, fibrosis and vasculopathy. There is striking heterogeneity in skin fibrosis that is likely to reflect the balance…
Abstract Number: 1055 • 2019 ACR/ARP Annual Meeting
Proteomic and Transcriptomic Analysis of Human Eosinophilic Fasciitis Fibroblasts
Benjamin Chaigne¹, Claire Fernandez ², Morgane le Gall ², Philippe Chafey ², Benjamin Saintpierre ², Virginie Salnot ², Francois Guillonneau ², Claire Le Jeunne ³ and Luc Mouthon ⁴, ¹Cochin University Hospital, Paris, France, ²Cochin Institute, Paris, France, ³Paris Descartes University, Cochin Hospital, Internal Medicine department, Paris, France, ⁴National Referral Center for Rare Systemic Autoimmune Diseases Paris Cochin, Paris, France
Background/Purpose: Eosinophilic fasciitis (EF) is a rare scleroderma-like disorder with less than 200 cases reported. Due to the rarity of the disease, data regarding its…
Abstract Number: 1056 • 2019 ACR/ARP Annual Meeting
Profibrotic Macrophage Activation in Systemic Sclerosis Is Dependent on the Mechanosensing MRTF-A Pathway
Tricia Lim¹, Kristina Krogmannova ¹, Shiwen Xu ¹, Bahja Ahmed Abdi ², David Abraham ¹, Christopher Denton ³ and Richard Stratton ¹, ¹University College London, London, United Kingdom, ²University College London, London, ³University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom
Background/Purpose: An M2-like alternative activation state of macrophages has been linked to the pathogenesis of several fibrotic disorders, including systemic sclerosis (SSc). MRTF-A is an…
Abstract Number: 1057 • 2019 ACR/ARP Annual Meeting
Dissecting the Cellular Mechanism of Prostacyclin Analog Iloprost in Reversing Vascular Dysfunction in Scleroderma
Pei-Suen Tsou¹, Nicholas Flavahan ² and Dinesh Khanna ³, ¹University of Michigan, Ann Arbor, MI, ²The Johns Hopkins University School of Medicine, Baltimore, MD, ³Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence, University of Michigan, Ann Arbor
Background/Purpose: Iloprost improves Raynaud‘s phenomenon and digital ulcers in scleroderma (SSc) patients. This is hypothesized to reflect anti-platelet and vasodilatory effects. Different trials and cohorts…
Abstract Number: 1058 • 2019 ACR/ARP Annual Meeting
Inhibition of Histone Readers Bromodomain and Extraterminal Domain Proteins Alleviates Scleroderma Fibrosis
Sirapa Vichaikul ¹, Phillip Campbell ², M. Asif Amin ³, Jeffrey H. Ruth ³, Dallas Rohraff ¹, David Fox ⁴, Dinesh Khanna ⁵, Amr Sawalha ⁶ and Pei-Suen Tsou³, ¹University of Michigan, Ann Arbor, ²Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ³University of Michigan, Ann Arbor, MI, ⁴Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence,University of Michigan, Ann Arbor, MI, ⁵Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence, University of Michigan, Ann Arbor, ⁶University of Pittsburgh & University of Michigan, Pittsburgh, PA
Background/Purpose: Epigenetic regulation, including histone acetylation, plays an important role in scleroderma (SSc) fibrosis. The binding of the bromodomain and extra-terminal domain proteins (BRDs) to…
Abstract Number: 1059 • 2019 ACR/ARP Annual Meeting
BDCA2 Targeting of Human Plasmacytoid Dendritic Cells via CBS004 Reverts Dependent IFN Activation and Tissue Fibrosis in vitro and in vivo
Rebecca Ross¹, Clarissa Corinaldesi ², Gemma Migneco ³, Yasser El-Sherbiny ⁴, Steve Holmes ⁵, Jörg Distler ⁶, Clive McKimmie ⁷ and Francesco Del Galdo ⁸, ¹Univesristy of Leeds, Leeds, England, United Kingdom, ²University of Leeds, Leeds, England, United Kingdom, ³University of Leeds, Leeds, United Arab Emirates, ⁴University of Nottingham, Nottingham, United Kingdom, ⁵Capella Bioscience, london, United Kingdom, ⁶Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, ⁷University of Leeds, Leeds, United Kingdom, ⁸University of Leeds and LTHT NIHR Biomedical Research Centre, Leeds, United Kingdom
Background/Purpose: Human plasmacytoid dendritic cells (pDCs) have been implicated in the pathogenesis of Systemic Sclerosis (SSc) through their ability to infiltrate the skin and secrete…
Abstract Number: 1060 • 2019 ACR/ARP Annual Meeting
The Diversity and Community Metrics of the Esophageal Microbiome of SSc Patients
Monica Espinoza¹, Bhaven Mehta ², Yue Wang ³, Aileen Hoffman ⁴, Kathleen Aren ⁵, Mary Carns ⁶, Noelle Kosarek ², Tammara Wood ³, Monique Hinchcliff ⁷ and Michael Whitfield ⁸, ¹Dartmouth College, Hanover, NH, ²Dartmouth College, Hanover, ³Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Northwestern University, Chicago, ⁵Northwestern.edu, Chicago, ⁶Northwestern University, Hanover, ⁷Yale University, Section of Rheumatology, Allergy and Immunology, New Haven, CT, ⁸Geisel School of Medicine at Dartmouth College, Biomedical Data Science at Dartmouth College, Hanover
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease characterized by fibrosis and inflammation. Multiple organ systems are affected including the skin, gastrointestinal tract, vasculature, and…
Abstract Number: 1061 • 2019 ACR/ARP Annual Meeting
PI3K-Akt Pathway Plays a Crucial Role in Production of Collagen in Fli1 Deficient Condition and Its Inhibitor Has the Therapeutic Potential in Treating Fibrosis
Yuko Ota¹, Atsushi Kitani ² and Warren Strober ², ¹Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ²Mucosal Immunity Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis of the skin and internal organs. Previous studies have shown that dermal fibroblast…
Abstract Number: 1062 • 2019 ACR/ARP Annual Meeting
Lymphocyte Subset Abnormalities in Early Diffuse Cutaneous Systemic Sclerosis
David Fox¹, Steven Lundy ², Michael Whitfield ³, Veronica Berrocal ⁴, Phillip Campbell ⁵, Stephanie Rasmussen ⁵, Ray Ohara ⁶, Alexander Stinson ⁶, Evan Wiewiora ⁷, Cathie Spino ⁷, Erica Bush ⁸, Daniel Furst ⁹, Shiv Pillai ¹⁰ and Dinesh Khanna ¹¹, ¹Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence,University of Michigan, Ann Arbor, MI, ²SystImmune, Inc., Redmond, WA, ³Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hannover, NH, ⁴Department of Biostatistics, School of Publich Health, University of Michigan, Ann Arbor, MI, ⁵Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ⁶Washington University, St. Louis, MO, ⁷Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, ⁸Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ⁹University of California, Los Angeles, CA, ¹⁰Ragon Institude of MGH, MIT and Harvard, Charlestown, MA, ¹¹Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence, University of Michigan, Ann Arbor
Background/Purpose: A variety of abnormalities in lymphocyte surface markers and functional subsets have been described in patients with systemic sclerosis (SSc), but conflicting results abound,…

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