Abstracts Archive - Page 1010 of 2425 - ACR Meeting Abstracts

Abstract Number: 79 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis (RA)-Associated Autoantibodies Are Present in the Periodontal Exudate of Patients with and without RA
Poerwati Soetji Rahajoe¹, Menke J. de Smit², Elisabeth Eelsing², Nyoman Kertia³, Arjan Vissink⁴ and Johanna Westra², ¹Oral Surgery, Dr. Sardjito General Hospital, Yogyakarta, Indonesia, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Rheumatology, Dr. Sardjito General Hospital, Yogyakarta, Indonesia, ⁴Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Seropositivity for anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) is a hallmark of RA and can be present years before clinical onset has…
Abstract Number: 80 • 2018 ACR/ARHP Annual Meeting
Prediction of Future Development of Rheumatoid Arthritis in Patients with Seropositive Arthralgia
Candice Low¹, Richard Conway², Francis Young³, Eamonn S. Molloy⁴, Anne Barbara Mongey⁴, Anthony G. Wilson⁵, Ursula Fearon⁶ and Douglas J. Veale¹, ¹Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, ²CARD Newman Research Fellow, University College Dublin, Dublin, Ireland, ³Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, ⁴Saint Vincent's University Hospital, Dublin 4, Ireland, ⁵UCD School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland, ⁶Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
Background/Purpose: Arthralgia in patients who are seropositive for rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) is a precursor to rheumatoid arthritis (RA) in some…
Abstract Number: 81 • 2018 ACR/ARHP Annual Meeting
Additive Effects of Functional Rheumatoid Arthritis (RA) LBH Risk Alleles on LBH Gene Transcription
Gyrid Nygaard, Deepa Hammaker, David L. Boyle and Gary S. Firestein, Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: LBH (Limb-bud and heart development gene) is dysregulated in RA, with a SNP associated with increased RA risk located in an upstream enhancer. This…
Abstract Number: 82 • 2018 ACR/ARHP Annual Meeting
Analysis of Intestinal Microbiome Profile of Patients with Established Rheumatoid Arthritis and Healthy Controls
Natalia Mena-Vazquez¹, Isabel Moreno-Indias², Patricia Ruiz-Limon³, Marta Rojas-Gimenez⁴, Clara Fuego⁴, Sara Manrique-Arija⁴, Inmaculada Ureña-Garnica⁴, Francisco G. Jimenez-Nuñez⁴, Francisco Jose Tinahones² and Antonio Fernandez-Nebro⁵, ¹UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain., Malaga, Spain, ²Research Group of Endocrine Diseases, Research Laboratory. Biomedical Research Institute of Malaga (IBIMA).Virgen de la Victoria Universitary Hospital, Malaga, Spain., Málaga, Spain, ³Research Group of Endocrine Diseases, Research Laboratory. Biomedical Research Institute of Malaga (IBIMA).Virgen de la Victoria Universitary Hospital, Malaga, Spain., Málaga, MA, Spain, ⁴UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain., Málaga, Spain, ⁵UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga Departamento de Medicina y Dermatología, Universidad de Málaga, MÁLAGA, Spain
Background/Purpose: To describe the fecal microbiome profile in RA patients and analyze the mechanisms involved in the pathogenesis of RAMethods: Design: Controlled, observational, cross-sectional study…
Abstract Number: 83 • 2018 ACR/ARHP Annual Meeting
The Risk of Developing Rheumatoid Arthritis Based on HLA-DQ Genotypes
Sami B. Kanaan¹, Oyku Sensoy² and J. Lee Nelson³, ¹Clinical Research Division, Fred Hutchinson Cancer Research Center, SEATTLE, WA, ²Clinical Research Division, Fred Hutchinson Cancer Research Center, seattle, WA, ³Fred Hutchinson Cancer Research Center, Seattle, WA
Background/Purpose: The strongest genetic risk for rheumatoid arthritis (RA) is contributed from the HLA region. RA-risk associated HLA-DRB1 alleles including *04:01/4/5/8, *01:01, *10:01, and *14:02…
Abstract Number: 84 • 2018 ACR/ARHP Annual Meeting
ACPA-Positive Risk-RA Subject without Subclinical Arthritis Are in High Risk for Later Arthritis Onset, Especially Carriers of HLA-SE Risk-Gene
Aase Hensvold^1,2, Yogan Kisten^1,2, Monika Hansson¹, Alexandra Cîrciumaru¹, Meng Sun¹, Hamed Rezaei³, Erik af Klint¹, Guozhong Fei², Aleksandra Antovic² and Anca I. Catrina^1,2, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Stockholm Health Services, Academic Specialist Center, Center for Rheumatology, Stockholm, Sweden, ³Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are predictive markers with pathological effects in rheumatoid arthritis (RA) development. Previous studies of ACPA-positive patients with musculoskeletal complaints (mainly…
Abstract Number: 85 • 2018 ACR/ARHP Annual Meeting
Antibodies to Citrullinated Protein Antigens (ACPAs) Induce Adipose Tissue Dysfunction Contributing to the Cardiovascular Disease Risk in Rheumatoid Arthritis. Modulation By Biological Dmards
Nuria Barbarroja¹, Ivan Arias de la Rosa², Miriam Ruiz-Ponce³, Maria Dolores de la Rosa-Garrido³, Patricia Ruiz-Limon⁴, Yolanda Jiménez-Gómez¹, Carlos Perez-Sanchez¹, Maria Carmen Abalos-Aguilera², Rocio Guzman-Ruiz⁵, Maria del Mar Malagon⁶, Francisco Jose Tinahones⁷, Eduardo Collantes-Estévez¹, Chary Lopez-Pedrera³ and Alejandro Escudero-Contreras², ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴Research Group of Endocrine Diseases, Research Laboratory. Biomedical Research Institute of Malaga (IBIMA).Virgen de la Victoria Universitary Hospital, Malaga, Spain., Málaga, MA, Spain, ⁵Department of Cell Biology, Physiology, and Immunology,, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain, ⁶Department of Cell Biology, Physiology, and Immunology,I, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain, ⁷Department of Clinical Endocrinology and Nutrition, Institute of Biomedical Research of Málaga (IBIMA), Hospital of Málaga (Virgen de la Victoria), University of Málaga (UMA), Málaga, Spain; CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Ca, Malaga, Spain
Background/Purpose: 1) To test the relationship among ACPAs and levels of adipocytokines and atherosclerosis in RA patients. 2) To analyze the effects of ACPAs on…
Abstract Number: 86 • 2018 ACR/ARHP Annual Meeting
Age Dependent Effects of Cholesterol and Smoking on the Risk of Rheumatoid Arthritis in Women – Results from a Nested Case Control Study
Carl Turesson^1,2, Ulf Bergström¹, Jan-Åke Nilsson^1,2 and Lennart Jacobsson³, ¹Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Department of Rheumatology, Skåne University Hospital, Malmö, Sweden, ³Dept of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Sweden, Gothenburg, Sweden
Background/Purpose: Smoking is an established risk factor for rheumatoid arthritis (RA). A positive association between body mass index (BMI) and the risk of RA in…
Abstract Number: 87 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patients with Circulating Extracellular Vesicles Positive for IgM Rheumatoid Factor Have Higher Disease Activity
Onno J. Arntz¹, Bartijn C.H. Pieters¹, Rogier Thurlings², Peter M. van der Kraan¹ and Fons A.J. van de Loo¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose:: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that mainly affects synovial joints. Most research on RA has focused on cytokines as main effectors…
Abstract Number: 88 • 2018 ACR/ARHP Annual Meeting
Lymphocyte DNA Methylation As a Mediator of Genetic Risk in Rheumatoid Arthritis
Alex Clark^1,2, Nisha Nair³, Andrew Skelton^1,2, Amy Anderson^1,2, Nishanthi Thalayasingam^1,2, Najib Naamane^1,2, Julie Diboll^1,2, Jonathan Massey⁴, Stephen Eyre^3,4, Anne Barton^3,4, John Isaacs^1,2, Louise Reynard⁵ and Arthur Pratt^1,2, ¹Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ²NIHR, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ³Arthritis Research UK Centre for Genetics and Genomics and Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, ⁴NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom, ⁵Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
Background/Purpose: Genome-wide association studies (GWAS) have to date identified over 100 genomic loci at which single nucleotide polymorphisms (SNPs) confer an increased risk of developing…
Abstract Number: 89 • 2018 ACR/ARHP Annual Meeting
Anti-Nuclear Antibodies (ANA) and Air Pollution: Ultrafine Particles and Ozone
Sasha Bernatsky¹, Shouao Wang², May Y Choi³, Scott Weichenthal⁴, Marianne Hatzopoulou⁵, Marvin J. Fritzler⁶ and Audrey Smargiassi⁷, ¹Divisions of Rheumatology and Clinical Epidemiology, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ³Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁴Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada, ⁵Civil and Mineral Engineering, University of Toronto, Toronto, ON, Canada, ⁶Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁷Public Health, Université de Montreal, Montreal, QC, Canada
Background/Purpose: Previous studies have suggested links between air pollution (particularly PM2.5) and serum antibodies related to rheumatic diseases. No one has yet examined anti-nuclear antibody…
Abstract Number: 90 • 2018 ACR/ARHP Annual Meeting
Deoxyribonuclease 1-like-3 Digests Self-DNA from Dead Cells and Prevents Autoimmunity
Shoichiro Inokuchi¹, Hiroki Mitoma², Shotaro Kawano², Masahiro Ayano², Yasutaka Kimoto³, Mitsuteru Akahoshi², Yojiro Arinobu², Koichi Akashi², Takahiko Horiuchi⁴ and Hiroaki Niro⁵, ¹Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan, ²Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ³Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan, ⁴Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, ⁵Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Background/Purpose: Deoxyribonuclease 1-like-3 (DNase1L3) belongs to Deoxyribonuclease 1(DNase1) family. This nuclease originally identified as one of apoptosis- and necrosis-related endonucleases that fragmentates intranucleosomal DNA. Unlike…
Abstract Number: 91 • 2018 ACR/ARHP Annual Meeting
Type I IFN Production Is Induced By Non-Haematopoietic Tissue Cells but Not Plasmacytoid Dendritic Cells in Preclinical Autoimmunity and SLE
Antonios Psarras^1,2,3, Adewonuola Alase¹, Agne Antanaviciute⁴, Ian Carr⁴, Miriam Wittmann^1,2, George C Tsokos⁵, Paul Emery^1,6 and Edward M Vital^1,2, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, ⁴Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom, ⁵Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁶Leeds Musculoskeletal Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: SLE is characterized by persistently high type I IFN activity. Plasmacytoid dendritic cells (pDCs) produce large amounts of IFNs in viral infections in response…
Abstract Number: 92 • 2018 ACR/ARHP Annual Meeting
Lupus Nephritis Serum Induces Neutrophil Chemotaxis Towards Glomerular Endothelial Cells in Vitro
Dayvia Russell¹, Margaret Markiewicz², Xian Zhang² and Jim C. Oates³, ¹Research Service, Ralph H. Johnson VA Medical Center, Charleston, SC, ²Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ³Medical Service, Ralph H. Johnson VA Medical Center, Charleston, SC
Title: Lupus Nephritis Serum Induces Neutrophil Chemotaxis towards Glomerular Endothelial Cells In Vitro Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease associated with…
Abstract Number: 93 • 2018 ACR/ARHP Annual Meeting
Biomarkers Associating Endothelial Function in Systemic Lupus Erythematous
Wan-Fang Lee¹, Chao-Yi Wu², Huang-Yu Yang³ and Jing-Long Huang^2,4, ¹Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang-Gung Memorial Hospital, Taoyuan city, Taiwan, ²Division of Allergy, Asthma and Rheumatology. Department of Pediatrics, Chang-Gung Memorial Hospital, Taoyuan city, Taiwan, ³Department of Nephrology,, Chang-Gung Memorial Hospital, Taoyuan city, Taiwan, ⁴Medicine, Chang-Gung University, Taoyuan city, Taiwan
Background/Purpose: The endothelium is a key element in the regulation of vascular homeostasis and its alteration is a precursor of vascular disease. Considering SLE is…

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