Background/Purpose During acute gout attacks neutrophils are activated and release a number of pro-inflammatory cytokines and enzymes. One of these enzymes is myeloperoxidase (MPO), which we have previously shown to be elevated in the circulation of patients with acute gout. Furthermore, MPO was associated with increased oxidation of urate as demonstrated by the increased concentration … Continue reading Oxidative Stress from Use of Allopurinol – Is There a Reason for Patients with Gout to Take Vitamin C?