ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2062

Omentin-1: Potential Biomarker of Cardiovascular Risk in Axial Spondyloarthritis? a Serological and Genetic Study

Fernanda Genre1, Javier Rueda-Gotor1, Sara Remuzgo-Martínez1, Verónica Pulito-Cueto1, Alfonso Corrales1, Verónica Mijares1, Leticia Lera-Gómez1, Virginia Portilla1, Rosa Expósito2, Cristina Mata2, Iván Ferraz-Amaro3, M. Vanesa Hernandez-Hernandez4, Santos Castañeda5, Esther Vicente5, Cristina Fernández-Carballido6, María Paz Martínez-Vidal7, David Castro-Corredor8, Joaquín Anino-Fernández8, Ricardo Blanco1, Oreste Gualillo9, Javier Martin10, Javier Llorca11, Raquel Lopez-Mejías1 and Miguel Angel González-Gay1,12, 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, 2Rheumatology Division, Hospital Comarcal de Laredo, Laredo, Spain, 3Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 4Rheumatology Division, Hospital Universitario de Canarias, La Laguna, Spain, 5Rheumatology Division, Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain, 6Rheumatology Division, Hospital General Universitario de Elda, Elda, Spain, 7Rheumatology Division, Hospital General Universitario de Alicante, Alicante, Spain, 8Rheumatology Division, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, 9SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), The NEIRID Group (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Santiago University Clinical Hospital, Santiago de Compostela, Spain, Santiago de Compostela, Spain, 10Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Granada, Spain., Granada, Spain, 11Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, 12School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: ,

Session Information

Date: Tuesday, October 23, 2018

Title: Spondyloarthritis Including Psoriatic Arthritis – Basic Science Poster

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Cardiovascular (CV) disease (mainly due to accelerated atherosclerosis) is one of the main causes of mortality in axial spondyloarthritis (axSpA). The higher incidence of CV risk factors and systemic chronic inflammation increase CV risk in axSpA.1 This is further enhanced by dysregulated production of adipokines, molecules with key metabolic and immunomodulatory functions. In this regard, low levels of circulating omentin-1, an anti-inflammatory adipokine, have been associated with metabolic dysfunction and CV disease in general population and other conditions different from axSpA.2,3 Therefore, the aim of this study was to evaluate the potential role of omentin-1 as a prognostic marker of CV disease in axSpA by assessing its association with subclinical atherosclerosis and CV risk factors in a large cohort of patients, both at the serological and genetic level.

Methods: 299 patients that fulfilled the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axSpA4 and 84 controls were recruited for this study. Clinical data was retrieved from medical records. Serum omentin-1 levels were assessed by ELISA. Carotid US was performed to evaluate the presence of subclinical atherosclerosis. One polymorphism of the gene coding Omentin-1 (ITLN-1 rs12409609), previously associated with coronary artery disease, was genotyped by TaqMan probes. Statistical analysis of the data was performed using STATA® v. 11.1, adjusting the results by potential confounding factors.

Results: Serum omentin-1 levels were significantly lower in axSpA when compared to controls (p=0.0001). Additionally, serum omentin-1 negatively correlated with body mass index (p=0.002) and atherogenic index (p=0.009) in axSpA. Interestingly, axSpA patients with inflammatory bowel disease exhibited lower omentin-1 serum levels when compared to patients not displaying this extra-articular manifestation (p=0.005). Neither serum omentin-1 levels nor ITLN-1 rs12409609 showed statistically significant association with markers of subclinical atherosclerosis. Likewise, ITLN-1 rs12409609 did not disclose a statistically significant association with omentin-1 serum levels.

Conclusion: Serum omentin-1 is linked to obesity and adverse lipid profiles in axSpA. Additionally, serum levels of this molecule are associated with the presence of inflammatory bowel disease in axSpA. These data support a role of omentin-1 as a CV risk biomarker in axSpA.

[1] Joint Bone Spine. 2014; 81(1):57-63. [2] Cardiovasc Hematol Disord Drug Targets. 2013; 13(1):59-72. [3] Curr Issues Pharm Med Sci. 2015; 28(3):176-80. [4] Ann Rheum Dis. 2009; 68(6):777-83.

This work was supported by funds of a NEXT-VAL grant (NVAL17/10)(IDIVAL). FG is a recipient of a Sara Borrell fellowship (Instituto de Salud Carlos III –ISCIII-, co-funded by European Social Fund –ESF-,“Investing in your future”,CD15/00095). SR-M is supported by funds of RETICS Program (RD16/0012/0009,ISCIII,co-funded by European Regional Development Fund,ERDF). RL-M is a recipient of a Miguel Servet type I fellowship (ISCIII, co-funded by ESF, CP16/00033). VM is supported by funds of a Miguel Servet type I programme (CP16/00033)(ISCIII, co-funded by ERDF).

Disclosure: F. Genre, None; J. Rueda-Gotor, None; S. Remuzgo-Martínez, None; V. Pulito-Cueto, None; A. Corrales, None; V. Mijares, None; L. Lera-Gómez, None; V. Portilla, None; R. Expósito, None; C. Mata, None; I. Ferraz-Amaro, None; M. V. Hernandez-Hernandez, None; S. Castañeda, None; E. Vicente, None; C. Fernández-Carballido, None; M. P. Martínez-Vidal, None; D. Castro-Corredor, None; J. Anino-Fernández, None; R. Blanco, None; O. Gualillo, None; J. Martin, None; J. Llorca, None; R. Lopez-Mejías, None; M. A. González-Gay, None.

To cite this abstract in AMA style:

Genre F, Rueda-Gotor J, Remuzgo-Martínez S, Pulito-Cueto V, Corrales A, Mijares V, Lera-Gómez L, Portilla V, Expósito R, Mata C, Ferraz-Amaro I, Hernandez-Hernandez MV, Castañeda S, Vicente E, Fernández-Carballido C, Martínez-Vidal MP, Castro-Corredor D, Anino-Fernández J, Blanco R, Gualillo O, Martin J, Llorca J, Lopez-Mejías R, González-Gay MA. Omentin-1: Potential Biomarker of Cardiovascular Risk in Axial Spondyloarthritis? a Serological and Genetic Study [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/omentin-1-potential-biomarker-of-cardiovascular-risk-in-axial-spondyloarthritis-a-serological-and-genetic-study/. Accessed .

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