ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2175

Novel Assessment of Interstitial Lung Disease Using the “Computer-Aided Lung Informatics for Pathology Evaluation and Rating” Software System in Idiopathic Inflammatory Myopathies

Patompong Ungprasert1, Katelynn Wilton2, Floranne C. Ernste3, Sanjay Kalra4, Cynthia S. Crowson5, Srinivasan Rajagopalan6 and Brian Bartholmai7, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Immunology, Mayo Clinic, Rochester, MN, 3Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, 4Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, 5Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, 6Mayo Clinic, Rochester, MN, 7Thoracic Radiology, Mayo Clinic, Rochester, MN

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords:

Session Information

Date: Tuesday, November 7, 2017

Title: Muscle Biology, Myositis and Myopathies Poster

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

 

Background/Purpose: The idiopathic inflammatory myopathies (IIM) are often associated with interstitial lung diseases (ILD).  Yet, pulmonary function testing (PFT) results can be confounded by patient effort, mixed obstructive/restrictive disease and pulmonary hypertension. Our purpose was to evaluate the correlation between measurements from quantitative thoracic high-resolution CT (HRCT) analysis with Computer-Aided Lung Informatics for Pathology Evaluation and Rating (CALIPER) software and PFTs in patients with IIM-associated ILD.

Methods: A cohort of patients with IIM-associated ILD seen at a single institution was identified from medical record review in 2003-2011.  Retrospective analysis of HRCT data and PFTs at baseline and 1 year was performed.  The abnormalities in HRCT were quantified using CALIPER software. Correlation between baseline CALIPER measurements and PFT measurements as well as correlation between changes of CALIPER measurements and PFT measurements at one year (compared with baseline) were assessed using Spearman correlation coefficients.  

Results: A total of 110 patients were identified.  At baseline, total interstitial abnormalities as measured by CALIPER, both by absolute volume and by percentage of total lung volume, had a significant negative correlation with diffusing capacity for carbon monoxide (DLCO), total lung capacity (TLC) and oxygen saturation (Table).  Analysis by subtype of interstitial abnormality revealed significant negative correlations between ground glass opacities (GGO) and reticular density (RD) with DLCO (p<0.001) and TLC (p<0.001). 

At one year, changes of total interstitial abnormalities compared with baseline had a significant negative correlation with changes of TLC and oxygen saturation (p = 0.015; p < 0.01).  Figure 1 demonstrates a sample of CALIPER analysis of a lung affected by progressive nonspecific interstitial pneumonia, 2009-2012.

Conclusion:  This study provides evidence of the utility of CALIPER software, as it is the first study to demonstrate the correlation between CALIPER measurements and functional measurements in patients with IIM-associated ILD. 


Table: Correlation between CALIPER measurements and PFT measurement at baseline

CALIPER measurements

TLC (n=87)

DLCO (n=104)

FEV1/FVC (n=110)

Oxygen saturation at rest (n=90)

Oxygen saturation during exercise (n=68)

 

r

p-value

r

p-value

r

p-value

r

p-value

r

p-value

 

LAA

Total volume

 

0.529

<0.001

0.491

<0.001

-0.232

0.015

0.258

0.014

0.322

0.007

Percentage

 

0.486

<0.001

0.461

<0.001

-0.202

0.033

0.282

0.007

0.352

0.003

GGO

Total volume

 

-0.235

0.029

-0.351

<0.001

0.205

0.031

-0.411

<0.001

-0.373

0.002

Percentage

 

-0.346

0.001

-0.455

<0.001

0.248

0.009

-0.414

<0.001

-0.365

0.002

HC

Total volume

 

0.288

0.007

0.207

0.034

-0.057

0.555

0.067

0.529

0.061

0.622

Percentage

 

0.259

0.015

0.168

0.088

-0.035

0.713

0.060

0.573

0.067

0.589

RD

Total volume

 

-0.112

0.303

-0.252

0.010

0.011

0.907

-0.190

0.073

-0.347

0.004

Percentage

 

-0.304

0.004

-0.397

<0.001

0.090

0.349

-0.198

0.062

-0.359

0.003

Total interstitial abnormality

Total volume

 

-0.231

0.031

-0.376

<0.001

0.154

0.108

-0.413

<0.001

-0.451

<0.001

Percentage

 

-0.397

<0.001

-0.513

<0.001

0.222

0.020

-0.421

<0.001

-0.444

<0.001

CALIPER, Computer-Aided Lung Informatics for Pathology Evaluation and Rating; GGO, ground glass opacity; RD, reticular densities; HC, honeycombing; LAA, low attenuation areas; TLC, total lung capacity; FVC, forced vital capacity; FEV1, forced expiratory volume in one second; DLCO, diffusing capacity for carbon monoxide; N, number; r, Spearman correlation coefficients

Disclosure: P. Ungprasert, None; K. Wilton, None; F. C. Ernste, None; S. Kalra, None; C. S. Crowson, None; S. Rajagopalan, None; B. Bartholmai, None.

To cite this abstract in AMA style:

Ungprasert P, Wilton K, Ernste FC, Kalra S, Crowson CS, Rajagopalan S, Bartholmai B. Novel Assessment of Interstitial Lung Disease Using the “Computer-Aided Lung Informatics for Pathology Evaluation and Rating” Software System in Idiopathic Inflammatory Myopathies [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/novel-assessment-of-interstitial-lung-disease-using-the-computer-aided-lung-informatics-for-pathology-evaluation-and-rating-software-system-in-idiopathic-inflammatory-myopathies/. Accessed .

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