ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 293

Measurement of Advanced Glycation Endproducts in the Skin of Patients with Idiopathic Inflammatory Myopathies

Simone Barsotti1, Chiara Saponaro2, Rosaria Talarico3, Alessandra Tripoli4, Claudia Ferrari5, Elisabetta Bianchini6, Nicole Di Lascio6, Melania Gaggini2, Amalia Gastaldelli2, Marta Mosca7, Maria Aurora Morales6 and Rossella Neri5, 1Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 2National Research Council, Institute of Clinical Physiology, Pisa, Italy, 3Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, 4University of Pisa, Rheumatology Unit, Pisa, Italy, 5Internal Medicine, University of Pisa, Pisa, Italy, 6Institute of Clinical Physiology, CNR, Pisa, Italy, 7University of Pisa, Pisa, Italy

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: ,

Session Information

Date: Sunday, November 8, 2015

Title: Muscle Biology, Myositis and Myopathies Poster

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:

Many data suggest that advanced glycation endproducts (AGEs) play an important role the development of atherosclerosis and cardiovascular (CV) disease. AGEs are produced and may accumulate during chronic inflammation, and may impact on patients with idiopathic inflammatory myositis (IIM). The aims of this study was to evaluate whether AGEs are increased in patients with IIM and to explore whether AGE accumulation is related to clinical data, disease activity and measures of subclinical atherosclerosis assessed by ultrasonography sampling of carotid artery. 

Methods: Twenty-seven IIM patients (F/M 19/8; mean age 56.7±12.3; mean disease duration 8.8±7 years, 13 polymyositis and 14 dermatomyositis) fulfilling the Bohan and Peter criteria were prospectively enrolled and compared with 29 healthy subjects (HS) matched for age, sex and classical cardiovascular risk factors (smoking habits, diabetes mellitus, hypertension, family history of CV disease, body mass index). AGEs were determined by skin autofluorescence at level of left forearm.

AGEs levels were correlated with demographic data, disease activity parameters (physician and patient’s activity using visual analogic scale, manual muscle test 8, muscular enzyme levels, health quality assessment questionnaire), disease duration, cumulative corticosteroids dose. We also collected markers of subclinical atherosclerosis including Intima-Media-Thickness (IMT), mean arterial diameter (mAD) and distensibility coefficient (DC) measured on B-mode ultrasound image sequences of right common carotid artery, 1 cm beneath the bifurcation. 

Results:

IIM patients presented higher subcutaneous AGEs than healthy subjects. (mean 2.83 ± 0.6360 DS vs 2.176 ±0.5773 DS) p<0.001.

In the IIM group, AGEs are significantly correlated with age (p=0.011), and with IMT (p<0.001) and mAD (p=0.035), while no correlation was found with DC. In healthy subjects, AGEs were significantly correlated with age (p<0.001), but no correlations were found between AGEs and IMT, mAD and DC.

In addition, in myositis patients, no correlations were observed between AGEs and gender, classic cardiovascular risk factors, disease duration, cumulative corticosteroid dose, disease activity parameters and laboratory data.

Conclusion:

Our data have shown that IIM patients presented higher AGEs than healthy subjects; a correlation between AGEs and age at the evaluation, and between AGEs and signs of premature atherosclerosis were found. These observations may suggest that, in myositis patients, AGEs may be an early marker of subclinical CV. Further data are necessary to confirm our observation.

Disclosure: S. Barsotti, None; C. Saponaro, None; R. Talarico, None; A. Tripoli, None; C. Ferrari, None; E. Bianchini, None; N. Di Lascio, None; M. Gaggini, None; A. Gastaldelli, None; M. Mosca, None; M. A. Morales, None; R. Neri, None.

To cite this abstract in AMA style:

Barsotti S, Saponaro C, Talarico R, Tripoli A, Ferrari C, Bianchini E, Di Lascio N, Gaggini M, Gastaldelli A, Mosca M, Morales MA, Neri R. Measurement of Advanced Glycation Endproducts in the Skin of Patients with Idiopathic Inflammatory Myopathies [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/measurement-of-advanced-glycation-endproducts-in-the-skin-of-patients-with-idiopathic-inflammatory-myopathies/. Accessed .

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