Mases Correlates Linearly with Disease Activity and Patient Related Outcomes in Patients with Axial Spondyloarthritis within the Scqm Cohort

Ruediger Mueller¹, Toni Kaegi², Nicole Graf³, Johannes von Kempis⁴ and J.J. Luime⁵, ¹Rheumatology, MD, St. Gallen, Switzerland, ²Kantonsspital St. Gallen, St. Gallen, Switzerland, ³graf biostatistics, Winterthur, Switzerland, ⁴Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland, ⁵Department of Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: axial spondyloarthritis, enthesis and spondylarthritis

Session Information

Date: Sunday, November 8, 2015

Title: Spondylarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment Poster I: Clinical Aspects and Assessments

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:

Enthesitis is one of the potential extra-axial manifestations found in patients with spondyloarthritis (SpA). Enthesitis can be quantified using the MASES (Maastrich Ankylosing Spondylitis Enthesitis Score), consisting 13 pre-defined entheses assessed for tenderness. There are few data on the MASES outside of RCTs. To better understand enthesitis real live data could be helpful.

Objective:

To analyse cross-sectionally the correlation of enthesitis with clinical and personal outcome parameters in patients with axial spondyloarthritis.

Methods:

We included all patients from the Swiss national registry SCQM with axial spondyloarthritis and valid MASES at baseline. Patients were analysed for demographics at baseline, medical history, physical assessments (BASMI, BASFI, BASDAI) and patient centred outcomes (SF36). Data was analysed using descriptive statistics and linear regression.

Results:

3241 patients were included into the study with MASES data available at baseline. 45.9% of the patient had no documented entheseal affection at baseline (MASES = 0). Patients had an average age of 41.6 years, symptom duration of 11.8 years and disease duration of 6.3 years since diagnosis on average. There was a predominance (57.5%) for the male gender. 59.7% of the patients were HLA B27 pos. and 60.5% of the patients were suffering from radiographic axial disease as defined by positivity for the New York criteria.

The percentage of patients with a higher MASES (0-13) decreased linearly (slope -63.5, R² = 0.48). In parallel, average clinical scores BASDAI, BASFI, BASMI, ASDAS, patient´s global assessment of disease activity increased linearly with increasing MASES (BASDAI: slope 0.23, R² = 0.89; BASFI: slope 0.27, R² = 0.87; BASMI: slope 0.09, R² = 0.82; ASDAS: slope 0.09, R² = 0.90, patient´s global: slope 0.23; R² = 0.85) whereas the SF 36 decreased (physical component score: slope -0.73, R² = 0.76; mental component score: slope -0.72, R² = 0.67).

Conclusion:

Entheseal involvement is a frequently occurring contributor to disease activity and function in patients with axial SpA. MASE scores correlate well with disease activity and patient centred outcomes.

Disclosure: R. Mueller, None; T. Kaegi, None; N. Graf, None; J. von Kempis, None; J. J. Luime, None.

To cite this abstract in AMA style:

Mueller R, Kaegi T, Graf N, von Kempis J, Luime JJ. Mases Correlates Linearly with Disease Activity and Patient Related Outcomes in Patients with Axial Spondyloarthritis within the Scqm Cohort [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/mases-correlates-linearly-with-disease-activity-and-patient-related-outcomes-in-patients-with-axial-spondyloarthritis-within-the-scqm-cohort/. Accessed .

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