Session Information
Date: Tuesday, November 7, 2017
Title: Fibromyalgia, Soft Tissue Disorders, Regional and Specific Clinical Pain Syndromes Poster II
Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Leptin, a 16 kDa protein, acts on receptors in brain neurons, especially in the hypothalamus. It could affect the hypothalamic-pituitary axis and be involved in the stress response. We analyzed leptin levels in the serum of patients with fibromyalgia and rheumatoid arthritis.
Methods: Leptin levels were assessed in 27 fibromyalgia syndrome patients and six rheumatoid arthritis patients followed in a rheumatology office practice. Leptin was measured by the University of Miami Immunology Laboratory.
Results: Leptin levels varied between 1.7 and 70.7 ng/ml (mean 28.0) in FMS patients and 0.6 to 33.0 ng/ml (mean 10.1) in rheumatoid arthritis patients. The mean leptin/BMI ratio for 20 FMS pts was 1.0. The mean leptin/BMI for RA was 0.50.
Conclusion: Leptin levels appear to be elevated in fibromyalgia patients and could provide a link between chronic stress, the hypothalamic-pituitary axis, and fibromyalgia. Leptin might be a potential therapeutic target in fibromyalgia.
Disclosure: R. S. Katz, None;
To cite this abstract in AMA style:
Katz RS. Leptin, a Hypothalamic Signaling Hormone, Is Elevated in Fibromyalgia Patients [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/leptin-a-hypothalamic-signaling-hormone-is-elevated-in-fibromyalgia-patients/. Accessed .« Back to 2017 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/leptin-a-hypothalamic-signaling-hormone-is-elevated-in-fibromyalgia-patients/