Lack of Association of a 6.7 Kbp Deletion of LILRA3 with Giant Cell Arteritis

Ana Márquez¹, Tamara Fernández-Aranguren², Maria C. Cid³, José Hernández-Rodríguez³, Roser Solans⁴, Marc Ramentol⁴, Santos Castañeda⁵, Jose A. Miranda-Filloy⁶, Inmaculada C. Morado⁷, Javier Narváez⁸, Eugenio De Miguel⁹, Bernardo Sopeña¹⁰, Jordi Monfort¹¹, Maria Jesus Garcia-Villanueva¹², Norberto Ortego-Centeno¹³, Torsten Witte¹⁴, Miguel Angel Gonzalez-Gay¹⁵, Javier Martín² and Spanish GCA Group, ¹Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada and Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ²Instituto de Parasitología y Biomedicina López- Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, ³Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ⁴Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d’Hebron, Autonomous University of Barcelona, Barcelona, Spain, ⁵Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ⁶Department of Rheumatology, Hospital Xeral-Calde, Lugo, Spain, ⁷Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ⁸Rheumatology Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain, ⁹Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain, ¹⁰Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Spain, ¹¹Department of Rheumatology, Grup de recerca cel•lular en inflamació i cartílag. IMIM (Institut de Recerca Hospital del Mar), Barcelona, Spain, ¹²Department of Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, ¹³Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ¹⁴Hannover Medical School, Hanover, Germany, ¹⁵Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Autoimmunity, giant cell arteritis and polymorphism

Session Information

Date: Monday, November 9, 2015

Title: Vasculitis Poster II

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Leukocyte immunoglobulin-like receptor A3 (LILRA3A) encodes a member of a family of immunoreceptors which is predominantly expressed on antigen presenting cells, acting as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Recently published studies have implicated a 6.7 kb genetic deletion of LILRA3, comprising the first seven exons of the gene, in the genetic predisposition to rheumatoid arthritis, multiple sclerosis, and Sjögren’s syndrome. Given the proposed role of LILRA3A in autoimmunity, we aimed to assess whether this deletion represents a novel genetic risk factor for GCA and its main clinical subgroups.

Methods: A total of 969 biopsy-proven GCA patients and 1593 healthy controls of Spanish Caucasian origin were included in the study. The LILRA3 deletion was genotyped by polymerase chain reaction using specific primers for detecting presence or absence of the complete gene.

Results: No statistically significant differences were found when allele and genotype distributions were compared between GCA patients and controls (allelic p-value= 0.924, OR=1.01, CI 95%=0.87-1.17). Likewise, the subphenotype analysis considering the main clinical complications of the disease (rheumatic polymyalgia, visual manifestations, jaw claudication and stroke) yield similar negative results.

Conclusion: Our data suggest that the LILRA3 deletion do not play a significant role in GCA susceptibility or severity.

Disclosure: A. Márquez, None; T. Fernández-Aranguren, None; M. C. Cid, None; J. Hernández-Rodríguez, None; R. Solans, None; M. Ramentol, None; S. Castañeda, None; J. A. Miranda-Filloy, None; I. C. Morado, None; J. Narváez, None; E. De Miguel, None; B. Sopeña, None; J. Monfort, None; M. J. Garcia-Villanueva, None; N. Ortego-Centeno, None; T. Witte, None; M. A. Gonzalez-Gay, None; J. Martín, None.

To cite this abstract in AMA style:

Márquez A, Fernández-Aranguren T, Cid MC, Hernández-Rodríguez J, Solans R, Ramentol M, Castañeda S, Miranda-Filloy JA, Morado IC, Narváez J, De Miguel E, Sopeña B, Monfort J, Garcia-Villanueva MJ, Ortego-Centeno N, Witte T, Gonzalez-Gay MA, Martín J. Lack of Association of a 6.7 Kbp Deletion of LILRA3 with Giant Cell Arteritis [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/lack-of-association-of-a-6-7-kbp-deletion-of-lilra3-with-giant-cell-arteritis/. Accessed .

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