Lack of Association Between ZHX2, Lepr, Gckr and ASCL1 and Carotid Intima-Media Thickness, Carotid Plaques and Cardiovascular Disease in Patients with Rheumatoid Arthritis

Raquel López-Mejías¹, Fernanda Genre¹, Sara Remuzgo-Martínez¹, Montserrat Robustillo-Villarino², Alfonso Corrales¹, Javier Llorca³, Carlos González-Juanatey⁴, Begoña Ubilla¹, Jose A. Miranda-Filloy⁵, Veronica Mijares¹, Trinitario Pina⁶, Ricardo Blanco⁶, Juan José Alegre², Marco A Ramírez Huaranga⁷, Maria D Mínguez Sánchez⁷, Carmen Gomez Vaquero⁸, Luis Rodriguez Rodriguez⁹, Benjamin Fernandez Gutierrez⁹, Alejandro Balsa¹⁰, Dora Pascual-Salcedo¹⁰, Francisco Lopez Longo¹¹, Patricia E. Carreira¹², Cesar Magro¹³, Enrique Raya¹⁴, Beatriz Tejera¹⁵, Ivan Ferraz-Amaro¹⁵, Esther Vicente¹⁶, Isidoro González-Alvaro¹⁶, Santos Castañeda¹⁷, Javier Martín¹⁸ and Miguel A. Gonzalez-Gay^1,19, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ²Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, ³Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁴Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ⁵Rheumatology Division, Hospital Lucus Augusti, Lugo, Spain, ⁶Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ⁷Rheumatology Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, ⁸Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁹Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ¹⁰Department of Rheumatology, Hospital La Paz, Madrid, Spain, ¹¹Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ¹²Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹³Rheumatology Department, Hospital Clínico San Cecilio, Granada, Spain, ¹⁴Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, ¹⁵Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, ¹⁶Rheumatology Department, Hospital Universitario la Princesa, IIS-Princesa, Madrid, Spain, ¹⁷Rheumatology, H.U. La Princesa, Madrid, Spain, ¹⁸Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain, ¹⁹Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Atherosclerosis, Cardiovascular disease, intima medial thickness, polymorphism and rheumatoid arthritis (RA)

Session Information

Date: Monday, November 9, 2015

Title: Rheumatoid Arthritis - Human Etiology and Pathogenesis Poster II

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. Recent studies have identified the ZHX2 rs11781551 polymorphism as the most relevant genetic variant associated with carotid intima-media thickness (cIMT) values and LEPR rs4420065, GCKR rs1260326 and ASCL1 rs10745954 as polymorphisms related to C-reactive protein levels in non-rheumatic Caucasians individuals. Accordingly, we evaluated the potential relationship between these 4 polymorphisms and subclinical atherosclerosis (assessed by cIMT and presence/absence of carotid plaques) and CV disease in RA.

Methods: 2,298 Spanish RA patients were genotyped for these 4 polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 907 of these patients by carotid ultrasound.

Results: No statistically significant differences were found when each polymorphism was assessed according to cIMT values and presence/absence of carotid plaques in RA after adjustment the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV disease after adjustment for potential confounders.

Conclusion: Our results do not confirm an association between ZHX2 rs11781551, LEPR rs4420065, GCKR rs1260326 and ASCL1 rs10745954 and subclinical atherosclerosis and CV disease in RA.

This study was supported by European Union FEDER funds and “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748 and PI12/00060) (Spain). This work was also partially supported by RETICS Programs RD12/0009 (RIER) from “Instituto de Salud Carlos III” (ISCIII) (Spain), and in part by grants from the European IMI BTCure Program. FG and BU are supported by funds from the RETICS Program (RIER) (RD12/0009/0013). RLM is a recipient of a Sara Borrell postdoctoral fellowship from the “Instituto de Salud Carlos III” at the Spanish Ministry of Health (Spain) (CD12/00425).

Disclosure: R. López-Mejías, None; F. Genre, None; S. Remuzgo-Martínez, None; M. Robustillo-Villarino, None; A. Corrales, None; J. Llorca, None; C. González-Juanatey, None; B. Ubilla, None; J. A. Miranda-Filloy, None; V. Mijares, None; T. Pina, None; R. Blanco, None; J. J. Alegre, None; M. A. Ramírez Huaranga, None; M. D. Mínguez Sánchez, None; C. Gomez Vaquero, None; L. Rodriguez Rodriguez, None; B. Fernandez Gutierrez, None; A. Balsa, None; D. Pascual-Salcedo, None; F. Lopez Longo, None; P. E. Carreira, None; C. Magro, None; E. Raya, None; B. Tejera, None; I. Ferraz-Amaro, None; E. Vicente, None; I. González-Alvaro, None; S. Castañeda, None; J. Martín, None; M. A. Gonzalez-Gay, None.

To cite this abstract in AMA style:

López-Mejías R, Genre F, Remuzgo-Martínez S, Robustillo-Villarino M, Corrales A, Llorca J, González-Juanatey C, Ubilla B, Miranda-Filloy JA, Mijares V, Pina T, Blanco R, Alegre JJ, Ramírez Huaranga MA, Mínguez Sánchez MD, Gomez Vaquero C, Rodriguez Rodriguez L, Fernandez Gutierrez B, Balsa A, Pascual-Salcedo D, Lopez Longo F, Carreira PE, Magro C, Raya E, Tejera B, Ferraz-Amaro I, Vicente E, González-Alvaro I, Castañeda S, Martín J, Gonzalez-Gay MA. Lack of Association Between ZHX2, Lepr, Gckr and ASCL1 and Carotid Intima-Media Thickness, Carotid Plaques and Cardiovascular Disease in Patients with Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/lack-of-association-between-zhx2-lepr-gckr-and-ascl1-and-carotid-intima-media-thickness-carotid-plaques-and-cardiovascular-disease-in-patients-with-rheumatoid-arthritis/. Accessed .

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