Session Information
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: Several studies show an association between asthma and RA. However, none have controlled for allergic disease, urban environment, or passive smoke exposure. We aimed to determine the association of asthma, allergic disease, and passive smoke exposure with RA risk.
Methods: We performed a case-control study using a biobank at a single center, identifying cases of RA using a rules-based algorithm combining self-report with two diagnosis codes (PPV = 88%). We matched each case to three controls based on age, sex, and location of residence at index date of survey. Data on exposures were self-reported on biobank surveys. Unconditional logistic regression models calculated the relationship between each exposure and RA after adjusting for potential confounders.
Results: We identified 1,149 RA cases and 3,441 controls. Mean age at survey date was 62 years (SD 13), and 72% were female. Asthma was associated with RA even after adjusting for allergies, urban environment, and passive smoke exposure (Table 1). History of allergic disease was also associated with RA (Table 1). Passive home smoke exposure duration and pack-years were modestly associated with development of RA, but the association with passive work smoke exposure was not statistically significant (Table 1).
Conclusion: Asthma, allergic diseases, and passive smoke exposure at home may be associated with increased risk of developing RA. Future studies investigating the relationship between atopy and autoimmunity are needed.
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Table 1. Association between asthma, allergy, passive smoke exposure and RA* |
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Number (%) or Median (IQR) |
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Characteristic |
Controls (N = 3441) |
RA cases (N = 1149) |
Adjusted Odds Ratio* (95% CI) |
Model N |
|
Asthma |
434 (13) |
198 (18) |
1.40 (1.16,1.69) |
4492 |
|
Asthma after further adjustment** |
434 (13) |
198 (18) |
1.31 (1.08,1.59) |
3295 |
|
urban environment |
2546 (75) |
833 (73) |
0.96 (0.82,1.12) |
3295 |
|
allergic disease |
1933 (57) |
718 (63) |
1.23 (1.06,1.43) |
3295 |
|
Passive home smoke exposure |
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|
Yes |
2095 (61) |
753 (66) |
1.1 (0.97,1.30) |
4555 |
|
Age it began*** |
3 (3,15) |
3 (3,15) |
1.00 (0.99,1.01) |
1966 |
|
Duration before RA, per 10 years |
18 (10,20) |
18 (10,21) |
1.12 (1.01,1.23) |
1795 |
|
Packs per day |
0.8 (0.5,1.5) |
0.8 (0.5,1.5) |
1.1 (0.97,1.33) |
1950 |
|
Pack-years before RA, per 10 years |
12 (7,24) |
14 (8,27) |
1.06 (1.01,1.13) |
1725 |
|
Passive work smoke exposure |
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|
Yes |
1219 (36) |
444 (39) |
1.0 (0.90,1.21) |
4552 |
|
Age it began*** |
25 (17,25) |
25 (17,25) |
1.01 (0.99,1.03) |
1110 |
|
Duration before RA, per 10 years |
10 (4,19) |
10 (5,19) |
0.99 (0.84,1.17) |
1003 |
|
Packs per day |
0.8 (0.5,1.5) |
0.8 (0.5,1.5) |
1.2 (0.99,1.36) |
1102 |
|
Pack-years before RA, per 10 years |
8 (3,15) |
8 (4,17) |
1.07 (0.99,1.16) |
941 |
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*adjusting for body mass index, race, education, personal smoking |
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**also adjusting for allergic disease, urban environment, and home/work smoke exposure |
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***also adjusting for the pack-years of passive smoke exposure |
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To cite this abstract in AMA style:
Kronzer VL, Crowson CS, Sparks JA, Vassallo R, Davis JM III. Investigating Asthma, Allergic Disease, Passive Smoke Exposure, and Risk of Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/investigating-asthma-allergic-disease-passive-smoke-exposure-and-risk-of-rheumatoid-arthritis/. Accessed .« Back to 2018 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/investigating-asthma-allergic-disease-passive-smoke-exposure-and-risk-of-rheumatoid-arthritis/