Background/Purpose: Takayasu’s Arteritis (TAK) is a granulomatous large-vessel vasculitis that affects the aorta and its branches, and it is more commonly observed in women. We aimed to describe the prevalence, comorbidities, and burden of admitted TAK patients in the United States

Methods: The 2016-2020 National Inpatient Sample database (NIS) was analyzed to identify adult hospitalizations with TAK, using International Classification of Diseases – 10 Clinical Modification (ICD-10-CM) codes. The studied primary outcome was to assess TAK inpatient comorbidities. A multivariate logistic regression, and linear regression analyses were used to adjust for possible confounders.

Results: 5439 hospitalizations of TAK were analyzed. Of these, 4389 (80.69%) were females. The mean age was 52.2. Logistic regression analysis showed that patients had a higher risk of ischemic stroke (adjusted Odds Ratio [aOR] of 2.5, 95% Confidence Interval [CI] 1.89-3.53), acute coronary syndrome (aOR: 1.73, CI: 1.32-2.28), aortic valve disease (aOR: 3.86, CI: 2.81-5.28), mitral valve disease (aOR: 1.57, CI: 1.12-2.21), acute kidney injury (aOR: 1.79, CI: 1.51-2.11), and chronic kidney disease (aOR: 1.79, CI: 1.45-2.19). There was no statically significant difference in peripheral vascular disease (aOR: 0.79, CI: 0.62-1.02). Patients with TAK required the use of more expensive imaging modalities (aOR: 2.84, CI: 1.40-5.74). Figure 1 shows the Forrest plot for multivariate analysis of in hospital morbidities when adjusted for patient demographics, comorbidities, and hospital characteristics.

Conclusion: Analysis of patients with TAK showed a higher risk of comorbidities including ischemic stroke, acute coronary syndrome, aortic valve disease, mitral valve disease, acute kidney injury, and chronic kidney disease.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/inpatient-prevalence-and-comorbidity-of-takayasus-arteritis-nationwide-inpatient-sample-2016-2020/