ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 2224

Influence of Caffeine on Opioid Analgesics in Fibromyalgia

J. Ryan Scott1, Daniel J. Clauw2, Chad M. Brummett1, Richard E. Harris1, Afton L. Hassett1 and Steven E. Harte3, 1Anesthesiology, University of Michigan, Ann Arbor, MI, 2Chronic Pain & Fatigue Research Center, University of Michigan, Ann Arbor, MI, 3Department of Anesthesiology, University of Michigan, Ann Arbor, MI

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: analgesics, Chronic pain, Fibromyalgia and opioids

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Tuesday, November 15, 2016

Session Title: Fibromyalgia, Soft Tissue Disorders, Regional and Specific Clinical Pain Syndromes - Poster II: Clinical Focus

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:  Caffeine’s action as an NSAID adjuvant are well understood, yet little clinical research has explored its effects on opioid analgesia. We present data from a large sample of fibromyalgia patients assessing the effect of caffeine use in the presence and absence of opioid analgesics.

Methods:  962 patients (67% female) presenting to a tertiary pain clinic and meeting the 2011 American College of Rheumatology (ACR) survey criteria for fibromyalgia were included. Patients completed the Brief Pain Inventory (BPI), Hospital Anxiety and Depression Survey (HADS), PROMIS fatigue measure, pain catastrophizing scale, and Oswestry Disability Index (ODI). Consumption of caffeinated beverages and opioid analgesics was assessed using a dichotomous item: patients indicated “yes” or “no” to daily consumption. General linear models were used to determine effect of caffeine use on independent measures. Gender and smoking status differed in univariate analysis and were controlled for as covariates. Adjusted mean differences (x) (standard error) are reported. Analyses were performed with SPSS 22.

Results:  568 (59%) patients were on current opioid therapy (66% female) and 394 (41%) were not (67% female). In patients on opioid therapy, caffeine consumers had significantly lower pain severity [F= 4.3, p= .04, x= .33(.16)], pain interference [F= 8.1, p< .001, x= 0.5(0.2)], fatigue [F= 14.2, p< .001, x= 2.5(0.7)], depression [F= 5.2, p= .01, x= 1.0(0.4)], catastrophizing [F= 11.0, p< .001, x= 3.8(1.2)] and disability [F= 12.9, p< .001, x= 3.3(0.9)] compared to non-caffeine consumers. Anxiety did not differ between caffeine groups. In the opioid negative group, caffeine consumers reported significantly less fatigue than non-consumers [F= 5.3, p= .02, x= 2.0(0.9)]. No other measures differed significantly between caffeine consumers and non-consumers in patients not on opioid therapy.

Conclusion:  Fibromyalgia patients on opioid therapy that also use caffeine reported significantly lower symptoms compared to patients that do not consume caffeine. However, in patients not on opioid therapy, caffeine consumers don’t share the same benefits seen in subjects on opioid therapy. These results suggest that consumption of caffeine in conjunction with opioid analgesics could possibly provide therapeutic benefits not seen with opioids or caffeine alone. Further research is needed to assess caffeine’s adjuvant effects on opioid analgesics in chronic pain.


Disclosure: J. R. Scott, None; D. J. Clauw, None; C. M. Brummett, None; R. E. Harris, None; A. L. Hassett, None; S. E. Harte, None.

To cite this abstract in AMA style:

Scott JR, Clauw DJ, Brummett CM, Harris RE, Hassett AL, Harte SE. Influence of Caffeine on Opioid Analgesics in Fibromyalgia [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/influence-of-caffeine-on-opioid-analgesics-in-fibromyalgia/. Accessed January 16, 2021.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2016 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/influence-of-caffeine-on-opioid-analgesics-in-fibromyalgia/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.