ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 3206

Inflammation on MRI in Sacroiliac-Joints and Spine Is Longitudinally Related to Disease Activity in Male but Not in Female Patients with Axial Spondyloarthritis: 2-Year Data from the DESIR Cohort

Victoria Navarro-Compán1, Sofia Ramiro2, Robert B. M. Landewé3, Maxime Dougados4, Corinne Miceli-Richard5, Pascal Richette6 and Désirée van der Heijde7, 1Rheumatology, University Hospital La Paz, Madrid, Spain, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Amsterdam Rheumatology & Immunology Center, Academic Medical Center, Amsterdam, Netherlands, 4Université Paris René Descartes and Hôpital Cochin, Paris, France, 5Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, 6Université Paris Diderot, UFR médicale, Paris, France; APHP Hôpital Lariboisière, Fédération de Rhumatologie and Inserm U1132, Hôpital Lariboisière, Paris, France, 7Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: ,

Session Information

Date: Tuesday, November 10, 2015

Title: Spondylarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment: Clinical Aspects, Imaging and Biomarkers

Session Type: ACR Concurrent Abstract Session

Session Time: 4:30PM-6:00PM

Background/Purpose: In patients with axial
spondyloarthritis (axSpA), clinical disease activity measures (DA) have been
longitudinally related to radiographic progression. Interestingly, a gender
disparity has been observed in this relationship, but the reason for this is
unclear. Here, we
investigate whether such a gender disparity also exists with respect to the
relationship between DA and inflammatory lesions on magnetic resonance imaging
(MRI) of the sacroiliac joints (SI) and the spine.

Methods: Two-year follow-up data from 167 patients fulfilling
ASAS axSpA criteria in the DESIR cohort with at least two MRIs of SI and/or spine
available during this period were analyzed. Baseline characteristics of
patients included were: 50% males, mean (SD) age: 33 (9) years, 81% HLA-27
positive and symptom duration: 18 (11) months. The association between inflammatory
lesions on MRI of SI/spine (measured by SPARCC/Berlin score, respectively) and
DA (ASDAS, BASDAI, patient«s global disease activity, night pain, CRP and ESR)
was investigated using generalized estimating equation (GEE) models: i) a model
of absolute-scores; and ii) a model of change-scores. All models were adjusted
for age, symptom duration and HLA-B27.

Results: The relationship between inflammatory lesions
on MRI and DA was different in males than in females. MRI-scores of SI/spine
(i) were statistically significantly associated to most of the DA in males, but
not in females (Figure 1A&1B). In the model of changes (ii),  ASDAS was
significantly associated with inflammatory lesions on MRI of either SI (Fig 2A)
or spine (Fig 2B) in males, but not in females.  Similar effects were seen
with different DA measures.

Conclusion: In male, but not in female patients with
axSpA, clinical disease activity is longitudinally associated with inflammatory
lesions on MRI. This observation supports the hypothesis that some aspects of axSpA
are different in males compared to females.

Figure:
Longitudinal
relationship between clinical disease activity measures and inflammation degree
(SPARCC/Berlin) on MRI-SI/spine stratified for gender. Markers and surrounding
lines represent beta values and 95%CI, respectively.

 

 

 

 

Disclosure: V. Navarro-Compán, None; S. Ramiro, None; R. B. M. Landewé, None; M. Dougados, None; C. Miceli-Richard, None; P. Richette, None; D. van der Heijde, None.

To cite this abstract in AMA style:

Navarro-Compán V, Ramiro S, Landewé RBM, Dougados M, Miceli-Richard C, Richette P, van der Heijde D. Inflammation on MRI in Sacroiliac-Joints and Spine Is Longitudinally Related to Disease Activity in Male but Not in Female Patients with Axial Spondyloarthritis: 2-Year Data from the DESIR Cohort [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/inflammation-on-mri-in-sacroiliac-joints-and-spine-is-longitudinally-related-to-disease-activity-in-male-but-not-in-female-patients-with-axial-spondyloarthritis-2-year-data-from-the-desir-cohort/. Accessed .

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