Increased Post-Thrombotic Syndrome Is Unassociated with Anticoagulant Use in Vascular Behcet’s Disease

Fatma Alibaz-Oner¹, Belgin Aldag¹, Mustafa Aldag², Ali Ugur Unal¹, Aydan Mutiş³, Tayfur Toptas⁴, Tulin Ergun⁵ and Haner Direskeneli⁶, ¹Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey, ²Dr.Siyami Ersek Cardiovascular Surgery Hospital,, Istanbul, Turkey, ³Marmara University, School of Medicine, Rheumatology, ISTANBUL, Turkey, ⁴Marmara University, School of Medicine, Hematology, Istanbul, Turkey, ⁵Marmara University, School of Medicine, Dermatology, Istanbul, Turkey, ⁶Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Behcet's syndrome and vasculitis

Session Information

Date: Tuesday, November 15, 2016

Title: Vasculitis - Poster III: Rarer Vasculitides

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Deep venous thrombosis (DVT) is the most common form of vascular involvement in Behcet’s disease (BD). Chronic post-thrombotic syndrome (PTS) develops frequently in patients with DVT and is associated with impaired quality of life (QoL). However, factors associated with PTS and venous disease spesific QoL is unsufficiently explored in patients with VBD.

Methods: This study included 94 patients (Male/Female: 75/19) with VBD and 29 age and gender-matched individuals (Male/Female: 18/11) with DVT associated with non-BD causes. Villalta scale was used to assess PTS. Venous Disability Score (VDS) and Venous Clinical Severity Score (VCSS) were used for the assessment of venous disease. Venous disease-specific QoL was measured through Venous Insufficiency Epidemiological and Economic Study Quality of Life/Symptom questionnaire (VEINES-QoL/Sym). Behçet’s Syndrome Activity Score (BSAS) questionnaire was used to assess disease activity.

Results: A high presence of PTS (61.7%) was observed in VBD. The rate of anticoagulant usage was significantly lower (63% vs 100%, p=0.001), and the number of DVT attacks were significantly higher in VBD (1.6 vs 1.3, p=0.001) compared to non-BD. VEINES-QoL and VEINES-Sym VCSS were significantly worse in VBD patients with PTS when compared to patients without PTS. BSAS was also significantly higher in patients with PTS. An inverse correlation was observed between VEINES-QoL and BSAS in multivariate analysis (p=-0.551, p< 0.001). There were no differences between anticoagulant users and non-users regarding the presence of PTS (60.8% vs 63.3%) and scores of all venous assessment tools in VBD (p>0.05).

Conclusion: A high presence of PTS and impaired venous disease spesific QoL, symptom severity and venous disability scores were observed in VBD. Venous disease spesific QoL negatively correlated with general disease activity. Better control of disease activity might decrease development of PTS and improve venouse disease spesific QoL, however, any additional benefit of anticoagulant treatment on the development of PTS and venous QoL was not observed.

Disclosure: F. Alibaz-Oner, None; B. Aldag, None; M. Aldag, None; A. U. Unal, None; A. Mutiş, None; T. Toptas, None; T. Ergun, None; H. Direskeneli, None.

To cite this abstract in AMA style:

Alibaz-Oner F, Aldag B, Aldag M, Unal AU, Mutiş A, Toptas T, Ergun T, Direskeneli H. Increased Post-Thrombotic Syndrome Is Unassociated with Anticoagulant Use in Vascular Behcet’s Disease [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/increased-post-thrombotic-syndrome-is-unassociated-with-anticoagulant-use-in-vascular-behcets-disease/. Accessed .

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