ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2064

Increase in IL-31 Serum Level in Recent Onset Spondyloarthritis – Data from the DESIR Cohort

Nicolas Rosine Jr.1, Adrien Etcheto2, Anna Moltó3, Yassine Taoufik4, Houria Chavez4, Christian Roux5, Karine Briot5, Maxime Dougados6 and Corinne Miceli5, 1Rheumatology Department, Hôpital Kremlin Bicêtre, Paris, France, 2Rheumatology B, Rheumatology B Department, Paris-Descartes University, Cochin Hospital, Paris, France, 3Paris Descartes University, Rheumatology Department, Cochin Hospital, AP-HP. INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité,, Paris, France, 4Biologic Immunology, Hopital Bicetre, Université Paris Sud, AP-HP, Kremlin Bicetre, France, 5Rheumatology B Department, Hôpital Cochin, Paris, France, 6Rheumatology B Department,, Paris-Descartes University, APHP, Cochin Hospital, Paris, France

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: ,

Session Information

Date: Monday, November 9, 2015

Title: Spondylarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment: Clinical Aspects

Session Type: ACR Concurrent Abstract Session

Session Time: 2:30PM-4:00PM

Background/Purpose: IL-31 is a newly-described cytokine mainly produced by activated Th2 cells. IL-31 acts through IL31-RA and oncostatin heterodimeric receptors that activate STAT3 and STAT5. So far, IL31 has been mainly involved in airway hypersensitivity and atopic dermatitis. More recent data suggest its involvement in psoriasis and inflammatory bowel disease. We aimed to assess IL-31 serum levels in patients with recent onset axial spondyloarthritis (SpA).

Methods: The DESIR cohort is a prospective, multicenter French cohort of 708 patients with early inflammatory back pain (IBP) (duration >3 months and <3 years) suggestive of AxSpA (mean age 33.8 years; 53.8% women, 57% fulfilled the ASAS criteria). IL-31 and sCD40L were assessed using the multiplex and high sensitive 17-Plex ELISA (Bio-Plex Pro Human Cytokine 17-Plex Immunoassay, BioRad). Serum levels were assessed at baseline in 3 subgroups of patients: i. patients from the DESIR cohort fulfilling the ASAS criteria (ASAS + group, n=443); ii. IBP patients from the DESIR cohort not fulfilling the ASAS criteria (ASAS – group, n= 265); iii. Healthy controls age and sex-matched to a random sample of the DESIR cohort patients (control group, n=80).

Results: IL31 was significantly increased (p<0,001) in the ASAS+ group (median= 7.7 pg/ml ± 15.4, mean 12.6 pg/ml) and ASAS – group (median 6.3 pg/ml ± 16, mean = 11.3 pg/ml) compared to the control group (median=0.0±3.1, mean=1.1 pg/ml). IL31 was correlated with sCD40L(r=0.62; p<0.0001), with DKK-1 (r=0.27; p<0,001), and weakly with IFNg (r=0.12; p=0,016). Patients exhibiting a high level of IL31 had increased CRP (p=0.04), a mSASSS score <1: Yes 7.7 ± 10.7 versus No 13.02±15.07 (p=0.005), and a diagnosis of osteoporosis: Yes 14.1±16.7 versus No 10.7±13.6 (p=0.005). These results were confirmed in the multivariate analyses with a significant and independent association between IL31 and IFNg (p<0.0001), sCD40L (p<0.0001), DKK1 (p=0.02) serum levels, and osteoporosis (p=0.002).

Conclusion: IL31 serum levels are correlated with cytokines involved in a Th1 polarization. IL31 is also significantly correlated with the Wnt signaling inhibitory protein DKK-1 and associated with the osteoporotic phenotype of the patients. These preliminary results suggesting that IL31 might be involved in bone loss observed among SpA patients need to be confirmed in more severe forms of the disease.

Disclosure: N. Rosine Jr., None; A. Etcheto, None; A. Moltó, None; Y. Taoufik, None; H. Chavez, None; C. Roux, None; K. Briot, None; M. Dougados, None; C. Miceli, None.

To cite this abstract in AMA style:

Rosine N Jr., Etcheto A, Moltó A, Taoufik Y, Chavez H, Roux C, Briot K, Dougados M, Miceli C. Increase in IL-31 Serum Level in Recent Onset Spondyloarthritis – Data from the DESIR Cohort [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/increase-in-il-31-serum-level-in-recent-onset-spondyloarthritis-data-from-the-desir-cohort/. Accessed .

« Back to 2015 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/increase-in-il-31-serum-level-in-recent-onset-spondyloarthritis-data-from-the-desir-cohort/