ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 815

Incidence in Large Vessel GCA in Northern Italy during a 11-Year Period

Luigi Boiardi1, Giovanna Restuccia2, Pierluigi Macchioni3, Pamela Mancuso4, Mariagrazia Catanoso5, Francesco Muratore6, Filippo Crescentini1, Giulia Pazzola1, Nicolò Pipitone1 and Carlo Salvarani7, 1Rheumatology Unit, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy, 2Rheumatology Unitn, Arcispedale S Maria Nuova, IRCCS, 42100, Italy, 3Rheumatology, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy, 4Interinstitutional Epidemiology Unit, Azienda USL di Reggio Emilia (Local Health Authority) and Azienda Ospedaliera IRCCS di Reggio Emilia,, Reggio Emilia, Italy, 5Rheumatology Service, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, 6Rheumatology Unit, Arcispedale Santa Maria Nuova - IRCCS; Università di Modena e Reggio Emilia, Reggio Emilia, Italy, 7Rheumatology Unit, Arcispedale Santa Maria Nuova - IRCCS; Università di Modena e Reggio Emilia, Reggio-Emilia, Italy

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: ,

Session Information

Date: Sunday, November 5, 2017

Title: Vasculitis Poster I: Large Vessel Vasculitis

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: there are few studies regarding the incidence of large vessel GCA (LV GCA). Purpose: to investigate the incidence in patients diagnosed with large vessel GCA in the Reggio Emilia Area from 2005 through to 2016.

Methods: All patients with incident large vessel GCA diagnosed between 1 January 2005 and 31 December 2016 and living in the Reggio Emilia area, were identified by capture and re-capture checking of computerized discharge diagnosis codes (ICD10) and using outpatients databases from rheumatology, internal medicine, surgery, pathology, imaging departments of Reggio Emilia Hospital as well as by examining the Reggio Emilia district database for rare diseases. To be included in the study, patients must satisfy the following 2 criteria: Age at disease onset ≥ 50 years; evidence of large-vessel vasculitis by angiography, MRA, CTA, PET/CT and/or ultrasonography; we included in the study also patients associating biopsy proven gca to evidence of LVV at the imaging.

Results: There were 81 incident cases of LV GCA (57 women) during the 11-year study period; Mean ± SD age at diagnosis was 70 ± 9 years. Incidence per 100,000 persons aged ≥50 years was 3.38 (95% confidence interval [95% CI 2.69, 4.20]). Incidence was significantly higher in women (4.39 [95% CI 3.25, 5.53) than in men (2.19 [95% CI 1.31, 3.07]) (p <0.0036). Incidence rates significantly increased by 11.1% every 3 years from 2.86 (2005-2007) to 4.06 (2014-2016). The highest incidence in women and in man was observed in the 70–79 years age group (women 3.55 [95% CI 2.17,5.48; men 2,48 95% CI 1.24.,4.43).

Conclusion: The incidence of LV GCA in the Reggio Emilia area was 3.38 and it was lower than that of patients with biopsy proven GCA (5.8) (1); the incidence of LV GCA was signicantly higher in women as in biopsy proven GCA and increase during the follow-up period.

References

(1) Catanoso M, Macchioni P, Boiardi L, Muratore F, Restuccia G, Cavazza A, Pipitone N, Mancuso P, Luberto F, Salvarani C. Incidence, Prevalence, and Survival of Biopsy-Proven Giant Cell Arteritis in Northern Italy During a 26-Year Period. Arthritis Care Res (Hoboken). 2017 Mar;69(3):430-438

Disclosure: L. Boiardi, None; G. Restuccia, None; P. Macchioni, None; P. Mancuso, None; M. Catanoso, None; F. Muratore, None; F. Crescentini, None; G. Pazzola, None; N. Pipitone, None; C. Salvarani, None.

To cite this abstract in AMA style:

Boiardi L, Restuccia G, Macchioni P, Mancuso P, Catanoso M, Muratore F, Crescentini F, Pazzola G, Pipitone N, Salvarani C. Incidence in Large Vessel GCA in Northern Italy during a 11-Year Period [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/incidence-in-large-vessel-gca-in-northern-italy-during-a-11-year-period/. Accessed .

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