ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2793

IL35 Serum Level Is Decreased in Patients with Primary Sjogren Syndrome, Essentially in Patients with the More Active Disease Data from the French Prospective Assess Cohort

Olivier Fogel1, Raphaèle Seror2, Gaetane Nocturne3, Elodie Rivière4, Saida Boudaoud5, Jacques Gottenberg6, Véronique Le Guern7, Xavier Mariette8, Jean-Jacques Dubost9 and Corinne Miceli-Richard10, 1INSERM U1012, Paris Sud University, Le Kremlin Bicêtre, France, 2Rheumatology, AP-HP Bicêtre Hospital / Paris-Sud University, Le Kremlin-Bicêtre, France, 3INSERM U1012, Université Paris Sud, Le Kremlin Bicêtre, France, 4Unité INSERM 1184 Université Paris Sud, le Kremlin Bicetre, France, 5INSERM U1012 - Université Paris XI, Le Kremlin Bicêtre, France, 6Hautepierre, Strasbourg, France, 7National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 8Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, 9Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, 10Rheumatology, Hôpitaux Paris Sud & INSERM U1184, Le Kremlin Bicêtre, France

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: ,

Session Information

Date: Tuesday, November 10, 2015

Title: Sjögren's Syndrome: Translational Insights into Sjögren's Syndrome

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Primary Sjögren’s Syndrome (pSS) is an autoimmune disease mediated by B-cells as evidenced by the occurrence of non-Hodgkin lymphoma and increased B-cell markers in salivary glands and serum of pSS patients. Interleukin 35 (IL35) is a new anti-inflammatory and immunosuppressive cytokine secreted by B-regulatory cells that could play a major role in controlling autoimmune diseases. We decided to study the link between IL35 and disease activity in pSS patients.

Methods: IL35 serum level was quantified using an ELISA kit (BioLegend®) on 385 patients from the French multicentric pSS ASSESS cohort and 50 healthy controls. The difference in IL35 serum level between patients and controls was assessed using a Mann Whitney test. The association between IL35 level and several subsets of patients was assessed using a chi-square test. IL35 high level has been defined as the upper quarter of cytokine level in ASSESS cohort.

Results: IL35 serum level was significantly decreased in pSS patients compared to healthy controls (p=0.0001, mean 7.31 [5.75-8.82] ng/ml and 8.66 [4.45-12.86] ng/ml, respectively). Within the cohort, we observed a higher proportion of patients with low disease activity defined by an ESSDAI score <5 in the group with high level of IL35 compared to those with low level of IL35 (72% and 60%, respectively; p=0.05). We observed that 99% of patients with high serum levels of IL35 did not developed lymphoma versus93% in the group with low IL35 (p=0.03).

Conclusion: This study suggests that the level of the immunosuppressive cytokine IL35, usually secreted by regulatory B cells and plasma cells, is decreased in the serum of patients with pSS and essentially in patients with the more active disease. Further studies in pSS on regulatory B cells and plasma cells as well as in animal models of autoimmune diseases assessing the effect of recombinant IL35, would help to decipher whether this regulatory cytokine could be of interest for future therapeutic approaches.

Disclosure: O. Fogel, None; R. Seror, None; G. Nocturne, None; E. Rivière, None; S. Boudaoud, None; J. Gottenberg, None; V. Le Guern, None; X. Mariette, None; J. J. Dubost, None; C. Miceli-Richard, None.

To cite this abstract in AMA style:

Fogel O, Seror R, Nocturne G, Rivière E, Boudaoud S, Gottenberg J, Le Guern V, Mariette X, Dubost JJ, Miceli-Richard C. IL35 Serum Level Is Decreased in Patients with Primary Sjogren Syndrome, Essentially in Patients with the More Active Disease Data from the French Prospective Assess Cohort [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/il35-serum-level-is-decreased-in-patients-with-primary-sjogren-syndrome-essentially-in-patients-with-the-more-active-disease-data-from-the-french-prospective-assess-cohort/. Accessed .

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